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All Journal Farmasains : Jurnal Farmasi dan Ilmu Kesehatan Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) Jurnal Farmasi Klinik Indonesia Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Sainstech Farma: Jurnal Ilmu Kefarmasian Jurnal Pengabdian Masyarakat (ABDIRA) Journal of Innovation Research and Knowledge Jurnal Farmasi Indonesia Journal of Research in Pharmacy and Pharmaceutical Sciences Medical Sains : Jurnal Ilmiah Kefarmasian Jurnal Sains dan Kesehatan Jurnal Serina Abdimas Berita Biologi
Annisa Farida Muti
Universitas Pembangunan Nasional Veteran Jakarta
Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Uji Teratogenik Air Rebusan Mie Instan Selama Masa Kehamilan Mencit Betina (Mus musculus L.) Melalui Pengamatan Kelainan Morfologi Fetus: Teratogenic Test of Instant Noodle Water During the Pregnancy of Female Mice (Mus musculus L.) through Observation of Fetus Morphological Disorder Sister Sianturi; Annisa Farida Muti; Moh. Benny Perdana
Jurnal Sains dan Kesehatan Vol. 2 No. 3 (2020): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v2i3.140

Abstract

Indonesia is one of the second ranked countries in the world consuming the most instant noodles. This product is liked by all people, especially pregnant women, so research is needed to determine the effect of consumption of instant noodles on fetal development. This study uses mice as a test animal. The purpose of this study was to determine the teratogenic effects of instant noodle cooking water on pregnant mice (Mus musculus L.) concentrations of 30%, 50%, and 70% based on morphological observations of fetal mice during pregnancy. This research is experimental with a completely randomized design (CRD) method using 60 experimental female mice in pregnancy divided into 10 groups, 1 group was given aquadest as a control group and 9 groups were given instant noodle cooking water in 3 different brands with a concentration of 30% , 50%, and 70% given on the 6th day of pregnancy until the 15th day of pregnancy. Then on the 18th day female mice were sacrificed by dislocation of the neck to see the teratogenic effects based on morphology in the fetus. The results of the statistical test showed that there were differences in the average number of dead fetuses in each group (p = 0.05), differences in body weight (p = 0.0001), and body length (p = 0.0001) and found one fetuses that experience cleftpalate or abnormalities in the palate of the fetus of mice in the treatment of instant noodle boiled water concentration of 70%
COMPARING ANTIMICROBIAL EFFICACY OF DIFFERENT HAND SANITIZERS IN PSEUDOMONAS AERUGINOSA AND STAPHYLOCOCCUS AUREUS Ramdhan, Zeashafa Zafira; Roqayyah; Salma Ika Rahmadani; Nasyia Qaanita; Anggita Virginia Naulina Manurung; Tirta Fitri Aryani; Nafis Ikhwana; Anggita Cahya Ningrum; Nasywa Dwi Ayu; Afdhal Raziq Hanania; Deskia Amanda Fitriyani; Kharazi Farand Vitonova; Pradana, Dhigna Luthfiyani Citra; Rahmi, Eldiza Puji; Muti, Annisa Farida
Journal of Research in Pharmacy and Pharmaceutical Sciences Vol 3 No 1 (2024): Vol.3 No.1 JUNI (2024)
Publisher : Pharmacy Program, Faculty of Medicine, UPN Veteran Jakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jrpps.v2i2.7017

Abstract

Human activities every day have a lot of physical contact with the environment, this can cause various kinds of diseases. These diseases can come from various types of microorganisms such as bacteria, fungi and viruses. Examples of bacteria that can cause disease are Escherichia coli and Staphylococcus aureus. Escherichia coli and Staphylococcus aureus are Gram-positive and Gram-negative bacteria that most commonly cause diarrhoea. To avoid these bacteria, humans need to wash their hands using soap and clean running water. However, washing hands cannot be done every time and in every place. Therefore, there is an innovation of hand sanitizer without using running water, namely hand sanitizer. Hand sanitizer is a waterless hand sanitizer innovation that contains antiseptic substances. Hand sanitizer works as an antibacterial in inhibiting and even killing bacteria. Antiseptics are chemical compounds used to inhibit or kill microorganisms in living tissue. The purpose of using antiseptics is to inhibit or kill bacteria by inhibiting bacterial enzymes and reducing the permeability of bacterial cell membranes through bacterial precipitation, oxidation, and halogenation. Antiseptics usually contain alcohol, chlorhexidine, and anilides. Antiseptics that are widely used in the medical world are antiseptics with alcohol content based on the ability of alcohol to kill bacteria.
Synergistic Effect Antibacterial Activity of The Combination of Andaliman (Zanthoxylum acanthopodium DC) Fruit Essential Oil and Erythromycin against Streptococcus mutans and Streptococcus pyogenes : Efek Sinergisme Aktivitas Antibakteri Kombinasi Minyak Atsiri Buah Andaliman (Zanthoxylum acanthopodium DC) dan Eritromisin terhadap Streptococcus mutans dan Streptococcus pyogenes Situmorang, Vania Clarissha; Rahmi, Eldiza Puji; Pradana, Dhigna Luthfiyani Citra; Septama, Abdi Wira; Muti, Annisa Farida
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 10 No. 2 (2024): (October 2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2024.v10.i2.16977

