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All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. Jurnal Kebidanan Althea Medical Journal Indonesian Journal of Tropical and Infectious Disease Majalah Obstetri dan Ginekologi Public Health of Indonesia Jurnal Ilmiah Kedokteran Wijaya Kusuma Jurnal Penelitian Kesehatan Suara Forikes Health Notions Jurnal Keperawatan Muhammadiyah Amerta Nutrition Care : Jurnal Ilmiah Ilmu Kesehatan Jurnal Pendidikan Kedokteran Indonesia: The Indonesian Journal of Medical Education JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga JURNAL ILMIAH OBSGIN : Jurnal Ilmiah Ilmu Kebidanan & Kandungan NURSING UPDATE JURNAL ILMIAH ILMU KEPERAWATAN Majalah Biomorfologi (Biomorphology Journal) Indian Journal of Forensic Medicine & Toxicology Jurnal Abdi Masyarakat Indonesia Asian Journal of Health Research Strada Jurnal Ilmiah Kesehatan (SJIK) JURNAL KEPERAWATAN Folia Medica Indonesiana
Hermanto Tri Joewono
Department Of Obstetrics And Gynecology, Faculty Of Medicine, Airlangga University
Humanities Biochemistry, Genetics & Molecular Biology Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Journal : Jurnal Kebidanan

 1 
Number of Glia Cells in the Cerebrum and Cerebellum of Newborn Rats After Administration of Mackerel Fish Oil During Pregnancy Nur Cholila; Widjiati Widjiati; Hermanto Tri Joewono
Jurnal Kebidanan Vol 13, No 1 (2024): February 2024
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/jk.13.1.2024.35-40

Abstract

Omega 3 intake during pregnancy can support fetal brain growth and development. Omega 3 plays an important role in making neuron cell membranes and glia and protecting nerve cells. Mackerel is a source of omega 3 which is abundant and easily accessible to the people of Indonesia. The purpose of this study was to analyze the effect of mackerel oil intake on the number of glial cells (astrocytes, oligodendrocytes, and microglia) of the cerebrum and cerebellum of newborn rats. This research was a true experimental design with a post-test only control group. A total of 30 pregnant rats were randomized into 3 groups, namely the control group (K1), mackerel oil (K2), and omega 3 supplements (K3). Each group was given treatment on days 1-17 of pregnancy. On the 18th day, the termination was carried out. 3 newborn rats were taken from each parent and made preparations from brain tissue. Hematoxylin-Eosin test to assess the number of glial cells. The results showed the highest mean±SD number of glial cells (astrocytes, oligodendrocytes, and microglia) in the cerebrum and cerebellum was the highest in the mackerel oil group (174,460±33,777; 21,080±6,937; 11,300±2,090), and (156,280 ±34,980; 22,260±4,302; 11,060±2,383). ANOVA test showed a significant difference in the number of glial cells in the cerebrum and cerebellum between groups with a p-value <0.05. The results of this study can be concluded that the administration of mackerel oil during pregnancy can increase the number of glial cells (astrocytes, oligodendrocytes, and microglia) in the cerebrum and cerebellum of newborn rats.
The Ratio of Bax And Bcl-2 in the Cerebrum of Newborn Rattus Novergius Given Mackerel Oil During Pregnancy Mikra Latisfian; Widjiati Widjiati; Hermanto Tri Joewono; Siti Nur Kholifah; Ali Medina
Jurnal Kebidanan Vol 12, No 2 (2023): August 2023
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/jk.12.2.2023.177-186

