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All Journal Perspektif : Review Penelitian Tanaman Industri Elkawnie Majalah Obat Tradisional Dentino: Jurnal Kedokteran Gigi Pharmascience Journal of Islamic Pharmacy JPSCR : Journal of Pharmaceutical Science and Clinical Research Abditani : Jurnal Pengabdian Masyarakat SRIWIJAYA JOURNAL OF MEDICINE Medika Kartika : Jurnal Kedokteran dan Kesehatan Perspektif, Review Penelitian Tanaman Industri Jurnal Buana Farma AJAD : Jurnal Pengabdian kepada Masyarakat Proceeding of Mulawarman Pharmaceuticals Conferences Medical Sains : Jurnal Ilmiah Kefarmasian Journal of Applied Agricultural Science and Technology Room of Civil Society Development Riset Informasi Kesehatan AGRIC kawanad Borneo Journal of Pharmacy Kartika : Jurnal Ilmiah Farmasi Medical Sains : Jurnal Ilmiah Kefarmasian Room of Civil Social Development Agroscript: Journal of Applied Agricultural Sciences
Fahrauk Faramayuda, Fahrauk
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Aerospace Engineering Agriculture, Biological Sciences & Forestry Arts Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Control & Systems Engineering Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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TINJAUAN LITERATUR: POTENSI TANAMAN OBAT SEBAGAI SUMBER ANTIOKSIDAN ALAMI Faramayuda, Fahrauk; Safrudin, Nurul Safirah; Windyaswari , Ari Sri
Jurnal Buana Farma Vol 6 No 1 (2026): Jurnal Buana Farma
Publisher : Fakultas Farmasi Universitas Buana Perjuangan Karawang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36805/jbf.v6i1.1623

Abstract

Oxidative stress is a major driver of degenerative diseases, while synthetic antioxidants may pose long-term safety risks. The need for safer natural antioxidants has accelerated the exploration of medicinal plants, which are rich in bioactive compounds with antioxidant potential, particularly flavonoids and polyphenols. This systematic review aimed to classify antioxidant compounds from medicinal plants according to their phytochemical groups and to appraise their therapeutic potential based on recent pharmacological evidence. Articles published between 2015 and 2025 were retrieved from PubMed, Google Scholar, Garuda. Fifteen studies met the inclusion criteria for antioxidant activity testing. The review identified dominant antioxidant constituents, classified by chemical structure, including phenols, polyphenols, flavonoids, quercetin, and flavonoid–hydroquinone derivatives, reported across multiple plant species (Table 1). Plants consistently described as antioxidant sources were reundeu (Straurogyne elongata), moringa (Moringa oleifera), Indonesian bay leaf (Eugenia polyantha), water clover (Marsilea crenata), mango leaves (Mangifera indica), raru wood (Cotylelobium lanceolatum), and Jamaican cherry (Muntingia calabura), exhibiting moderate to strong antioxidant activity mainly in DPPH and FRAP assays. Overall, the findings indicate that antioxidant activity correlates with structural features such as the number and position of hydroxyl (–OH) groups, conjugated systems, and metal-chelating capacity. However, these compounds still face challenges related to poor stability and low bioavailability, suggesting that nanotechnology-based delivery systems may enhance formulation effectiveness. In conclusion, the plants reviewed contain promising antioxidant constituents, with quercetin and flavonoids emerging as the most active compounds, supporting their development as candidates for natural antioxidant-based phytopharmaceutical raw materials in Indonesia.
Metabolite Profiling of The Antioxidant Properties of The Aquatic Plant Cyperus involucratus Employing UHPLC-HRMS Windyaswari, Ari Sri; Faramayuda, Fahrauk; Billa, Salsa Rizqyana; Miarsih, Maria Tri; Ayu, Inna Puspa; Pratiwi, Niken Tunjung Murti; Krisanti, Majariana; Dwiyanti, Fifi Gus
Journal of Pharmascience Vol 13, No 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.24618

Abstract

The genus Cyperus is widely recognized as decorative flora. Empirically, Cyperus plants have been utilized to treat wounds, inflammation, and digestive disorders. While the genus is reported to exhibit antioxidant properties, scientific data regarding Cyperus involucratus remains limited. This research aimed to identify antioxidant compounds in C. involucratus using Ultra-High-Performance Liquid Chromatography-High Resolution Mass Spectrometry (UHPLC-HRMS). The C. involucratus methanolic extract was obtained through maceration using a 70% methanol solvent. Separation was performed using a UHPLC gradient system with a flow rate of 0.3 mL/min , while compound identification was conducted using a Quadrupole-Orbitrap MS detector in positive mode. The radical scavenging activity was evaluated using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay. The analysis identified 175 metabolites within the methanolic extract. Based on mzCloud library matching with confidence scores of 97.4–100%, 12 primary bioactive compounds were identified: oleamide, α -linolenic acid, kaempferol, scutellarin, hexadecanamide, 1-linoleoyl glycerol, 1-stearoy-rac-lglycerol, adenine, adenosine, L-tyrosine, stearamide and nootkatone. The extract possessed a moderate radical scavenger with an IC50 value of 57.94 μg/mL. These findings provide a scientific foundation for further investigation of C. involucratus as a potential natural antioxidant, although further in vivo studies are required to validate its broader pharmacological outcomes.
Impact of Drying Time and Temperature Variation on the Antioxidant Activity of Cat's Whiskers (Orthosiphon stamineus Benth) Faramayuda, Fahrauk; Syam, Akhirul Kahfi; Prasetyo, Chandra Putra; Farhan, Farhan
Journal of Pharmascience Vol 13, No 1 (2026): Jurnal Pharmascience
Publisher : Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jps.v13i1.23323

