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All Journal ACTA VETERINARIA INDONESIANA Jurnal Pengolahan Hasil Perikanan Indonesia Prosiding Seminar Nasional MIPA Natural B Indonesian Journal of Tropical and Infectious Disease JURNAL KESEHATAN LINGKUNGAN (Journal of Environmental Health) The Indonesian Biomedical Journal Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Medik Veteriner WIDYA LAKSANA Bhakti Persada Jurnal Aplikasi IPTEKS INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY Jurnal Media Sains Journal of Applied Veterinary Science and Technology Indian Journal of Forensic Medicine & Toxicology Jurnal Pengabdian kepada Masyarakat Wahana Usada Seminar Ilmiah Nasional Teknologi, Sains, dan Sosial Humaniora (SINTESA) Seminar Nasional Aplikasi Iptek (SINAPTEK) Jurnal Kesehatan Terpadu DEDIKASI : Jurnal Pengabdian Kepada Masyarakat Paradharma: Jurnal Aplikasi IPTEK Journal of Fisheries & Marine Biosaintifika: Journal of Biology & Biology Education Jurnal Bioteknologi & Biosains Indonesia (JBBI) Jurnal Bioteknologi & Biosains Indonesia
I Gede Widhiantara
Program Studi Biologi, Universitas Dhyana Pura
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY

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Blumea balsamifera and Sargassum aquifolium extracts reduce fatty liver damage through lipid metabolism signalling pathways Widhiantara, I Gede; Wiradana, Putu Angga; Permatasari, Anak Agung Ayu Putri; Sari, Ni Kadek Yunita; Rosiana, I Wayan; Sandhika, I Made Gde Sudyadnyana; Panjaitan, Novaria Sari Dewi
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 6 No 2 (2024): Promising and Valuable Research Towards Diagnosis, Prognosis and Treatment of Dis
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v6i2.5697

Abstract

Non-alcoholic fatty liver disease (NAFLD) is a condition marked by excessive fat accumulation in the liver and poses a significant health challenge. The leaves of Blumea balsamifera and Sargassum aquifolium have been reported to have anti-atherogenic effects. This study aims to determine the effectiveness of B. balsamifera extract (BBLE) and S. aquifolium extract (SAE) in preventing and treating liver fat accumulation in Wistar rats induced by a high-cholesterol diet through the expression of the AMP-activated protein kinase (AMPK)/ Sirtuin 1 (SIRT1)/peroxisome proliferator-activated receptor γ (PPARγ) pathway, and the leptin receptor. The experimental design of this study is laboratory-based, involving, 20 Wistar rats were fed a high-cholesterol diet over a period of 21 days. The rats were divided into four groups for the evaluation of BBLE and SAE effect: negative control (P0): induced with a high-cholesterol diet + distilled water, positive control (P1): induced with a high-cholesterol diet + simvastatin, P2: induced with a high-cholesterol diet + 4 mg/kg/bw BBLE, and P3: induced with a high-cholesterol diet + 4 mg/kg/bw BBLE and 4 mg/kg/bw SAE. The treatment duration extended over three months. Immunohistochemical analyses were performed on liver tissues to measure AMPK, SIRT1, PPARγ, and leptin receptor expression. The results indicated that leptin expression was lower in the BBLE+SAE group compared to the simvastatin group, and differences were significant between the BBLE and BBLE+SAE groups. No significant differences were noted in AMPK, SIRT1, and PPARγ expression between the simvastatin and BBLE+SAE groups (p≥0.05). In conclusion, BBLE and SAE effectively reduce liver lipid accumulation and enhance fat metabolism in hypercholesterolemic rats.
Antidyslipidaemic effect of Ipomoea batatas L. extract with increased PCSK-9 levels in atherosclerotic rats Yasa, I Wayan Putu Sutirta; Jawi, I Made; Mahendra, Agung Nova; Wiradana, Putu Angga; I Gede Widhiantara
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 8 No 1 (2026): Integration of Molecular Approaches in Addressing Drug Resistance and Changing Gl
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v8i1.7260