Abstract

The quality of a nation is determined by nutritional intake during pregnancy. Pregnancy is the right time to prepare the brain's potential optimally, one of which is the intake of mackerel oil which is rich in omega-3. Omega-3 fatty acids can stimulate gene expression and nerve activity, increase synaptogenesis and neurogenesis, and prevent apoptosis. This study aims to analyze the intake of mackerel oil during pregnancy to the ratio of Bcl-2 / Bax in the cerebrum. This research is a true experiment with a posttest-only control group design. 30 pregnant Rattus norvegicus mothers aged 2-3 months were divided into 3 groups, namely the control group (K), the mackerel fish oil group (P1), and the omega-3 supplement group (P2). This research was conducted at the Experimental Animal Cages and Pathology Laboratory, Faculty of Veterinary Medicine, Airlangga University. The mean Bcl-2 / Bax cerebrum ratio was 1.127 ± 0.342 (K), 3.928 ± 1.984 (P1), and 2.526 ± 1.122 (P2). The ANOVA test on the Bcl-2 / Bax ratio in the cerebrum showed a significant difference with a p-value of 0.000. The Bcl-2 / Bax ratio in the cerebrum of Rattus norvegicus newborns treated with mackerel oil on Rattus norvegicus mothers during pregnancy showed higher results than the other groups.
Effect of Mackerel Oil During Pregnancy on Synapsin Expression in Newborn Rattus Novergius Cerebrum Siti Nur Kholifah; Widjiati Widjiati; Hermanto Tri Joewono; Ali Medina; Mikra Latisfian
Jurnal Kebidanan Vol 12, No 2 (2023): August 2023
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/jk.12.2.2023.169-176

Abstract

The increase in the number of cells indicates a good synapse function, so that it can be linked to human intelligence. The rapid rate of synaptogenesis, myelination occurs in the first 1000 days of life. The public has not realized the importance of nutrition during pregnancy which contributes to the intelligence of the baby that will be born later. One of them is mackerel oil which contains omega 3. This study aims to analyze the effect of mackerel oil during pregnancy on synapsin expression in the cerebrum. This type of research is true experimental with a posttest-only control group design. The research samples were 30 pregnant Rattus norvegicus mothers aged 2-3 months. The 3 groups were randomly divided namely the control group (K1), the mackerel fish oil treatment group (K2), and the treatment group who were given omega-3 supplements (K3). This research was conducted at the Experimental Animal Cages and Pathology Laboratory, Faculty of Veterinary Medicine, Airlangga University. ANOVA test results on synapsin expression in the cerebrum showed that there was a significant difference with a p-value of 0.000. Synapsin expression in the cerebrum of newborn Rattus norvegicus which was given mackerel oil in the mother of Rattus norvegicus during pregnancy showed higher results than other groups.
Effect of Administration of Mackerel Oil During Pregnancy on the Expression of Brain Derived Neurotrophic Factor (BDNF) in the Cerebrum of Newborn Mice Sofiyanti Miftakhurohmah; Widjiati Widjiati; Hermanto Tri Joewono
Jurnal Kebidanan Vol 13, No 1 (2024): February 2024
Publisher : Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26714/jk.13.1.2024.67-72

