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All Journal The Journal of Experimental Life Sciences (JELS) Journal of Educational, Health and Community Psychology Journal of Biomedicine and Translational Research AlphaMath: Journal of Mathematics Education Biomedical Journal of Indonesia Jurnal Medik Veteriner Manuju : Malahayati Nursing Journal Majalah Patologi Indonesia JURNAL AKUNTANSI KEUANGAN DAN MANAJEMEN Jurnal Ilmiah Wahana Pendidikan Journal of Community Development Jurnal Abdi Masyarakat Indonesia GANESHA MEDICINA Makara Journal of Science Jurnal Pijar : Studi Manajemen dan Bisnis Jurnal Fisioterapi dan Kesehatan Indonesia Innovative: Journal Of Social Science Research Riset Informasi Kesehatan Jurnal Penyakit Dalam Indonesia Indonesian Journal of Agricultural, Resource and Environmental Economics Metathesis: Journal of English Language, Literature, and Teaching Policy Brief Pertanian, Kelautan, dan Biosains Tropika Journal of Business Application Observasi: Jurnal Publikasi Ilmu Psikologi Journal of Career and Entrepreneurship International Health Sciences Journal Afeksi: Jurnal Psikologi Kajian Ilmiah Mahasiswa Administrasi Publik (KIMAP) CJPP
Dewi Sukmawati
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Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Proteksi Kombinasi Minyak Wijen dan α-tocopherol Terhadap Glomerular Injury Melalui Penghambatan Stres Oksidatif Tikus Hiperkolesterolemia Sukmawati, Dewi
The Journal of Experimental Life Science Vol. 3 No. 2 (2013)
Publisher : Graduate School, Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1330.4 KB) | DOI: 10.21776/ub.jels.2013.003.02.04

Abstract

Minyak wijen (MW) kaya akan polyunsaturated fatty acid (PUFA) terutama linoleat yang diketahui dapat menurunkan kadar lipid dalam darah. Namun, salah satu kelemahan PUFA sebagai hipolipidemik adalah cenderung mudah untuk teroksidasi karena struktur ikatan rangkapnya. Vitamin E (α-tocopherol) diketahui dapat melindungi struktur PUFA terhadap oksidasi serta dapat menghambat stres oksidatif. Peningkatan stres oksidatif pada hiperkolesterolemia diduga kuat berperan penting dalam patogenesa glomerular injury. Tujuan penelitian ini untuk membuktikan bahwa penambahan α-tocopherol pada minyak wijen mempunyai efek sinergis dalam mencegah glomerular injury melalui penurunan stres oksidatif. Penelitian ini menggunakan Rattus novergicus strain Wistar jantan (200 g) yang dibagi menjadi tujuh kelompok masing - masing 4 ekor, kelompok hiperkolesterol (HK), kelompok ke-2, ke-3 dan ke-4 adalah kelompok HK + MW (dosis masing-masing 0,3; 0,6, dan 1,2 ml), sedangkan kelompok ke-5, ke-6 dan ke-7 adalah kelompok  HK + MW (dosis masing - masing 0.3, 0.6 dan 1.2 ml) + α-tochopherol 20 mg). Pengukuruan kadar kolesterol total, Low Density Lipoprotein (LDL), ureum dan kreatinin darah dilakukan pada minggu ke-10. Aktivitas stres oksidatif jaringan ginjal diukur dari kadar malondialdehide (MDA) menggunakan uji thiobarbituric acid (TBA) dan kadar superoxyde dismutase (SOD) jaringan dengan uji Nitroblue tetrazolium (NBT). Pemeriksaan histologis dilakukan untuk melihat deposit matriks dan jumlah sel mesangial pada glomerulus dengan pengecatan  Periodic Acids Schiff (PAS). Hasil penelitian ini menunjukkan adanya perbedaan bermakna penurunan kadar MDA antara kelompok MW dengan MW + α-tocopherol pada dosis 0.3 (p = 0.000) dan 0.6ml (p = 0.001) yang menunjukkan interaksi sinergistik MW + α-tocopherol serta kecenderungan penurunan kadar SOD. Terdapat dugaan interaksi secara potensiasi dengan penambahan α-tocopherol pada minyak wijen terhadap penurunan kadar kolesterol total dan LDL. Gambar  histologis glomerular injury menunjukkan bahwa kombinasi  MW + α-tocopherol dapat menghambat peningkatan jumlah sel (p = 0.000) dan matriks mesangial (p = 0.614). Hasil ini menunjukkan bahwa penambahan α-tochopherol pada minyak wijen mempunyai efek yang lebih baik dibanding minyak wijen sendiri dalam menghambat glomerular injury melalui penghambatan stres oksidatif di jaringan ginjal secara sinergis. Kata kunci: α-tocopherol, glomerular injury, minyak wijen, stres oksidatif.
Intermittent hypobaric hypoxia induces oxidative stress and vascular remodeling in rat pulmonary arteries Ardi, Sri Nurbowo; Putra, Muhammad Arza; Sukmawati, Dewi; Wuyung, Puspita Eka; Mulyawan, Wawan; Wardaya; Wiyono, Wiwien Heru
Jurnal Medik Veteriner Vol. 9 No. 1 (2026): April
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jmv.vol9.iss1.2026.29-40

