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All Journal Prosiding Seminar Nasional Sains Dan Teknologi Fakultas Teknik As-syifaa Jurnal Farmasi Adi Widya : Jurnal Pengabdian Masyarakat Journal of Dedicators Community JPSCR : Journal of Pharmaceutical Science and Clinical Research Jurnal Farmasi Indonesia Journal Syifa Sciences and Clinical Research (JSSCR) Jurnal Biomedika Cendekia Journal of Pharmacy CERATA Jurnal Ilmu Farmasi Jurnal Analis Farmasi Abdimas UNWAHAS : Jurnal Pengabdian Masyarakat UNWAHAS Jurnal Farmasi Jurnal Farmasi dan Sains Indonesia (JFSI) Jurnal Pengabdian kepada Masyarakat JAF (Jurnal Analis Farmasi) Medical Sains : Jurnal Ilmiah Kefarmasian Media Farmasi Indonesia Parapemikir Jurnal Ilmiah Farmasi CERATA Medical Sains : Jurnal Ilmiah Kefarmasian
Vivin Nopiyanti
Faculty Of Pharmacy, Setia Budi University
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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PENGARUH METODE PENGGERUSAN TABLET VITAMIN C TERHADAP KADAR AKTIF DENGAN MENGGUNAKAN METODE SPEKTROFOTOMETRI UV-VIS Marryna Dyah Putri Santoso; Vivin Nopiyanti
CERATA Jurnal Ilmu Farmasi Vol 13 No 1 (2022): Cerata Jurnal Ilmu Farmasi
Publisher : UNIVRSITAS MUHAMMADIYAH KLATEN

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Meracik sediaan serbuk merupakan salah satu bentuk pelayanan resep. Sediaan pulveres yang biasa disebut puyer biasanya berasal dari sediaan tablet. Teknik penggerusan sediaan pulveres umumnya menggunakan mortir-stamper dan alat blender (pulverization). Penggerusan dengan menggunakan alat blender dapat mempercepat proses penggerusan dan lebih praktis, tetapi panas yang ditimbulkan pada alat blender dikhawatirkan mampu menurunkan kadar aktif pada suatu sediaan yang memiliki bahan aktif tidak stabil terhadap adanya panas. Penelitian ini bertujuan untuk mengetahui kadar aktif pada tablet vitamin C yang telah dilakukan penggerusan dengan metode blender dan mengetahui apakah penggerusan dengan metode blender dapat mempengaruhi kadar aktif terhadap tablet vitamin C. Sampel pada penelitian ini ada 3 macam merek tablet vitamin C yang dijual di salah satu apotek di Surakarta. Ada 2 macam perlakuan yaitu tablet vitamin C yang digerus dengan metode blender dan tablet vitamin C yang tanpa perlakuan. Uji kualitatif dilakukan dengan menggunakan pereaksi KMnO4, Iodium, Fehling A dan Fehling B yang menunjukkan hasil positif. Uji kuantitatif menggunakan metode Spektrofotometri UV-Vis dengan panjang gelombang 266nm. Hasil penelitian ini pada tablet vitamin C dengan metode Spektrofotometri UV-Vis terdapat kadar asam askorbat pada sediaan tablet vitamin C blender (1) 45,11±0,494mg/tablet, tablet vitamin C blender (2) 45,93±0,275, tablet vitamin C blender (3) 44,12±0,684mg/tablet. Berdasarkan penelitian ini penggerusan dengan metode blender dapat menyebabkan penurunan kadar vitamin C dibandingkan dengan hasil tablet vitamin C yang tanpa perlakuan.
FORMULATION AND TEST OF ANTIBACTERIAL Staphylococcus aureus PAPERSOAP SOURSOP’S LEAVES EXTRACT (Annona muricata L.) WITH VARIATIONS OF GLYCERIN AS PLASTICIZER Vivin Nopiyanti; Din Samsudin; Anita Nilawati
Jurnal Farmasi (Journal of Pharmacy) Vol 11, No 2 (2022)
Publisher : SEKOLAH TINGGI ILMU KESEHATAN NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37013/jf.v11i2.208