Abstract

Cat's whiskers (Orthosiphon stamineus Benth.) is an herbal plant known for its significant antioxidant activity, making it a valuable resource in traditional medicine. This study aims to investigate the effects of different drying temperatures and durations on the antioxidant activity of cat's whiskers using the DPPH (2,2-diphenyl-1-picrylhydrazyl) reagent. The research was conducted through a systematic analysis of drying temperatures of 40, 50, and 60°C over 1, 2, and 3 days, to establish a correlation between drying parameters and antioxidant activity. Statistical analysis using two-way ANOVA revealed that drying conditions significantly influenced antioxidant activity, whereas water content remained stable across all treatments. Based on the results, the optimal drying condition is 60°C for 1 day, which exhibited the highest antioxidant activity, with an IC50 of 13.62 μg/mL and a water content of 3.69%. This study advances scientific knowledge, particularly regarding the most effective drying methods for cat's whiskers to preserve the stability of the plant's bioactive compounds. Ultimately, these findings provide a scientific basis for developing standardized drying protocols to maximize the therapeutic benefits of cat's whiskers in health applications.
Co-Authors Adella Shindy Pratiwi Adely, Alyaa Muliahati Adinda Fitriani Adriana, Reyhan Akbar, Tzazkia Febriyana Akhirul Kahfi Syam Amedea, Esanda Zulfi Ami Soega Dwigantina Ananda Tunjung Pertiwi Anggita Esa Putri Fitrichia Aprilia, Trialisa Ari Sr Windyaswari Ari Sri Widyaswari Ari Sri Windyaswari Ari Sri Windyaswari Ari Sri Windyaswari, Ari Sri Ayu, Inna Puspa Bambang WIJIANTO Billa, Salsa Rizqyana Chandani Nurul Hafizah Choirunnisa, Dinda dessy ratnasari Dewi, Renti Mutiara Dhimas Ariya Wibiksana Dwi Ayu Pratiwi Dwi Nurahmanto Dwigantina, Ami Soega Dyah Nur Azizah, Dyah Nur Elfahmi Elfahmi Elfahmi Elfahmi, Elfahmi Ema Mutya Endang Kumolowati Esanda Zulfi Amedea Euis Reni Yuslianti Evi Umayah Ulfa Faizal Hermanto Farhan Farhan Farhan Fifi Gus Dwiyanti Fikri Alatas Fitriani, Adinda Fitrichia, Anggita Esa Putri Gazzali, Amirah Mohd Iis Inayati Rakhmat Ismail, Nursafira Khairunnisa Jaka Permana Jovie Mien Dumanauw Julia Ratnawati Julia Ratnawati Khairunisa Harizqi Nurul Husna Limbong, Remare Halomoan Lina Winarti Liza Pratiwi Majariana Krisanti Melani, Putri Dwi Miarsih, Maria Tri Mufidah, Fania Mufti Muhamad Raihan Maulana Muhammad Irwan Mutya, Ema Niken Tunjung Murti Pratiwi Nira Purnamasari, Nira Nur Achsan Al-Hakim Nur Fauziyyah, Salma Alifia Nurhalizah, Dinda Siti Nurhayati, Viola Aditya Nursafira Khairunnisa Ismail Oktiyas Muzaky Luthfi Oktovia El Shara Paramita, Veronika Santi Pertiwi, Ananda Tunjung Prasetyo, Chandra Putra Pratiwi, Dwi Ayu Purnama, Uwan Purwoko, Agus Putri, Dhiffa Namira Alifia Ramelan, Riska Sigit Remare Halomoan Limbong Renti Mutiara Dewi Reyhan Adriana Deris Ridwan Ilyas Ridzka Magfirah Rifaz Muhammad Sukma Riska Sigit Ramelan Rizka Khoirunnisa Guntina Rizka Khoirunnisa Guntina RIZKA KHOIRUNNISA GUNTINA, RIZKA KHOIRUNNISA Safrudin, Nurul Safirah Septiani, Usi Sigid Pamungkas Wicaksono Silvy Julian Siti Muslichah Soraya Riyanti Soraya Riyanti Soraya Riyanti, Soraya Sufyan Zainul Arifin Sugiyanto Sukrasno Sukrasno Sukrasno Sukrasno Sukrasno Sukrasno Sultan Salahudin Jamal SURYANI Suwidjiyo Pramono Totik Sri Mariani Totik Sri Mariani Totik Sri Mariani Totik Sri Mariani Tresa Tri Rayani Tresa Tri Rayani, Tresa Tri Trialisa Aprilia Tzazkia Febriyana Akbar Usi Septiani Viola Aditya Nurhayati Weni Widy Astuti Winda Nur Halimah Windyaswari , Ari Sri Wulandari, Yesi Yeni Karlina Yeni Karlina Yeni Karlina, Yeni Yenni Karlina, Yenni Yesi Desmiaty, Yesi Yesi Wulandari Yuslianti, Euis Reni Zaini Alfahmi