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All Journal HAYATI Journal of Biosciences Jurnal Kedokteran Brawijaya Majalah Kedokteran Bandung Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Cancer Chemoprevention Folia Medica Indonesiana Global Medical and Health Communication Majalah Obat Tradisional Science and Technology Indonesia Journal of Medicine and Health Berkala Ilmiah Kedokteran Duta Wacana Celebes Abdimas: Jurnal Pengabdian Kepada Masyarakat Medika Kartika : Jurnal Kedokteran dan Kesehatan Jurnal Abdimas Ilmiah Citra Bakti (JAICB) Pharmaceutical Sciences and Research (PSR) Journal of Medicine and Health JuTISI (Jurnal Teknik Informatika dan Sistem Informasi)

Teresa Liliana Wargasetia

Faculty Of Medicine, Maranatha Christian University, Bandung, West Java

Author-ID : 410321

Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Efek Larvasida Ekstrak Etanol Daun Pandan Wangi (Pandanus amaryllifolius Roxb.) terhadap Larva Nyamuk Culex sp. Regina Putri; Teresa Liliana Wargasetia; Susy Tjahjani
Global Medical & Health Communication (GMHC) Vol 5, No 2 (2017)
Publisher : Universitas Islam Bandung

Salah satu cara pemberantasan nyamuk Culex yang merupakan vektor beberapa penyakit antara lain filariasis, Japanese encephalitis, St. Louis encephalitis, dan West Nile virus ialah dengan larvasida. Larvasida berbahan kimia (temephos) memiliki efek samping berbahaya bagi kesehatan dan lingkungan. Oleh sebab itu, dilakukan penelitian penggunaan daun pandan wangi (Pandanus amaryllifolius Roxb.) sebagai larvasida alami. Tujuan penelitian mengetahui apakah ekstrak etanol daun pandan wangi memiliki efek larvasida alami terhadap larva Culex sp. Penelitian dilakukan di Fakultas Kedokteran, Universitas Kristen Maranatha pada Februari–Juli 2016. Desain penelitian bersifat eksperimental laboratorik dengan metode rancangan acak lengkap. Efek larvasida ekstrak daun pandan wangi (EDPW) diuji terhadap 6 kelompok perlakuan (n=30, r=4) larva Culex sp. Kelompok I (EDPW 4%), II (EDPW 2%), III (EDPW 1%), IV (EDPW 0,5%), V (temephos sebagai kontrol positif), dan VI (akuades sebagai kontrol negatif). Data yang diambil ialah jumlah larva mati setelah pemberian bahan uji selama 24 jam. Analisis data dengan ANAVA dan uji Tukey HSD dengan nilai α=0,01. Hasil penelitian berupa persentase larva mati pada kelompok I (96,67%), II (79,17%), III (50%), dan IV (17,5%) menunjukkan perbedaan yang signifikan (p≤0,01) terhadap kelompok VI (1,67%). Tidak terdapat perbedaan signifikan (p>0,01) antara kelompok I dan V (100%). Simpulan, EDPW berefek sebagai larvasida terhadap larva nyamuk Culex sp dan EDPW 4% memiliki potensi setara dengan temephos.LARVICIDE EFFECT OF FRAGNANT PANDAN LEAVES ETHANOL EXTRACT (PANDANUS AMARYLLIFOLIUS ROXB.) AGAINTS CULEX SP. MOSQUITO LARVAEOne way to eradicate Culex mosquitoes that are vector for several diseases such as filariasis, Japanese encephalitis, St. Louis encephalitis, and West Nile virus is with larvicide. Larvicide made from chemical (temephos) have harmful side effects to health and environment. Therefore research of fragnant pandan leaves (Pandanus amaryllifolius Roxb.) as natural larvicide was conducted. This study aims to find out whether fragnant pandan leaves ethanol extract has natural larvicide effect against Culex sp. larvae. The study was conducted at Faculty of Medicine, Maranatha Christian University in February to July 2016. This study design was laboratoric experimental with complete randomized design. Larvicidal effect of fragnant pandan leaves extract (FPLE) was tested against 6 groups (n=30, r=4) Culex larvae. Group I (FPLE 4%), II (FPLE 2%), III (FPLE 1%), IV (0,5%), V (temephos as a positive control), and VI (aquadest as a negative control). The taken data was the number of larvae that died after administration of the substance for 24 hours. Data was analyzed by ANOVA and Tukey HSD test using α=0,01. The results of the study were the percentage of dead larvae in group I (96,67%), II (79,17%), III (50%), and IV (17,5%) showed a significant difference (p≤0,01) to group VI (1,67%). There were no significant difference (p>0,01) between group I and group V (100%). The conclusion of this study is there was an effect of FPLE as larvicide against Culex mosquito larvae and FPLE 4% had equivalent potential to temephos.