Abstract

Papersoap is a thin printed solid soap product as a unique innovation because it resembles paper. Soursop leaves contain flavonoid compounds, tannins, alkaloids and saponins that are useful as antibacterial. preparations papersoap with soursop leaf extract require glycerin as a plasticizer is believed to produce good physicochemical properties. This study aims to determine the physical quality of papersoap from the effect of soursop leaf extract and variations of glycerin and to test the antibacterial activity of the Papersoap against Staphylococcus aureus ATCC 25923.Soursop leaf extract was obtained by maceration method with 96% ethanol as solvent. The concentration of soursop leaf extract 5% was formulated into papersoap with three variations of glycerin formula, namely 10%, 15%, and 20%.preparation papersoap includes organoleptic, pH, homogeneity, foam stability, water content, and free alkali tests which have passed the curing for two weeks as the preparation evaluation stage. Antibacterial activity test against Staphylococcus aureus ATCC 25923 using well diffusion method. The data obtained were processed using Shapiro-wilk, one way ANOVA/Kruskal.The results showed that the formula of the papersoap preparation of soursop leaf ethanol extract (Annona muricata L.) with glycerin variations can provide differences in the physical quality of papersoap preparations and have an inhibitory diameter against Staphylococcus aureus bacteria ATCC 25923 successively 25.26; 24,67; 23.47 mm
UJI AKTIVITAS ANTIOKSIDAN FRAKSI n-HEKSAN, ETIL ASETAT, DAN AIR EKSTRAK DAUN BIWA (Eriobotrya japonica (Thunb.) Lindl.) DENGAN METODE DPPH Kristi Melsi; Vivin Nopiyanti; Endang Sri Rejeki
As-Syifaa Jurnal Farmasi Vol 14, No 2 (2022): AS-SYIFAA JURNAL FARMASI
Publisher : Fakultas Farmasi UMI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.56711/jifa.v14i2.851

Abstract

Loquat leaf (Eriobotrya japonica (Thunb.) Lindl.)  have been known to contain flavonoid compounds, alkaloids, tannins, saponins, triterpenoids and glycosides, these compounds have the potential to be antioxidants and can ward off free radicals. The purpose of this study was to determine the fraction of n-hexane ethyl acetate and water with extract of loquat leaf which have antioxidant activity, and to find out, respectively, which fraction had the most active activity from the IC50 value in activity antioxidant. The extraction method of loquat was macerated using 96% ethanol and then fractionated with n-hexane, ethyl acetate, and water. The obtained fraction was tested for antioxidant activity against free radicals using the DPPH method using UV-Vis spectrophotometer at the wavelength of 516 nm. The results of the loquat leaf fraction test have antioxidant activity which can be seen from the IC50 value, namely the n-hexane fraction is 1792 ppm, the ethyl acetate fraction is 89.60 ppm, the water fraction is 394.99 ppm, and quercetin is 13.03 ppm, so the most active antioxidant is obtained ethyl acetate
PELATIHAN PEMBUATAN SEDIAAN PERMEN SIRSAT SEBAGAI ANTIOKSIDAN SEBAGAI DAYA TAHAN TUBUH DI WILAYAH KERTEN LAWEYAN SURAKARTA: PELATIHAN PEMBUATAN SEDIAAN PERMEN SIRSAT SEBAGAI ANTIOKSIDAN SEBAGAI DAYA TAHAN TUBUH DI WILAYAH KERTEN LAWEYAN SURAKARTA Vivin Nopiyanti; Reslely Harjanti; Siti Aisiyah; Titik Sunarni; Suhartinah Suhartinah; Ilham Kuncahyo
Adi Widya : Jurnal Pengabdian Masyarakat Vol. 6 No. 2 (2022): Adi Widya: Jurnal Pengabdian Masyarakat
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33061/awpm.v6i2.6889

Abstract

Soursop fruit contains vitamin C and polyphenolic compounds that have the potential as a source of antioxidants. It is hoped that by consuming a lot of soursop fruit it will provide an increase in memory and to maintain cell damage due to free radicals. Making soursop candy preparations will allow use which is relatively easy to use and gives a good taste so that not only adults consume it but also for children. Service activities are divided into several stages starting from surveys and observations, followed by training in the form of tutorials then mentoring from the service team and ending with activity evaluation. Making soursop candy preparations is easy, simple and uses simple tools. We often encounter soursop fruit in the yard and for additional materials for making soursop preparations, it is easy to find on the market and the price is cheap. The principle of making it is all the ingredients are boiled until it becomes a semi-solid dough. Then wait until it cools down. Once cool, cut according to taste and wrapped in an attractive wrapper. Service activities carried out in RT 1/RW 1, Laweyan District, Surakarta went well while still implementing health protocols. In addition to providing training on making soursop candy preparations for PKK cadres in Kerten Laweyan Surakarta, training was also held related to opportunities to be developed as community independent businesses. The conclusion of the activity and evaluation of the preparation of soursop candy is considered to have the potential to be developed so that it can be used as an independent business product that is marketed commercially.
Formulasi Sabun Mandi Padat Ekstrak Daun Jeruk Bali (Citrus Maxima Merr.) sebagai Antibakteri terhadap Staphyloccous aureus Noela Riski Riani Sumbung; Vivin Nopiyanti; Siti Aisiyah; Reslely Harjanti
Journal Syifa Sciences and Clinical Research Vol 5, No 1 (2023): Volume 5 Edisi 1 2023
Publisher : State University of Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37311/jsscr.v5i1.16874

