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Hubungan Kadar D-dimer dan C-Reactive Protein terhadap Berat Gejala pada Pasien COVID-19 Sang Ayu Nyoman Putri Pradnyasari; Moulid Hidayat; Prima Belia Fathana
Unram Medical Journal Vol 11 No 4 (2022): volume 11 no 4
Publisher : Faculty of Medicine Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jku.v11i4.864

Abstract

Background: Coronavirus disease 19 (COVID-19) is an acute respiratory infectious disease by SARS-CoV-2. This disease was discovered in Wuhan, China. In some cases, COVID-19 can be life-threatening due to an uncontrolled inflammatory phase characterized by increased levels of D-dimer and C-reactive protein (CRP) in the body. This condition can lead to complications such as ARDS, shock, and even death. This study aims to determine the relationship between D-dimer and CRP levels with the disease severity in COVID-19 patients at the Mataram University Hospital. Methods: This study is an observational analytic study with a cross-sectional design. Data collection took place in March-May 2022 at the Mataram University Hospital. Subjects were selected using consecutive sampling methods through medical record data. The statistical test used the Chi-square and Mann-Whitney comparative tests. Results: A total of 64 subjects were selected, of which 48 subjects underwent a D-dimer examination and 58 underwent a CRP examination. Most subjects were in the age group 18-59 years (64.1%), with the male gender (56.3%). There were 10 subjects (20.8%) had normal D-dimer levels, and 38 subjects (79.2%) had elevated D-dimer levels. Normal CRP levels were found in 6 subjects (10.3%), and 52 subjects (89.7%) had elevated CRP levels. The results of the bivariate test analysis showed p-value = 0.002 for D-dimer levels with severe symptoms, and CRP levels with severe symptoms showed p-value = 0.02. Conclusion: There is a significant correlation statistically and clinically between D-dimer and C-reactive protein levels with the disease severity in COVID-19 patients.
Relationship of Comorbidity and Age to the Severity of Clinical Symptoms of COVID-19 at Mataram University Hospital I Made Arya Yogiswara Mahayasa; Moulid Hidayat; Prima Belia Fathana; Indana Eva Ajmala
Jurnal Biologi Tropis Vol. 23 No. 1 (2023): January - March
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v23i1.4581

Abstract

COVID-19 disease is a disease that arises due to infection with the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). The purpose of this study was to determine differences in clinical symptoms in elderly and non-elderly patients, as well as patients who had comorbidities and did not have comorbidities. This research is a type of cross-sectional study that was conducted by reviewing the medical records of COVID-19 patients undergoing treatment at Mataram University Hospital in 2021. Data was collected using a consecutive sampling technique. The statistical test used is the Chi-square comparative test. To assess the relationship of age and comorbidities to the severity of symptoms in COVID-19 patients. In this study, 86 subjects were selected based on the inclusion and exclusion criteria applied. The majority of subjects were in the 15-59 year age group, namely 66 (23.3%). With male sex 51 (60.5%) people. The majority of patients with comorbidities experienced severe/critical symptoms 16 (44.4%) and patients without comorbids experienced no symptoms or experienced mild symptoms 35 (35%). The majority of elderly patients experienced severe-critical symptoms 9 (45%) and the majority of non-elderly patients experienced no symptoms or experienced mild symptoms 42 (63.6%). The results of the bivariate analysis test showed a p-value = 0.001 for comorbids with severe symptoms, and a p-value = 0.003 for age with severe symptoms. There is a significant relationship between comorbidities and age on the severity of symptoms in COVID-19 patients.
SEMINAR AWAM: KENALI ASMA DAN TANGANI DENGAN TEPAT Jurnal Pepadu; Indana Eva Ajmala; Rina Lestari; Prima Belia Fathana; Moulid Hidayat
Jurnal Pepadu Vol. 4 No. 1 (2023): Jurnal Pepadu
Publisher : LPPM UNIVERSITAS MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/pepadu.v4i1.2236