The Potential of MiRNAs as Biomarkers and Therapy Targets for Cancer Teresa L. Wargasetia
Journal of Medicine and Health Vol. 1 No. 3 (2016)
Publisher : Universitas Kristen Maranatha

MicroRNAs (miRNAs) are involved in the signaling circuits regulation within a cell andtheir deregulation plays an important role in cancer development and progression. In thisreview, we discussed miRNA biogenesis, miRNA function and the effect of miRNA abnormalitiesin cellular pathways that led to transformation of normal cells into cancer cells, as well as theindication of miRNAs as diagnostic and prognostic biomarkers of various types of cancer, asbiomarkers to predict the response to cancer therapy and the potential for development ofmiRNAs as cancer targeted therapy.Keywords: miRNA, cancer, diagnostic biomarker, prognostic biomarker, cancer therapy

Prevalence and Characteristics of Liver Cancer Patients in Immanuel Hospital Bandung within January 2013 until December 2014 Period Achmad R. Permadi; Hana Ratnawati; Teresa L. Wargasetia
Journal of Medicine and Health Vol. 1 No. 4 (2016)
Publisher : Universitas Kristen Maranatha

Liver cancer is the fifth most common cancer in Indonesia. This research is to find out the prevalence and characteristics of liver cancer patients in Immanuel Hospital Bandung within the January 2013 until December 2014 period based on age, gender, clinical symptoms and predilections. This study was a descriptive verificative research with data retrieval of patients medical records that have been diagnosed with liver cancer that were hospitalized in Immanuel Hospital Bandung within January 2013 until December 2014 period. The study showed that the liver cancer patient prevalence in Immanuel Hospital Bandung within the period of January 2013 until December 2014 was 46 people. Characteristics of liver cancer patients in Immanuel Hospital Bandung within January 2013 until December 2014 period showed that the most liver cancer patients were male, compare with female with ratio 4:1, the most common age group of 56-65 years old, the most common clinical symptoms were abdominal pain with or without reffered pain to the right scapular bone and the most common predilection was right lobe of the liver.Â Key words: liver cancer, patients' characteristics, prevalenceÂ

Repair of Cerebrospinal Fluid Leak After Functional Endoscopy Sinus Surgery Mohamad I Sapta; Teresa L Wargasetia
Journal of Medicine and Health Vol. 1 No. 5 (2017)
Publisher : Universitas Kristen Maranatha

Cerebrospinal fluid (CSF) leak is one of Functional Endoscopic Sinus Surgery (FESS)complications. Since 2001, it was reported that there is one case of CSF leak as FESScomplication in ENT-HN Department, Faculty of Medicine, Maranatha Christian University -Immanuel Hospital in Bandung. The purpose of this case report is present clinical findings andmanagement of CSF leak as FESS complication. A-45 year old male with headache as chiefcomplain after undergone FESS five days before. There was a clear rhinorrhea running frompatientâ€™s right nose. In nasoendoscopic examination, it was showed there was a defect in laminacribrosa. The result of paranasal sinus computed tomography scanning showed an air columnin brain ventricular system. The defect in lamina cribrosa was repaired by transnasalendoscopic using materials such as surgicel, cartilages, and fat tissues. The conclusion is weroll out one case about repair of CSF leak as a FESS complication and it was done with a goodresult.Keywords: cerebrospinal fluid leak, functional endoscopic sinus surgery

Lung Cancer Patient Description in Immanuel Hospital Bandung from January 2013 to December 2014 Ida AKT Bulan; Hana Ratnawati; Teresa L Wargasetia
Journal of Medicine and Health Vol. 1 No. 6 (2017)
Publisher : Universitas Kristen Maranatha

Lung cancer is a disease which has high incidence and mortality rate. It makes lung cancer become one of the biggest public health problems. The aim of this study is to find out the description of lung cancer patients in Immanuel Hospital Bandung from January 2013 to December 2014 based on the prevalence, gender, age, clinical features, metastasis, and mortality percentage. The method design was a descriptive retrospective method with data retrieval and collection of patient medical records that have been diagnosed with lung cancer in Immanuel Hospital Bandung from January 2013 to December 2014 period. This study showed that lung cancer prevalence was 51 patients, the majority of patients were males compared to females with the ratio of 2.7:1, the most common age group was 61â€“70 years old, the most common clinical features were dyspnea and cough, the most common site of metastasis was liver, and the mortality percentage was 33.33%.Keywords: Immanuel hospital Bandung, lung cancer, patientâ€™s description