Abstract

Solid bath soap is one of the most common cosmetic preparations used by the public to clean the body from dirt. Grapefruit leaves contain flavonoids that are able to maintain healthy skin, and can inhibit the growth of bacteria. The purpose of this study was to formulate the leaf extract of grapefruit into a solid bath soap that has good physical and stability qualities and to determine its antibacterial effect against S. aureus. Grapefruit leaves were macerated with 96% ethanol solvent then the extract obtained was formulated into solid soap preparations with extract variations, namely 1; 3 and 5%. Furthermore, physical quality and stability tests have been carried out as well as testing the antibacterial activity of the bath soap preparations against S. aureus bacteria by agar diffusion method by means of wells. The final stage was statistical data analysis. The results showed that the solid bath soap preparations with grapefruit leaf extract had good physical quality and stability, the formulation of solid bath preparations with extract concentrations of 1%, 3%, and 5% had antibacterial activity with an average diameter of the inhibition zone against S. aureus bacteria were 5.6 mm, 7 mm and 10.8 mm, respectively, which were included in the moderate to strong category. The formulation with the addition of 5% extract had the most effective antibacterial activity with an average inhibition zone of 10.8 mm.
UJI AKTIVITAS ANTIDEPRESAN EKSTRAK ETANOL DAUN PEPAYA (Carica papaya L.) PADA MENCIT PUTIH JANTAN (Mus musculus L.): ANTIDEPRESSANT ACTIVITY TEST OF PAPAYA LEAF ETHANOL EXTRACT (Carica papaya L.) AT MALE WHITE MICE (Mus musculus L.) Astatin Ardhiasari; Vivin Nopiyanti; Jena Hayu Widyasti
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 2 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i2.453

Abstract

Depresi merupakan suatu gangguan emosional dalam waktu jangka yang panjang yang disebabkan turunnya kadar neurotransmiter didalam otak. Daun pepaya (Carica papaya L.) memiliki kandungan senyawa alkaloid, flavonoid, saponin, dan tanin yang digunakan sebagai antidepresan. Tujuan dari penelitian ini adalah untuk mengetahui aktivitas antidepresan dan dosis yang efektif pada ekstrak etanol daun pepaya (Carica papaya L.). Pada penelitian ini menggunakan ekstrak etanol daun pepaya dengan uji antidepresan dan metode forced swimming test dengan mengamati immobility time pada mencit. Sebanyak 25 ekor mencit jantan dibagi kedalam 5 kelompok uji. Kelompok pertama diberi CMC Na 0,5% sebagai kontrol negatif. Kelompok kedua diberi amitriptilin dengan dosis 0,065 mg/20 g BB mencit sebagai kontrol positif. Kelompok ekstrak daun pepaya (Carica papaya L.) dibuat dengan menggunakan metode maserasi dan pelarut etanol 96% dengan 3 variasi dosis (150 mg/kgBB; 250 mg/kgBB; dan 350 mg/kgBB). Masing masing kelompok uji sebelumnya telah diinduksi depresi selama 7 hari dengan cara direnangkan. Setelah itu mencit diberi perlakuan sampai hari ke-14. Pengamatan Immobility time pada mencit diamati pada hari ke 1, 7, dan 14. Hasil dari penelitian ini menunjukkan bahwa ekstrak daun pepaya mempunyai aktivitas sebagai antidepresan yang dilihat dari immobility time dengan metode forced swimming test. Dosis yang paling efektif untuk menurunkan waktu imobilitas secara signifikan pada mencit adalah dosis 350 mg/kgBB. Kata kunci : Antidepresan; ekstrak daun pepaya; immobility time; forced swimming test
PELATIHAN PEMBUATAN BALSEM STIK GONDOPURO DI WILAYAH KERTEN LAWEYAN SURAKARTA YANG BERPOTENSI SEBAGAI USAHA MANDIRI WARGA Siti Aisiyah; Reslely Harjanti; Vivin Nopiyanti; Titik Sunarni; Suhartinah Suhartinah; Ilham Kuncahyo
J-ABDI: Jurnal Pengabdian kepada Masyarakat Vol. 3 No. 2: Juli 2023
Publisher : Bajang Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53625/jabdi.v3i2.6008