Abstract

Omega 3 contained in mackerel oil extract is an important constituent of neuron cell walls and the raw material for building fetal brain cells. DHA and EPA in omega 3 regulate BDNF synthesis through a p38-MAPK dependent mechanism. BDNF has a role in regulating cell survival and programming cell death (apoptosis) in the brain. This study aims to determine the effect of giving mackerel oil during pregnancy on BDNF expression in the cerebrum of newborn rats. Posttest research design only control group with true experimental type. A sample of 30 rats with 10 each per group. The first group was the control group (K), the second group was mackerel oil (P1), and the third group was omega 3 supplements (P2). BDNF expression examination methods with immunohistochemistry. The data were analyzed analytically with ANOVA and continued with post hoc LSD. There was a significant difference in the expression of BDNF cerebral newborn rats between groups with a value of p = 0.000 (2.780 ± 0.52 in the control group, 3.670 ± 0.36 in the mackerel oil group, and 3.670 ± 0.45 in the omega 3 supplement group ) . The conclusion of this study was that the group given mackerel oil extract had a higher BDNF cerebral expression than the other groups.
Co-Authors , Ernawati Abdullah, Aya Ali Achmad Zam Zam Aghasy Agnes Krisylva Agus Sulistyono Agustina Hidayati Agustina Mar&#039;atus Sholichah Ahmed, Samar A. A. Al-Qadhi, Tasnim Mohammed Aldika Akbar, Muhammad Ilham Ali Madinah Ali Medina Ali Medina Ali, Lamia A. S. Almothana, Hebah H. M. Alselwi, Sarah A. D. Alsoufi, Fardous G. Amila, Ukhti Mukminah ilmi Amishinta, Ancha Ayu Amishinta, Ancha Ayu Anas, Jimmy Yanuar Ancha Ayu Amishinta Andita Hapsari Andriani, Linda Aprilawati, Dwi Askandar Tjokroprawiro Ayu Putri Yani Bachnas, Muhammad Adrianes Binta Dwi Novitasari Chandra, Cecilia Felicia Dedi Kuswandi Dessy Hidayati Fajrin Diana Estu Rumahastuti Dwi Budi Santoso Dwi Nurdi Puspita Sari Dwi Puji Wijayanti Ecccita Raheestyningtyas Eka Fitriani Sujitno Eka Nasrur Maulana Eko Budi Koendhori, Eko Budi Ernawati Ernawati Esti Nugraheny Fajrin, Dessy Hidayati Fitria Desky Frisilia Octaviana Yolanda Gatut Hardianto, Gatut Hafiza Amadhin Rusti Hajj, Suha Ali Al Harry Mangasi Binsar Panjaitan Hasan, Helmia Henky Mohammad Masteryanto HERAWATI, LILIK Herlina Alvianti N Herlina Puji Angesti Herman, Sriyana Heryana, Achmad Yuniari Jihanifa Hega Salsabiila Jimmy Yanuar Anas Khanisyah Erza Gumilar Khasanah, Rima Nur Laksana, Muhammad Ardian Cahya Margarita Maramis, Margarita Maria Inge Lusida Martono Tri Utomo Mikra Latisfian Mikra Latisfian Mikra Latisfian Mohammed, Haitham T. S. Muhammad Adrianes Bachnas Muhammad Miftahussurur Muhdi, Nalini Nabeel Usama Okbah Nareswari Imanadha Cininta Marcianora Naura Ega Kahayani Ningrum, Nyna Puspa Nur Cholila Nur Laila Faizah Nurvy Alief Aidillah Nyna Puspa Ningrum Okta Margarita Susiana Pamarga Priyambodo Pitria Permatasari Pudji Lestari PUNGKY MULAWARDHANA, PUNGKY Raheestyningtyas, Ecccita Rejeki, Purwo Sri Risa Etika, Risa Sabrina Kemala Hapsari Sakina Samsriyaningsih Handayani Siti Nur Kholifah Siti Nur Kholifah Siti Nur Kholifah Sofiyanti Miftakhurohmah Sonea Venugopal Sulistiawati Sulistiawati Sulistiawati Sulistiawati Tanadi, Melina Rosita Thabet, Habib Thabit, Riyadh A. S. Ucik Nurul Hidayati Ukhti Mukminah ilmi Amila Ummah, Fithriyah Cholifatul Wardhana, Manggala Pasca Wati, Yunita Kholilaili Saras Widati Fatmaningrum Widjiati Widjiati w Widjiati Widjiati Widjiati Widjiati Widjiati Widjiati Widjiati Widjiati Widjiati Widjiati Widjiati Widjiati Widjiati Widjiati Widjiati Widjiati Widjiati Widjiati Widjiati Widjiati, Widjiati Widjiati, DR Widjiati, DR Windhu Purnomo Wironegoro, Rio Yaner, Nurul Ramadhani Yanti Yanti Yasyviena Za’ima Elnabila Yulia Putri Permatasari Zumroh Hasanah