Abstract

Flight crews frequently experience intermittent hypobaric hypoxia (IHH), which may trigger oxidative stress and vascular remodeling in the pulmonary arteries. This study investigated the effects of IHH exposure on oxidative stress markers, tunica media thickness, and the expression of LR11 and HIF-1α proteins in rat pulmonary arteries using five groups of healthy male Sprague–Dawley rats (n = 5 per group). Twenty-five male Sprague–Dawley rats were divided into five groups: a control group and four treatment groups exposed to simulated altitudes of 25,000 ft (7,620 m) for 5 minutes per day over 1, 3, 7, or 14 days. Levels of HIF-1α and LR11 were measured using ELISA, oxidative stress markers such as γ-glutamyl-cysteinyl-glycine (GSH) and malondialdehyde (MDA) were analyzed spectrophotometrically, and tunica media thickness was assessed histologically. HIF-1α levels peaked after acute hypoxia exposure and declined with prolonged exposure, whereas LR11 levels progressively increased, peaking in the 14-day group. MDA levels, reflecting oxidative stress, were highest after 3 days of exposure, while GSH levels decreased in all hypoxia groups compared with the control. Histological analysis showed the greatest tunica media thickness in the 3-day exposure group, followed by gradual reductions. Although no statistically significant correlations were found between protein levels and tunica media thickness, similar directional trends suggest biologically relevant associations. Intermittent hypobaric hypoxia (IHH) induces dynamic changes in oxidative stress and vascular remodeling in rat pulmonary arteries. Acute hypoxia increases HIF-1α expression and oxidative stress, whereas repeated exposures appear to trigger compensatory adaptations, including LR11 upregulation and tunica media remodeling. These findings demonstrate measurable molecular and structural alterations underlying pulmonary vascular responses to repeated high-altitude exposure.
Co-Authors Afina Aurellya Kamal Aqilah, Nayra Ardi, Sri Nurbowo Ardiansyah, Rangga Arizal Hamizar Arleni Bustami Aulya, Yenny Ayu Made Ratna Dewi, Ida Ayun, Tresya Hesi Qurrata Azwar, Herlyssa Barasila, Atikah Chalida Biantara, I Dewa Gede Bagus Cecilia Syifa Citra Shabira Davi Abdulloh Haidzam Dwi Anita Suryandari Erbi, Mesa Taja Izza Jannati Fadhillah, Muhamad Rizqy Falatehan, Citra Shabira Farlikhatun, Lili Febriana Catur Iswanti Gani, Adamas Rizky Ghaniyyatul Khudri Gumelar Adhimandala, Dwiki Cacala Hanifah Harita, Adiwignya Nugraha Widhi Hartanti, Retno Heri Wibowo Indrawanto, Mochammad Fahrin Izzati, Indah Nur Jaelan Usman, Jaelan Jeanne A. Pawitan Junaidi Junaidi Khatimah, Mutiara Khusnul Khatimah, Nurul Gusti Kusmardi Kusmardi Kusnanda, Raniah Ratna Brillianti Laila Hayati, Laila Lindawati Kartika Luh Komang Widnyani Wulan Laksmi Luluk Yunaini Maharani, Cynthia Wulan Maharani, Sofya Devi Mega Sylvia Dewi Meita Santi Budiani, Meita Santi Mone, Ansyari Muhammad Luthfi Multazam, Arvy Yanasta Mulyana, Phonny Aditiawan Nindyantoro Nurhidayati, Asti OKTAVIANA, MIMBAR Olievia Prabandini Mulyana, Olievia Prabandini Pajar Pratama, Galuh Puspita Eka Wuyung Putra, Muhammad Arza Putri, Ellyana Ilsan Eka Rahayu Puji Haryanti Raniswati, Sholekhania Novita Ria Kodariah Safrudin Safrudin Salsabila, Hanum Santosa, Rizky Putra Shabira, Citra Siauta, Jenny Anna Sri Mulyeni Sri Sukamti, Sri Sukmawati, Rizda Yuli Suprapto, Mariana Nadhira Yuli Syah, Onke Alvin Syahroni, Vika Yulian Tangke, Diar Muzna Trian Maulana, Trian Triana, Novi Ubaydillah, Haliza Ihza Umi Anugerah Izzati, Umi Anugerah Wanasurya , Deasy Febriyanti Wardaya Wardhana, Diva Ayu Wawaimuli Arozal Wawan Mulyawan Widyastutik Wiwien Heru Wiyono Yuda Nabella Prameswari Yuni Putri Yustisi Yunia Dwie Nurchayanie Yunus Indra Purnama, Yunus Indra Zaskiyanti, Alifah Anggellia