Abstract

Background: The concept of synergism is one of the approaches taken to combat the problems related to antibiotic resistance. Objectives: The goal of this study was to determine the synergistic effect of the antibacterial activity of a combination of essential oil of Zanthoxylum acanthopodium DC fruit and erythromycin against Streptococcus mutans and Streptococcus pyogenes. Methods: The broth microdilution assay was used to determine the Minimum Inhibitory Concentration (MIC) of Z. acanthpodium DC fruit essential oil and erythromycin. The synergistic effects were assessed using the checkerboard method. Results: MIC value of Z. acanthopodium DC fruit essential oil against both bacteria was 2500 mg/mL. The combination of Z. acanthopodium DC fruit essential oil and erythromycin had a synergistic effect against S. mutans and S. pyogenes with fractional inhibitory concentration index (FICI) values of 0.375 and 0.0872, respectively. Conclusions: These results suggest that a combination of herbal plants and conventional antibiotics could be used as an alternative therapy for bacterial infections.
Edukasi Pemanfaatan Tanaman Obat Indonesia untuk Penyakit Degeneratif di Meruyung-Depok Rahmi, Eldiza Puji; Muti, Annisa Farida; Revina, Rika; Citra Pradana, Dhigna Luthfiyani
Jurnal Pengabdian Masyarakat (ABDIRA) Vol 5, No 1 (2025): Abdira, Januari
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/abdira.v5i1.564

Abstract

Currently, degenerative diseases have become a problem for every country throughout the world, including Indonesia. The use of medicinal plants in the surrounding area to prevent degenerative diseases is one strategy to improve public health. This Community Service Activity aims to educate the public in recognizing and utilizing medicinal plants to prevent degenerative diseases. This activity was carried out at the UPNVJ Meruyung Housing Complex, Depok. The method used was community education through counseling by providing explanations about degenerative diseases, conducting socialization of types of medicinal plants, their benefits and applications, in addition the level of knowledge of participants was also measured using questionnaires for pre- and post-tests. This activity was attended by the community, especially women at the UPNVJ Meruyung Depok Housing Complex. The results of the activity provided knowledge about degenerative diseases and the use of Indonesian medicinal plants for degenerative diseases. The knowledge and understanding of the community about degenerative diseases and recognizing and utilizing medicinal plants increased significantly (p 0.001) after the activity by 61.36%.
Penghambat SGLT-2 untuk Menurunkan Tekanan Darah dan Albuminuria pada Diabetes Melitus Tipe 2 dengan Hipertensi: Sebuah Telaah Sistematik Azzahra, Fatimah; Muti, Annisa Farida; Dewi, Suzy Yusna; Herardi, Ryan
Indonesian Journal of Clinical Pharmacy Vol 13, No 1 (2024)
Publisher : Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15416/ijcp.2024.13.1.45

