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All Journal Jambura Journal of Health Sciences and Research Journal On Teacher Education (Jote) Proceeding of Mulawarman Pharmaceuticals Conferences

Yurika Sastyarina

Laboratorium Penelitian dan Pengembangan Kefarmasian “Farmaka Tropis”, Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Author-ID : 4295738

Biochemistry, Genetics & Molecular Biology Chemistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Mathematics Medicine & Pharmacology Nursing Public Health Social Sciences Other

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Studi Literatur: Aktivitas Antidiabetes Bawang Dayak (Eleutherine americana) dan Serai (Cymbopogon citratus) Miranda Aurora Pratiwi; Febrina Mahmudah; Yurika Sastyarina
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 12 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Diabetes mellitus is a metabolic disease characterized by hyperglycemia. The Indonesian government is currently advising the public to consume traditional-based medicines because of their low side effects. One of the traditional medicines used is lemongrass and dayak onions. This study aims to determine the chemical compound content and antidiabetic activity of lemongrass and dayak onions. The research method used is the literature review method. Data searches were performed online on the PubMed, Science Direct, Google, Elsevier, and Google Scholar databases as well as other journal search websites. The scientific journals used are scientific journals published in the last 13 years. From 9 literature that has been studied, it shows that dayak onion tubers identify the presence of tannin compounds, saponins, flavonoids, alkaloids, steroids, terpenoids, glycosides, and anthraquinones while lemongrass contains tannin compounds, saponins, flavonoids, alkaloids, steroids, terpenoids, essential oils, phenolic, anthraquinones, carbohydrates, and glycosides. From 14 literature it is known that dayak onion tubers and lemongrass have antidiabetic activity. Compounds that have anti-diabetic activity properties include flavonoids, tannin and alkaloids contained in dayak onion and lemongrass, other than that essential oils contained in lemongrass.

Studi Literatur: Aktivitas Senyawa [6]?Gingerol dari Rimpang Jahe (Zingiber officinale) sebagai Imunomodulator Nanda Uswatun Hasanah; Dewi Rahmawati; Yurika Sastyarina
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 12 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Immunomodulator is a substance that can change or affect the body's immune system to normal. One of the plants that has immunomodulatory activity is ginger rhizome. Ginger rhizome (Zingiber officinale) is a tribe of Zingiberaceae which is widespread in Southeast Asia, empirically used as a cooking spice and traditional medicine to treat various medical conditions such as diabetes, arthritis, rheumatism, soreness, sore throat, constipation, indigestion, hypertension, dementia, fever, infectious diseases, and helminthiasis. The purpose of this study is to examine the literature regarding the compound [6] -Gingerol from ginger rhizome which has immunomodulatory activity. This research method is a literature study conducted by an online search process using the Google Chrome application, journals obtained on the ScienceDirect, PubMed, and Google Scholar. The journals are national and international journals without any publication time limit for cited journals. There are 7 pieces of literature showing that the compound [6] -Gingerol from ginger rhizome (Zingiber officinale) has activity as an immunomodulator.

Literatur Review: Aktivitas Antibakteri Terhadap Bakteri Penyebab Gangren Diabetik dari Minyak Atsiri Berbagai Tanaman Herbal Riska Novianti; Mirhansyah Ardana; Yurika Sastyarina
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 12 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Diabetic gangrene is a complication caused by infection due to the presence of a bacteria or a wound inflammatory process associated with diabetes mellitus. One of the therapies given is by taking antibiotics and currently the problem of antimicrobial resistance is a problem that is often faced which makes people start using drugs from natural ingredients. This literature search aims to determine the antibacterial activity of essential oils of various herbal plants against bacteria that cause diabetic gangrene. The method used is literature review with journal searches on indexed journal databases. The results obtained from 12 literature show that the essential oil of a herbal plant that has antibacterial activity against bacteria that cause diabetic gangrene, namely Cymbopogon citratus essential oil, Juglans regia L, Zataria multiflora Boiss, Ocimum gratissimum L, Satureja spicigera, Cinnamomum osmophloeum, a combination of essential oils masoyi and cinnamon, citronella (Cymbopogon bernadus L), jeringau rhizome (Acorus calamus Linn), Piper gibbilimbum C, kaffir lime (Citrus hystrix DC) and clove flower essential oil (Syzygium arimaticum).