Abstract

Atherosclerosis is the largest cause of mortality worldwide, and Low-Density Lipoprotein (LDL) is a primary risk factor for this illness. The purpose of this research was to determine the effect of purple sweet potato (Ipomoea batatas L.) extract on cholesterol, LDL, PCSK9, and MDA levels in rats fed a high-cholesterol diet. This true experimental study used a randomised pre-test-post-test control group design. Wistar rats were randomly assigned to three groups. Purple sweet potato extract (PSPE) was prepared by 24-hour maceration with 70% ethanol. All rats were fed a high-cholesterol diet for 14 days, followed by pre-test measurements of cholesterol, LDL, PCSK9, and MDA on day 15. Rats were then randomly divided into control (no treatment), PSPE (200 mg/day), and Simvastatin (0.9 mg/kg BW) groups. After one month of treatment, post-test analyses were performed for all parameters. The results showed an increase in serum cholesterol, LDL and MDA levels in rats fed a high-cholesterol diet (p<0.05) compared to the PSPE and Simvastatin groups. The high-cholesterol diet also resulted in a significant (p<0.05) decrease in PCSK9 when compared to the PSPE and Simvastatin groups. In the PSPE group there was a decrease in cholesterol, LDL, and MDA, and PSPE (p<0.05) compared to the control group. In the Simvastatin group, the increase in PCSK9 was very low compared to the PSPE group. PSPE has antidyslipidaemic activity by reducing total cholesterol status, LDL, and oxidative stress while promoting PCSK-9 function. Further research is still needed to provide a comprehensive understanding of the mechanism of action of PSPE as an antioxidant source in patients with atherosclerosis.
Co-Authors Adi Sofyan Ansori, Muhammad Adnorita Fandah Oktariani Adnyana, Gabriel Firsta Afta Daniel Zato Waruwu Agoes Soegianto Agung Nova Mahendra Agung Wahyu Permadi Anak Agung Ayu Putri Permatasari Anak Agung Ngurah Subawa Aprodita, Ni Wayan Seila Aris Jatmiko Aryaswari, Ni Kadek Dwi Liopita Aulia Iefan Datya Bagus Komang Satriyasa Bambang Yulianto Bambang Yulianto Chela Krisna Denata Datya, Aulia Iefan Desak Made Widyanthari Desyandri Desyandri Dewi, Ni Putu Eny Sulistya Dewi, Pande Putu Indira Prima Ferbian Milas Siswanto Fimaputra, Jatu Maranatha Garry Ganvis Jonteo Hani Herdiansyah, Mochammad Aqilah I Gusti Agung Manik Karuniadi I Gusti Ayu Wita Kusumawati I Made Endra Puniawan I Made Gde Sudyadnyana Sandhika I Made Jawi I Made Murna I Made Sujana Wisnu Prananta I Made Wisnu Adhi Putra I Nyoman Mangku Karmaya I Wayan Putu Sutirta Yasa I Wayan Rosiana Imanuel Yacob Wila Indah Pramita J. A. Pangkahila Kadek Dwi Adi Mas Putrayana Kusala, Muhammad Khaliim Jati Kusala Luh Putu Widiastini Made Nyandra Maharianingsih, Ni Made Manuaba, I.A Ratih Wulansari Matius Victorino Ola Dame Mochammad Aqilah Herdiansyah Muhammad Khaliim Jati Kusala Naw, Sin War Ni Kadek Dwipayani Lestari Ni Kadek Wini Ewintiani NI KADEK YUNITA SARI Ni Komang Widiastuti Ni Luh Sunarsih Ni Putu Eny Purwita Dewi Ni Putu Eny Sulistyadewi Novaria Sari Dewi Panjaitan Pande Putu Indira Prima Dewi Panjaitan, Novaria Sari Dewi Panjaitan, Novaria Sari Dewi Panjaitan Pelupessy, Yesha Ainesis El Gracianita Permatasari , A.A. Ayu Putri Permatasari , Anak Agung Ayu Putri Permatasari, A. A. Ayu Putri Permatasari, Anak Agung Ayu Putri Permatasari, Anak Agung Ayu Putri Permatasari Putri, Fadillaisyia Riandani Putu Angga Putu Angga Wiradana Putu Eka Sudaryatma Putu Eka Sudaryatma Putu Wida Gunawan Raden Joko Kuncoroningrat Susilo Rahmadi Prasetijo Razaq, Imanuddin Rizqy, Aimatun Nisfia Sandhika, I Made Gde Suadnyana Sari, Ni Kadek Yunita Sari Setyo Budi Kurniawan Sri Puji Astuti Wahyuningsih Sutema, Ida Ayu Manik Partha Teguh Hari Sucipto, Teguh Hari Waruwu, Ernawati Wiartini, Ni Wayan Ayu Wiartini Widowati, I Gusti Ayu Rai - Wimpie I Pangkahila Win Darmanto Wiradana , Putu Angga Wiradana, Putu Angga Wiradana Yesha Ainensis El G. Pelupessy