Abstract

Potensi penggunaan metil salisilat untuk pereda nyeri otot yang digunakan secara topikal sangat besar di Indonesia. Bentuk balsem stik merupakan inovasi yang muncul dikarenakan adanya keluhan tidak nyaman dan lengket pada tangan saat diaplikasikan. Sehingga sediaan balsem yang dianggap kuno oleh sebagian orang, kini semakin elegan dengan dibuat dalam bentuk mini stik yang praktis digunakan. Kegiatan pengabdian kepada masyarakat ini dilakukan dengan metode penyuluhan dan pelatihan kepada kader PKK di wilayah Kerten Laweyan Surakarta. Penggunaan bahan-bahan yang murah dan mudah diperoleh serta dengan pengembangan label kemasan, maka hasil pelatihan yang sudah dilakukan dinilai mempunyai potensi untuk dikembangkan sebagai usaha mandiri warga.
Penetapan Kadar Asam Lemak Bebas (Alb) Pada Minyak Goreng Kemasan Dan Minyak Goreng Curah Dengan Perlakuan Berdasarkan Lama Waktu Pemanasan Khoirul Mahmudah; Vivin Nopiyanti
CERATA Jurnal Ilmu Farmasi Vol 10 No 1 (2019): Cerata Jurnal Ilmu Farmasi
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61902/cerata.v10i1.67

Abstract

Cooking oil is one of the ingredients needed by the community, especially house wives and made from oi lpalm. Free fatty acids are not separated from cooking oil which causes bad effects on humans. This study aims to determine the levels of free fatty acids (FFA) in packagedcookingoilandbulkcookingoilbytreatmentbasedonheatingtime .This study uses the sample used in this study, bulk cooking oil taken from the markets of Mojosongo, Surakarta and 3 samples of packaged cooking oil which are sold in Surakarta Supermarket in January 2019. This research method uses acid base titration. The time used for analysisis 0 ', 15', 30 ', 45', 60 ', 75'at 160 and compares the levels with the Cooking Oil Quality Standards .The results of this study indicate the levels of free fatty acids in cooking oil, sample A heating to 0,1,2,3 was 0,16%; 0,20%; 0,22%; 0,25% according to SNI while heating to 4, 5 was 0,33%; 0,40% did not meet SNI standards. Sample B warmed up to 0,1,2,3,4,5 which were 0,12%; 0,14%; 0,15%; 0,17%; 0,21%; 0,24%, Sample C warmed up to 0,1,2,3,4,5 which were 0,12%; 0,16%; 0,19%; 0,21%; 0,22%; 0,24%; Sample D warms up to 0,1,2, 3,4,5 whichwere 0,12%; 0,14%; 0,16%; 0,18%; 0,21%; 0,24% according to the Cooking Oil Quality Standards.
Formulasi dan Uji Aktivitas Perlindungan Tabir Surya Emulgel Ekstrak Etanol Kulit Bawang Merah (Allium cepa L.) secara In Vitro dan In Vivo Vivin Nopiyanti; Lisa Wulandari; Suhartinah
CERATA Jurnal Ilmu Farmasi Vol 12 No 1 (2021): Cerata Jurnal Ilmu Farmasi
Publisher : Universitas Muhammadiyah Klaten

