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All Journal Jurnal Gizi dan Pangan Jurnal Anestesiologi Indonesia JURNAL GIZI INDONESIA Jurnal Kedokteran Diponegoro Journal of Nutrition College Jurnal Kesehatan Masyarakat Media Ilmu Keolahragaan Indonesia Jurnal Keolahragaan Journal of Biomedicine and Translational Research JURNAL PENDIDIKAN KEPERAWATAN INDONESIA GIZI INDONESIA JOURNAL SPORT AREA Indonesian Journal of Medicine Jurnal Ilmu Keperawatan Komunitas Jurnal Health Sains Diponegoro International Medical Journal (DIMJ) Jurnal Locus Penelitian dan Pengabdian Jurnal Kebidanan dan Keperawatan Aisyiyah JHeS (Journal of Health Studies) Eduvest - Journal of Universal Studies JSSF : Journal of Sport Science and Fitness
Hardhono Susanto
Jurusan Bagian Anatomi Fakultas Kedokteran Universitas Diponegoro
Aerospace Engineering Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Education Electrical & Electronics Engineering Environmental Science Health Professions Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Low sEng Level in Preeclampsia with MFTHFR Gene Polymorphism Suggesting a Protective Factor Pramono, M. Besari Adi; Faradz, Sultana MH; Suhartono, Suhartono; Susanto, Hardhono; Rachmawati, Banundari; Pramono, Noor
Journal of Biomedicine and Translational Research Vol 11, No 3 (2025): December 2025
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v11i3.29375

Abstract

Background: Preeclampsia is one of the most serious complications of pregnancy and the leading cause of maternal and fetal mortality. Various studies have shown that Glutathione Peroxidase (GPx) deficiency and increased Soluble endoglin (sEng) level are consistently associated with the incidence of preeclampsia. Several studies also show the role of MTHFR A1298C and C677T gene polymorphisms in preeclampsia.Objective: This study investigated association between blood GPx, sEng levels, MTHFR A1298C and C677T gene polymorphisms in Preeclampsia.Methods: This analytic observational case-control study was conducted on 70 cases of preeclampsia and 70 controls. Blood GPx and sEng levels were measured using Enzyme Linked Immunosorbent Assay (ELISA). MTHFR A1298C and C677T gene polymorphism was genotyped using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP). The data obtained were analyzed using the Mann-Whitney U test, chi-square test, and independent T-test.Results: There were no significant differences in GPx levels or MTHFR A1298C/C677T genotype distribution between groups. sEng levels were significantly higher in the preeclampsia group than controls (p=0.001). ROC analysis identified a cut-off of 7.75 ng/mL. Among preeclampsia patients, those with the MTHFR 1298AC/CC genotypes had lower sEng levels than wildtype (p=0.027), suggesting a potential protective effect. No association was found for C677T.Conclusion: We found no significant difference in GPx level, MTHFR A1298C and C677T gene polymorphism between preeclampsia and control group. Soluble endoglin (sEng) level in the preeclampsia group (mean: 11.0±5.22) were significantly different (p=0.001) compared to the control group (mean: 8.1±5.31). Increased level of sEng is associated with incidence of preeclampsia. A key finding in this study is the significantly lower sEng levels observed in preeclampsia patients carrying the MTHFR 1298AC and 1298CC alleles compared to the control group (p=0.027). This indicates a protective factor where in preeclampsia with MTHFR gene alleles 1298AC and 1298CC sEng levels are lower compared to wildtype.
The Effect of Tactile – Kinesthetic Stimulation on Bone Mineralization, Osteocalcin Levels and Body Height Among Stunting Children Aged 6-11 Months Sutarmi, Sutarmi; Susanto, Hardhono; Mexitalia, Maria; Medise, Bernie
Jurnal Pendidikan Keperawatan Indonesia Vol 10, No 1 (2024): Volume 10, Nomor 1, Juni 2024
Publisher : Universitas Pendidikan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17509/jpki.v10i1.71210

Abstract

Introduction: Stunting is growth faltering caused by as poor nutrition, recurrent infections, a lack of psychosocial stimulation. Growth faltering is associated to bone growth disorder.  In order to prevent and overcome stunting not only nutrition but also an adequate stimulation is needed. Objective: This study looked at the effects of tactile–kinesthetic stimulation on bone mineralization, osteocalcin levels and body height among stunting children. Methods: Eighty (80) stunting children (mean of age 8 ± 1,71) were randomly assigned into two groups. Tactile–Kinesthetic Stimulation (TKS) was administrated by trained parents twice daily for three months in the intervention group. The control group was given a routine care of stunting program from public health center. The bone mineralization (osteocalcin serum) and length of body in both groups were measured at enrollment and after week twelve. Results: During three (3) months TKS period, the intervention group had a significant increment in length and osteocalcin serum compared to control group (p 0.005) at 3.17 cm and 11.5 ng/ml respectively. Moreover, this study also showed that providing TKS demonstrated a strong correlation in a positive direction to length. The TKS treatment could increase the body height of stunting children by 86.5%. There was a positive correlation among osteocalcin levels, intake of vitamin A, protein and calcium on improving length (p0.05). Conclusion: TKS was significantly effective in promoting bone mineralization particularly osteocalcin levels and length among stunting children. There was also a strong correlation that TKS could elevate the length of 0.865-times. 
DETERMINANTS OF QUALITY OF LIFE OF LOW BACK PAIN PATIENTS Julianti, Hari Peni; Hadisaputro, Soeharyo; Susanto, Hardhono; Tulaar, Angela Bibiana Maria; Athaya, Arina Rezky
Jurnal Kedokteran Diponegoro (Diponegoro Medical Journal) Vol 15, No 3 (2026): JURNAL KEDOKTERAN DIPONEGORO (DIPONEGORO MEDICAL JOURNAL)
Publisher : Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v15i3.54310

