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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin MEDISAINS Biomedika Indonesian Journal of Medicine Health and Medical Journal Budapest International Research and Critics Institute-Journal (BIRCI-Journal): Humanities and Social Sciences JOURNAL LA MEDIHEALTICO Cermin Dunia Kedokteran Jurnal Impresi Indonesia JURNAL INOVASI DAN PENGABDIAN MASYARAKAT INDONESIA Media Dermato-Venereologica Indonesiana Journal of General Procedural Dermatology and Venereology Indonesia Jurnal Bioteknologi & Biosains Indonesia (JBBI) Indonesian Basic and Experimental Health Sciences Jurnal Bioteknologi & Biosains Indonesia
Prasetyadi Mawardi
Universitas Sebelas Maret
Religion Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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THE PATHOPHYSIOLOGY OF CUTANEOUS MANIFESTATIONS RELATED TO COVID-19 Mawardi, Prasetyadi
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 10 No. 2 (2023)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55981/jbbi.2023.2977

Abstract

Covid-19 is a respiratory infection caused by the newly emerging coronavirus. Covid-19 can also cause skin abnormalities, although the pathophysiology of manifestations of skin disorders associated with Covid-19 has not been understood with certainty. This study aims to discuss the pathophysiology of cutaneous manifestation related to Covid-19. The study was conducted based on literature and data mining related to Covid-19 using PubMed and Google Scholar. Eligible papers provided pathophysiology of cutaneous manifestations related to Covid-19. Papers not available in English were excluded. As a result of the presence of edema, vasodilation, and cellular infiltration, skin lesions such as rash, urticarial, or extensive purpura, or even thrombosis and haemorrhage, arise if damage to the vessels became severe. The pathophysiology of Covid-19-associated skin manifestations is estimated through some different mechanisms, such as lesions found in various Covid-19 patients, namely, the presence of varicella such as eruption, non-characteristic rash, and urticarial. Further studies are required to establish a Covid-19 diagnosis based on skin manifestations.
ULKUS GENITAL ET CAUSA HERPES GENITALIS PADA PASIEN GERIATRI IMUNOKOMPROMI DENGAN KEGANASAN PARU Lamsir, Seno; Mawardi, Prasetyadi; Yustin Ellistasari, Endra; Prasetya Primisawitri, Pratiwi
Media Dermato-Venereologica Indonesiana Vol 53 No 1 (2026): Media Dermato Venereologica Indonesiana
Publisher : Perhimpunan Dokter Spesialis Kulit dan Kelamin Indonesia (PERDOSKI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33820/mdvi.v53i1.604

Abstract

   Pendahuluan: Herpes genitalis pada pasien geriatri imunokompromi kerap bermanifestasi atipikal, meningkatkan risiko misdiagnosis. Tujuan laporan kasus ini adalah untuk mengetahui dan memahami manifestasi klinis, alur diagnosis, serta menekankan pentingnya terapi antivirus sistemik yang adekuat dan edukasi komprehensif sebagai pilar utama dalam penatalaksanaan herpes genitalis terutama pada pasien geriatri dan keganasan. Kasus: Tn. P (60 tahun) dengan tumor paru kanan stadium lanjut (manifestasi sesak, massa paru, dan metastasis hepar), dikonsulkan akibat ulkus genital nyeri. Pemeriksaan fisik menunjukkan ulkus multipel berbatas tegas pada penis. Meski apus Tzanck negatif, diagnosis herpes genitalis ditegakkan berdasarkan gambaran klinis khas pada imunokompromi dan dikonfirmasi melalui respons penyembuhan signifikan pasca-terapi asiklovir, menyingkirkan diagnosis banding ulkus mole. Diskusi: Penuaan menyebabkan immunosenescence yang melemahkan respons seluler terhadap virus. Kondisi ini diperberat oleh supresi imun sistemik akibat keganasan paru, memicu reaktivasi HSV dengan presentasi klinis atipikal (seperti ulkus tanpa vesikel) dan menurunkan sensitivitas pemeriksaan penunjang standar. Simpulan: Terdapat hubungan erat antara penurunan imunitas pada usia tua dan keganasan paru dengan kejadian, atipikalitas gejala, dan tantangan diagnostik herpes genitalis.
Henoch–Schönlein Purpura with Gastrointestinal Involvement in an Adult Patient: A Case Report Lamsir, Seno; Yustin Ellistasari, Endra; Rosmarwati, Ervina; Mawardi, Prasetyadi
Indonesian Basic and Experimental Health Sciences Vol. 14 No. 2 (2026): April
Publisher : Rumah Sakit Umum Daerah Dr. Moewardi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/ibehs.vol14iss2pp111-115