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61902/cerata.v12i1.150

Abstract

Sunscreen is a preparation used on the surface of the skin that works to absorb, scatter, or reflect ultraviolet light. Skin of red onion (Allium cepa L.) is one of the natural ingredients that can be used as sunscreen, especially the. Skin of red onion contains flavonoid and tannin compounds that have the potential as sunscreen. This study aims to find out the ethanol extract skin of red onion in the form of emulgel preparations that have good physical quality and stability, SPF value and sunscreen protection activities. Ethanol extract skin of red onion is obtained by maceration using 50% ethanol solvents. Emulgel ethanol extract skin of red onion is made in 4 formulas with variations in extract concentrations of 0,05% ; 0,1% and 0,2%. Emulgel preparations are carried out physical quality test, stability, determination of SPF value (Sun Protection Factor) in vitro using UV-Vis spectrophotometry. The SPF value is calculated by the Mansyur equation. The in vivo test used a male rabbit (New Zealand) were irradiated with a UV B exoterra lamp for 24 hours to see the resulting effects of erythema. The results showed that the onion peel ethanol extract emulgel had good quality and stability. Sunscreen protection tests in vitro and in vivo showed that the sunscreen protection activity met the requirements for the effectiveness of sunscreen with an SPF value of emulgel with a concentration of 0,05% ; 0,1% and 0,2% of 9,59 classified as protection extra, 21,14 and 35,85 were classified as ultra protected and the erythema score after 24 hours of UV exposure was 0.
UJI AKTIVITAS ANTIDEPRESAN EKSTRAK ETANOL DAUN PEPAYA (Carica papaya L.) PADA MENCIT PUTIH JANTAN (Mus musculus L.): ANTIDEPRESSANT ACTIVITY TEST OF PAPAYA LEAF ETHANOL EXTRACT (Carica papaya L.) AT MALE WHITE MICE (Mus musculus L.) Astatin Ardhiasari; Vivin Nopiyanti; Jena Hayu Widyasti
Medical Sains : Jurnal Ilmiah Kefarmasian Vol 8 No 2 (2023)
Publisher : Sekolah Tinggi Farmasi Muhammadiyah Cirebon

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37874/ms.v8i2.453

Abstract

Depresi merupakan suatu gangguan emosional dalam waktu jangka yang panjang yang disebabkan turunnya kadar neurotransmiter didalam otak. Daun pepaya (Carica papaya L.) memiliki kandungan senyawa alkaloid, flavonoid, saponin, dan tanin yang digunakan sebagai antidepresan. Tujuan dari penelitian ini adalah untuk mengetahui aktivitas antidepresan dan dosis yang efektif pada ekstrak etanol daun pepaya (Carica papaya L.). Pada penelitian ini menggunakan ekstrak etanol daun pepaya dengan uji antidepresan dan metode forced swimming test dengan mengamati immobility time pada mencit. Sebanyak 25 ekor mencit jantan dibagi kedalam 5 kelompok uji. Kelompok pertama diberi CMC Na 0,5% sebagai kontrol negatif. Kelompok kedua diberi amitriptilin dengan dosis 0,065 mg/20 g BB mencit sebagai kontrol positif. Kelompok ekstrak daun pepaya (Carica papaya L.) dibuat dengan menggunakan metode maserasi dan pelarut etanol 96% dengan 3 variasi dosis (150 mg/kgBB; 250 mg/kgBB; dan 350 mg/kgBB). Masing masing kelompok uji sebelumnya telah diinduksi depresi selama 7 hari dengan cara direnangkan. Setelah itu mencit diberi perlakuan sampai hari ke-14. Pengamatan Immobility time pada mencit diamati pada hari ke 1, 7, dan 14. Hasil dari penelitian ini menunjukkan bahwa ekstrak daun pepaya mempunyai aktivitas sebagai antidepresan yang dilihat dari immobility time dengan metode forced swimming test. Dosis yang paling efektif untuk menurunkan waktu imobilitas secara signifikan pada mencit adalah dosis 350 mg/kgBB. Kata kunci : Antidepresan; ekstrak daun pepaya; immobility time; forced swimming test
Co-Authors Ahmad Fahrezi, Mukhlis Aisiyah , Siti Amin, Farizal Azizi Apriyani Evalina Lema Astatin Ardhiasari Bambang Iskamto Daryono Hadi Tjahjono Dewi, Serlyna Mutiara Din Samsudin Dwi Ningsih Dwiningsih Dwiningsih Dyah Putri Santoso, Marryna Dyah Susilowati Endang Sri Rejeki Gregorius Prima Indra Budianto, Gregorius Prima Indra Ika Purwidyaningrum Ilham Kuncahyo Ilham Kuncahyo, Ilham Ismi Rahmawati Khoirul Mahmudah Kristi Melsi Lidia Kurniawati Lisa Wulandari Marlia Singgih Wibowo Marlina, Dian Marryna Dyah Putri Santoso Nahira, Nahira Nilawati, Anita Nilawati, Anita Noela Riski Riani Sumbung Nuryani Nuryani Pangesti, Clara Priyanto, Widodo Pudiastuti R.S.P Putri Pamungkas, Retno Rahayuningsih, Dwinata Reslely Harjanti Samsudin, Din Sasangka, Nur Anggreini Dwi Siti Aisiyah Siti Aisiyah Siti Aisiyah Suhartinah Suhartinah Suhartinah Suhartinah Suhartinah Suhartinah, Suhartinah Titik Sunarni Titik Sunarni Tri Wijayanti Widyasti, Jena Hayu Yari Mukti Wibowo