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Journal : INDONESIAN JOURNAL OF PHARMACY

Identification of physical interaction between trimethoprim and sulfamethoxazole by contact method kofler and crystallization reaction Zaini, Erizal
INDONESIAN JOURNAL OF PHARMACY Vol 21 No 1, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1024.512 KB) | DOI: 10.14499/indonesianjpharm0iss0pp31-37

Abstract

Identification of solid state interaction between TMP and SMZ by hot contact method Kofler and crystallization reaction had been carried out. The results of hot contact method Kofler shown formation a new crystalline habit as long and thin needle shaped on contact zone (mixing zone) between Solid TMP and SMZ. It had a different melting point in compared to its single component. Crystallization reaction between two of supersaturated solution of component TMP and SMZ in methanol solvent also indicated the growth of crystal habit as similar as  hot contact method Kofler. Solid state interaction between TMP and SMZ was confirmed by microscopic SEM, powder X-ray diffraction, and thermal DSC. Microscopic analysis by SEM showed significantly the change of habit and morphology of  crystal as long and thin needle shaped. New powder X-ray diffraction (PXRD) interferences peaks were observed in addition to PXRD interference peaks of each component that proved formation of cocrystalline phase. Thermogram DSC indicated a new  endothermic peak corresponding to melting point of a new cocrystalline phase at temperature 178,82 °C.Key words : trimethoprim, sulfamethoxazole, physical interaction, cocrystalline phase
Identification of physical interaction between trimethoprim and sulfamethoxazole by contact method koflerand crystallization reaction Erizal Zaini; Yeyet C. Sumirtapura; Sundani N. Soewandhi; Auzal Halim
Indonesian Journal of Pharmacy Vol 21 No 1, 2010
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (734.118 KB) | DOI: 10.14499/indonesianjpharm0iss0pp32-39

Abstract

Identification  of  solid  state  interaction  between  TMP  and  SMZ  by  hot contact  method Kofler and  crystallization  reaction  had  been  carried  out.  The results of hot contact method Koflershown formation a new crystalline habit as long  and thin needle  shaped  on  contact  zone  (mixing  zone) between Solid  TMP and SMZ. It had a different melting point in compared to its single component. Crystallization  reaction  between  two  of  supersaturated  solution  of  component TMP and  SMZ  in methanol  solvent  also  indicated  the  growth  of crystal  habit  as similar as   hot contact method Kofler.  Solid  state  interaction between  TMP  and SMZ  was confirmed  by  microscopic  SEM, powder  X-ray diffraction,  and  thermal DSC.  Microscopic  analysis by  SEM  showed significantly  the  change  of habit and morphology  of   crystal  as  long  and  thin  needle  shaped.  New  powder  X-ray diffraction  (PXRD)  interferences  peaks  were  observed  in  addition  to  PXRD interference  peaks  of  each  component  that  proved  formation  of  cocrystalline phase.  Thermogram  DSC  indicated  a  new   endothermic  peak  corresponding  to melting point of a new cocrystalline phase at temperature 178,82 °C.Key words : trimethoprim, sulfamethoxazole, physical interaction, cocrystalline phase
Co-Authors -, Salman Adhitya Jessica Agusri Boestari Agustina, Annisa Akmal Djamaan Amri Bakhtiar Andarifera, Alya Zahira Annisa Agustina Aprilianti, Hizra Dwi Arif, Zhafira Asiska Permata Dewi Asiska Permata Dewi Asiska Permatadewi Auzal Halim Auzal Halim Azzahra, Cindy Maynia Ben, Elfi Sahlan Deni Anggraini Deni Noviza Dhea Sultana Lutfiyah DINI HANIFA, DINI Dwi Setyawan Ellyza Nasrul Elpa Giovana Zola Elsa Badriyya Elvi Rahma Yulisman Elvita Sari Fadhila, Muthia Fauzi Saputra Fifi Harmely Friardi Ismed Gaesari, Sherly Rahmah Gaesari, Sherly Rahmah Gumala, Azhoma Habibie Deswilyaz Ghiffari Hansen Nasif Haq AH, Ahdi Dinil Hasmiwati Helen Sonita Henny Lucida Hulwa Salsabila Ihsan, Ikhwanul Ima Kurniati Irna Kurniati Jessica, Adhitya Kiki Rizky Wirza Kurniati, Irna Lili Fitriani Mai Efdi Maria Dona Octavia Melanny Ika Sulistyowaty Melisa Melisa Melzi Octaviani Mohd Amin, Mohd Cairul Iqbal Muhammad Taher Muthia Fadhila Mutiara Zulkarnaini Najmi Hilaliyati Netty Novitasari Nova Syafni Novica Sari Prameswari, Putu Pradnya Mimba Raden Joko Kuncoroningrat Susilo Rahmadasmi, Nola Rahmadevi Rahmi Nofita Rahmi Yosmar Rahmi Yosmar Resva Meinisasti Revila, Gusti Reza Safitri Rifka Naura Rini Agustin Rini Agustin Rizky, Fattihatul Rosaini, Henni Rose Intan Perma Sari Rustini Rustini Rustini Rustini S, Agnes Saafrida Saafrida Saafrida Saafrida Saafrida Salman - Salman - Salman Salman Salman Umar Sari, Elvita Sayyidina, Fasqina Simbolon, Clara Alverina Sundani N. Soewandhi Sundani N. Soewandhi, Sundani N. Syofyan Syofyan SYUKRAN HAMDENI Syukriati Chaira Tahta Amrillah Trisfa Augia Try Andy Sahputra Try Andy Sahputra Usman, Hendrizal Uswatul Hasanah Uswatul Hasanah, Uswatul Verlia Nisrina Putri Vike Zulia Putri Vina Oktavia Yeni Novita Sari Yeyet C. Sumirtapura Yufri Aldi Yuliza, Sukma Yuska Noviyanty Zahara Gayo Zidan, Sabry A. H. Zulhadjri Zulhadjri