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All Journal Jurnal Skolastik Keperawatan (e-Journal) JURNAL PENDIDIKAN KEPERAWATAN INDONESIA JURNAL PENDIDIKAN JASMANI DAN OLAHRAGA Jurnal Penelitian Pendidikan IPA (JPPIPA) Jurnal Keperawatan Padjadjaran Nursing Current : Jurnal Keperawatan Jurnal Kreativitas PKM Jurnal Keperawatan Komprehensif (Comprehensive Nursing Journal) Jurnal Keperawatan Widya Gantari Indonesia Abdi: Jurnal Pengabdian dan Pemberdayaan Masyarakat JURNAL PENELITIAN PERAWAT PROFESIONAL Jurnal Ners Jurnal PORKES Jurnal Kepelatihan Olahraga JSH: Journal of Sport and Health Jurnal Keperawatan 'Aisyiyah Jurnal of Community Health Development (JCHD) International Journal of Health Sciences Journal Medical Informatics Technology Indonesian Journal of Community Development Malahayati International Journal of Nursing and Health Science Holistik Jurnal Kesehatan Jurnal Info Kesehatan
Lisna Anisa Fitriana, Lisna Anisa
Universitas Pendidikan Indonesia
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Dentistry Education Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Impact of Mangosteen Peel and Centella asiatica on Cognitive Function in Healthy Older Adults Fitriana, Lisna Anisa; Rahmi, Upik; Ghaida, Nafisa Siti; Komarudin, Komarudin; Fitri, Mustika
Jurnal Pendidikan Keperawatan Indonesia Vol 11, No 2 (2025): Volume 11, Nomor 2, Desember 2025
Publisher : Universitas Pendidikan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17509/jpki.v11i2.95087

Abstract

Introduction: The increasing elderly population in Indonesia is accompanied by a growing risk of cognitive decline and dementia. Current pharmacological interventions have limited effectiveness and may cause adverse effects, highlighting the need for safe, natural-based alternatives. Mangosteen peel (Garcinia mangostana) and gotu kola (Centella asiatica) possess neuroprotective, antioxidant, and anti-inflammatory properties that may enhance cognitive function in older adults. Objective: This study aimed to evaluate the effectiveness of mangosteen peel and Centella asiatica extract supplementation in improving cognitive function among the elderly. Methods: A quasi-experimental pretest–posttest two-group study was conducted among 26 elderly residents at Griya Lansia Garut selected by purposive sampling. The intervention group received combined mangosteen peel and Centella asiatica supplementation for four weeks. Cognitive function was measured using MMSE, TMT-A, and Forward Digit Span, with data analyzed using Wilcoxon and Mann–Whitney tests (p0.05). Results: The intervention group showed significant improvements in MMSE scores (Δ=2.15; p0.001), processing speed and attention as measured by TMT-A (p=0.021), and working memory as measured by Forward Digit Span (p0.001). Between-group comparisons revealed significant differences in MMSE (p0.001) and TMT-A score changes (p=0.008), whereas no significant difference was observed for Forward Digit Span (p=0.458). Conclusion: Supplementation with mangosteen peel and Centella asiatica extracts may improve global cognitive function and attention in elderly individuals. This combined botanical intervention shows promise as a supportive non-pharmacological strategy for preventing cognitive decline; however, larger randomized controlled trials are required to confirm its efficacy and safety.
The Effect of Kang Duding Exercise on The Quality of Life in Menopausal Women Fitri, Mustika; Mukarrahmah, Laillah; Fitriana, Lisna Anisa; Sulastri, Afianti; Zaky, Muhammad; Williyanto, Septian; Darmawati, Irma; Zainal Abidin, Nor Eeza
Jurnal Pendidikan Keperawatan Indonesia Vol 9, No 2 (2023): Volume 9, Nomor 2, Desember 2023
Publisher : Universitas Pendidikan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.17509/jpki.v9i2.64021

Abstract

Menopause is recognized for inducing various complaints in women, including common experiences such as dizziness, fatigue, and anxiety. Physical exercise has been scientifically proven to enhance both physical and psychological performance. Regular exercise contributes to improved cardiovascular health, increased strength and endurance, reduced stress and anxiety, enhanced cognitive function, and overall well-being and quality of life. Quality of life encompasses an individual's satisfaction with various aspects of life, including the physical, psychological, social, and environmental dimensions. This study seeks to investigate the impact of exercise on the quality of life among menopausal women, employing an experimental design with a control group and a 12-week pre and post-test. The study involved 32 women aged 45-55 years, divided into two groups: one engaging in Kang Duding exercises (2 sessions of 60 minutes per week) and a control group without intervention. The assessment of quality of life utilized the WHO-QoL questionnaire. The results revealed a significant improvement in all domains of quality of life (QoL) among menopausal women engaging in Kang Duding exercise on physical (p=0.009), psychological (p=0.006), social (p=0.008), and environmental (p=0.029). Physical activity emerges as a key factor contributing to enhanced quality of life, operating through various mechanisms. In conclusion, this study establishes that Kang Duding exercise effectively enhances the quality of life in menopausal women. The findings underscore the significance of incorporating structured physical activity interventions to promote the overall well-being of women during the menopausal transition.
Survivorship Care Effects on Gynecological and Breast Cancer Survivors: A Systematic Review and Meta-Analysis Nasution, Lina Anisa; Fitriana, Lisna Anisa; Darmawati, Irma; Pragholapati, Andria; Dharmansyah, Dhika; Sunairattanaporn, Usa
JURNAL INFO KESEHATAN Vol 24 No 1 (2026): JURNAL INFO KESEHATAN
Publisher : Research and Community Service Unit, Poltekkes Kemenkes Kupang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31965/infokes.Vol24.Iss1.2166

