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All Journal HAYATI Journal of Biosciences Jurnal Kedokteran Brawijaya Majalah Kedokteran Bandung Pharmaciana: Jurnal Kefarmasian Indonesian Journal of Cancer Chemoprevention Folia Medica Indonesiana Global Medical and Health Communication Majalah Obat Tradisional Science and Technology Indonesia Journal of Medicine and Health Berkala Ilmiah Kedokteran Duta Wacana Celebes Abdimas: Jurnal Pengabdian Kepada Masyarakat Medika Kartika : Jurnal Kedokteran dan Kesehatan Jurnal Abdimas Ilmiah Citra Bakti (JAICB) Pharmaceutical Sciences and Research (PSR) Journal of Medicine and Health JuTISI (Jurnal Teknik Informatika dan Sistem Informasi)
Teresa Liliana Wargasetia
Faculty Of Medicine, Maranatha Christian University, Bandung, West Java
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Effects of Metformin, Avocado Seed, and Diabetic Ingredients Infusion to Weight and Fasting Blood Glucose on Sucrose Diet Rats Jasaputra, Diana Krisanti; Wargasetia, Teresa Liliana; Elizabeth, Elizabeth
Global Medical & Health Communication (GMHC) Vol 7, No 1 (2019)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (881.279 KB) | DOI: 10.29313/gmhc.v7i1.2917

Abstract

Metformin, an oral hypoglycemic drug which has metabolic effects and weight loss after 6–9 months; however, after 18 months, these effects disappear. Oral hypoglycemic drugs with no effect on raising the weight are needed. The objective of the study is comparing the effects of metformin, avocado seed infusion (AS), and diabetic ingredients/DI (green chiretta, Java tea, and bitter grapes) in increasing weight and fasting blood glucose of rats with sucrose diet. The research was conduct at the Pharmacology Laboratory, Faculty of Medicine Universitas Kristen Maranatha in February–August 2017. The results showed that metformin within six weeks reduced weight (75.55%) compared to control (+) with a hypercaloric diet (114.36%). Metformin and hypercaloric diet in rats for 14 weeks showed a 125.66% increase in weight, higher than control (+) (114.36%), although not significant (p>0.05). Weight in rats with hypercaloric and AS diet for 14 weeks was 94.30% and 81.68% in DI was lower than control (+) (114.36%), but not significant (p>0.05). Fasting blood glucose (FBG) of dietary hypercaloric rats and metformin was 123.75 mg/dL, higher than control (+), which was 85.75 mg/dL (p<0.01), whereas FBG infusion of AS and DI during 14 weeks: 85.75 mg/dL, and 99.50 mg/dL, not significant to control (+) (p>0.05). In conclusions, metformin increased rats body weight even though not significantly and fasting blood glucose in rats fed a hypercaloric diet for 14 weeks, while avocado seed infusion and diabetec ingredients infusion did not. EFEK METFORMIN, INFUSI BIJI ALPUKAT, DAN INFUSI RAMUAN DIABETES TERHADAP BERAT BADAN DAN GLUKOSA DARAH PUASA PADA TIKUS DIET SUKROSAMetformin, obat hipoglikemik oral berefek metabolik dan menurunkan berat badan (BB) setelah 6–9 bulan, namun setelah 18 bulan efek ini hilang. Diperlukan obat hipoglikemik oral yang tidak berefek meningkatkan BB. Tujuan penelitian ini membandingkan efek metformin, infusi biji alpukat (BA), dan infusi ramuan diabetes/RD (sambiloto, kumis kucing, dan bratawali) dalam meningkatkan BB dan glukosa darah puasa pada tikus diet sukrosa. Penelitian dilaksanakan di Laboratorium Farmakologi, Fakultas Kedokteran Universitas Kristen Maranatha periode Februari–Agustus 2017. Hasil penelitian menunjukkan metformin dalam waktu 6 minggu mengurangi penambahan BB (75,55%) dibanding dengan kontrol (+) diet hiperkalori (114,36%). Pemberian metformin dan diet hiperkalori pada tikus selama 14 minggu menunjukkan kenaikan BB 125,66%, lebih tinggi dibanding dengan kontrol (+) (114,36%), walaupun tidak signifikan (p>0,05). Berat badan pada tikus dengan diet hiperkalori dan infusi BA selama 14 minggu adalah 94,30% dan  RD 81,68%, lebih rendah dibanding dengan kontrol (+) (114,36%), namun tidak signifikan (p>0,05). Glukosa darah puasa (GDP) tikus diet hiperkalori dan metformin adalah 123,75 mg/dL, lebih tinggi dibanding dengan kontrol (+) 85,75 mg/dL (p<0,01), sedangkan GDP infusi BA dan RD selama 14 minggu adalah 85,75 mg/dL dan 99,50 mg/dL, tidak signifikan terhadap GDP kontrol (+) (p>0,05). Simpulan, metformin meningkatkan berat badan tikus walau tidak signifikan dan meningkatkan glukosa darah puasa pada tikus diet hiperkalori selama 14 minggu, sedangkan infusi biji alpukat dan ramuan diabetes tidak.
The Antiaging Potential of Serum Formulations from Centella asiatica, Curcuma longa, Aloe vera, Rosa centifolia, and Salmon DNA on Injured Human Fibroblast Cells Girsang, Ermi; Wargasetia, Teresa Liliana; Rahmat, Deni; Gondokesumo, Marisca Evalina; Harjanti, Mathelda Weni; Widowati, Wahyu; Zahiroh, Fadhilah Haifa; Saufa, Zahra Qisthi; Takasenserang, Oktaviana; Hadiprasetyo, Dhanar Septyawan
HAYATI Journal of Biosciences Vol. 32 No. 3 (2025): May 2025
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.32.3.623-631

