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All Journal MPI (Media Pharmaceutica Indonesiana) Jurnal Fitofarmaka Indonesia As-syifaa Jurnal Farmasi Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Review Pendidikan dan Pengajaran (JRPP) Pharmaceutical Sciences and Research (PSR) Jurnal Farmasi Indonesia Celebes Journal of Community Services Jurnal Sains dan Kesehatan Makassar Natural Product Journal MPSJ
Virsa Handayani
Universitas Muslim Indonesia
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Physics Social Sciences Other

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A Standardisasi Buah Dengen (Dillenia serrata Thumb.) Handayani, Virsa; Putri, Andra Audina; Handayani, Selpida
Makassar Pharmaceutical Science Journal (MPSJ) Vol 2 No 1 (2024)
Publisher : PHARMACY UMI JOURNAL SYSTEM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mpsj.v2i1.156

Abstract

Dengen (Dillenia serrata Thumb.) merupakan tumbuhan endemik yang tumbuh liar di Sulawesi. Buahnya memiliki beberapa manfaat salah satunya sebagai obat sariawan karena memiliki kadar vitamin C tinggi. Penelitian ini bertujuan mengidentifikasi dan menentukan nilai parameter spesifik dan non spesifik ekstrak buah dengen (Dillenia serrata Thumb.). Sampel diperoleh dari Kecamatan Malili, Kabupaten Luwu Timur Provinsi Sulawesi Selatan, dimaserasi dengan etanol 96% sebanyak 3 L kemudian dilakukan pengujian parameter spesifik dan non spesifik. Penelitian menunjukkan ekstrak buah dengen (Dillenia serrata Thumb.) memberikan hasil sesuai parameter standar umum ekstrak tumbuhan obat dengan nilai parameter spesifik sebagai berikut: ekstrak berbentuk kental, berwarna coklat pekat kehitaman, berbau khas; kadar senyawa larut dalam air yakni 16,0384%; kadar senyawa larut dalam etanol yakni 16,9811%; positif mengandung senyawa alkaloid, polifenol, flavanoid, terpenoid dan saponin; dan nilai parameter non spesifik sebagai berikut: susut pengeringan yakni 0,0615%; kadar air yakni 3,8052%; kadar abu total yakni 5,0599%, kadar abu tidak larut dalam asam yakni 0,4807%.
REVIEW ARTIKEL : IDENTIFIKASI BAHAN KIMIA OBAT (BKO) JAMU PELANGSING YANG BEREDAR DI INDONESIA suada, renata aini; Handayani, Virsa; Dahlia, Andi Amaliah
Makassar Natural Product Journal (MNPJ) Januari 2025
Publisher : UNIVERSITAS MUSLIM INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/mnpj.v2i4.244

Abstract

Jamu pelangsing merupakan ramuan bahan alam yang diracik dengan sedemikian rupa sehingga dapat membantu manusia dalam menjaga dan menurunkan berat badan. Adanya Bahan Kimia Obat (BKO) yang ditambahkan dalam jamu pelangsing dapat memberikan efek samping yang berbahaya bagi konsumen. Kromatografi Lapis Tipis (KLT) adalah salah metode pemisahan fisikokimia. Lapisan yang memisahkan yang terdiri atas bahan berbutir-butir (fase diam) ditempatkan pada penyangga berupa plat gelas atau logam. Campuran yang akan dipisahkan berupa larutan, ditotolkan berupa bercak. Kemudian plat dimasukan dalam bejana tertutup rapat yang berisi larutan pengembang yang cocok (fase gerak). Tujuan review artikel ini untuk mengetahui dan merangkum BKO apa saja yang terdapat pada jamu pelangsing dan penyebarannya. Penulis melakukan studi literatur melalui database elektronik seperti Portal Garuda, google scholar, PubMed, dll. Studi literatur dilakukan terhadap beberapa jurnal penelitian nasional dan internasional yang dipublikasi dalam sepuluh tahun terakhir. Pada jamu pelangsing, Bahan Kimia Obat (BKO) yang mungkin ditambahkan di antaranya adalah furosemid, sibutramin HCl, amphetamine, bumetanide, ephedra, orlistat, rimonabant, bisakodil dan fenoftalein.
Kajian Literatur Bioaktivitas, Fitokimia, dan Potensi Dermatologis Carthamus tinctorius L. Virsa Handayani; Akrom; Aktsar Roskiana Ahmad
Jurnal Penelitian Pendidikan IPA Vol 12 No 2 (2026)
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v12i2.13479

