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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin MEDISAINS Biomedika Indonesian Journal of Medicine Health and Medical Journal Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences JOURNAL LA MEDIHEALTICO Cermin Dunia Kedokteran Jurnal Impresi Indonesia Media Dermato-Venereologica Indonesiana Journal of General Procedural Dermatology and Venereology Indonesia Jurnal Bioteknologi & Biosains Indonesia (JBBI) Indonesian Basic and Experimental Health Sciences Jurnal Bioteknologi & Biosains Indonesia
Prasetyadi Mawardi
Universitas Sebelas Maret
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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THE PATHOPHYSIOLOGY OF CUTANEOUS MANIFESTATIONS RELATED TO COVID-19 Mawardi, Prasetyadi
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 10 No. 2 (2023)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2023.2977

Abstract

Covid-19 is a respiratory infection caused by the newly emerging coronavirus. Covid-19 can also cause skin abnormalities, although the pathophysiology of manifestations of skin disorders associated with Covid-19 has not been understood with certainty. This study aims to discuss the pathophysiology of cutaneous manifestation related to Covid-19. The study was conducted based on literature and data mining related to Covid-19 using PubMed and Google Scholar. Eligible papers provided pathophysiology of cutaneous manifestations related to Covid-19. Papers not available in English were excluded. As a result of the presence of edema, vasodilation, and cellular infiltration, skin lesions such as rash, urticarial, or extensive purpura, or even thrombosis and haemorrhage, arise if damage to the vessels became severe. The pathophysiology of Covid-19-associated skin manifestations is estimated through some different mechanisms, such as lesions found in various Covid-19 patients, namely, the presence of varicella such as eruption, non-characteristic rash, and urticarial. Further studies are required to establish a Covid-19 diagnosis based on skin manifestations.
ULKUS GENITAL ET CAUSA HERPES GENITALIS PADA PASIEN GERIATRI IMUNOKOMPROMI DENGAN KEGANASAN PARU Lamsir, Seno; Mawardi, Prasetyadi; Yustin Ellistasari, Endra; Prasetya Primisawitri, Pratiwi
Media Dermato-Venereologica Indonesiana Vol 53 No 1 (2026): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v53i1.604

Abstract

   Pendahuluan: Herpes genitalis pada pasien geriatri imunokompromi kerap bermanifestasi atipikal, meningkatkan risiko misdiagnosis. Tujuan laporan kasus ini adalah untuk mengetahui dan memahami manifestasi klinis, alur diagnosis, serta menekankan pentingnya terapi antivirus sistemik yang adekuat dan edukasi komprehensif sebagai pilar utama dalam penatalaksanaan herpes genitalis terutama pada pasien geriatri dan keganasan. Kasus: Tn. P (60 tahun) dengan tumor paru kanan stadium lanjut (manifestasi sesak, massa paru, dan metastasis hepar), dikonsulkan akibat ulkus genital nyeri. Pemeriksaan fisik menunjukkan ulkus multipel berbatas tegas pada penis. Meski apus Tzanck negatif, diagnosis herpes genitalis ditegakkan berdasarkan gambaran klinis khas pada imunokompromi dan dikonfirmasi melalui respons penyembuhan signifikan pasca-terapi asiklovir, menyingkirkan diagnosis banding ulkus mole. Diskusi: Penuaan menyebabkan immunosenescence yang melemahkan respons seluler terhadap virus. Kondisi ini diperberat oleh supresi imun sistemik akibat keganasan paru, memicu reaktivasi HSV dengan presentasi klinis atipikal (seperti ulkus tanpa vesikel) dan menurunkan sensitivitas pemeriksaan penunjang standar. Simpulan: Terdapat hubungan erat antara penurunan imunitas pada usia tua dan keganasan paru dengan kejadian, atipikalitas gejala, dan tantangan diagnostik herpes genitalis.
Co-Authors Abas, Ervianti Adjie, Sugih Primas Alia, Vrenda Aliwardani, Ambar Anandita, Benedikta Lauda Ayu Kusuma Dewi Damayanti, Willa Dewi, Putti Fatiharani Dharmawan, Nugrohoaji Elistasari, Endra Yustin Ellistasari, Endra Yustin Esa Putri, Osdatilla Esa Fatiharani Dewi, Putty Febrianto, Bobby fitriani, fatimah Heryadi, Fanny Fauziyyah Indah Julianto, Indah Irawanto, Muhammad Eko Irfanti, Rakhma Tri Ivani, Ivani Lamsir, Seno Lidjaja, Lifesia Natali Mardiana Mardiana Mochtar, Moerbono Muhammad Riza Murasmita , Alamanda Murasmita, Alamanda Murastami , Ammarilis Murastami, Ammarilis Mustifah, Etty Farida Negara, Wisuda Putra Nila Kusumasari Nurfaiqoh, Elok Nurrachmat Mulianto Octarica , Stella Gracia Octarica, Stella Gracia Oktaviani, Trya Oktavriana , Triasari Oktriana, Putri Pradestine, Sesia Prasetya Primisawitri, Pratiwi Prasetyorini, Budi Eko Prihadi, Irfany Arafiasetyanto Primisawitri , Pratiwi Prasetya Primisawitri, Pratiwi Prasetya Putri , Osdatilla Esa Putri, Osdatilla Esa Ratih Pramuningtyas Rini Hastuti Risman, Muhammad Rosyid , Azhar Shelly Lavenia Sambodo Sulistyo Sulistyo Tansil, Ivana Tri Irfanti, Rakhma Triana, Agung Triasari Oktavriana Trisnarizki, Leonardo Ulya, Imroatul Utama, Rahmat Firdaus Dwi Yuliarto, Danu Yustin Ellistasari, Endra