Abstract

Background: Low back pain (LBP) is a common condition that leads to significant physical and mental health challenges worldwide. It is the primary contributor to years lived with disability (YLDs) and adversely affects quality of life (QoL). In Indonesia, there is a lack of research on the factors affecting QoL among patients with LBP. Objective:  This study aims to investigate the factors that influence the QoL of LBP patients at William Booth Hospital in Semarang, Indonesia. Methods: An analytic observational study with a cross-sectional design was conducted from July to August 2023, involving 95 LBP patients. Data were collected using questionnaires, including the SF-36v1 for QoL assessment. The data were analyzed using chi-square tests and binary logistic regression to identify significant determinants. Results:  The study found that 82.1% of respondents reported poor physical health, while 87.4% indicated good mental health. Factors such as older age, subacute to chronic LBP, severe pain, low education levels, and dependency in daily living activities significantly impacted the physical health domains. No significant associations were observed between QoL and gender, BMI, or occupational risk. Severe pain and limited independence in daily tasks emerged as critical determinants of reduced QoL. Conclusion: The findings emphasize the need for targeted interventions, such as pain management, rehabilitation programs, and educational initiatives, to enhance the QoL of LBP patients—especially among older adults and those with low education levels. These measures are essential to reduce the socioeconomic burden of LBP in Indonesia.
Nutrition intake, insulin-like growth factor-1 hormone levels, somatotype score, and strength performance of adolescent athletes Zetta, Adelia Paradya; Susanto, Hardhono; Noer, Etika Ratna; Muniroh, Muflihatul; Widyastiti, Nyoman Suci
Journal Sport Area Vol 9 No 3 (2024): December
Publisher : UIR Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25299/sportarea.2024.vol9(3).17017

Abstract

Background Problems: Currently, there is still limited identification of nutritional intake, hormonal, and physical performance in adolescent athletes in Indonesia. Research Objectives: This study aims to identify anthropometric, nutritional intake, IGF-1 hormone level, and adolescent athletes’s performance. Methods: The research method used a cross-sectional study. A convenient sample of 58 athletes under Balai Pemusatan Pendidikan dan Latihan Pelajar. The research instrument used Bioelectrical Impedance Analysis (BIA), leg dynamometer, hand grip dynamometer, tape measure, height stature, SQ-FFQ Form, and body fat caliper. Blood samples were collected and tested by a professional laboratory. Data analysis techniques used Pearson’s test for normally distributed data and Spearman’s rank for non-normally distributed data. Findings and Results: The result of this study found a significant (p < 0.05) correlation between energy intake, anthropometric measurement of z score (BMI/Age), and endomorph score with an athlete’s muscle strength. We also found significant differences (p < 0.05) in macronutrient and micronutrient consumption in male and female athletes, and we also found significant differences in somatotype score and muscle strength in male and female athletes. Conclusion: We conclude that many athletes are not consuming the recommended levels of carbohydrates, fat, protein, and some micronutrients. We found a correlation between energy intake and fat intake with leg muscle strength. However, there was no correlation between IGF-1 hormone levels and athlete strength. Intake is thought to indirectly affect grip strength and leg strength.
Co-Authors Abdul Hakam Adriyan Pramono Agus Subagio Ahmad Zainuddin Ajoekesoema, Tanti Ali Rosidi Anak Agung Gede Sugianthara Anindita Soetadji Anjani, Gemala Annastasia Ediati Aria Nurahman Hendra Kusuma Arie Nugroho, Arie Arulita Ika Fibriana Athaya, Arina Rezky Bahrudin Bahrudin Banundari Rachmawati Baskoro, Adhi Gunawan Crisdayani, Carissa Putri Deny Yudi Fitranti Dewi, Ni Putu Puspita Adhytiarini Diana Nur Afifah, Diana Nur Djuara P Lubis Dwi Pudjonarko Dwiantoro, Luky Esri Rusminingsih - Etika Ratna Noer Hari Peni Julianti Ign. Riwanto Ignatius Riwanto, Ignatius Iqlima Safitri, Iqlima Iriyanti Harun Kurniawati, Yovie Kusman Ibrahim M. Besari Adi Pramono, M. Besari Adi Mahalul Azam Maria Mexitalia Martha Irene Kartasurya Medise, Bernie Meidiana Dwidiyanti Miftahul Adnan Mohammad Zen Rahfiludin Muhammad Hatta Muniroh, Muflihatul Neni Susilaningsih Noor Pramono Nur Amin, Nur Nurahmatika, Prisma Nyoman Suci Widyastiti Prawara, Ananta Sidhi Radityo Prakoso Rahfilludin, M. Zen Rahima Rahima Rostika Flora Rr. Sri Ratna Rahayu S.Pd. M Kes I Ketut Sudiana . Satyagraha, Muhammad Thifan Sefri Noventi Sofia Setyarsih, Liani Siti Baitul Mukarromah Soeharyo Hadisaputro Solly Aryza Suhartono SUKENDRO SUKENDRO, SUKENDRO Sultana MH Faradz Sumardi Widodo Supriyadi Supriyadi Sutarmi, Sutarmi Syaravina, Elita SyarofilAnam, Moh. Tandiyo Rahayu Tulaar, Angela B. M. Tulaar, Angela Bibiana Maria Udin Bahrudin, Udin Ummu Muntamah Untung Sujianto Wibowo, Judiono Widiastuti Samekto Widyastuti, Trioni Yance Anas Yuswo Supatmo Zetta, Adelia Paradya