Abstract

Hipertensi pada pasien diabetes melitus (DM) tipe 2 sebagai penyakit komorbid berpotensi meningkatkan risiko mortalitas, morbiditas, dan disabilitas. Penghambat SGLT-2 merupakan golongan obat antidiabetik lini ke-2 yang diindikasikan pada pasien dengan penyakit kardiovaskular aterosklerotik, penyakit ginjal kronik dengan catatan laju filtrasi glomerulus (LFG) >60 ml/menit, risiko rentan hipoglikemia, serta masalah peningkatan berat badan. Penghambat SGLT-2 terbukti memiliki efek positif terhadap tekanan darah dan albuminuria. Studi ini bertujuan untuk menilai pengaruh penghambat SGLT-2 pada tekanan darah dan albuminuria pasien DM tipe 2 yang juga menderita hipertensi. Studi ini merupakan tinjauan pustaka sistematis dengan basis data yang digunakan untuk pencarian artikel adalah PubMed, ScienceDirect, Google Scholar, dan EBSCOhost dengan tetap menyesuaikan kriteria eksklusi dan kriteria inklusi, yakni artikel penelitian dengan subjek pasien DM tipe 2 dengan hipertensi. Literatur yang diperoleh kemudian diseleksi menggunakan metode PRISMA 2020 dan dievaluasi kualitasnya menggunakan JBI Critical Appraisal Tools sesuai dengan desain penelitian studi yang ada. Dari hasil seleksi, ditemukan tujuh artikel yang memenuhi kriteria. Sebagian besar penelitian yang mengkaji pengaruh penghambat SGLT-2 terhadap tekanan darah menunjukkan hasil yang signifikan, dengan empat dari enam penelitian mendukung temuan tersebut. Di sisi lain, hanya satu dari dua penelitian yang mengkaji pengaruh SGLT-2 inhibitor terhadap albuminuria yang menunjukkan hasil signifikan. Jenis penghambat SGLT-2 yang digunakan dalam penelitian tersebut antara lain canagliflozin, empagliflozin, dan dapagliflozin dengan canagliflozin terbukti memberikan hasil yang paling signifikan baik pada albuminuria maupun tekanan darah. Secara keseluruhan, penghambat SGLT-2 terbukti dapat menurunkan tekanan darah dan albuminuria, yang dapat menjadi pertimbangan dalam terapi kombinasi untuk pasien DM tipe 2 dengan hipertensi.
Analysis of Potential Drug-drug Interactions in Liver Cirrhosis Patients: Analisis Interaksi Obat-obat Potensial pada Pasien Sirosis Hati Muti, Annisa Farida; Anindya, Chanica
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 7 No. 1 (2021): (March 2021)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2021.v7.i1.15148

Abstract

Background: Patients with liver cirrhosis are at a high risk of drug interactions due to the use of multi-drug combination regimens. Objectives: This study analyzed potential drug-drug interactions in the liver cirrhosis patients at Gatot Soebroto Army Hospital, Jakarta in 2016. Material and Methods: This study employed an observational-cross sectional design with retrospective data collection of liver cirrhosis patients' medical records. The data of potential drug-drug interactions were identified using Drug Interaction Facts 2012 including the mechanism type, the severity and the onset of drug interactions. Results: As many as 88% of the liver cirrhosis patients experienced potential drug-drug interactions with a total of 35 cases. The highest proportions of the cases were found in the pharmacokinetic mechanism by approximately 25 cases (71.43%), minor severity comprising 29 cases (82.86%) and rapid onset by 19 cases (54.29%). The highest potential drug-drug interactions were furosemide-propranolol combination in 16 cases (45.72%). Conclusions: The high incidence of potential drug interactions in patients with liver cirrhosis requires high vigilance and close monitoring of all health professionals in achieving optimal therapeutic outcomes for the patients.
AKTIVITAS ANTIKANKER EKSTRAK n-HEKSANA DAN EKSTRAK METANOL HERBA PACAR AIR (Impatiens balsamina Linn) TERHADAP SEL KANKER PAYUDARA T47D Rahmawati, Emma; Sukardiman, Sukardiman; Muti, Annisa Farida
Media Farmasi: Jurnal Ilmu Farmasi Vol. 10 No. 2: September 2013
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/mf.v10i2.1172

