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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Folia Medica Indonesiana Indonesian Journal of Tropical and Infectious Disease Jurnal Mikologi Indonesia J-Dinamika: Jurnal Pengabdian Kepada Masyarakat Bioscientia Medicina : Journal of Biomedicine and Translational Research JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Jurnal Abdi Insani Majalah Biomorfologi (Biomorphology Journal) Jurnal Layanan Masyarakat (Journal of Public Service) CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Jurnal Kesehatan Tambusai Bioscientia Medicina : Journal of Biomedicine and Translational Research International Journal of Science and Society (IJSOC) Jurnal Widya Medika

Pepy Dwi Endraswari, Pepy Dwi

Departemen Clinical Microbiology, Faculty Of Medicine, Universitas Airlangga, Dr. Soetomo General Academic Teaching Hospital, Surabaya, Department Of Clinical Microbiology, Universitas Airlangga Teaching Hospital, Surabaya

Author-ID : 563319

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Dentistry Earth & Planetary Sciences Economics, Econometrics & Finance Education Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Law, Crime, Criminology & Criminal Justice Materials Science & Nanotechnology Mathematics Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Other

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Antibacterial Activity of Ethanol Extract of Kemuning (Murraya Paniculata) Against Klebsiella pneumoniae ESBL by In Vitro Test Wiyogo, Illona Okvita; Endraswari, Pepy Dwi; Setiawati, Yuani
Indonesian Journal of Tropical and Infectious Disease Vol. 9 No. 2 (2021)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v9i2.9328

Klebsiella pneumoniae Extended-spectrum β-lactamase (ESBL) was one of the microorganism that cause nosocomial infection which resistant to beta-lactams antibiotics. Orange Jessamine (Murraya paniculata) was traditional medicine which believed has antibacterial components, such as: ï¬‚ avonoids, alkaloids, essential oils, coumarins, terpenoids, tannins, and saponins. In the previous studies, there was antibacterial activity in ethanolic extract of Murraya paniculata againsts E.coli, K.pneumoniae, S.typhi, E.faecalis, P.aeruginosa, S.ï¬‚ exneri, S.aureus, and S.sonneii with concentration 200 mg/ mL. There has not experiment about ethanolic extract of Murraya paniculata against Klebsiella pneumoniae ESBL yet. The aim of this study was to ï¬ nd out the in vitro antibacterial activity of ethanol extracts of Murraya Paniculata against Klebsiella pneumoniae ESBL Broth dilution method with concentration 200 mg/mL, 100 mg/mL, 50 mg/mL, 25 mg/mL, 12,5 mg/mL, 6,25 mg/mL, and 3,125 mg/mL were used for the determination of the Minimal Inhibitory Concentration (MIC). While the Minimal Bacterial Concentration (MBC) was assessed using streaking method in Nutrient Agar Plate. The highest concentration in this study was obtained from 100 g of Murraya paniculata leaves dissolved in 500 mL of 40% ethanol. The study was carried out 4 times replication. At the time of the sterility test extract, germ growth appeared on Nutrient Agar Plate media, so the extract was ï¬ ltered before being used for research. After incubation at 37 °C for 24 hours, growth of bacterial colonies on all agar plates was observed. The concentration of the ethanol extract of Murraya Paniculata (200 mg/mL) did not inhibit the growth of Klebsiella pneumoniae ESBL. The ethanol extracts of Murraya paniculata in concentration 200 mg/mL had no antibacterial activity against Klebsiella pneumoniae ESBL.

Gastric Perforation Associated with Candidiasis and NSAIDS Aquaresta, Febriana; Kawilarang, Arthur Pohan; Endraswari, Pepy Dwi
Indonesian Journal of Tropical and Infectious Disease Vol. 8 No. 3 (2020)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v8i3.16084

Invasive candidiasis is an important health-care-associated fungal infection. Candida is often described as an opportunistic pathogen. It is commensal flora in the gastrointestinal tract. Invasive candidiasis can happen usually because of a consequence of increased or abnormal colonization together with a local or generalized defect in host defenses. Candidiasis can occur in patients with HIV, therapy with a broad-spectrum antibiotic, transplant organ, and immunocompromised. Most cases of gastric perforation occur as complications of Peptic Ulcer Disease (PUD), Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and gastric neoplasms, but candidiasis as a cause of gastric perforation is very rare. This study aims to reveal the correlation between gastric perforation with candidiasis and NSAIDs. It was reported that a 57-year-old East Java Indonesian female presented with severe epigastric pain, generalized peritonitis, fever, nausea also vomiting and had a history of NSAIDs used for five years. The patient was taken to the general surgery of Dr. Sutomo Surabaya Hospital and performed exploratory laparotomy. A gastric perforation was discovered in the antrum. Microbiology culture examination from biopsy gastric tissue revealed an intense fungal growth from sabouraudagar medium and there is no other microorganism that grew in aerobic culture. Candida albicans was identified by VITEK® 2 COMPACT. Histopathological examination from biopsy gastric tissue was performed by Olympus CX-21 microscope, showed invasive Candida albicans consisting of numerous fungal yeasts and pseudohyphae invading and destroying the gastric wall. The patient was subsequently treated with fluconazole anti-fungal and discharge home after nine days postoperative period in good condition. From this result, we suggest using an antifungal treatment for patients who use NSAIDs for long periods to prevent candidiasis.

