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Susi Rahayu
Program Studi Fisika, Fakultas Matematika Dan Ilmu Pengetahuan Alam, Universitas Mataram
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Astronomy Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Library & Information Science Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Nursing Physics Public Health Social Sciences Other

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Journal : Indonesian Journal of Pharmaceutical Science and Technology

 1 
Isolation of Chitosan Biopolymer from Nacre (Pinctada maxima) as Bone Scaffold Candidate Taufik S, Ahmad; Alawiyah, Geby; Rahayu, Susi; Kurniawidi, Dian W; Handayana, I Gusti Ngurah Yudi; Cahyawati, Triyana Dyah; Purnaning, Dyah; Amin, Muhamad
Indonesian Journal of Pharmaceutical Science and Technology Vol 12, No 1 (2025)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v12i1.44794

Abstract

The rising incidence of bone injuries necessitates researching and developing safe bone replacement materials. Chitosan biopolymer is one of the available materials. Because it is non-toxic, biocompatible, and biodegradable, chitosan can be employed as a bone scaffold material. According to the European Pharmacopeia 6.0 (Eur: Ph 6.0), chitosan, with a deacetylation level of more than 70%, is safe for medicinal usage. The purpose of this research was to analyze the  characteristics of chitosan isolated from nacre and the influence of nacre powder mass  on the degree of deacetylation of  chitosan. Chitosan was extracted by the processes of deproteination, demineralization, and deacetylation. Organoleptic tests, yield calculations for each stage, examination of the degree of deacetylation, creation of functional groups, and vibrational modes based on Fourier Transform Infrared (FTIR) data were performed on the isolated chitosan. The produced chitosan exhibited the properties of being beige color, odorless, and in powder form. The yield of insulation results obtained by the mass of chitosan. 3.7 % of the mass of nacre powder. The resultant chitosan has the formation of hydroxyl (OH) and amine (NH2) groups and vibrational stretching and bending modes. The variation in nacre powder mass throughout the isolation procedure altered the degree of deacetylation of the resultant chitosan and the wave number spectra of the hydroxyl (OH) and amine (NH2) groups. Chitosan, with a mass of 80 grams of nacre powder and a value of 76.94%, exhibited the highest degree of deacetylation. Considering that the functional groups generated in chitosan are comparable to those in bone, chitosan is a potential material for bone scaffolds.
Co-Authors ABDUL GANI abdurrouf Abdurrouf Afiatul Hafifah Agista, Wida Puteri Agus Saputra Agus Wahid H Ahmad Risandi F. Ahmad Taufik Ahmad Taufik S Ahmad Taufik S Akhyar, Halil Alaa, Siti Alaa, Siti Alawiyah, Geby Alaydrus, Alfina T. Alaydrus, M. Mukaddam Alaydrus, Mukaddam Alda Berlian Alfina Alaydrus Alfina Taurida Alaydrus Alhaqiqi, Candra Alimuddin Alimuddin Amirrah, Reffa Amrul Ikhsan Amrulloh, Ashfia Anggie Dwi P. Anggriani, Ni Ketut Ansyori, Maz Isa Arif Budianto Arif Budianto Arif Budianto Arum, Maysaroh Arzyl Akbar Baiq Niswatul Khair Baiq R. S. Yusuf Bakti Sukrisna Cahyawati, Triyana Dyah Deasy Mariyani Desti Olga Safitri Destrianingtyas, Aulia Safitri Dewi Handayani Dewi, Diah L. Diah L. Dewi Diah L. Dewi Dian W Kurniawidi Dian W Kurniawidi Dian W. Kurniawidi Dian W. Kurniawidi Dian W. Kurniawidi Dian Wijaya Kurniawidi Dian Wijaya Kurniawidi Dian Wijaya Kurniawidi Djoko H Santjojo Djoko H. Santjojo Dodi Mariadi Dona, Dona Dwiyansaputra, Ramaditia Eka Rahmawati Eka Rahmawati Enggar Juwanda K. Ervina Sandra Dewi Eva Nurhaliza Eva Nurhaliza Fadila, Naila Fadli Robiandi Fajriah, Baiq Nurul Fidya, Karina Alma Fitri Bimantoro Geby Alawiyah Habib Ridwansyah Hadi, Kasnawi Al Halil Akhyar Halil Akhyar Hamidi, Mohammad Zaenuddin Handayana, I Gusti Ngurah Yudi Handayana, I Gusti Ngurah Yudi Hasanah, Khofizzatul Hendri Maradona, Hendri Hiden - Hiden Huan Ahmad T. Hurnah Hurnah, Hurnah Huwaida, Maitsa I G N Yudi Handayana I Wayan Sudiarta Inatsa, Najma Intan Utami Intan Utami Isa A.A, Maz Iwan Sumarlan Jannah, Sahlli Jazuly, Zaky Juniarti, Rosita Kasnawi Al Hadi Kholik Hidayatullah Khusnul Khotimah Kiki Yasdomi Kormil Saputra Kurniawidi, Dian W Kurniawidi, Dian W. Kurniawidi, Dian Wijaya Laeli, Ida Laili Mardiana Lalu A Didik Lalu A Didik Lalu A. Didik Lalu Sahrul Hudha Legi Aprila Lestari, Sintya Dewi Lily Maysari Angraini Liza Umitasari Mammi Dwi R. Marlina, Resti Marzuki Marzuki Marzuki Marzuki Masruroh Masruroh Maulana, Sutan Fajri Meilani, Dini Moh. Bahtiar Muh. Alfaris Muhamad Ali Muhamad Ali Muhamad Ali Muhamad Amin Muhamad Amin Muhammad Fajrin Muhammad Maulana Nadila Rahmawati Nafsiatil Afro', Maulina Nurfadilah Nurhidayati Nurhidayati Nurlaili Nurlaili NURUL QOMARIYAH Oktri P, Awanda Pertiwi, Shavira Purnaning, Dyah Putraji, L.M. Guguh Putri Arifatul Fajriyah Ramadian Ridho Illahi Reza Alfian Rohani Sayuti Rosita Juniarti RR. Delima S. Rubi'ah, Siti Sabrina, Sovia sasabila sasabila Septiani, Nonik Setyawan P Sakti Setyawan P. Sakti Sinta Devi Hariyanti Siti Alaa Siti Alaa Siti Alaa' Siti Alaa` Siti Alaa’ Siti Ema Nurmaulida Sri Mulyani Suhayat Minardi Suhayat Minardi Sunita, Asfa Syamsuddin Syamsuddin Syamsuddin Syamsuddin Syamsuddin Teguh Ardianto, Teguh Thathit Suprayogi Utami, Urfi Wahana, Lidia Wahyudi, Sopian Ari Wijaya Kurniawidi, Dian Wirawan, Rahadi Wirawan, Rahadi Zahrah Ramadlan Mubarokah