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All Journal HAYATI Journal of Biosciences Jurnal Kedokteran Brawijaya Majalah Kedokteran Bandung Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Cancer Chemoprevention Global Medical and Health Communication Majalah Obat Tradisional Science and Technology Indonesia Journal of Medicine and Health Berkala Ilmiah Kedokteran Duta Wacana Celebes Abdimas: Jurnal Pengabdian Kepada Masyarakat Medika Kartika : Jurnal Kedokteran dan Kesehatan Jurnal Abdimas Ilmiah Citra Bakti (JAICB) Pharmaceutical Sciences and Research (PSR) Journal of Medicine and Health JuTISI (Jurnal Teknik Informatika dan Sistem Informasi) Folia Medica Indonesiana
Teresa Liliana Wargasetia
Faculty Of Medicine, Maranatha Christian University, Bandung, West Java
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An in Vitro Assay Reveals the Anti-Aging Properties of Temulawak Extract (Curcuma xanthorrhiza L.) Wargasetia, Teresa Liliana; Widowati, Wahyu; Muthmainnah, Anis Syabani; , Rizal
Folia Medica Indonesiana Vol. 59, No. 4
Publisher : Folia Medica Indonesiana

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Abstract

Highlights: 1. This study investigated the potential of temulawak extract as a cost-effective option for cosmeceutical applications in the treatment of aging. 2. Temulawak extract was found to have the ability to inhibit elastase, hyaluronidase, and tyrosinase activities, thus making it a suitable option for cosmeceutical applications. Abstract Aging is the gradual loss of a tissue's capacity to heal and maintain normal or physiological form and function. Elastase, hyaluronidase, and tyrosinase are the enzymes that contribute to the process of skin aging. The anti-aging effect is connected to the inhibition of these enzymes' activities. Numerous medicinal plants with active metabolites have been extensively utilized to treat aging. The active compounds of temulawak (Curcuma xanthorrhiza L.), such as phenolics, curcuminoids, and xanthorrhizol, have promising properties that may be used as anti-aging agents. This study aimed to determine whether temulawak extract, a potential option for cosmeceuticals, has anti-aging properties that can inhibit the enzymes elastase, hyaluronidase, and tyrosinase. A stock solution was made by dissolving 20 mg of temulawak extract in 1 mL of 100% dimethyl sulfoxide (DMSO). The stock solution was then diluted to produce working solutions with concentrations ranging from 31.25 to 1000"‰Î¼g/mL. An in vitro assay was carried out in three replications to examine the anti-aging activity of the temulawak extract. The in vitro assay investigated the inhibition of the enzyme elastase, hyaluronidase, and tyrosinase at seven different concentrations, with the following ranges: 2.08–66.67 μg/mL for the anti-elastase, 5.21–166.67 μg/mL for the anti-hyaluronidase, and 3.125–100 μg/mL for the anti-tyrosinase. IBM SPSS Statistics for Windows, version 20.0 (IBM Corp., Armonk, N.Y., USA) was used to perform the statistical analysis, with a significance level of"¯p<0.05. Temulawak extract exhibited the highest inhibition rates, reaching 82.72%, 89.41%, and 94.17% for the anti-tyrosinase, anti-elastase, and anti-hyaluronidase activities, respectively. The median inhibitory concentrations (IC50) were 10.66, 70.39, and 55.87 μg/mL for the elastase, hyaluronidase, and tyrosinase activities, respectively. This study revealed that temulawak extract has strong anti-aging properties as it effectively inhibits the activities of elastase, tyrosinase, and hyaluronidase. In conclusion, temulawak extract can be considered a promising candidate for cosmeceutical applications.
Co-Authors , Rizal Abdullah Rasyad Ziyad Achmad R. Permadi Achmad R. Permadi, Achmad R. Ade Kurnia Surawijaya Ahmad Faried Alya Mardhotillah Azizah Andi Wahju Rahardjo Emanuel Andi Wahju Rahardjo Emanuel Anis Syabani Muthmainnah Azis, Rizal Chandra Risdian Chandra Risdian Dani Dani Diana Krisanti Jasaputra Didik Priyandoko Elisabeth, Mariska Elizabeth Yohanes Ermi Girsang Fanny Rahardja Fauziyah, Nida Firyal Ginting, Chrismis Novalinda Girsang, Ermi Gunadi, Michael Sebastian Hadiprasetyo, Dhanar Septyawan Halim, Nathanael HANA RATNAWATI Hana Ratnawati Hanna Sari Widya Kusuma, Hanna Sari Widya Harjanti, Mathelda Weni Harry Murti Haryanti, Mathelda Weni Heddy Herdiman I Nyoman Ehrich Lister Ida AKT Bulan Ida AKT Bulan, Ida AKT Jeffrey ., Jeffrey Khie Khiong Khie Khiong Maranatha, Timothy Imanuel Maria Christine Marisca Evalina Gondokesumo, Marisca Evalina Meganita Marthania Meganita Marthania Meganita Marthania Michael Sebastian Gunadi Michael Sebastian Gunadi Michael Sebastian Gunadi Mohamad I Sapta Mohamad I Sapta, Mohamad I Muthmainnah, Anis Syabani Nainggolan, Ita Margaretha Nathanael Halim Nathanael Halim Nindia Salsabila Mia Dewi Nindya, Faradhina Salfa Ningrum, Siti Ratu Rahayu Putri, Fanny Karuna Qlintang, Sandy RAHMAT, DENI Ratnadewi . Regina Putri Ria Aprilia Tri Puteri Permata Akbar Rizal Rosida Tiurma Manurung Sabrina, Adilah Hafizha Nur Santiadi, Sherly Sarwono, Sylvie Saufa, Zahra Qisthi Sherly Santiadi Sherly Santiadi Sherly Santiadi Sijani Prahastuti Subangkit, Mawar Surawijaya, Ade Kurnia Susy Tjahjani Takasenserang, Oktaviana Teddy Marcus Zakaria Teddy Marcus Zakaria Teddy Marcus Zakaria Teddy Markus Zakaria The Fransiska Eltania Tjandrawati Mozef Tjandrawati Mozef Triharsiwi, Dwi Nur Vinna Kurniawati Sugiaman, Vinna Kurniawati Wahyu Widowati WAHYU WIDOWATI Wahyu Widowati Wahyu Widowati Wahyu Widowati Zahiroh, Fadhilah Haifa