Studi Literatur: Penggunaan Obat Remdesivir dan Favipiravir dalam Terapi Covid-19 Sri Lestari; Dewi Mayasari; Yurika Sastyarina
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 12 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Coronavirus Disease 2019 (COVID-19) is a respiratory disease caused by the new coronavirus and is spreading rapidly throughout the world. Several studies were conducted to find these antiviral agents, one of which is Remdesivir and Favipiravir. This literature study aims to examine the use of Remdesivir and Favipiravir as therapy in COVID-19 patients with a literature study. The research method used is a literature review with an electronic database of indexed journals with a journal publication time limit for 2019-2020 using the appropriate keywords. From the 10 literature that has been reviewed, it shows that the use of Remdesivir and Favipiravir in the treatment of COVID-19 provides an improvement in the patient's health condition.

Studi Literatur: Skrining Fitokimia dan Aktivitas Farmakologi Tanaman Kelor (Moringa oleifera Lam) Nur Amiiroh Isyraqi; Dewi Rahmawati; Yurika Sastyarina
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 12 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Indonesia has a wide variety of plants that can be used as medicinal ingredients. Biodiversity in Indonesia has a lot of potential as medicine so that it needs to be further explored regarding its properties for health. Moringa (Moringa oleifera Lam) belongs to the genus Moringaceae. Moringa plants have been widely used by the community as an herbal treatment to treat various diseases. The purpose of this study was to collect information related to phytochemical compounds and pharmacological activities of moringa plants using literature study methods. Literature search using appropriate keywords online using national and international indexed databases for the last 10 years (2010 to 2020). Based on the 18 literature that has been collected, the results obtained are chemical compounds identified in Moringa plants, including Alkaloids, Flavonoids, Saponins, Triterpenoids, Tannins, and Steroids. While the pharmacological activities found in moringa are antioxidant, anti-hyperuricemic, analgesic, anti-cancer, antihyperglycemic, anti-inflammatory, antihyperlipidemic, and antimicrobial activities.

Studi Literatur: Aktivitas Imunomodulator Tanaman Jintan Hitam (Nigella sativa L.) Tanti Dwi Gunawati; Febrina Mahmudah; Yurika Sastyarina
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 12 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

An immunomodulator is a substance or agent that can cause immunomodulatory activity by changing or affecting the immune system or producing an unwanted immune response through dynamic regulation of the target immune system. Black cumin (Nigella sativa L.) or better known to the public with Habbatus saudah already included in the Ranunculaceae plant family has properties to treat various diseases such as strengthening the immune system, asthma, bronchitis, diabetes, anti-histamine, anti-oxidant, anti-tumor. digestive tract and bacteria. This study aims to analyze the literature related to the immunomodulatory activity of black cumin plants. The research method used is a literature study. Data searches were carried out using online search engine instruments such as Google Scholar, Pubmed, Science Direct, Elsevier, NCBI without any time limit for cited journals. The results of research from 10 journals that have been analyzed show that black cumin (Nigella sativa L.) has acted as an immunomodulator.

Studi Literatur: Tanaman yang Memiliki Aktivitas Peluruh Kalsium Batu Ginjal Secara In Vitro Yustika Rahayu; Nur Mita; Yurika Sastyarina
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 12 (2020): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Kidney stones are a disease that is often found in society due to various causes. This disease is characterized by hardened deposits in the kidneys, mostly containing calcium oxalate and calcium phosphate. The medical treatment used is most effective with surgery. But this can carry significant risks, unwanted side effects, and is relatively expensive. So that herbal medicine becomes an alternative. This study aims to determine which plants have the activity of calcium kidney stone breaking. The research method used is online data search using appropriate keywords, carried out online in indexed journal databases. Based on several studies, there are several plants that have in vitro activity so that they can provide an overview of certain herbal plants that have the potential to decay calcium kidney stones, namely Cocor Bebek (Bryophyllum Pinnatum Lam), Kelor Leaves (Moringa oleifera Lam.), combination of Soursop Leaves ( Annona muricata) and pegagan (Centella asiatica L.Urb) , Adam Hawa leaves (Rhoeo discolor Hance), starfruit leaves (Averrhoa bilimbii L.), Moonflower leaves (Tithonia diversifolia), and celery (Apium graveolens L.)The part of tamanan leaves studied has a good affinity for releasing kidney stones calcium.