Abstract

Pacar Air (Impatiens balsamina Linn.) adalah tanaman yang berfungsi sebagai antikanker, antiinflamasi, antirematik, analgesik, emenagog, dan dapat melunakkan benjolan yang keras (tumor). Tujuan penelitian ini adalah untuk menguji aktivitas antikanker ekstrak n-heksana dan metanol dari herba pacar air terhadap sel kanker payudara T47D secara in vitro dengan metode MTT (microculture tetrazolium salt). Herba pacar air dikatakan memiliki aktivitasnya dilihat dari jumlah sel hidup yang telah diujikan terhadap sel kanker payudara (sel T47D) dengan metode MTT dalam rentang waktu 24 jam setelah pemberian konsentrasi larutan uji kemudian ditentukan harga IC50 dengan menggunakanprobit analysis. Ekstrak n-heksan memiliki harga IC50 97,493 µg/ml sehingga dikatakan moderate aktif terhadap sel kanker payudara T47D. Sedangkan ekstrak metanol memiliki harga IC50 295,359 µg/ml. Hasil uji KLT terbukti adanya kandungan flavonoid dan steroid.
AKTIVITAS ANTIBAKTERI ANTOSIANIN DAUN UNGU (GRAPTOPHYLLUM PICTUM L. GRIFF) TERHADAP STAPHYLOCOCCUS AUREUS DAN PENGEMBANGANNYA DALAM SEDIAAN GEL ANTI JERAWAT Revina, Rika; Rifkia, Via; Annisa Farida Muti
Journal of Innovation Research and Knowledge Vol. 5 No. 5 (2025): Oktober 2025
Publisher : Bajang Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Penelitian ini bertujuan untuk mengisolasi dan mengevaluasi aktivitas antibakteri antosianin dari daun ungu (Graptophyllum pictum L. Griff) terhadap Staphylococcus aureus serta melakukan formulasi ke dalam sediaan gel antijerawat. Isolasi antosianin dilakukan secara maserasi menggunakan pelarut metanol-HCl dan diidentifikasi menggunakan Kromatografi Lapis Tipis (KLT) dengan hasil nilai Rf sebesar 0,38. Aktivitas antibakteri diukur menggunakan metode difusi cakram terhadap S. aureus, menunjukkan zona hambat signifikan yang meningkat secara dosis-respons, di mana konsentrasi 100% menghasilkan diameter hambat 17,27 mm (kuat). Sediaan gel antijerawat antosianin memiliki karakteristik fisik yang baik dengan pH 5,6, viskositas 190455,5 cP, dan daya sebar 48,62 mm. Hasil ini menunjukkan antosianin daun ungu layak dikembangkan sebagai bahan aktif antibakteri dalam sediaan topikal, dengan efektivitas dan karakter fisik yang relevan jika dibandingkan referensi sejenis. Pemanfaatan bahan alami ini juga merupakan solusi alternatif menghadapi masalah resistensi antibiotik pada terapi jerawat.
PENDAMPINGAN KADER KESEHATAN KECAMATAN CINERE DEPOK DALAM UPAYA MENCEGAH STUNTING DENGAN METODE CARA BELAJAR INSAN AKTIF Pradana, Dhigna Luthfiyani Citra; Sartika, Luthfiah Dewi; Rahmi, Eldiza Puji; Muti, Annisa Farida; Syarifah, Andiri Niza; Ilmi, Primayanti Nurul
Jurnal Serina Abdimas Vol 1 No 4 (2023): Jurnal Serina Abdimas
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat Universitas Tarumanagara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24912/jsa.v1i4.28336