Abstract

This study systematically reviews the bioactivity, phytochemistry, and dermatological potential of Carthamus tinctorius L. using a structured synthesis of nine eligible research articles. The purpose of this review is to consolidate scientific evidence regarding the antioxidant activity, phytochemical composition, molecular mechanisms, and skin-related relevance of this plant across diverse study designs. The findings indicate that Carthamus tinctorius contains polysaccharides, phenolic compounds, flavonoids, and fatty acids that exhibit strong antioxidant activity, enzyme inhibition, and cellular protective effects. Several studies demonstrate its ability to modulate oxidative pathways, inhibit collagen-degrading enzymes, and support skin barrier integrity, highlighting its promising dermatological applications. Variations in bioactivity were influenced by genotype, environmental conditions, and extraction techniques, underscoring the importance of plant origin and processing methods. Overall, the review concludes that Carthamus tinctorius possesses significant potential as a natural source of therapeutic compounds relevant to skin health, anti-aging applications, and future product development. This synthesis also identifies methodological gaps that may guide further experimental, molecular, and formulation-based research.
Xanthine Oxidase Inhibitory and Antioxidant Activities of Kasumba Turate and Secang Extracts Combination Malik, Abd.; Dahlia, Andi Amaliah; Handayani, Virsa; Widiastuti, Harti; San, Htoo Tint; Ahmad, Aktsar Roskiana
MPI (Media Pharmaceutica Indonesiana) Vol. 8 No. 1 (2026): JUNE
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v8i1.8473

Abstract

Kasumba turate flower and Secang lignum have been commonly known as traditional medicinal widely grown in South Sulawesi. Both contain active constituents, including coloring agents such as carthamin in Kasumba turate and brazillin in Secang. These plants have been commonly used in traditional medicine to treat conditions such as high cholesterol, bacterial and viral infections, gout, and as antioxidants. Gout and high cholesterol are closely related. The combination of Kasumba turate and Secang extracts was intended to enhance activity. The evaluation of the xanthine oxidase inhibitor (XOD) and antioxidant activity (AO) was performed using the reducing uric acid and antioxidant FRAP methods. The XOD inhibitory study found that the extracts have activities as follow Sample A, B, C, and Allopurinol of 1.40; 2.1967; 2.24; and 1.39 μg/mL, respectively. The antioxidant capacity of Kasumba turate, Secang extract and their combination was 122.88; 17.36; and 197.31 μg/mL, respectively. We concluded that the combination did not increase the XOD inhibitory and antioxidant capacity. The Kasumba turate extract has the highest activity among the tested extracts.
Co-Authors -, Auliawati A Amaliah Dahlia Abd. Malik Abd. Malik Abd. Malik ABD. MALIK Abdul Rasyid, Faradiba Abdullah Mahmud Ahamd, Aktsar Roskiana Ahmad Najib Ahmad, Akstar Roskiana Ahmad, Aktsar Roskiana Akrom Alfirah Angraeni AMINAH Andi Afifah Amdar Andi Amaliah Dahlia Andi Fenny Nurvadillah Andi Nur Alam Amaliah Andi Surahman Batara Anisa, Rianti Asfar, Akbar Asni Amin Asriani Suhaenah Dedy Putra Wahyudi Dwiyanti Puspitasari Fadliyah, Nurfadhilah Ganoko, Marwan Ahmad Gazali, Anggun Hamidu, La Hamsinah Harti Widiastuti Hasnaeni hasnaeni, Hasnaeni HM, Nur Rahmah Isti Aprilyanie Kamase, Jeni Miswati Sudir, Miswati Murfat, Moh Zulkifli Murfat, Zulkifli Nur Rezky Khairun Nisaa Nurfadillah Nurfadillah Nurlinda Nurlinda Nurul Hasanah Nurul Ilmi Mufidah PRAHAYU, ADE CAHYA Putri, Andra Audina Rais Razak, Rais Reski Amriati Syarif Rezki Amriati Syarif Rezki Amriati Syarif Rezki Amriati Syarif Risda Waris Risda Waris Risda Waris, Risda Safriani Rahman Safriani Rahman, Safriani San, Htoo Tint Selpida Handayani Selpida Handayani, Selpida suada, renata aini Sudarman Suriyanti Tadjuddin Naid Tonang, Maswa Ruslan Umasangaji, Ria Fitriani Zainal Abidin