Abstract

Survivorship care aims to address the long-term physical and psychosocial needs of cancer survivors, yet evidence regarding its effectiveness and optimal components remains inconsistent. This study aimed to evaluate the effectiveness of survivorship care interventions on quality of life and related outcomes among gynecological and breast cancer survivors and explored intervention components associated with improved outcomes with PRISMA guidelines. Seven databases were searched for English-language studies involving adult gynecological and/or breast cancer survivors who had completed primary treatment and received survivorship care interventions compared with usual care. A random-effects model was used to estimate pooled effects. Heterogeneity was assessed using the I² statistic, and subgroup analyses and meta-regression were performed. Risk of bias was evaluated using the Cochrane Risk of Bias tool. The review was registered in PROSPERO (CRD42023402234). Eight randomized controlled trials comprising 1,464 participants were included. Survivorship care interventions significantly improved overall quality of life (SMD = 0.26; 95% CI: 0.08–0.44), physical well-being (SMD = 0.26; 95% CI: 0.12–0.41), mental well-being (SMD = 0.17; 95% CI: 0.03–0.31), and reduced depressive symptoms (SMD = 0.20; 95% CI: 0.00–0.41), with low to moderate heterogeneity across outcomes. Subgroup analyses indicated that multimodal interventions incorporating lectures, discussions, consultations, and online coaching particularly those supported by mobile health applications were associated with greater benefits, especially in physical well-being. Several studies demonstrated moderate risk of bias, mainly related to randomization and reporting. Survivorship care interventions provide small to moderate clinically meaningful improvements in quality of life and psychosocial outcomes among gynecological and breast cancer survivors. These findings support the integration of structured, multidisciplinary, and technology assisted survivorship care into routine oncology practice, while highlighting the need for higher quality, context sensitive trials.        
Depression and sleep quality in older adults Ghaida, Nafisa Siti; Fitriana, Lisna Anisa; Suparto, Tirta Adikusuma
Malahayati International Journal of Nursing and Health Science Vol. 9 No. 2 (2026): Volume 9 Number 2
Publisher : Program Studi Ilmu Keperawatan-fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/minh.v9i2.2209

Abstract

Background: Aging causes physiological and psychological changes that increase elderly vulnerability to depression and sleep disturbances, negatively impacting quality of life. Purpose: To analyze the relationship between depression and sleep quality among the elderly at Garut residential care facility for the elderly. Method: A quantitative cross-sectional study was conducted using purposive sampling (n=53). Instruments included the Geriatric Depression Scale (GDS) and the Pittsburgh Sleep Quality Index (PSQI). Data were analyzed using univariate and bivariate methods. Results: Univariate analysis showed that 79.2% of respondents had poor sleep quality, and 47.2% experienced depression (35.8% mild, 5.7% moderate, 5.7% severe). Bivariate analysis revealed a statistically significant, positive, but weak correlation between depression and sleep quality (r=0.303; p=0.028). Conclusion: This study reveals a weak yet significant link between depression and sleep quality among elderly residents, with other emotional, social, physical, and environmental factors also contributing. The findings highlight the need to address both mental health and environmental conditions to improve overall quality of life.
Pengaruh ekstrak kombinasi brokoli dan pegagan terhadap tingkat depresi pada lansia Lestari, Puput Legia; Fitriana, Lisna Anisa; Suparto, Tirta Adikusuma
Holistik Jurnal Kesehatan Vol. 20 No. 2 (2026): Volume 20 Nomor 2
Publisher : Program Studi Ilmu Keperawatan-fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/hjk.v20i2.2377