Abstract

Malnutrition in children who are stunted occurs from the baby in the womb to after birth or commonly called the First 1,000 Days of Life (HPK). Stunting prevention is more effective than stunting treatment. Therefore, the purpose of this community service is to assist health cadres of Cinere sub-district in preventing stunting. The method used in this community service is education on how to learn active people and participants are given pre-test and post-test. The activeness of community service participants is expected to make it easier to understand stunting prevention education by seeing and discussing vitamins and minerals needed in stunting prevention. The results of community service were followed by 113 people divided into 4 villages in Cinere District, Depok City. Most of the participants were mothers so that information and implementation of stunting prevention could be seen immediately. There was a significant difference of 0.000 between pretest and posttest values analyzed using the Wilcoxon test on SPSS. The results of the pre-test and post-test assessments, attitudes and understanding of health cadres in Cinere sub-district increased by an average of around 87, so it can be assumed that the participants had understood the educational material for stunting prevention in Cinere sub-district, Depok city. Kekurangan gizi pada anak yang mengalami stunting terjadi sejak bayi dalam kandungan hingga setelah lahir atau biasa disebut 1.000 Hari Pertama Kehidupan (HPK). Pencegahan stunting lebih efektif dibandingkan pengobatan stunting. Oleh karena itu tujuan dari pengabdian masyarakat ini adalah untuk mendampingi kader Kesehatan kecamatan cinere dalam mencegah kejadian stunting. Metode yang digunakan dalam pengabdian masyarakat ini yaitu edukasi cara belajar insan aktif serta para peserta diberikan pre-test dan post-test. Keaktifan para peserta pengabdian masyarakat diharapkan dapat memudahkan untuk memahami edukasi pencegahan stunting dengan melihat serta mendiskusikan vitamin dan mineral yang dibutuhkan dalam pencegahan stunting. Hasil pengabdian masyarakat diikuti 113 orang yang terbagi menjadi 4 kelurahan di Kecamatan Cinere Kota Depok. Sebagian besar peserta adalah seorang ibu sehingga informasi dan penerapan pencegahan stunting langsung dapat dilihat hasilnya. Terdapat perbedaan yang signifikan 0,000 antara nilai pretest dan posttest yang dianalisis menggunakan uji Wilcoxon pada SPSS. Hasil penilaian pre-test dan post-test sikap dan pemahaman kader kesehatan di Kecamatan Cinere meningkat rata-rata sekitar 88 sehingga dapat diasumsikan bahwa para peserta telah paham materi edukasi pencegahan stunting di kecamatan cinere kota depok.
EFFECT OF SOLVENT TYPE ON THE PHYTOCHEMICAL CONTENT AND THE SPECIFIC AND NON-SPECIFIC PARAMETERS OF JOMBANG (Taraxacum officinale) LEAF EXTRACTS Syafriana, Vilya; Azzahra, Hudia Akmalia; Vasya, Zahra Ifany; Subaryanti, Subaryanti; Muti, Annisa Farida
Berita Biologi Vol 24 No 1 (2025): Berita Biologi
Publisher : BRIN Publishing (Penerbit BRIN)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/berita_biologi.2025.8979

Abstract

Jombang (Taraxacum officinale) is a wild plant commonly used by the Javanese as a traditional medicine. This study aimed to perform phytochemical screening and analyze both specific and non-specific characteristics of Jombang leaf extracts obtained using four different solvents: ethyl acetate, 80% ethanol, 50% ethanol, and aqueous. Specific parameters included sample identity and organoleptic properties, while non-specific parameters covered drying loss, specific gravity, ash content, and water content. All tests refer to the Indonesian Materia Medika and the Indonesian Herbal Pharmacopeia as standards for medicinal plants. The phytochemical content of each extract varied, with tannins present in all four extracts. Flavonoids were not found in the 80% ethanol extract. Steroids were detected in both the ethyl acetate and aqueous extracts, while triterpenoids and alkaloids were present only in the ethanol extracts. Saponins were found in the 50% ethanol and aqueous extracts. Non-specific characteristics showed that the organic solvent extracts met the drying loss requirement of no more than 11%, whereas the aqueous extract exceeded this limit with a value of 13.72%. The specific gravity of the four extracts ranged between 0.04 and 0.10 g/mL, and the water content of all extracts met the standards, not exceeding 10%. Meanwhile, the ash content of the 80% ethanol extract did not meet the requirement as it exceeded 8.5%, while the other three extracts fulfilled the standards.
Co-Authors Abdi Wira Septama Adia, Risa Afdhal Raziq Hanania Alhaque, Nitya Fithra Salsabila Alya Andina Dasuki Anggita Cahya Ningrum Anggita Virginia Naulina Manurung Anindya, Chanica Asri Yani Azzahra, Hudia Akmalia Deskia Amanda Fitriyani Dhigna Luthfiyani Citra Pradana Dian Mega Sugiyarto Emma Rahmawati Emma Rahmawati Fatimah Azzahra Hany Yusmaini Kharazi Farand Vitonova Moh. Benny Perdana Nafis Ikhwana Nasyia Qaanita Nasywa Dwi Ayu Nurul Octavia Primayanti Nurul Ilmi Pritha Maya Savitri Rahmawati, Emma Rahmi, Eldiza Puji Ramdhan, Zeashafa Zafira Refdanita Refdanita Revina, Rika Rifkia, Via Roqayyah Ryan Herardi Salma Ika Rahmadani Sartika, Luthfiah Dewi Sister Sianturi Situmorang, Vania Clarissha Subaryanti, Subaryanti Sukardiman Syarifah, Andiri Niza Tirta Fitri Aryani Vasya, Zahra Ifany Veronica Anggelita Putri Yanti Harjono Hadiwiardjo