Abstract

Asma adalah penyakit pernapasan kronis umum yang mempengaruhi 1–18% populasi di berbagai negara. Telah terjadi peningkatan tajam dalam prevalensi global, morbiditas, mortalitas, dan beban ekonomi yang terkait dengan asma selama 40 tahun terakhir. Saat ini sebagian besar penderita asma merupan asma tidak terkontrol. Pengetahuan mengenai asma sangat penting dalam mencapai kontrol asma. Pasien dan keluarga pasien yang memahami penyakit asma dengan baik secara sadar akan menghindari faktor-faktor pencetus serangan, menggunakan obat secara benar dan berkonsultasi kepada dokter secara tepat. Tujuan kegiatan ini adalah meningkatkan pengetahuan masyarakat mengenai pengertian, gejala, penyebab dan pencetus, pengobatan dan pencegahan asma. Narasumber melakukan presentasi, dilanjutkan dengan diskusi. Peningkatan pengetahuan diukur dengan pre-test dan post-test yang dianalisa dengan menggunakan t-paired test. Kegiatan diikuti oleh 33 peserta dari anggota DWP RSUD Provinsi NTB dan anggota PORPI cabang NTB. Setelah diberikan materi oleh narasumber, terdapat peningkatan pengetahuan yang bermakna pada peserta seminar. Selisih skor peningkatan pengetahuan adalah 14,7532 (p 0.002, 95% IK -23.6579-(-5.8484). Terdapat peningkatan pengetahuan peserta seminar mengenai asma.
TUBERKULOSIS PARU DENGAN DIABETES MELLITUS TIPE 2 SETELAH MENYELESAIKAN TERAPI ANTI TUBERKULOSIS 9 BULAN: LAPORAN KASUS Paulus Taufik; Prima Belia Fathana
Jurnal Medika Malahayati Vol 7, No 2 (2023): Volume 7 Nomor 2
Publisher : Prodi Kedokteran Fakultas Kedokteran Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jmm.v7i2.10427

Abstract

Abstrak : Tuberkulosis Paru Dengan Diabetes Mellitus Tipe 2 Setelah Menyelesaikan Terapi Anti Tuberkulosis 9 Bulan: Laporan Kasus. Tuberkulosis (TB) adalah penyakit menular yang disebabkan oleh bakteri Mycobacterium tuberculosis. Sebagian besar bakteri Mycobacterium tuberculosis menyerang paru-paru menyebabkan penyakit TB paru, tetapi dapat juga menyerang organ tubuh lainnya. Lima dari 8 negara dengan insiden TB tertinggi termasuk di antara 10 negara dengan prevalensi DM tertinggi. Individu yang rentan menghirup Mycobacterium tuberculosis melalui aerosol. Diabetes Mellitus ditemukan meningkatkan risiko tertular TB hingga tiga kali lipat, Diabetes Mellitus berdampak buruk pada hasil pengobatan TB karena efek imunosupresif dari DM itu sendiri, interaksi obat-obat, efek samping dari obat-obatan, kepatuhan pengobatan yang kurang optimal, berkurangnya bioavailabilitas obat-obatan dan faktor-faktor lain. Penatalaksanaan diabetes melitus (DM) selama pengobatan tuberkulosis (TB) ditujukan untuk meningkatkan hasil pengobatan TB dan menurunkan morbiditas dan mortalitas terkait DM. Laporan kasus ini menunjukan perbaikan klinis, kembalinya aktifitas fisik, meningkatnya berat badan dan meningkatnya kualitas hidup dari pasien yang menjalani pengobatan obat-anti tuberculosis pada pasien TB Paru dengan DM tipe 2 selama 9 bulan.
Physical Measurement Analysis in Pre-Utility Covid-19 Isolation Room: A Case Study Universitas Mataram Teaching Hospital Eustachius Hagni Wardoyo; Ida Bagus Alit; Monalisa Nasrul; Didit Yudhanto; Prima Belia Fathana; Rini Srikus Saptaningtyas
The Indonesian Journal of Infectious Diseases Vol. 7 No. 2 (2021): The Indonesian Journal of Infectious Disease
Publisher : Rumah Sakit Penyakit Infeksi Prof Dr. Sulianti Saroso

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32667/ijid.v7i2.121

Abstract

Background: Negative pressure room is recommended for the treatment of COVID-19 patients. Aim this study to describe physical measurement analysis of isolation room Universitas Mataram Teaching Hospital. Methods: Newly developed negative pressure isolation room was physical measure using following instruments: anemometer, moisture meter, hygrometer and pressure gauge.  Results: This study showed physical measurement as follow: 1) ACH (air change per hour) 23.3 / hour [minimum: 12+ ACH]; 2) the difference in pressure gradient between the inpatient room and anteroom -30 Pa [minimum -15 Pa]; 3) the mean of air temperature 24.8°C [21-24]; 4) air humidity 58% [maximum 65%] and 5) concrete moisture 22.45%. Conclusion: The COVID-19 isolation room at the Universitas Mataram Teaching Hospital meets the standard criteria.
STUDI LITERATUR : PATOGENESIS DAN DIAGNOSIS TUBERKULOSIS RESISTEN OBAT Indrasari, Annisa Diyanabila; Fathana, Prima Belia
Jurnal Medika Malahayati Vol 8, No 1 (2024): Volume 8 Nomor 1
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jmm.v8i1.13377

