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Impact of Mangosteen Peel and Centella asiatica on Cognitive Function in Healthy Older Adults Fitriana, Lisna Anisa; Rahmi, Upik; Ghaida, Nafisa Siti; Komarudin, Komarudin; Fitri, Mustika
Jurnal Pendidikan Keperawatan Indonesia Vol 11, No 2 (2025): Volume 11, Nomor 2, Desember 2025
Publisher : Universitas Pendidikan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17509/jpki.v11i2.95087

Abstract

Introduction: The increasing elderly population in Indonesia is accompanied by a growing risk of cognitive decline and dementia. Current pharmacological interventions have limited effectiveness and may cause adverse effects, highlighting the need for safe, natural-based alternatives. Mangosteen peel (Garcinia mangostana) and gotu kola (Centella asiatica) possess neuroprotective, antioxidant, and anti-inflammatory properties that may enhance cognitive function in older adults. Objective: This study aimed to evaluate the effectiveness of mangosteen peel and Centella asiatica extract supplementation in improving cognitive function among the elderly. Methods: A quasi-experimental pretest–posttest two-group study was conducted among 26 elderly residents at Griya Lansia Garut selected by purposive sampling. The intervention group received combined mangosteen peel and Centella asiatica supplementation for four weeks. Cognitive function was measured using MMSE, TMT-A, and Forward Digit Span, with data analyzed using Wilcoxon and Mann–Whitney tests (p0.05). Results: The intervention group showed significant improvements in MMSE scores (Δ=2.15; p0.001), processing speed and attention as measured by TMT-A (p=0.021), and working memory as measured by Forward Digit Span (p0.001). Between-group comparisons revealed significant differences in MMSE (p0.001) and TMT-A score changes (p=0.008), whereas no significant difference was observed for Forward Digit Span (p=0.458). Conclusion: Supplementation with mangosteen peel and Centella asiatica extracts may improve global cognitive function and attention in elderly individuals. This combined botanical intervention shows promise as a supportive non-pharmacological strategy for preventing cognitive decline; however, larger randomized controlled trials are required to confirm its efficacy and safety.
The Effect of Kang Duding Exercise on The Quality of Life in Menopausal Women Fitri, Mustika; Mukarrahmah, Laillah; Fitriana, Lisna Anisa; Sulastri, Afianti; Zaky, Muhammad; Williyanto, Septian; Darmawati, Irma; Zainal Abidin, Nor Eeza
Jurnal Pendidikan Keperawatan Indonesia Vol 9, No 2 (2023): Volume 9, Nomor 2, Desember 2023
Publisher : Universitas Pendidikan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17509/jpki.v9i2.64021

Abstract

Menopause is recognized for inducing various complaints in women, including common experiences such as dizziness, fatigue, and anxiety. Physical exercise has been scientifically proven to enhance both physical and psychological performance. Regular exercise contributes to improved cardiovascular health, increased strength and endurance, reduced stress and anxiety, enhanced cognitive function, and overall well-being and quality of life. Quality of life encompasses an individual's satisfaction with various aspects of life, including the physical, psychological, social, and environmental dimensions. This study seeks to investigate the impact of exercise on the quality of life among menopausal women, employing an experimental design with a control group and a 12-week pre and post-test. The study involved 32 women aged 45-55 years, divided into two groups: one engaging in Kang Duding exercises (2 sessions of 60 minutes per week) and a control group without intervention. The assessment of quality of life utilized the WHO-QoL questionnaire. The results revealed a significant improvement in all domains of quality of life (QoL) among menopausal women engaging in Kang Duding exercise on physical (p=0.009), psychological (p=0.006), social (p=0.008), and environmental (p=0.029). Physical activity emerges as a key factor contributing to enhanced quality of life, operating through various mechanisms. In conclusion, this study establishes that Kang Duding exercise effectively enhances the quality of life in menopausal women. The findings underscore the significance of incorporating structured physical activity interventions to promote the overall well-being of women during the menopausal transition.
Survivorship Care Effects on Gynecological and Breast Cancer Survivors: A Systematic Review and Meta-Analysis Nasution, Lina Anisa; Fitriana, Lisna Anisa; Darmawati, Irma; Pragholapati, Andria; Dharmansyah, Dhika; Sunairattanaporn, Usa
JURNAL INFO KESEHATAN Vol 24 No 1 (2026): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol24.Iss1.2166

Abstract

Survivorship care aims to address the long-term physical and psychosocial needs of cancer survivors, yet evidence regarding its effectiveness and optimal components remains inconsistent. This study aimed to evaluate the effectiveness of survivorship care interventions on quality of life and related outcomes among gynecological and breast cancer survivors and explored intervention components associated with improved outcomes with PRISMA guidelines. Seven databases were searched for English-language studies involving adult gynecological and/or breast cancer survivors who had completed primary treatment and received survivorship care interventions compared with usual care. A random-effects model was used to estimate pooled effects. Heterogeneity was assessed using the I² statistic, and subgroup analyses and meta-regression were performed. Risk of bias was evaluated using the Cochrane Risk of Bias tool. The review was registered in PROSPERO (CRD42023402234). Eight randomized controlled trials comprising 1,464 participants were included. Survivorship care interventions significantly improved overall quality of life (SMD = 0.26; 95% CI: 0.08–0.44), physical well-being (SMD = 0.26; 95% CI: 0.12–0.41), mental well-being (SMD = 0.17; 95% CI: 0.03–0.31), and reduced depressive symptoms (SMD = 0.20; 95% CI: 0.00–0.41), with low to moderate heterogeneity across outcomes. Subgroup analyses indicated that multimodal interventions incorporating lectures, discussions, consultations, and online coaching particularly those supported by mobile health applications were associated with greater benefits, especially in physical well-being. Several studies demonstrated moderate risk of bias, mainly related to randomization and reporting. Survivorship care interventions provide small to moderate clinically meaningful improvements in quality of life and psychosocial outcomes among gynecological and breast cancer survivors. These findings support the integration of structured, multidisciplinary, and technology assisted survivorship care into routine oncology practice, while highlighting the need for higher quality, context sensitive trials.