Abstract

Introduction Henoch–Schönlein purpura (HSP), also known as IgA vasculitis, is a systemic small-vessel vasculitis characterized by IgA immune complex deposition. Although predominantly a childhood disease with a generally favorable prognosis, adult cases often exhibit more severe systemic involvement, particularly affecting the gastrointestinal tract and kidneys. Case A 22-year-old female presented with palpable purpura on the extremities, arthralgia, and melena. Physical examination revealed confluent purpuric lesions over the arms and legs. Endoscopy revealed esophagitis and antral gastritis. Skin biopsy demonstrated flattening of rete ridges and perivascular infiltrates, consistent with leukocytoclastic vasculitis. The patient was treated with intravenous methylprednisolone and supportive therapy, resulting in significant improvement of skin lesions, joint pain, and resolution of gastrointestinal bleeding. Discussion Adult HSP is less common but typically has a more severe course compared to pediatric cases. Gastrointestinal involvement, as seen in this case, may present as bleeding, ischemia, or ulceration, and can be life-threatening. Corticosteroids are effective in controlling inflammation and alleviating symptoms but do not prevent renal complications. Continuous renal monitoring is crucial, as kidney involvement remains the primary determinant of long-term prognosis. Conclusion This case highlights the clinical relevance of HSP in adults, where gastrointestinal manifestations may predominate and require aggressive management. Long-term follow-up, especially for renal involvement, is essential to improve outcomes.
Intervensi Edukasi Reproduksi untuk Cegah Infeksi Menular Seksual pada Remaja Melalui Sekolah Ellistasari, Endra Yustin; Mawardi, Prasetyadi; Primisawitri, Pratiwi Prasetya
JURNAL INOVASI DAN PENGABDIAN MASYARAKAT INDONESIA Vol 5 No 2 (2026): April
Publisher : Fakultas Kesehatan Masyarakat, Universitas Muhammadiyah Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Latar belakang: Remaja merupakan kelompok usia yang rentan terhadap infeksi menular seksual (IMS) dan human immunodeficiency virus/acquired immuno deficiency syndrome (HIV/AIDS) akibat kurangnya akses terhadap informasi kesehatan yang akurat dan edukatif. Kondisi ini menunjukkan perlunya intervensi edukatif yang sistematis dan berbasis sekolah guna meningkatkan pemahaman remaja mengenai kesehatan reproduksi serta pencegahan IMS dan HIV/AIDS. Tujuan: Kegiatan ini bertujuan untuk meningkatkan pengetahuan siswa terkait kesehatan reproduksi dan pencegahan IMS serta HIV/AIDS melalui penyuluhan interaktif berbasis sekolah. Metode: Metode pelaksanaan menggunakan desain pre-test dan post-test. Peserta kegiatan sebanyak 50 siswa kelas XI dan XII SMA Negeri 1 Surakarta. Evaluasi dilakukan menggunakan instrumen berupa 10 soal pilihan ganda yang diberikan sebelum dan sesudah penyuluhan. Data dianalisis menggunakan uji paired t-test dengan tingkat signifikansi p < 0,05. Hasil: Hasil menunjukkan peningkatan rerata skor dari 5,52 ± 1,11 (pre-test) menjadi 9,18 ± 0,75 (post-test). Uji paired t-test menunjukkan perbedaan signifikan (p< 0,000). Sesi diskusi juga menunjukkan antusiasme tinggi dari peserta dan mengungkap adanya miskonsepsi yang umum mengenai HIV/IMS. Kesimpulan: Penyuluhan terbukti efektif dalam meningkatkan pemahaman peserta tentang kesehatan reproduksi dan IMS, serta memperkuat sikap positif terhadap pencegahan penyakit menular seksual. Diperlukan