Abstract

External aging factors such as UV exposure, pollution, and lifestyle choices contribute to skin aging, resulting in deep wrinkles, fine lines, and rough skin, which can lower self-confidence. Plant extracts have been widely studied for their antiaging potential, while Salmon DNA has shown promise in stimulating collagen production. This study explores the formulation of a serum combining Centella asiatica, Curcuma longa, Aloe vera, Rosa centifolia, and Salmon DNA for its antiaging effects on injured human fibroblast cells. The serum was formulated using extracts from C. asiatica, C. longa, A. vera, R. centifolia, and Salmon DNA. Antioxidant activity was evaluated with the DPPH method, cytotoxicity using the WST-8 assay, and gene expression through qRT-PCR for COL1A1, TGF-β1, HYAL-1, and FGF-2. The serum exhibited weak antioxidant activity (IC50 = 373.33 µg/ml) and reduced cell viability at high concentrations. Gene expression analysis revealed increased expression of COL1A1, TGF-β1, and FGF-2, along with reduced HYAL-1 expression in injured BJ cells. The formulated serum shows potential as an antiaging agent, promoting collagen production and reducing hyaluronidase activity.
EDUKASI DAN PEMERIKSAAN KULIT: UPAYA MENINGKATKAN KESADARAN MASYARAKAT TENTANG PERAWATAN KULIT Widowati, Wahyu; Wargasetia, Teresa Liliana; Elisabeth, Mariska; Haryanti, Mathelda Weni; Rahmat, Deni; Girsang, Ermi; Gondokesumo, Marisca Evalina; Nindya, Faradhina Salfa; Triharsiwi, Dwi Nur
Jurnal Abdimas Ilmiah Citra Bakti Vol. 6 No. 1 (2025)
Publisher : STKIP Citra Bakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.38048/jailcb.v6i1.4471