Abstract

Abstrak: Studi Literatur : Patogenesis dan Diagnosis Tuberkulosis Resisten Obat. Tuberkulosis yang resistan terhadap obat adalah suatu kondisi di mana seseorang telah terinfeksi oleh bakteri Mycobacterium tuberculosis yang telah resisten terhadap OAT lini pertama. Tuberkulosis resisten obat (TB RO) saat ini merupakan salah satu masalah kesehatan masyarakat yang utama pada banyak negara di seluruh dunia dan masih menjadi ancaman bagi pengendalian tuberkulosis. Indonesia termasuk salah satu dari tujuh negara dengan beban tertinggi dalam hal jumlah kasus TB-MDR. Dibandingkan dengan kasus baru, TB RO lebih banyak terjadi pada kasus yang pernah menjalani pengobatan TB sebelumnya. Oleh karena itu, penting untuk memahami tanda-tanda dan diagnosis penyakit TB resisten obat dan mekanisme resistensinya. Artikel ini ditulis untuk membahas TB RO secara keseluruhan berdasarkan literatur yang ada.
Diagnosis and Treatment of Aspergillosis Harliza, Baiq Fanindya; Fathana, Prima Belia
Jurnal Biologi Tropis Vol. 24 No. 4 (2024): Oktober - Desember
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i4.7682

Abstract

Aspergillosis is an infection caused by the fungus Aspergillus , which typically affects individuals with weakened immune systems. One of the more serious forms of this infection is chronic pulmonary aspergillosis, which has a mortality rate of over 50%. This infection is estimated to affect approximately 3 million people worldwide, making it a significant global health issue. Accurate diagnosis and effective management are crucial to reducing morbidity and mortality. This article aims to explore the diagnosis and management of aspergillosis. The method employed is a literature review, with data obtained from various scientific articles through databases such as PubMed, Google Scholar, and ScienceDirect, with a publication limit of the last 10 years. Diagnosis of aspergillosis is based on clinical manifestations and supported by laboratory, radiological, and mycological examinations. Management of aspergillosis includes the administration of oral corticosteroids, antifungal drugs, surgery, and immunomodulatory therapy. Diagnosis is established based on clinical symptoms and relevant supporting examinations, while treatment is adjusted according to the severity of the infection and the patient's overall health condition. The conclusion of this article emphasizes the importance of early diagnosis and appropriate management in reducing the mortality rate associated with aspergillosis.
Aspiration Pneumonia: Patophysiology, Diagnosis and Treatment Kirana, Devi Chandra; Fathana, Prima Belia; Ristia, Ovia Intan; Mario, Andina Nabilah; Lukman, Dian Azizah; Abdiman, I Made Tobias; Putra, Made Raditya Arhya; Salsabila, Maida Sania
Jurnal Biologi Tropis Vol. 24 No. 1b (2024): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i1b.7897

Abstract

Aspiration pneumonia is one of the diseases that is often hidden and under-recognized. This disease contributes to a higher mortality rate compared to other types of pneumonia. This study aims to analyze the pathophysiology, diagnosis and management of aspiration pneumonia. The method used is a literature study by searching for literature published in PubMed, ScienceDirect, and Researchgate with the keywords "aspiration pneumonia", "aspiration pneumonia pathophysiology", "aspiration pneumonia diagnosis and treatment". Aspiration pneumonia can occur due to micro mechanisms or macro mechanisms. Micro mechanisms are mechanisms that cannot be observed while macro mechanisms often occur due to impaired swallowing. Aspiration experienced by pneumonia patients causes inflammation and disruption of the epithelium. The diagnosis of aspiration pneumonia can be established based on clinical symptoms and supporting examinations such as radiology and laboratory examinations. Management that can be carried out on aspiration pneumonia can be done with pharmacological and non-pharmacological management.
Literature Review: Acute Respiratory Distress Syndrome (ARDS) Oneiya, Baiq Aisha Aryuni; Ramadhita, Nova Izza Salsa; Makbul, Ini Hidayat; Mutia, Baiq Marceliya Anjani; Fidelia, Puspa Zalika; Amanullah, Mohammad Sany Rosafi; Rivlan, Muhammad Zaidan Fadlurrohman; Fathana, Prima Belia
Jurnal Biologi Tropis Vol. 24 No. 1b (2024): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i1b.8037