Uji Aktivitas Antibakteri Ekstrak Kombinasi Umbi Bawang Tiwai dan Kulit Buah Lemon Terhadap Pertumbuhan Staphylococcus aureus dan Escherichia coli: Antibacterial Activity Test of Combination of Tiwai Onion Bulbs and Lemon Peel on the Growth of Staphylococcus aureus and Escherichia coli Adinda Niti Meilaningrum; Novita Eka Kartab Putri; Yurika Sastyarina
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Tiwai onion (Eleutherine americana (Aubl.) Merr) is a plant that contains several groups of secondary metabolites, one of which is the alkaloid group. Lemon rind (Citrus limon) is a plant that contains more than 2.5% essential oil and hesperidin. Several classes of secondary metabolite compounds from these two plants have antibacterial activity. This study aims to determine the characteristics of the extract and the antibacterial activity of the extract combination. The extract characteristics were tested in the form of organoleptic, pH and solubility. Meanwhile, the antibacterial activity test was carried out by using the well diffusion method. The results obtained were the characteristics of the tiwai bulb extract and lemon peel in the form of organoleptic (color: blackish red and yellow, thick texture, distinctive aroma of onion bulbs and lemon peel); pH (6.4 and 4.8); solubility (soluble in ethanol, methanol and aquades) and antibacterial activity at a concentration of 12: 3 with an average of 8.75mm (S. aureus) and 7mm (E.coli); 12: 6 with a mean of 11mm (S.aureus) and 7.25mm (E.coli); 12: 8 with an average of 12.25mm (S.aureus) and 13.75mm (E.coli). It can be concluded that at a concentration of 12: 8 the combination of these extracts had the highest average inhibition zone in inhibiting the two bacteria.

Simulasi Docking Senyawa Napthoquinones Umbi Bawang Tiwai (Eleutherine americana Merr.) terhadap Bakteri Mycobacterium tuberculosis: Docking Simulation of Umbi Bawang Tiwai Napthoquinones Compound (Eleutherine americana Merr.) against Mycobacterium tuberculosis bacteria Irmayanti Irwan; Hajrah Hajrah; Yurika Sastyarina
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Bawang tiwai (Eleutherine americana Mirr.) is a plant empirically used as an antituberculosis. This plant is thought to have potential because having a compound naphthoquinone potential antituberculosis seen from the average value of the MIC between 206,6 and 12.5 ?M. This study aims to examine a model of the interaction of compounds derived naphthoquinone of bawang tiwai against the side of the fastener from the bacterium Mycobacterium tuberculosis. The method used is docking molecular using AutoDock tools, and Biovia 2020, the prediction of physicochemical which refers to the law of the five Lipinski of using pkCSM online tool. The receptor proteins used were InhA (PDB: 2X23) and the test ligands of elecanacin, eleutherin, eleutherol, and isoeleutherin. The results show that the four compounds comply with Lipinski's five laws, and the docking analysis data is the value of free bond energy (?G) of the four compounds, respectively, -5.82, -4.80, - 5.06, -5.52. The ?G value is below the natural ligand, namely -8, 19, and no hydrogen bonding interaction. It can be concluded that the four naphthoquinone derivative compounds in bawang tiwai lack the potential to bind to the binding site of the Mycobacterium tuberculosis bacteria.

