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Teresa Liliana Wargasetia
Faculty Of Medicine, Maranatha Christian University, Bandung, West Java
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Potential of Secretome Hydrogel for Wound Healing in LPS- and Scratch-Induced BJ Cells as an Inflammation Model Widowati, Wahyu; Rahmat, Deni; Faried, Ahmad; Nainggolan, Ita Margaretha; Priyandoko, Didik; Wargasetia, Teresa Liliana; Sugiaman, Vinna Kurniawati; Triharsiwi, Dwi Nur; Qlintang, Sandy; Murti, Harry; Azis, Rizal; Jeffrey, Jeffrey
Science and Technology Indonesia Vol. 10 No. 4 (2025): October
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.4.1242-1254

Abstract

Wound healing often requires specialized interventions to accelerate recovery due to prolonged inflammation and limited regenerative factors. Umbilical Cord Mesenchymal Stem Cells secretome (UCMSCs) comprises various cytokines and growth factors that can promote wound healing. This study aims to analyze the potential of a secretome-based hydrogel as a wound-healing agent using BJ fibroblast cells induced by lipopolysaccharide (LPS) and scratch injury as an inflammation model. The secretome hydrogel was formulated using Carbopol, Hydroxypropyl Methylcellulose (HPMC), Hydroxyethyl Cellulose (HEC), and secretome. Cytotoxicity was conducted using the WST-8 assay, while cell migration was evaluated through a scratch assay. Tumor Necrosis Factor-???? (TNF-????), Nuclear Factor kappa-B (NF-????B), and Interleukin-8 (IL-8) gene expression were analyzed via qRT-PCR. Additionally, malondialdehyde (MDA) levels were measured for oxidative stress assessment, whereas Connective Tissue Growth Factor (CTGF) and Transforming Growth Factor-????1 (TGF-????1) levels were quantified using ELISA and colorimetric assays. The secretome hydrogel exhibited no cytotoxic effects on BJ fibroblast cells and significantly enhanced cell migration. Moreover, it reduced the TNF-????, IL-8, and NF-????B expression, indicating anti-inflammatory activity. The hydrogel also decreased MDA levels while increasing TGF-β1 and CTGF expression, suggesting antioxidant properties and enhanced tissue regeneration in the inflammatory model. The secretome-based hydrogel presents a promising therapeutic approach for promoting chronic wound healing by modulating inflammation, reducing oxidative stress, enhancing tissue regeneration, and stimulating fibroblast migration.
Co-Authors Abdullah Rasyad Ziyad Achmad R. Permadi Achmad R. Permadi, Achmad R. Ade Kurnia Surawijaya Ahmad Faried Alya Mardhotillah Azizah Andi Wahju Rahardjo Emanuel Andi Wahju Rahardjo Emanuel Anis Syabani Muthmainnah Azis, Rizal Chandra Risdian Chandra Risdian Dani Dani Diana Krisanti Jasaputra Didik Priyandoko Elisabeth, Mariska Elizabeth Yohanes Ermi Girsang Fanny Rahardja Fauziyah, Nida Firyal Ginting, Chrismis Novalinda Girsang, Ermi Gunadi, Michael Sebastian Hadiprasetyo, Dhanar Septyawan Halim, Nathanael Hana Ratnawati HANA RATNAWATI Hanna Sari Widya Kusuma, Hanna Sari Widya Harjanti, Mathelda Weni Harry Murti Haryanti, Mathelda Weni Heddy Herdiman I Nyoman Ehrich Lister Ida AKT Bulan Ida AKT Bulan, Ida AKT Jeffrey ., Jeffrey Khie Khiong Khie Khiong Maranatha, Timothy Imanuel Maria Christine Marisca Evalina Gondokesumo, Marisca Evalina Meganita Marthania Meganita Marthania Meganita Marthania Michael Sebastian Gunadi Michael Sebastian Gunadi Michael Sebastian Gunadi Mohamad I Sapta Mohamad I Sapta, Mohamad I Nainggolan, Ita Margaretha Nathanael Halim Nathanael Halim Nindia Salsabila Mia Dewi Nindya, Faradhina Salfa Ningrum, Siti Ratu Rahayu Putri, Fanny Karuna Qlintang, Sandy RAHMAT, DENI Ratnadewi . Regina Putri Ria Aprilia Tri Puteri Permata Akbar Rizal Rosida Tiurma Manurung Sabrina, Adilah Hafizha Nur Santiadi, Sherly Sarwono, Sylvie Saufa, Zahra Qisthi Sherly Santiadi Sherly Santiadi Sherly Santiadi Sijani Prahastuti Subangkit, Mawar Surawijaya, Ade Kurnia Susy Tjahjani Takasenserang, Oktaviana Teddy Marcus Zakaria Teddy Marcus Zakaria Teddy Marcus Zakaria Teddy Markus Zakaria The Fransiska Eltania Tjandrawati Mozef Tjandrawati Mozef Triharsiwi, Dwi Nur Vinna Kurniawati Sugiaman, Vinna Kurniawati Wahyu Widowati Wahyu Widowati Wahyu Widowati Wahyu Widowati WAHYU WIDOWATI Zahiroh, Fadhilah Haifa