In Vitro Comparison of Antifungal Activity between Epigallocatechin Gallate EGCG) and Nystatin on Candida Sp. Stored Isolates in HIV/AIDS Patients with Oral Candidiasis Wibisono, Yusuf; Hidayati, Afif Nurul; Sawitri, Sawitri; Prakoeswa, Cita Rosita Sigit; Zulkarnain, Iskandar; Ervianti, Evy; Rahmadewi, Rahmadewi; Hendradi, Esti; Endraswari, Pepy Dwi; Murtiastutik, Dwi
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 33 No. 2 (2021): AUGUST
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V33.2.2021.103-109

Background: Oral candidiasis is an oral infection caused by Candida albicans. It is one of the most common opportunistic infections found in patients with Human Immunodeficiency Virus (HIV)/Acquired Immune Deficiency Syndrome (AIDS). Due to growing resistance and side effects to common antifungal drugs in recent years, there have been many studies on naturalsubstances as antifungal agents. In this study, Epigallocatechin gallate (EGCG) were examined for in vitro antifungal activity against Candida strains. Purpose: To compare the in vitro antifungal activity of EGCG and nystatin towards Candida sp. isolate in HIV/AIDS patients with oral candidiasis. Methods: This research was an experimental laboratory study conducted at the Dr. Soetomo General Academic Hospital, Surabaya. Forty isolates of Candida albicans and Candida non-albicans were included. The isolates were tested for antifungal activity using the well diffusion and microdilution method for nystatin 1000 IU and EGCG 1.25%. Result: Diffusion test results showed a greater inhibition zone for nystatin against all analyzed Candida strains with an average diameter for Candida albicans formed by EGCG of 2.15 mm and 7.4 mm for Candida non-albicans. Meanwhile, based on the microdilution test, EGCG was better than nystatin towards all analyzed Candida strains. This study showed EGCG Minimum Fungicidal Concentration (MFC) as high as 50% (p < 0.05). Conclusion: Nystatin antifungal activity was better than EGCG supported by a greater inhibition zone in the well diffusion method. However, the antifungal activity of EGCG was better than nystatin based on microdilution methods.

Antifungal Activity of Rosemary (Rosmarinus officinalis L.) Emulsion Gel Compared to Nystatin on Candida albicans Stored Isolate from HIV/AIDS Patients with Oral Candidiasis Wardiana, Maya; Astindari; Ervianti, Evy; Afif Nurul Hidayati; Diah Mira Indramaya; Pepy Dwi Endraswari; Budi Utomo; Dwi Murtiastutik
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 35 No. 2 (2023): AUGUST
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V35.2.2023.88-92

Background: Oral candidiasis (OC), frequently caused by Candida albicans, is the most common opportunistic infection in HIV/AIDS patients. Topical treatment for OC is limited. In vitro study revealed rosemary (Rosmarinus officinalis L.) essential oil has an antifungal effect. However, the essential oil is volatile and is not recommended to be applied to the skin and mucosa; therefore, emulsion gel (emulgel) is made. Purpose: This study was conducted to evaluate the antifungal activity of rosemary emulgel 6.25%, 25%, 37.5%, and 50% compared to nystatin. Methods: This study is an in vitro test using the disk diffusion method to d etermine the antifungal activity shown by the inhibitory zones of rosemary emulgel at 6.25%, 25%, 37.5%, and 50% compared to nystatin to stored isolates of C. albicans from HIV/AIDS patients with OC. Result: Rosemary emulgel 6.25% dan 25% did not show antifungal activity because no inhibitory zone was shown. The inhibitory zone diameter provided by rosemary emulgel 37.5%; 50%; and nystatin against C. albicans isolates were 3.17±3.763 mm; 7.00±4.107 mm; and 30.13±5.319 mm respectively. Significant differences in antifungal activity were shown by the inhibitory zone diameter provided between rosemary emulgel 37.5%, 50%, and nystatin (p<0,05). Conclusion: Rosemary emulgel 37.5% dan 50% had antifungal activity showed by the formation of inhibitory zone against Candida species isolates in disk diffusion method even though it was weaker compared to nystatin as a standard antifungal.