Formulasi Sediaan Lipbalm Ekstrak Bawang Tiwai (Eleutherine Americana Merr) Sebagai Pelembab Bibir: Lipbalm Formulation of Tiwai Onion Extract (Eleutherine Americana Merr) as Lip Moisturizer Mutiara Citra Refordayanti; Novita Eka Kartab Putri; Yurika Sastyarina
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 13 (2021): Proc. Mul. Pharm. Conf.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Tiwai onion (Eleutherine Americana Merr) is a typical Kalimantan plant that is known to have various benefits. Local people use tiwai onions as a remedy for various types of diseases and plants which are provided as colorants in food or in cosmetic products because they have a red color caused by anthocyanin pigments. This study aims to make a lipbalm formulation from the extract (Eleutherine Americana Merr). The method used is experimental research methods. The test of the extract reaction was in the form of organoleptic, pH and solubility. The results obtained were the extract of tiwai onion extract in the form of organoleptic (color: brick red, thick extract, distinctive odor of tiwai onion), pH (5.86), solubility (soluble in ethanol, methanol and distilled water) which was in accordance with the parameters with Deng The results of the tiwai onion extract which can be formulated in lipbalm formulations (F1, F2, F3) have homogeneity in accordance with the parameters, the appropriate pH is F1 (5.79-6.20), F2 (5.87-6). , 21), and F3 (5,91-6,14) and for F1 organoleptics (color: milk orange, oleum rosae distinctive aroma, soft and smooth texture), F2 (color: light orange, oleum rosae distinctive aroma, soft texture and smooth, and F3 (color: orange, distinctive aroma of oleum rosae, soft and smooth texture). It can be neglected that tiwai onion extract can be formulated in lipbalm preparations.

Co-Authors Abdul Mutalib Adinda Niti Meilaningrum Aditya Fridayanti Amalia Srikurniawati Ameilia Rachmadianty Andi Tenri Kawareng Angga Cipta Narsa Aprilia Wulandari Arsyik Ibrahim Asri Wido Mukti Asti Rahayu Asti Rahayu Aulia Alfath Rahmawati Ayida Mawarda Cindy Puspita Perdana Cyntia Bella Anggraini Dewi Mayasari Dewi Perwito Sari Dewi Rahmawati Dhea Amanda Sabilla Fauzi Enggar Wijayanti Erwin Samsul Febrina Mahmudah Fidhia Rara Lande Fika Aryati Fika Aryati Fitriani Miranda Ganjar Firmansyah Hadi Kuncoro Hajrah Hajrah Hajrah Hajrah Hajrah Hajrah Hajrah Hajrah Hanny Chynthia Vehrawati Hardani, Prisma Trida Herman Herman Hidayatunnikmah, Nina Intan Ayu Kusuma Pramushinta Irmayanti Irwan Islamudin Ahmad Istnaini Reiza Fatimah Jaka Fadraersada Junaidi Khotib Khusnul Khatimah Rukhayyah Lisna Meylina M. Arifuddin M. Khalid Akbar Mahfuzun Bone Martalena Ramli Maulidya Maulidya Miranda Aurora Pratiwi Mirhansyah Ardana Mirhansyah Ardana Muhamad Handoyo Sahumena Muhamad Handoyo Sahumena Muhammad Faisal Muhammad Yusuf Mutiara Citra Refordayanti Nanda Uswatun Hasanah Novita Eka Kartab Putri Novita Eka Kartab Putri Nur Amiiroh Isyraqi Nur Aprilianti Nur Mita Nurul Fitriani Purbosari, Ira R. Ukun M.S. Soedjanaatmadja Rahmadani, Agung Ridha Siti Ruhama Rifaldy Rahmadillah Riska Novianti Rizal Adi Saputra Rizki Noor Amelia Sari, Dewi Perwito Shofia Siza Maulidia Sri Lestari Sukardiman Tanti Dwi Gunawati Tri Woro Widyanti Triani Yastuti Kuling Wa Ode Rungaya Ningsih Komala Wahyu Trimadianti Wahyu Widayat Yoni Miftahun Nafsiyah Agustin Yuspian Nur Yustika Rahayu Zuhrotun Nafisah

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