Abstract

Penuaan kulit merupakan proses alami yang tidak dapat dihindari oleh setiap individu. Proses penuaan ini dapat dipengaruhi secara intrinsik maupun ekstrinsik. Faktor penuaan ekstrinsik yang berlebih dapat memberikan pengaruh signifikan pada kesehatan kulit. Di saat bersamaan, sejumlah masyarakat belum mengetahui pentingnya menjaga kualitas kulit. Maka dari itu, bersama dengan Universitas Kristen Maranatha, diselenggarakan penyuluhan untuk meningkatkan kesadaran penjagaan kualitas kulit hingga memperoleh kulit yang optimal. Kegiatan ini juga dilengkapi dengan pemeriksaan kulit menggunakan Skin Analyzer, serta pemberian skincare berbasis ekstrak bahan alam. Penyuluhan disampaikan dengan metode ceramah yang dilengkapi dengan presentasi visual. Kegiatan yang dilaksanakan dievaluasi melalui pengisian formulir evaluasi oleh seluruh peserta. Kegiatan penyuluhan ini dihadiri oleh 129 orang dengan mayoritas peserta berasal dari kelompok usia dewasa. Hasil formulir evaluasi penyuluhan menunjukkan bahwa mayoritas peserta (>50%) menilai bahwa sistematika penyuluhan, isi penyuluhan, organisasi, dan media yang digunakan selama kegiatan tergolong sangat baik. Hasil formulir evaluasi produk menunjukkan lebih dari 60% peserta yang mengikuti pemeriksaan kulit dapat menilai bahwa tekstur, kemasan, kandungan, kualitas, informasi produk, aroma, dan warna dari produk perawatan kulit berada dalam kategori sangat baik. Hasil formulir penilaian menunjukkan tujuan dari penyuluhan telah tercapai, yaitu kemampuan dalam pemahaman terkait karakteristik produk perawatan kulitdan memperoleh respons baik dari peserta. Setelah penelitian ini diharapkan masyarakat dapat lebih selektif dalam menggunakan produk perawatan kulit.
Potential of Bitter Melon (Momordica charantia L.) Extract for Chronic Kidney Disease Based on In Vitro Study via TGF/SMADs Signaling, Antioxidant, Antiinflammation, Apoptosis Inducer Activities Prahastuti, Sijani; Rahardja, Fanny; Wargasetia, Teresa Liliana; Zahiroh, Fadhilah Haifa; Sabrina, Adilah Hafizha Nur; Kusuma, Hanna Sari Widya; Azis, Rizal; Hadiprasetyo, Dhanar Septyawan; Ningrum, Siti Ratu Rahayu; Widowati, Wahyu; Sarwono, Sylvie
Science and Technology Indonesia Vol. 10 No. 2 (2025): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.2.538-551

Abstract

Chronic kidney disease (CKD) is a physiological abnormality in the kidneys whose prevalence is expected to continue to increase. On the other hand, Bitter melon (Momordica charantia L.) is known to have the potential to manage CKD. This study explores the compound content of M. charantia ethanol extract (MCEE) and its potential for CKD based on in vitro assays. To model chronic kidney disease (CKD), SV40 MES-13 (mouse glomerular mesangial) cells were exposed for 3 days to 20 mM glucose. After glucose induction, the cells were subjected with different concentrations of MCEE (Momordica charantia L. ethanolic extract). The chemical profile of MCEE was analyzed using LC/MS-MS. Cell viability was examined through the WST assay, while intracellular ROS and apoptosis levels were measured by flowcytometry. Colorimetry was used to analyze SOD, MDA, and CAT levels. ELISA was used to analyze inflammatory proteins (TGF-β 1, IL-6, TNF-α, IL-1β ) levels. Meanwhile, the relative gene expression of SMAD-2, SMAD-3, SMAD-4, SMAD-7 was examined through qRT-PCR. The results exhibited that MCEE contains cucurbitane p-coumaric, ferulic acid, caffeic acid, gallic acid, chlorogenic acid, and epicatechin. MCEE was also known to be non-toxic to SV40 MES-13 cells. In addition, MCEE reduced intracellular ROS levels, MDA, necrosis levels, and inflammatory proteins, while also regulating SMAD-2, SMAD-3, and SMAD-4 gene expression. MCEE increased levels of CAT, and SOD, and regulated SMAD-7 gene expression in the CKD cells model. The most effective MCEE is MCEE 50 μg/mL. MCEE demonstrated potential as a CKD treatment based on in vitro studies through TGF/SMADs signaling activity, antioxidant, anti-inflammatory, and apoptosis inducer.
The Potential of MiRNAs as Biomarkers and Therapy Targets for Cancer Teresa L. Wargasetia
Journal of Medicine and Health Vol 1 No 3 (2016)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v1i3.523

Abstract

MicroRNAs (miRNAs) are involved in the signaling circuits regulation within a cell andtheir deregulation plays an important role in cancer development and progression. In thisreview, we discussed miRNA biogenesis, miRNA function and the effect of miRNA abnormalitiesin cellular pathways that led to transformation of normal cells into cancer cells, as well as theindication of miRNAs as diagnostic and prognostic biomarkers of various types of cancer, asbiomarkers to predict the response to cancer therapy and the potential for development ofmiRNAs as cancer targeted therapy.Keywords: miRNA, cancer, diagnostic biomarker, prognostic biomarker, cancer therapy
Prevalence and Characteristics of Liver Cancer Patients in Immanuel Hospital Bandung within January 2013 until December 2014 Period Achmad R. Permadi; Hana Ratnawati; Teresa L. Wargasetia
Journal of Medicine and Health Vol 1 No 4 (2016)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v1i4.531