Effects of Clove Leaf Essential Oil (Syzygium aromaticum) in Inhibiting Biofilm Formation on Candida albicans Isolate Rifai, Achmad; Endraswari, Pepy Dwi; Setiawati, Yuani; Koendhori, Eko Budi
JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Vol. 15 No. 2 (2024): Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/juxta.V15I22024.70-75

Highlights: Candida albicans is capable of forming biofilm, which can lead to resistance to antifungal treatments. Clove leaf essential oil, which can inhibit biofilm formation, making it a potential anti-biofilm agent. Abstract Introduction: Candida albicans (C. albicans) has a virulence factor, like biofilm formation. Biofilm is a three-dimensional structure that plays a role in antimicrobial resistance, thus requiring antibiofilm agents to address this problem. One of them is Clove leaf (S. aromaticum). S. aromaticum has active phytochemicals (eugenol, β-caryophyllene, and others) that can inhibit biofilm formation in microorganisms, including fungi. This study aimed to prove the effect and to find a concentration of Clove leaf essential oil that affects the biofilm formation of C. albicans isolate. Methods: This study used a microtiter plate with a two-fold dilution technique. The tested concentrations were 6.25%, 3.125%, and 1.5625%. The positive control was 200 µL of C. albicans biofilm suspension, and the negative control was 200 µL of tryptic soy broth media, and all were repeated four times. The biofilm was observed using crystal violet and evaluated using optical density. The data was analyzed statistically using the International Business Machines Corporation (IBM) Statistical Package for the Social Sciences (SPSS) version 26, with a p<0.05 considered statistically significant. Results: The Optical density (O.D.) of the isolate was 2.039, while the negative control was 0.349, indicating that the isolate was a strong biofilm former. The concentrations of 6.25%, 3.125%, and 1.5625% showed inhibition percentages of 8.533%, 17.214%, and 8.484%, respectively. The Optical density was found to be normally distributed but not homogeneous p>0.05, The Kruskal-Wallis’s test was significant, and the Mann-Whitney test was not significant between test groups and positive control. Conclusion: Clove leaf essential oil has inhibitory effects on C. albicans biofilm isolates. However, statistically, there was no significant difference between the test groups and the positive control.

Antifungal Potential of Propolis Extract Against Candida Albicans: Literature Review Olivia Maheswari Soerjanto; Pepy Dwi Endraswari; Abdul Khairul Rizki Purba
International Journal of Science and Society Vol 5 No 5 (2023): International Journal of Science and Society (IJSOC)
Publisher : GoAcademica Research & Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54783/ijsoc.v5i5.963

The increasing rate of Candida resistance against pharmacological drugs has become a particular focus in the medical world, especially considering the high mortality rate due to systemic infections caused by Candida. It is evident that the urgency of developing alternative medicines applies for potential natural ingredients like propolis. This literature review aims to discuss the antifungal effectiveness of propolis against C. albicans which is described by the MIC (minimum inhibitory concentration) and MFC (minimum fungicidal concentration) values from the test results. The search for relevant literature was conducted using the Google Scholar, ScienceDirect, and PubMed databases using the keywords "Propolis AND MIC AND MFC AND Candida albicans". There were nine articles that had been adjusted to the inclusion and exclusion criteria based on the PICOS Framework. The propolis in the article uses various solvents with various extraction methods, and various antifungal tests are carried out on standardized and clinical isolates of C. albicans. All the reviewed articles consistently support the finding that propolis has a strong ability to inhibit the growth and kill the pathogenic fungus C. albicans. The lowest MIC value found was 0.06 μg/mL, and the MFC value was 0.121 μg/mL. Propolis has potential as an ingredient that can be further developed as a non-pharmacological therapy for pathogenic fungal infections.

Pemberdayaan Guru Yayasan Pendidikan Al Khairaat Yogyakarta pada Penanggulangan Antimicrobial Resistance: dari UNAIR untuk Indonesia Wahyunitisari, Manik Retno; Koendhori, Eko Budi; Endraswari, Pepy Dwi; Purwono, Priyo Budi; Juniastuti, Juniastuti; Wiqoyah, Nurul; Sardjono, Lindawati Alim; Vermasari, Naritha; Muna, Nafdzu Makhmudatul; Setiawan, Firman; Lindarto, Wira Widjaya; Widyatama, Fikri Sasongko
J-Dinamika : Jurnal Pengabdian Masyarakat Vol 9 No 3 (2024): Desember
Publisher : Politeknik Negeri Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25047/j-dinamika.v9i3.5481

Antibiotics are compounds created by microorganisms to live by destroying their competitors. Antibiotics are commonly used without a prescription to treat symptoms caused by non-bacterial infections. Antibiotic resistance is a global problem. Continuous education is needed by agents of change to overcome this problem. Community service collaboration between the Department of Microbiology-Parasitology, FK Unair, and the Department of Microbiology, Faculty of Medicine, Public Health, and Nursing, Gadjah Mada University with partnerships for the goals teachers from the Al Khairaat Yogyakarta educational foundation, aim to provide an understanding of the proper use of antibiotics. The initial target of transfer of knowledge was successfully measured by increasing participants' post-test results.

ANTIBODY ANTI-DENGUE PROFILE IN DENGUE HEMORRHAGIC FEVER PATIENTS AT DR. SOETOMO HOSPITAL, SURABAYA Waskito, Langgeng A; Notopuro, Paulus B; Endraswari, Pepy Dwi
Folia Medica Indonesiana Vol. 51 No. 3 (2015): July - September 2015
Publisher : