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All Journal Medical Journal of Indonesia Indonesian Journal of Urology Jurnal Ilmu Komunikasi Journal of SouthEast Asian Human Rights ETTISAL Journal of Communication Jurnal Pemberdayaan Masyarakat Madani (JPMM) Jurnal SOLMA ISM (Intisari Sains Medis) : Jurnal Kedokteran Best Journal (Biology Education, Sains and Technology) Jurnal Abdi Insani Aspirasi : Jurnal Masalah-masalah Sosial Jurnal Layanan Masyarakat (Journal of Public Service) Jurnal Pengabdian kepada Masyarakat Nusantara Biokultur Journal of Education Research Pedagogy : Jurnal Pendidikan Matematika Jurnal Ilmu Pendidikan Indonesia Jurnal Pengabdian Papua Makara Journal of Health Research Journal of Governance and Administrative Reform Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education and Research Institute Journal of Law and Legal Reform Merpsy Journal
Irfan Wahyudi
Departement Of Urology, Faculty Of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta
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Comprehensive Histopathological Properties of Dartos Tissue Associated with Hypospadias Severity and Chordee: A Prospective Study Raharja, Putu Angga Risky; Birowo, Ponco; Rachmadi, Lisnawati; Wibowo, Heri; Kekalih, Aria; Duarsa, Gede Wirya Kusuma; Wahyudi, Irfan
Proceedings Book of International Conference and Exhibition on The Indonesian Medical Education Research Institute Vol. 8 No. - (2024): Proceedings Book of International Conference and Exhibition on The Indonesian M
Publisher : Writing Center IMERI FMUI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69951/proceedingsbookoficeonimeri.v8i-.243

Abstract

Background: The cause of chordee in hypospadias is not fully understood. Dartos fascia resection has been shown to correct penile curvature, suggesting its potential involvement. This study aimed to evaluate the histopathological properties of dartos tissue and their association with hypospadias severity and chordee.Methods and Materials: Dartos tissue samples were collected from 37 children with hypospadias and ten controls undergoing circumcision between March and October 2024. Histopathological analysis using hematoxylin-eosin and Masson’s trichrome staining assessed for collagen, smooth muscle, and vascular density. Assessment and quantification of all histopathological components were blinded. Results: The hypospadias group showed lower collagen density (60.85±6.75% vs. 67.31±4.61%; p=0.003) and higher smooth muscle density (7.34±4.92% vs. 2.51±2.24%; p<0.001) compared to controls, with no significant difference in vessel density. Sub-analysis showed severe chordee was linked to lower collagen density compared to mild (Mean Difference [MD] -6.24±2.41%; p=0.014) and moderate chordee (MD -5.73±2.54%; p=0.031). Conclusions: The dartos tissue in hypospadias patients exhibited lower collagen density and higher smooth muscle density, with chordee severity specifically linked to decreased collagen density.
Co-Authors Agus Rizal Ardy Hariandy Hamid, Agus Rizal Ardy Hariandy Alam, Gampo Albertus Marcelino Alfarissi, Fekhaza Alfarissi, Fekhaza Andika Rendy Aria Kekalih ARIANTO, EKO Arry Rodjani Asy'ari, Nur Aini Shofiya Bagong Suyanto Bagus Baskoro Bettisari Napitupulu Bramono, Ikhlas A Chaidir A. Mochtar Chaidir Arif Mochtar CHAIDIR MOCHTAR, CHAIDIR Danurdoro, Aria Delta Bayu Murti Edhi Hapsari Endang Susalit Ervita Mediana Fatan Abshari, Fatan Fortuna, Edyna GAMPO ALAM IRDAM, GAMPO ALAM Gede Wirya Kusuma Duarsa Gerhard Reinaldi Situmorang, Gerhard Reinaldi Ginanda Putra Siregar, Ginanda Putra Happy Lumbantobing, Happy Heri Wibowo Hery Tiera Hutabarat, Ida M. Iannone, Aniello Ilham Wahyudi Ilmi, Irfan Immanuel Hutasoit, Yonas Intan Fitranisa Irdam, Gampo A Isnaini, Santi Johannes Aritonang, Johannes Jose RL Batubara Kanadi Sumadipradja Kholid, Irwan Layli Hamida Lisnawati Rachmadi Mandala, Opan Maradona, Maradona Mariati Hutabarat, Ida Maruhum B.H. Marbun Mohammad Fariz Muhamad Taufik Nadeak, Masaulina Klara Naiborhu, Rusdin Nainggolan, Ebram NICHOLAS TAMBUNAN, NICHOLAS Nur Rasyid Nuraini, Dini Rahmatun Pakpahan, Romauli Pangestu, Chandra Trisna Parenden, Natasya I. Ponco Birowo Prahara Yuri Prasetyo, Dimas Tri Putra, Ida Bagus Oka Widya Putra, Prima Ciko Ade Rachmah Ida Radian Januari Situmeang Raharja, Putu Angga Risky Rahayu, Titik Puji Rama Firmanto, Rama Ramadhiansyah, Dimas Rani Sukma Ayu Suteja Ratih Puspa Romadhona, Mochamad Kevin Romdhi Fatkhur Rozi Ronaldo Kho Samosir, Ernita Santi, Lintia N. Santoso, Yuniawan Heru Saparudin Efendi Sapto Andriyono Saputra, Hijrah Sa’diyah, Kamila Sa’diyah, Kamilah Septiani, Dina Setyo Hariyanto, Didik Sholeh, Rio Nur Sihotang, Retta Catherina Soeroto, Adhitama A. Sri Endah Kinasih Tanaya Ghinorawa Taufik Rakhman Taher Toetik Koesbardiati Widi Atmoko Widia, Fina Widodo, Suko Wijaya, Gustaf Yacob Ruru Yonas Immanuel Hutasoit, Yonas Immanuel Yopie T Satyawan Yopie Tjandradiguna Satyawan Yosep, Eska Yudha Alfanius Hutahaean, Andre