perluasan program serupa secara berkelanjutan untuk menjangkau lebih banyak remaja dan mengoptimalkan dampak edukatif dalam jangka panjang. Kata kunci: edukasi berbasis sekolah, HIV/AIDS, infeksi menular seksual, penyuluhan kesehatan, remaja _________________________________________________________________________________ Abstract Background: Adolescents are a vulnerable population with respect to sexually transmitted infections (STIs) and human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS), primarily due to limited access to accurate and comprehensive health information. This condition underscores the need for systematic, school-based educational interventions to enhance adolescents’ understanding of reproductive health and the prevention of STIs and HIV/AIDS. Objective: This program aimed to improve students’ knowledge of reproductive health and the prevention of STIs and HIV/AIDS through interactive, school-based health education. Method: The program employed a pre-test and post-test design without a control group. A total of 50 students in grades XI and XII at SMA Negeri 1 Surakarta participated in the activity. Evaluation was conducted using a 10-item multiple-choice questionnaire administered before and after the educational session. Data were analyzed using a paired t-test, with a significance level set at p < 0.05. Result: The results demonstrated an increase in the mean score from 5.52 ± 1.11 (pre-test) to 9.18 ± 0.75 (post-test). The paired t-test indicated a statistically significant difference (p< 0.001). The discussion session also revealed high participant enthusiasm and identified common misconceptions regarding HIV and STIs. Conclusion: The educational intervention was effective in improving participants’ understanding of reproductive health and STIs, as well as in strengthening positive attitudes toward the prevention of sexually transmitted infections. The expansion of similar programs on a sustained basis is recommended to reach a broader adolescent population and to optimize long-term educational outcomes. Keywords: school-based education, HIV/AIDS, sexually transmitted infections, health education, adolescents
Co-Authors Abas, Ervianti Adjie, Sugih Primas Alia, Vrenda Aliwardani, Ambar Anandita, Benedikta Lauda Ayu Kusuma Dewi Damayanti, Willa Dewi, Putti Fatiharani Dharmawan, Nugrohoaji Elistasari, Endra Yustin Ellistasari, Endra Yustin Esa Putri, Osdatilla Esa Fatiharani Dewi, Putty Febrianto, Bobby Heryadi, Fanny Fauziyyah Indah Julianto, Indah Irawanto, Muhammad Eko Irfanti, Rakhma Tri Ivani, Ivani Lamsir, Seno Lidjaja, Lifesia Natali Mardiana Mardiana Mochtar, Moerbono Muhammad Riza Mujahidah, Fatimah Fitriani Murasmita , Alamanda Murasmita, Alamanda Murastami , Ammarilis Murastami, Ammarilis Mustifah, Etty Farida Negara, Wisuda Putra Nila Kusumasari Nurfaiqoh, Elok Nurrachmat Mulianto Octarica , Stella Gracia Octarica, Stella Gracia Oktaviani, Trya Oktavriana , Triasari Oktriana, Putri Pradestine, Sesia Prasetya Primisawitri, Pratiwi Prasetyorini, Budi Eko Prihadi, Irfany Arafiasetyanto Primisawitri , Pratiwi Prasetya Primisawitri, Pratiwi Prasetya Putri , Osdatilla Esa Putri, Osdatilla Esa Ratih Pramuningtyas Rini Hastuti Risman, Muhammad Rosmarwati, Ervina Rosyid , Azhar Shelly Lavenia Sambodo Sulistyo Sulistyo Tansil, Ivana Tri Irfanti, Rakhma Triana, Agung Triasari Oktavriana Trisnarizki, Leonardo Ulya, Imroatul Utama, Rahmat Firdaus Dwi Yuliarto, Danu Yustin Ellistasari, Endra