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Journal : Journal of Global Pharma Technology

ND3 Mitochondrial Polimorphism G-10399-A and C-10401-T Significantly Associated with Elevated Serum 8-OHDG Concentration and Increased Risk of Malignant Behavior in Breast Cancer Wayan Tianing
Journal of Global Pharma Technology .
Publisher : Journal of Global Pharma Technology

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Abstract

Introduction: ND3¬ gene polymorphisms had been associated with the risk of breast cancer. However, it association with cancer cell behavior and progression is yet to be evaluated and thus this research evaluate the relationship between ND3 gene polymorphisms with 8-OHdG concentration that represent oxidative DNA damage and with the risk of malignant cancer behavior. Method: A case-control study was conducted in Faculty of Medicine Udayana University and Sanglah General Hospital from January to December 2016. The case group was defined as sample with lymph vascular invasion and histological grade III. The blood samples were obtained to evaluate the polymorphism and serum 8-OHdG concentration. The polymorphisms were detected using PCR and sequencing while serum 8-OHdG concentration was determined using ELISA. Result: 70 subjects were enrolled in this study with 35 samples for each group. Increased serum 8-OHdG were associated with the presence of ND3 polymorphism [375.37±203.56ng/mL in wild type vs 610.65±271.9ng/mL (G-10399-A) and 636.18±287.75ng/mL (C-10401-T); p<0.05] and the number of polymorphism [391.45±210.97ng/mL for no polymorphism vs 487.52±227.18ng/mL in one polymorphism and 861.36±253.27ng/mL for two polymorphism; p<0.05]. Finally, the presence of polymorphism increased the risk of more malignant cancer behavior (OR: 4.792; 95%CI: 1.741 – 13.188). Conclusion: G-10399-A and C-10401-T ND3 polymorphism clearly increased oxidative DNA damage and the risk of malignant cancer behavior in breast cancer patients.Keywords: ND3 gene polymorphism G-10399-A and C-10401-T, 8-OHdG, malignant behavior, breast cancer
Co-Authors - Daryono A A Ngurah Wisnu Prayana A.A Arista Shinta Adhitya, I Putu Gde Surya Adiniti, Ni Made Wulan Handayani Adiniti Agung Wiwiek Indrayani Alit Triwahyuni Anak Agung Gede Angga Puspa Negara Anak Agung Gede Eka Septian Utama Antari, Ni Komang Ayu Juni Ari Wibawa Ari Wibawa Aria Wibawa Aryaning Dwi Antyesti Awan Setya Dewanta Ayunindya, Dewa Ayu Agung Megaretha Bagas Dwi Raharjo Catarina Budi P CHOIRUL ANWAR Crisanty, Putu Aristya Deasy Virka Sari Desak Made Dewi Mahayuni Desak Nyoman Puspa Indah Saraswati Desak Putu Mirah Sawitri Dessyta Luxsmadewi Aryadhe Dewa Ayu Diah Agung Maheswari Dewa Putu Gede Purwa Samatra Dewi, Anak Ayu Nyoman Trisna Narta Dewi, Kadek Ayu Rosita Dwitia Putri, Thania Dyah Pradnyaparmita Duarsa Fayza Angelica Mupti Gede Parta Kinandana Gede Parta Kinandana Grady Daniel I Dewa Ayu Inten Dwi Primayanti I Dewa Ayu Inten Dwi Primayanti I Dewa Putu Sutjana I Gusti Ayu Artini I Gusti Ayu Mega Purwani I Gusti Ayu Wiratni I Gusti Bagus Ari Pradnyana Putra I Made Hardi Wira Dharma I Made Krisna Dinata I Made Muliarta I MADE MULIARTA . I Made Niko Winaya I Made Winarsa Ruma I Nyoman Adi Putra I Nyoman Mangku Karmaya I Putu Adiartha Griadhi I Putu Gede Adiatmika I Putu Mahendra Putra I Putu Mahendra Putra I Putu Yudi Pramana Putra I Wayan Gede Sutadarma I Wayan Reinaisen Kertiyasa Bumi Ida Ayu Dewi Wiryanthini Ida Bagus Komang Ari Krisnayana Ihsan, Muammar Indah Pramita Indira Vidiari Juhanna Indira Vidiari Juhanna Indraswari, I Dewa Ayu Agung Friska Putri J. A. Pangkahila Juniantari, Ni Komang Ayu Kadek Dwi Pradnya Lestari Kadek Meitri Ariyantini Kadek Trimayunika Julia Kadek Yowanda Pangestu Kamayoga, I Dewa Gede Alit Ketut Mascita Hening Pratiwi Ketut Trisandy Kurniawati, , Ida Luh Ita Mahendrayani Luh Made Indah Sri Handari Adiputra Luh Made Nia Sari Devi Luh Putu Ratna Sundari Luh Putu Ratna Sundari M Widnyana M. Ali Imron M. Irfan Made Eva Nata Putri Made Hendra Satria Nugraha Made Intan Swandari Made Niko Winaya Made Risma Caesar Witayanti Made Wahyu Cahyadi Made Widnyana Melin Natalia L Mezzi Wulandari Arenza Muammar Ihsan Muh. Irfan Mutiah Munawarah Nacha Najabilubaba Ni Kadek Yuni Fridayani Ni Ketut Dewita Putri Ni Koman Gorin Sabatini Ni Komang Ayu Juni Antari Ni Komang Mega Junianti Ni Luh Nopi Andayani Ni Luh Putu Gita Karunia Saraswati Ni Nyoman Ayu Dewi Ni Nyoman Ayu Dewi Ni Nyoman Ayu Dewi Ni Nyoman Jesica Salsabilla Maharani Ni Putu Ayu Dika Utami Ni Putu Dwi Larashati Ni Wayan Sri Wahyuni Sri Wahyuni Nila Wahyuni Nila Wahyuni Nitaya Putri Nur Hidayat Nyoman Harry Nugraha Pande Komang Indra Pramadewa Pradnyani, Tjokorda Istri Agung Rosanthi Putra, I Putu Yudi Pramana Putu Aditya Mahardika Putu Arnaya Aryataka Putu Ayu Sita Saraswati Putu Dita Rastiti Putu Rian Pradhiva Putu Sutha Nurmawan R. A.T. Kuswardhani S. Indra Lesmana S. Indra Lesmana S. Indra Lesmana Sawitri, Anak Agung Sagung Sayu Aryantari Putri Thanaya Sherly Lena Waromi Sugijanto - Susy Purnawati Sutha Nurmawan Syahmirza Indra Lesmana Thanaya, Sayu Aryantari Putri Trisnarini, Silviya Anindhita Valerie, Regina Vidya Rahmayunissa Swandi Putri Vimala Krishna Prasada Virny Dwiya Lestari Vittala, Govinda Wahyuddin Wahyuddin, Wahyuddin Wahyuni Novianti, I Gusti Ayu Sri