MEMAHAMI KAITAN OBESITAS DAN KANKER: PELUANG UNTUK PENCEGAHAN KANKER Teresa Liliana Wargasetia
Berkala Ilmiah Kedokteran Duta Wacana Vol 1, No 3 (2016): BERKALA ILMIAH KEDOKTERAN DUTA WACANA
Publisher : Faculty of Medicine Universitas Kristen Duta Wacana

Jumlah kasus kanker yang disebabkan oleh obesitas diperkirakan sebesar 20%. The International Agency for Research into Cancer dan the World Cancer Research Fund melaporkan bahwa kanker yang sering dialami oleh penderita obesitas adalah kanker endometrium, adenokarsinoma esofagus, kolorektal, payudara postmenopause, prostat, dan ginjal. Risiko keganasan yang meningkat dipengaruhi distribusi lemak tubuh dan peningkatan berat badan yang menyebabkan transfer lipid dari adiposit ke tumor. Sejumlah studi melaporkan bahwa kelebihan berat badan dan obesitas berkorelasi dengan tingkat kematian akibat kanker hepar, pankreas, kolon, endometrium, ginjal, payudara postmenopause, mieloma, dan Hodgkin’s lymphoma. Empat sistem yang teridentifikasi sebagai penyebab kanker pada obesitas adalah peningkatan lipid, respons inflamasi, resistensi insulin, dan adipokin. Konsumsi sejumlah makanan yang bersifat antikanker dan antiobesitas bersama dengan restriksi kalori dan aktivitas fisik membantu dalam pencegahan kanker yang berkaitan dengan obesitas.

Antioxidant Activities of Ginger (Zingiber officinale) and Telang Flower (Clitoria ternatea L.) Combination Tea Wahyu Widowati; Teresa Liliana Wargasetia; Teddy Marcus Zakaria; Meganita Marthania; Michael Sebastian Gunadi; Nathanael Halim; Nindia Salsabila Mia Dewi; Sherly Santiadi
Majalah Kedokteran Bandung Vol 54, No 3 (2022)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v54n3.2729

Tea is widely consumed for health purposes to prevent and treat various diseases. This paper reports the antioxidant activities of a herbal tea namely jahe (ginger, Zingiber officinale) telang (Clitoria ternatea L.), and the combination namely JaTe (jahe and telang). Each of jahe, telang, and JaTe teas were made of 2g ginger, 5 buds dried telang flower, and the combination respectively. The teas were boiled in 200 mL for 5 minutes. The dried ginger, telang, and JaTe formulation were evaluated for antioxidant activities. Total phenolic content was evaluated by Folin-Ciocalteu using the gallic acid equivalent (GAE), while total flavonoid content was evaluated by aluminum chloride colorimetric assay using the quercetin equivalent (QE). The antioxidant activity was measured using 2,2-diphenyl-1picrylhydrazyl (DPPH), and 2,2'-Azino-Bis-3-Ethylbenzothiazoline-6-sulfonic acid (ABTS), hydrogen peroxide (H₂O₂) scavenging activities, and ferric reducing antioxidant power (FRAP) assay. The highest phenolic and flavonoid contents were found in ginger tea with 23.62 μg GAE/100% concentration and 7.22 μg QE/100% concentration, followed by telang tea with 16.20 μg GAE/100% concentration and 4.88 μg QE/100% concentration. Ginger tea has the strongest DPPH scavenging activity with IC₅₀=7.76% followed by telang tea 17.07%. JaTe tea has the strongest ABTS scavenging activity with IC₅₀=1.01% followed by ginger tea with IC₅₀=1.26%. Ginger tea has the strongest H₂O₂ scavenging activity with IC₅₀=13.23% and followed by JaTe tea with IC₅₀=14.66%. JaTe tea has the strongest FRAP activity with IC₅₀=3.59%, followed by ginger tea with IC₅₀=4.94%. Overall, JaTe herbal tea formulation has a strong antioxidant activity.