Abstract

Liver cancer is the fifth most common cancer in Indonesia. This research is to find out the prevalence and characteristics of liver cancer patients in Immanuel Hospital Bandung within the January 2013 until December 2014 period based on age, gender, clinical symptoms and predilections. This study was a descriptive verificative research with data retrieval of patients medical records that have been diagnosed with liver cancer that were hospitalized in Immanuel Hospital Bandung within January 2013 until December 2014 period. The study showed that the liver cancer patient prevalence in Immanuel Hospital Bandung within the period of January 2013 until December 2014 was 46 people. Characteristics of liver cancer patients in Immanuel Hospital Bandung within January 2013 until December 2014 period showed that the most liver cancer patients were male, compare with female with ratio 4:1, the most common age group of 56-65 years old, the most common clinical symptoms were abdominal pain with or without reffered pain to the right scapular bone and the most common predilection was right lobe of the liver. Key words: liver cancer, patients' characteristics, prevalence 
Repair of Cerebrospinal Fluid Leak After Functional Endoscopy Sinus Surgery Mohamad I Sapta; Teresa L Wargasetia
Journal of Medicine and Health Vol 1 No 5 (2017)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v1i5.545

Abstract

Cerebrospinal fluid (CSF) leak is one of Functional Endoscopic Sinus Surgery (FESS)complications. Since 2001, it was reported that there is one case of CSF leak as FESScomplication in ENT-HN Department, Faculty of Medicine, Maranatha Christian University -Immanuel Hospital in Bandung. The purpose of this case report is present clinical findings andmanagement of CSF leak as FESS complication. A-45 year old male with headache as chiefcomplain after undergone FESS five days before. There was a clear rhinorrhea running frompatient’s right nose. In nasoendoscopic examination, it was showed there was a defect in laminacribrosa. The result of paranasal sinus computed tomography scanning showed an air columnin brain ventricular system. The defect in lamina cribrosa was repaired by transnasalendoscopic using materials such as surgicel, cartilages, and fat tissues. The conclusion is weroll out one case about repair of CSF leak as a FESS complication and it was done with a goodresult.Keywords: cerebrospinal fluid leak, functional endoscopic sinus surgery
Lung Cancer Patient Description in Immanuel Hospital Bandung from January 2013 to December 2014 Ida AKT Bulan; Hana Ratnawati; Teresa L Wargasetia
Journal of Medicine and Health Vol 1 No 6 (2017)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v1i6.548

Abstract

Lung cancer is a disease which has high incidence and mortality rate. It makes lung cancer become one of the biggest public health problems. The aim of this study is to find out the description of lung cancer patients in Immanuel Hospital Bandung from January 2013 to December 2014 based on the prevalence, gender, age, clinical features, metastasis, and mortality percentage. The method design was a descriptive retrospective method with data retrieval and collection of patient medical records that have been diagnosed with lung cancer in Immanuel Hospital Bandung from January 2013 to December 2014 period. This study showed that lung cancer prevalence was 51 patients, the majority of patients were males compared to females with the ratio of 2.7:1, the most common age group was 61–70 years old, the most common clinical features were dyspnea and cough, the most common site of metastasis was liver, and the mortality percentage was 33.33%.Keywords: Immanuel hospital Bandung, lung cancer, patient’s description
Sinkronisasi Pangkalan Data Rumah Sakit dengan Aplikasi Open Source SymmetricDS Andi Wahju Rahardjo Emanuel; Teresa Liliana Wargasetia; Ade Kurnia Surawijaya
Jurnal Teknik Informatika dan Sistem Informasi Vol 3 No 3 (2017): JuTISI
Publisher : Maranatha University Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jutisi.v3i3.689

Abstract

Health is an important supporting factor in the society.  One of the curative implementation of the healthcare is hospital.  Supporting system based on Information Technology of hospital is called Hospital Information System (SIRS) in which this system is mandatory in every hospital.  Unfortunately, this system is developed individually by the hospital so that the integration of the system in higher levels is difficult.  This research demonstrates integration of Hospital Information System in small scale using SymmetricDS Open Source database replication software.  It can be shown that the integration of Hospital Information System is highly possible to enable higher scale healthcare support system in the future.
MATRIKS METALOPROTEINASE (MMP), ENZIM PENDEGRADASI KOLAGEN SEBAGAI TARGET UNTUK ANTIPENUAAN Putri, Fanny Karuna; Wargasetia, Teresa Liliana; Ratnawati, Hana
Medika Kartika : Jurnal Kedokteran dan Kesehatan Vol 8 No 2 (2025): Medika Kartika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran Universitas Jenderal Achmad Yani

