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Journal : Medicina

IDENTIFICATION OF G10398A VARIAN OF ND3 GENE MITHOCONDRIA DNA IN BREAST CANCER PATIENT Tianing, Ni Wayan
Medicina Vol 43 No 3 (2012): September 2012
Publisher : Medicina

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Abstract

ND3  gene is a mitochondria DNA gene which code for NADH dehydrogenase enzime, part of complex 1  respiratory  chain  oxidation  and  involved  in  phosphorilation  prosess  to  synthesize ATP  (Adenosin Triphosphat). The present of G10398A variant at mtDNA result in changing the amino acid code for alanine (GCC) to threonine (ACC). This changing induce elevation the ROS (Reactive Oxygen Species) concentration in mitochondria. ROS can cause oxidation of DNA, mutation of DNA,oxidative stress and cancer. The other effect of ROS can affect redox-cycling estrogen metabolism. Individual   with G10398A variant has   60% risk for breast cancer.  The purpose of this research are to identify G10398A variant and its proportion in ND3 gene with non experimental descriptive method within 32 samples and 5 control. This research has done with sequence of steps with an isolation and total DNA amplification electrophoresis, sequencing and analysis by comparing with gene bank.  This research identify G10399A variant that causes changing code from serine (AGC) amino acid in to asparagines (AAC) in 16 samples. Another variant found in this research is C10401T variant the cause changing in codon that code from arginin (CGA) in to triptopan (TGA) within 14 samples. In the control groups 2 samples identify with G10399A variant, 2 samples with C10401T and 1 control match like gene-bank. For this research, ND3 gene homology that was amplified found in the average of  96%.
Co-Authors - Daryono A A Ngurah Wisnu Prayana A.A Arista Shinta Adhitya, I Putu Gde Surya Adiniti, Ni Made Wulan Handayani Adiniti Agung Wiwiek Indrayani Alit Triwahyuni Anak Agung Gede Angga Puspa Negara Anak Agung Gede Eka Septian Utama Antari, Ni Komang Ayu Juni Ari Wibawa Ari Wibawa Aria Wibawa Aryaning Dwi Antyesti Awan Setya Dewanta Ayunindya, Dewa Ayu Agung Megaretha Bagas Dwi Raharjo Catarina Budi P CHOIRUL ANWAR Crisanty, Putu Aristya Deasy Virka Sari Desak Made Dewi Mahayuni Desak Nyoman Puspa Indah Saraswati Desak Putu Mirah Sawitri Dessyta Luxsmadewi Aryadhe Dewa Ayu Diah Agung Maheswari Dewa Putu Gede Purwa Samatra Dewi, Anak Ayu Nyoman Trisna Narta Dewi, Kadek Ayu Rosita Dwitia Putri, Thania Dyah Pradnyaparmita Duarsa Fayza Angelica Mupti Gede Parta Kinandana Gede Parta Kinandana Grady Daniel I Dewa Ayu Inten Dwi Primayanti I Dewa Ayu Inten Dwi Primayanti I Dewa Putu Sutjana I Gusti Ayu Artini I Gusti Ayu Mega Purwani I Gusti Ayu Wiratni I Gusti Bagus Ari Pradnyana Putra I Made Hardi Wira Dharma I Made Krisna Dinata I Made Muliarta I MADE MULIARTA . I Made Niko Winaya I Made Winarsa Ruma I Nyoman Adi Putra I Nyoman Mangku Karmaya I Putu Adiartha Griadhi I Putu Gede Adiatmika I Putu Mahendra Putra I Putu Mahendra Putra I Putu Yudi Pramana Putra I Wayan Gede Sutadarma I Wayan Reinaisen Kertiyasa Bumi Ida Ayu Dewi Wiryanthini Ida Bagus Komang Ari Krisnayana Ihsan, Muammar Indah Pramita Indira Vidiari Juhanna Indira Vidiari Juhanna Indraswari, I Dewa Ayu Agung Friska Putri J. A. Pangkahila Juniantari, Ni Komang Ayu Kadek Dwi Pradnya Lestari Kadek Meitri Ariyantini Kadek Trimayunika Julia Kadek Yowanda Pangestu Kamayoga, I Dewa Gede Alit Ketut Mascita Hening Pratiwi Ketut Trisandy Kurniawati, , Ida Luh Ita Mahendrayani Luh Made Indah Sri Handari Adiputra Luh Made Nia Sari Devi Luh Putu Ratna Sundari Luh Putu Ratna Sundari M Widnyana M. Ali Imron M. Irfan Made Eva Nata Putri Made Hendra Satria Nugraha Made Intan Swandari Made Niko Winaya Made Risma Caesar Witayanti Made Wahyu Cahyadi Made Widnyana Melin Natalia L Mezzi Wulandari Arenza Muammar Ihsan Muh. Irfan Mutiah Munawarah Nacha Najabilubaba Ni Kadek Yuni Fridayani Ni Ketut Dewita Putri Ni Koman Gorin Sabatini Ni Komang Ayu Juni Antari Ni Komang Mega Junianti Ni Luh Nopi Andayani Ni Luh Putu Gita Karunia Saraswati Ni Nyoman Ayu Dewi Ni Nyoman Ayu Dewi Ni Nyoman Ayu Dewi Ni Nyoman Jesica Salsabilla Maharani Ni Putu Ayu Dika Utami Ni Putu Dwi Larashati Ni Wayan Sri Wahyuni Sri Wahyuni Nila Wahyuni Nila Wahyuni Nitaya Putri Nur Hidayat Nyoman Harry Nugraha Pande Komang Indra Pramadewa Pradnyani, Tjokorda Istri Agung Rosanthi Putra, I Putu Yudi Pramana Putu Aditya Mahardika Putu Arnaya Aryataka Putu Ayu Sita Saraswati Putu Dita Rastiti Putu Rian Pradhiva Putu Sutha Nurmawan R. A.T. Kuswardhani S. Indra Lesmana S. Indra Lesmana S. Indra Lesmana Sawitri, Anak Agung Sagung Sayu Aryantari Putri Thanaya Sherly Lena Waromi Sugijanto - Susy Purnawati Sutha Nurmawan Syahmirza Indra Lesmana Thanaya, Sayu Aryantari Putri Trisnarini, Silviya Anindhita Valerie, Regina Vidya Rahmayunissa Swandi Putri Vimala Krishna Prasada Virny Dwiya Lestari Vittala, Govinda Wahyuddin Wahyuddin, Wahyuddin Wahyuni Novianti, I Gusti Ayu Sri