Antioxidant activity of panJe tea combination of pandan (Pandanus amaryllifolius) and jahe (Zingiber officinale) Wahyu Widowati; Teresa Liliana Wargasetia; Teddy Marcus Zakaria; Michael Sebastian Gunadi; Sherly Santiadi; Meganita Marthania; Abdullah Rasyad Ziyad
Pharmaciana Vol 13, No 1 (2023): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Herbal tea are popular because of their potential herbal medicine, a blend of herbal ingredients, promised to provide a specific purpose. The main purpose is to determine antioxidant activity in herbal teas (pandan mixed ginger) and in their infusions, as well as to obtain more complex information about the tea products. In this study, DPPH radical scavenging, H2O2 scavenging, ABTS reduction, and FRAP reduction assay were carried out. These assays are proved that the IC50 values of ginger are higher than PanJe and pandan. For DPPH scavenging, H2O2 scavenging, FRAP scavenging, ABTS reduction activities, PanJe resulted IC50 14.69 ¼g/mL, 27.70 ¼g/mL, 7.09 ¼g/mL, and 411.28 µg/mL, while ginger yielded IC50 7.76 ¼g/mL, 13.23 Î¼g/mL, 4.94 ¼g/mL ,and 125.95 respectively. Otherwise, the highest total phenolic and flavonoid of panje were shown at 1.60 ± 0.26 µg QE / 100% extract and 8.67 ± 0.80 µg QE/100% extract respectively. Based on these results, PanJe, pandan and ginger are concluded as an active natural product because it exhibited antioxidant activities from two mixed compounds.

An in Vitro Assay Reveals the Anti-Aging Properties of Temulawak Extract (Curcuma xanthorrhiza L.) Teresa Liliana Wargasetia; Wahyu Widowati; Anis Syabani Muthmainnah; Rizal
Folia Medica Indonesiana Vol. 59 No. 4 (2023): December
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/fmi.v59i4.44944

Highlights:1. This study investigated the potential of temulawak extract as a cost-effective option for cosmeceutical applications in the treatment of aging. 2. Temulawak extract was found to have the ability to inhibit elastase, hyaluronidase, and tyrosinase activities, thus making it a suitable option for cosmeceutical applications. AbstractAging is the gradual loss of a tissue's capacity to heal and maintain normal or physiological form and function. Elastase, hyaluronidase, and tyrosinase are the enzymes that contribute to the process of skin aging. The anti-aging effect is connected to the inhibition of these enzymes' activities. Numerous medicinal plants with active metabolites have been extensively utilized to treat aging. The active compounds of temulawak (Curcuma xanthorrhiza L.), such as phenolics, curcuminoids, and xanthorrhizol, have promising properties that may be used as anti-aging agents. This study aimed to determine whether temulawak extract, a potential option for cosmeceuticals, has anti-aging properties that can inhibit the enzymes elastase, hyaluronidase, and tyrosinase. A stock solution was made by dissolving 20 mg of temulawak extract in 1 mL of 100% dimethyl sulfoxide (DMSO). The stock solution was then diluted to produce working solutions with concentrations ranging from 31.25 to 1000 μg/mL. An in vitro assay was carried out in three replications to examine the anti-aging activity of the temulawak extract. The in vitro assay investigated the inhibition of the enzyme elastase, hyaluronidase, and tyrosinase at seven different concentrations, with the following ranges: 2.08–66.67 μg/mL for the anti-elastase, 5.21–166.67 μg/mL for the anti-hyaluronidase, and 3.125–100 μg/mL for the anti-tyrosinase. IBM SPSS Statistics for Windows, version 20.0 (IBM Corp., Armonk, N.Y., USA) was used to perform the statistical analysis, with a significance level of p<0.05. Temulawak extract exhibited the highest inhibition rates, reaching 82.72%, 89.41%, and 94.17% for the anti-tyrosinase, anti-elastase, and anti-hyaluronidase activities, respectively. The median inhibitory concentrations (IC50) were 10.66, 70.39, and 55.87 μg/mL for the elastase, hyaluronidase, and tyrosinase activities, respectively. This study revealed that temulawak extract has strong anti-aging properties as it effectively inhibits the activities of elastase, tyrosinase, and hyaluronidase. In conclusion, temulawak extract can be considered a promising candidate for cosmeceutical applications.

