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All Journal International Journal of Public Health Science (IJPHS) Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Brawijaya Jurnal Kesehatan Masyarakat Journal of Innovation and Applied Technology Erudio: Journal of Educational Innovation Jurnal Teknik Pengairan: Journal of Water Resources Engineering Global Medical and Health Communication Public Health of Indonesia Majalah Kesehatan FKUB Medical Laboratory Technology Journal Belitung Nursing Journal Jurnal Aisyah : Jurnal Ilmu Kesehatan International Journal of Educational Management and Innovation (IJEMI) Devotion: Journal of Research and Community Service Narra J International Journal of Science and Society (IJSOC) Jurnal Kesehatan dan Pengelolaan Lingkungan Berita Kedokteran Masyarakat Journal of Nursing Science Update Journal of Community Health and Preventive Medicine (JOCHAPM) JMMR (Jurnal Medicoeticolegal dan Manajemen Rumah Sakit) Journal of Agriprecision & Social Impact
Lilik Zuhriyah
Department Of Public Health Science, Faculty Of Medicine, University Brawijaya, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Journal : Narra J

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Effective probiotic regimens for bacterial vaginosis treatment and recurrence prevention: A systematic review Udjianto, Udjianto; Sirat, Noorhamdani A.; Rahardjo, Bambang; Zuhriyah, Lilik
Narra J Vol. 5 No. 1 (2025): April 2025
Publisher : Narra Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52225/narra.v5i1.1671

Abstract

Probiotics represent a promising alternative therapy for bacterial vaginosis; however, consensus on the most effective species, strains, and doses remains lacking, and long-term safety data are limited. The aim of this study was to evaluate the effectiveness of probiotics in managing bacterial vaginosis, considering species, strain, clinical outcomes, optimal dosage, duration, and side effects. This study included randomized-controlled trials (RCTs) published in English (2014–2024) on probiotic treatment for bacterial vaginosis, assessing species, strain, dose, duration, and efficacy. A systematic search was conducted on December 20, 2024, in Scopus, Web of Science, and PubMed using the keywords "vaginosis," "bacterial vaginosis," and "probiotic." Data were extracted and synthesized, and study quality was assessed using the Risk of Bias 2 tool, while NVivo 14 software facilitated thematic analysis. The systematic search yielded 1,560 initial records, of which 16 RCTs were included. The findings revealed that Lactobacillus rhamnosus TOM 22.8 (10×10⁹ CFU/day for 10 days) was the most effective strain and dose, significantly improving Nugent scores, vaginal pH, and microbiota composition and reducing bacterial vaginosis recurrence rate. Alternative strains, including L. crispatus, L. plantarum, and L. acidophilus, showed therapeutic potential at doses of 1×10⁸ to 5.4×10⁹ CFU/day for treatment durations ranging from 6 days to 4 months. The reported side effects were mild and self-limiting. This study supports the use of probiotics as an adjunctive or alternative bacterial vaginosis treatment, emphasizing the need for a personalized approach based on patient characteristics. However, limitations such as small sample sizes and heterogeneous outcome measures necessitate further research. Larger, well-designed trials with standardized methodologies are required to refine probiotic recommendations.
Co-Authors AA Sudharmawan, AA Adeliza Firzarosany Afiatur Rohimah Agung Indrawan, I Wayan Agung Prasetia Ahmad Ikbal P Ahmad Yunus Ainun Ganisia Aldila Putri Rahayu Alfryan Janardhana Aliesya Patricia Wulandari Andi Arahmadani Arasy Anggun Setyaningrum Arasy, Andi Arahmadani Ardy mahendra Ariani Ariani Arum Sulistyarini Asrini Kaninta Asti Melani Astari Aswin Djoko Baskoro Azzahra, Shabrina Laila Bambang Rahardjo Cahyani, Dinar Yuni Awalia Anilam Candra Novi Dermawan Cicin Ulfinah Cornelia Fransiska Sandehang Denny Ahmad Fauzi DEWI ARIANI Dewi Santosaningsih Dian Handayani Dian Pitaloka Priasmoro, Dian Pitaloka Dina Dewi Sartika Lestari Ismail Dinar Yuni Awalia Anilam Cahyani Dradjat, Respati S. Dwi Wahyudi Ekkel Aisyiyah Eleonora Sucahyo Fariza Kusuma W Fiella Rachmatika Flavianus Riantiarno Frasia, Yhummei Veronia Frits Hendrik Kaiya Hari Kusnanto Haripradiantoi, Tito Hariyanto, Engelbert Harun Al Rasyid Harun Al Rasyid Harun Al Rasyid Helen Lioni Herwendanasari, Deltania I Wayan Agung Indrawan Ifit Bagus Apriantono Indriani Ningrum Ineke Permatasari Iris Juita Kastianti Isnadiyah Juhdi Jihan Arabikum Juhdi, Isnadiyah Kartika, Annisa Wuri Ken Diah Mangar Nastiti Kristianingrum, Niko Dima Kristina Haloho, Sri Dewi Kumboyono Kumboyono Kumoro Asto Lenggono Kuncoro, Wahyudi Kuswantoro Rusca Putra Lilik Supriati Linda Prasetyorini Loeki Enggar Fitri Marji Marji Martha Nurani P Mira Fatmawati Mujahidin Mujahidin Mukhamad Fathoni Nadya Karlina Megananda Nafisa Naaz Nanik Setijowati Nastiti, Ken Diah Mangar Natalia Damaiyanti Putri Raden Natasha Halim, Angie Ni Made Sintha Pratiwi Nikma Fitriasari Ninik Djajati Nugroho Nurponco Priyanto Nur Hidayati Azhar, Nur Hidayati Panjaitan, Damaris Gabrielle Valentine Pedro gonzales Pradina, Fifin Prahadiani, Saesar Revita Proscilla Maiselina Putri Fitri Alfiantya Rahayu, Aldila Putri Rahmad Rahmad Rahmah Dara Lufira Rahmawati Aminingrum Rakhmani, Alidha Nur Respati Suryanto Dradjat Rifqi Rinanto Rinik Eko Kapti, Rinik Eko Rivo Yudhinata Brian Nugraha Rochelle siem Safrina Dewi Ratnaningrum, Safrina Dewi Sakinah Annura Satwika Desantina Muktiningsih Satwika Desantina Muktiningsih Satwika Desantina Muktiningsih Satwika Desantina Muktiningsih, Satwika Desantina Sirat, Noorhamdani A. Sitawati Sitawati Siti Dwi Astuti Sri Andarini Sri Andarini Sri Andarini Sri Hayati, Yati Sutrisno . Thalia Suharli Tita Hariyanti Tri Baskoro Tunggul Satoto Tri Wahyu Sarwiyata Udjianto, Udjianto Ulina Sagala, Hotma Wandira Lalitya Wardani, Diajeng Setya Wening Prastowo Wicaksana, Anang Panca Windarwati, Heni Dwi Wurjatmiko, Adi Try Yahya Irwanto Yati Sri Hayati Yulia Dwi Setia Yulianto, Wahyu YUNI ASRI, YUNI Zahra Zahra Zainal Arifin Zainal Ulu Zaroan Supriadi