Abstract

Background: Depression is a common mental health issue in older adults that can reduce quality of life and the ability to perform daily activities. The treatment of depression often involves pharmacological therapy, which can lead to side effects due to polypharmacy. Therefore, safer complementary therapy interventions are needed. Broccoli (Brassica oleracea) and gotu kola (Centella asiatica) are natural ingredients with antioxidant and neuroprotective activity that have the potential to reduce the symptoms of depression. Purpose: To assess the effect of administering a combination of broccoli and gotu kola extracts on depression levels in the elderly population. Method: This study used a quasi-experimental design with a pretest-posttest control group approach, involving 36 elderly individuals divided into intervention and control groups. The intervention group received a combination extract of broccoli and gotu kola (2x1000mg/day) for six weeks, while the control group received no intervention. The level of depression was measured using the Geriatric Depression Scale-15 (GDS-15). Data analysis was performed using the independent samples t-test. Results: The average depression score in the intervention group significantly decreased from 5.78 ± 3.49 to 3.61 ± 2.23 (p < 0.001). The control group did not show a significant difference in the decrease of depression scores (p = 0.079). Conclusion: The administration of a combination of broccoli and gotu kola extract can reduce the level of depression in the elderly as a complementary therapy. Suggestion: Research with larger samples and placebo groups, as well as measurements of biomarkers related to oxidative stress, inflammation, and neurotransmitter function.   Keywords: Broccoli; Depression; Elderly; Gotu Kola.   Pendahuluan: Depresi adalah masalah kesehatan mental umum pada lansia yang dapat menurunkan kualitas hidup dan kemampuan menjalani aktivitas sehari-hari. Penanganan depresi sering melibatkan terapi farmakologis, yang dapat menyebabkan efek samping akibat polifarmasi. Oleh karena itu, dibutuhkan intervensi terapi komplementer yang lebih aman. Brokoli (Brassica oleracea) dan pegagan (Centella asiatica) adalah bahan alami dengan aktivitas antioksidan dan neuroprotektif yang berpotensi mengurangi gejala depresi. Tujuan: Untuk menilai pengaruh pemberian ekstrak kombinasi brokoli dan pegagan terhadap tingkat depresi pada populasi lanjut usia. Metode: Penelitian ini menggunakan desain quasi-eksperimen dengan pendekatan pretest-posttest control group melibatkan 36 lansia yang dibagi menjadi kelompok intervensi dan kontrol. Kelompok intervensi menerima ekstrak kombinasi brokoli dan pegagan (2x1000mg/hari) selama 6 minggu, sedangkan kelompok kontrol tidak menerima intervensi. Tingkat depresi diukur dengan Geriatric Depression Scale-15 (GDS-15). Analisis data dilakukan menggunakan uji independet sample t-test. Hasil: Skor depresi rata-rata pada kelompok intervensi menurun secara signifikan dari 5.78 ± 3.49 menjadi 3.61 ± 2.23 (p < 0.001). Kelompok kontrol tidak menunjukkan perbedaan signifikan dalam penurunan skor depresi (p = 0.079). Simpulan: Pemberian ekstrak kombinasi brokoli dan pegagan dapat menurunkan tingkat depresi pada lansia sebagai terapi komplementer. Saran: Penelitian selanjutnya dapat menambahkan besaran sampel dan kelompok plasebo serta pengukuran biomarker terkait stres oksidatif, inflamasi, dan fungsi neurotransmitter.   Kata Kunci: Brokoli; Depresi; Lansia; Pegagan.
Co-Authors Afianti Sulastri, Afianti Andria Pragholapati Anggraeni, Syifa Fadhilah Asep Mulyadi Asilah Sholeha Budi Somantri, Budi Dadang Darmawan Dadang Darmawan Darmawati, Irma Darmawati, Irma Dharmansyah, Dhika Dhika Dharmansyah Dyna Apriany Erna Irawan, Erna Erni Rustiani Fabianti, Vanny Fariz, Ahsan Ghaida, Nafisa Siti Hasim Asyari Hazar, Fatih Herawadi, Sella Putri I Ketut Adnyana Istiqomah, Vinanda Kayubi Kayubi Komarudin Komarudin Kusnandar Anggadiredja Lena Helen Supriatna Lestari, Puput Legia Linda Amalia Luu, Puu Taa Maidartati, M Marsono Marsono Mery Tania Mukarrahmah, Laillah Murtiani, Farida Mustika Fitri Nasution, Lina Anisa Natasya Natasya Nazhifa Ufamy Ningrum, Ayu Nita Arisanti Norma Norma Novi Malisa, Novi Nurul Iklima, Nurul Perdani, Agni Laili Purwandari Wahyoe Puspita, Asih Puspita, Asih Purwandari Wahyoe Rinawan, Fedri Ruluwedarata Rizkia Sukma Nurhaliza Rutiani, Clara Ega Ayu Salasa, Sehabudin Saskia Putri, Mutiara Septian Andriyani, Septian Setiawan . Setiawan Setiawan Setiawan, Guling Setyarini, Elizabeth Ari Siti Nurbaeti, Siti Slamet Rohaedi, Slamet Sri Sumartini Suci Tuty Putri, Suci Tuty Sunairattanaporn, Usa Susi Gustina Tasnim, Marwan Tirta Adikusuma Suparto, Tirta Adikusuma Tita Puspita Ningrum Ufamy, Nazhifa Upik Rahmi, Upik Wahdini, Ridha Wardany, Nadia Sintia Williyanto, Septian Yoppy Indra Wahyudi Zainal Abidin, Nor Eeza Zaky, Muhammad