Antioxidant Activities of RoJa Herbal Tea: Combination of Rosella Flower (Hibiscus sabdariffa L.) and Ginger Rhizome (Zingiber officinale Rosc.) Widowati, Wahyu; Wargasetia, Teresa Liliana; Zakaria, Teddy Marcus; Gunadi, Michael Sebastian; Halim, Nathanael; Santiadi, Sherly; Kusuma, Hanna Sari Widya; Fauziyah, Nida Firyal
Pharmaceutical Sciences and Research Vol. 10, No. 3
Publisher : UI Scholars Hub

Show Abstract | Download Original | Original Source | Check in Google Scholar

Herbal teas and plant-based medicines have been widely used worldwide for their therapeutic and healing qualities. Rosella (Hibiscus sabdariffa L.) has various benefits in preventing digestive problems, liver disease, fever, and others. Ginger (Zingiber officinale Rosc.) or known as jahe in Indonesia is believed to benefit numerous clinical conditions linked to oxidative stress, including pancreatitis, hypertension, diabetic kidney disease, Alzheimer’s disease, and tumor development. They have been utilized in traditional medical practice to treat conditions such as fever, nausea, and headaches. In this study, we aimed to determine the antioxidant activities of rosella flower tea, ginger tea, and a combination of both, namely RoJa (Rosella-Jahe) tea. Antioxidant activities were analyzed by the 2,2-diphenyl-1-picrylhydrazyl (DPPH), hydrogen peroxide (H2O2), 2-2′-Azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) scavenging activities, and Ferric Reducing Antioxidant Power (FRAP) assay, as well as by measuring the amount of total phenolic and flavonoid content. Rosella tea had the greatest activity in the DPPH assay, with an IC50 value of 0.412 mg/ml. Ginger tea had the greatest activity for the ABTS, FRAP, and H2O2 tests, with IC50 values of 12.595 mg/ml, 0.494 mg/ml, and 1.323 mg/ml, respectively. Ginger tea also had the highest amount of total phenolic (3.61 µg GAE/g sample) and flavonoid content (11.81 µg QE/g). In conclusion, ginger tea showed the highest antioxidant activities, as well as total phenolic and flavonoid content, compared to rosella and RoJa tea.

Co-Authors Abdullah Rasyad Ziyad Achmad R. Permadi Achmad R. Permadi, Achmad R. Ade Kurnia Surawijaya Ahmad Faried Alya Mardhotillah Azizah Andi Wahju Rahardjo Emanuel Andi Wahju Rahardjo Emanuel Anis Syabani Muthmainnah Azis, Rizal Chandra Risdian Chandra Risdian Dani Dani Diana Krisanti Jasaputra Didik Priyandoko Elisabeth, Mariska Elizabeth Yohanes Ermi Girsang Fanny Rahardja Fauziyah, Nida Firyal Ginting, Chrismis Novalinda Girsang, Ermi Gunadi, Michael Sebastian Hadiprasetyo, Dhanar Septyawan Halim, Nathanael Hana Ratnawati HANA RATNAWATI Hanna Sari Widya Kusuma, Hanna Sari Widya Harjanti, Mathelda Weni Harry Murti Haryanti, Mathelda Weni Heddy Herdiman I Nyoman Ehrich Lister Ida AKT Bulan Ida AKT Bulan, Ida AKT Jeffrey ., Jeffrey Khie Khiong Khie Khiong Maranatha, Timothy Imanuel Maria Christine Marisca Evalina Gondokesumo, Marisca Evalina Meganita Marthania Meganita Marthania Meganita Marthania Michael Sebastian Gunadi Michael Sebastian Gunadi Michael Sebastian Gunadi Mohamad I Sapta Mohamad I Sapta, Mohamad I Nainggolan, Ita Margaretha Nathanael Halim Nathanael Halim Nindia Salsabila Mia Dewi Nindya, Faradhina Salfa Ningrum, Siti Ratu Rahayu Putri, Fanny Karuna Qlintang, Sandy RAHMAT, DENI Ratnadewi . Regina Putri Ria Aprilia Tri Puteri Permata Akbar Rizal Rosida Tiurma Manurung Sabrina, Adilah Hafizha Nur Santiadi, Sherly Sarwono, Sylvie Saufa, Zahra Qisthi Sherly Santiadi Sherly Santiadi Sherly Santiadi Sijani Prahastuti Subangkit, Mawar Surawijaya, Ade Kurnia Susy Tjahjani Takasenserang, Oktaviana Teddy Marcus Zakaria Teddy Marcus Zakaria Teddy Marcus Zakaria Teddy Markus Zakaria The Fransiska Eltania Tjandrawati Mozef Tjandrawati Mozef Triharsiwi, Dwi Nur Vinna Kurniawati Sugiaman, Vinna Kurniawati Wahyu Widowati Wahyu Widowati Wahyu Widowati Wahyu Widowati WAHYU WIDOWATI Zahiroh, Fadhilah Haifa

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