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All Journal Jurnal Ilmu dan Teknologi Hasil Hutan Indonesian Journal of Forestry Research Jurnal Ilmu dan Teknologi Kayu Tropis JOURNAL OF WETLANDS ENVIRONMENTAL MANAGEMENT Indonesian Journal of Forestry Research Jurnal Penelitian Hasil Hutan
Gustan Pari
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Agriculture, Biological Sciences & Forestry Chemical Engineering, Chemistry & Bioengineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Engineering Environmental Science Materials Science & Nanotechnology

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PERAN GLUKOMANAN-ARANG AKTIF SEBAGAI HIPOKOLESTEROLEMIK PADA TIKUS SPRAGUE DAWLEY Agus Malik Ibrahim; Irma Herawati Suparto; Tetty Kemala; Gustan Pari
Jurnal Penelitian Hasil Hutan Vol. 34 No. 4 (2016): Jurnal Penelitian Hasil Hutan
Publisher : BRIN Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20886/jphh.2016.34.4.359-371

Abstract

Cholesterol is a metabolite which contains sterol fat, which is important to support cell functions and generate vitamin D, cortisol and reproduction hormones. Higher cholesterol content known as hypercholesterolemia is a predisposing towards cardiovascular disease. Previous study reported that glucommanan and activated charcoal individually can lower cholesterol levels, however combination both of them for lowering the cholesterol level has not been studied intensively. This paper examines the ability of glucommannan derived from Amorphophallus flour and activated charcoal in reducing cholesterol level of Sprague Dawley rat. Firstly, glucommanan was isolated from Amorphophallus flour and activated charcoal was produced from teak sawdust and coconut fiber. Both component were formulated and characterized using Fourier Transform Infra Red (FTIR), x-ray diffractometer and scanning electron microscope. Thirty five adult male Sprague Dawley rat with body weight of 160 to 200 g were divided into seven treatment groups: high-fat diet (DTL) and glucommanan, DTL and teak's activated charcoal (TC), DTL and cocout fiber's activated charcoal (CC), DTL and glucommanan and CC (1:1), DTL and glucommanan and CC (2:1), DTL and glucommanan and CC (1:2) and DTL without treatment as control. Initial rat cholesterol level was measured and it was compared with those after five weeks. Results show that the greatest cholesterol reduction (37.4%) is recorded from rat with DTL and glucommanan and CC (1:1) and low density lipoprotein reduction by about 49.7% and triglyceride reduction by 18.3%.
Co-Authors ADI SANTOSO Agus Malik Ibrahim Akhiruddin Maddu Akhirudin Maddu Andi D Yunianti Ani Suryani Arya Sokanandi Buchari Bunga Ayu Safitri Dadang Setiawan Daniel P.O Laia Dede Hermawan Dede Hermawan1 Deded Sarip Nawawi Dian Anggraini Indrawan Djeni Hendra Dodik Ridho Nurrochmat Efrida Basri Emma Sahara Endang Sri Lestari Erlina Nurul Aini Erliza Hambali Erliza Noor Esti Rini Satiti Gunawan Pasaribu Gunawan Pasaribu Gunawan Santosa Gusmailina Han Roliadi Hardjanto Herman Siruru Heru Satrio Wibisono Heru Wibisono I Nyoman Jaya Wistara I.M. Sulastiningsih Imam Wahyudi Indrawan, Imam Wahyudi Imas Aisyah Irma Herawati Suparto Iskandar Z Siregar Ismail Budiman Jajang Sutiawan Jasni Jessica Hendrik Karnita Yuniarti Krisdianto Krisdianto Sugiyanto Kurnia Sofyan Lisna Efiyanti Luciasih Agustini Mahpudin Mamat Rachmat Mody Lempang Mohamad Iqbal Mohammad Khotib Mohammad WIJAYA Muhammad Sadir Muji Harsini Novitri Hastuti Novitri Hastuti Novitri Hastuti, Lisna Efiyanti Nur Adi Sapura Nur Adi Saputra Nuryati Juli R. Esa Pangersa Gusti Rina Novia Yanti Rossi Margareth Tampubolon Saepulloh Saepuloh Santiyo Wibowo Saptadi Darmawan Saptadi Darmawan Sri Komarayati SUBYAKTO SUBYAKTO Suci Aprianty Wati Sukadaryati Sutanto T.A. Prayitno Teddi Her anto Teddi Heriyanto Teddi Heryanto Tetty Kemala Titi Kalima Totok K. Waluyo Totok K.Waluyo Totok K.Waluyo K. Waluyo Tun Tedja Irawadi Wasrin Syafii Yusuf Sudo Hadi