Abstract

Acute Respiratory Distress Syndrome (ARDS) is a clinically and biologically heterogeneous disease with a wide range of etiologies and manifestations. ARDS contributes significantly to high morbidity, mortality, and treatment costs associated with lung disease incidence. This study aims to evaluate the clinical characteristics, diagnostic strategies, and effective management approaches in ARDS treatment to enhance clinical guidelines in intensive care practice. This study employs a literature review method by collecting relevant articles from scientific databases, including PubMed, ScienceDirect, Cochrane Library, Google Scholar, and Proquest. Selected articles are full-text publications in Indonesian and English, published between 2010 and 2023. A total of 15 articles that met the selection criteria were analyzed in this study. ARDS is a serious medical condition with a still concerning prognosis. Optimal management approaches, especially through the use of protective ventilation and prone positioning, have been shown to benefit patients. However, personalized therapy based on biomarkers and further molecular research is needed to further reduce mortality.
Immunobiology and Molecular Approaches to Myasthenic Crisis in the Context of Tropical Biology Ningsih, Nur Aulia Ahya; Rifki, Muhammad; Firdaus, Nadine Aisyah Sultan; Latifa, Nindy Citra; Fathana, Prima Belia
Jurnal Biologi Tropis Vol. 25 No. 4a (2025): Special Issue
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v25i4a.10513

Abstract

Myasthenic crisis is a severe acute complication of myasthenia gravis (MG) characterized by respiratory and bulbar muscle insufficiency due to impaired neuromuscular transmission, with pathogenesis involving autoantibodies targeting acetylcholine receptors (AChR), muscle-specific kinase (MuSK), and low-density lipoprotein receptor-related protein 4 (LPR4) that disrupt the integrity of the neuromuscular junction. This review aims to examine the immunobiological mechanisms of myasthenic crisis and explore the potential of modern biotechnological therapies and tropical bioactive compounds as adaptive treatment strategies for tropical populations. A comprehensive literature review was conducted focusing on genetic factors, tropical environmental influences, and advancements in molecular therapies. Genetic factors, including HLA class II and non-HLA genes, interact with tropical environmental conditions such as endemic infections, high temperature, extreme humidity, air pollution, and vitamin D deficiency, potentially exacerbating immune dysregulation and increasing crisis risk. Modern molecular therapies, including rituximab (anti-CD20), eculizumab (anti-C5), and efgartigimod (FcRn inhibitor), have demonstrated efficacy in reducing pathogenic autoantibodies and improving neuromuscular function, while tropical bioactive compounds such as curcumin and andrographolide show potential as adjuvant immunomodulators. Integrating biotechnological approaches with tropical bioprospecting provides a more adaptive and sustainable therapeutic strategy aligned with the biological characteristics of tropical populations. It is recommended that further clinical studies evaluate the safety, optimal dosing, and long-term efficacy of combined biotechnological and bioactive therapies in these populations.
Co-Authors Abdiman, I Made Tobias Adnanto Wiweko Ahmad Taufik S Amanullah, Mohammad Sany Rosafi Ardiana Ekawanti Arfi Syamsun Auliana Puji Lestari Devi Rahmadhona Devi Ramadhona Dewi Suryani Didit Yudhanto Eustachius Hagni Wardoyo Fidelia, Puspa Zalika Firdaus, Nadine Aisyah Sultan Gede Wira Buanayuda Harliza, Baiq Fanindya I Made Arya Yogiswara Mahayasa Ida Bagus Alit Ika Nurfiria Tauhida Ima Arum Lestarini Indah Sapta Wardani Indana Eva Ajmala Indana Eva Ajmala Indrasari, Annisa Diyanabila Jurnal Pepadu Kirana, Devi Chandra Komang Pranayoga Prandhana Putra Nartha Latifa, Nindy Citra Lukman, Dian Azizah Makbul, Ini Hidayat Mario, Andina Nabilah Mohammad Rizki Monalisa Nasrul Moulid Hidayat Muhammad Rifki Mutia, Baiq Marceliya Anjani Ningsih, Nur Aulia Ahya Oneiya, Baiq Aisha Aryuni Paulus Taufik Putra, Made Raditya Arhya Putri, Novia Andansari Putri, Novia Andansari Ramadhita, Nova Izza Salsa Rifana Cholidah, Rifana Rina Lestari Ristia, Ovia Intan Rivlan, Muhammad Zaidan Fadlurrohman Salsabila, Maida Sania Sang Ayu Nyoman Putri Pradnyasari Srikus Saptaningtyas, Rini Vini Fardila, Vini Wahyu Sulistya Affarah Wahyu Sulistya Affarah Yuliyani, Eka Arie