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Makin bertambahnya usia, orang dewasa mengalami kondisi kulit yang menua. Faktor yang dapat menyebabkan proses terjadinya penuaan kulit yaitu faktor intrinsik dan ekstrinsik. Faktor ekstrinsik utama sebagai penyebab dalam mempercepat proses penuaan kulit yaitu pajanan sinar matahari yang mengandung sinar ultraviolet (UV), sehingga penuaan kulit tersebut sering disebut sebagai photoaging. Matriks metaloproteinase (MMP) adalah kelompok enzim pendegradasi kolagen yang diketahui berperan penting dalam peningkatan penuaan kulit secara ekstrinsik akibat pajanan sinar matahari (photoaging) pada kulit. Radiasi sinar ultraviolet dari sinar matahari menyebabkan akumulasi reactive oxygen species (ROS) sehingga semakin meningkat pula kadar matriks metaloproteinase dan kerusakan kolagen pada kulit. Secara spesifik, MMP1 menginisiasi degradasi dari serat kolagen tipe I dan III, yang selanjutnya degradasi dilanjutkan oleh MMP3 dan MMP9. Oleh karena itu pengetahuan mendalam terkait enzim-enzim MMP yang berperan dalam degradasi kolagen menjadi penting sebagai target pencegahan penuaan kulit dan terapi antipenuaan kulit. Kata kunci: MMP, penuaan kulit, photoaging DOI : 10.35990/mk.v8n2.p185-197
Co-Authors Abdullah Rasyad Ziyad Achmad R. Permadi Achmad R. Permadi, Achmad R. Ade Kurnia Surawijaya Ahmad Faried Alya Mardhotillah Azizah Andi Wahju Rahardjo Emanuel Andi Wahju Rahardjo Emanuel Anis Syabani Muthmainnah Azis, Rizal Chandra Risdian Chandra Risdian Dani Dani Diana Krisanti Jasaputra Didik Priyandoko Elisabeth, Mariska Elizabeth Yohanes Ermi Girsang Fanny Rahardja Fauziyah, Nida Firyal Ginting, Chrismis Novalinda Girsang, Ermi Gunadi, Michael Sebastian Hadiprasetyo, Dhanar Septyawan Halim, Nathanael Hana Ratnawati HANA RATNAWATI Hanna Sari Widya Kusuma, Hanna Sari Widya Harjanti, Mathelda Weni Harry Murti Haryanti, Mathelda Weni Heddy Herdiman I Nyoman Ehrich Lister Ida AKT Bulan Ida AKT Bulan, Ida AKT Jeffrey ., Jeffrey Khie Khiong Khie Khiong Maranatha, Timothy Imanuel Maria Christine Marisca Evalina Gondokesumo, Marisca Evalina Meganita Marthania Meganita Marthania Meganita Marthania Michael Sebastian Gunadi Michael Sebastian Gunadi Michael Sebastian Gunadi Mohamad I Sapta Mohamad I Sapta, Mohamad I Nainggolan, Ita Margaretha Nathanael Halim Nathanael Halim Nindia Salsabila Mia Dewi Nindya, Faradhina Salfa Ningrum, Siti Ratu Rahayu Putri, Fanny Karuna Qlintang, Sandy RAHMAT, DENI Ratnadewi . Regina Putri Ria Aprilia Tri Puteri Permata Akbar Rizal Rosida Tiurma Manurung Sabrina, Adilah Hafizha Nur Santiadi, Sherly Sarwono, Sylvie Saufa, Zahra Qisthi Sherly Santiadi Sherly Santiadi Sherly Santiadi Sijani Prahastuti Subangkit, Mawar Surawijaya, Ade Kurnia Susy Tjahjani Takasenserang, Oktaviana Teddy Marcus Zakaria Teddy Marcus Zakaria Teddy Marcus Zakaria Teddy Markus Zakaria The Fransiska Eltania Tjandrawati Mozef Tjandrawati Mozef Triharsiwi, Dwi Nur Vinna Kurniawati Sugiaman, Vinna Kurniawati Wahyu Widowati Wahyu Widowati Wahyu Widowati Wahyu Widowati WAHYU WIDOWATI Zahiroh, Fadhilah Haifa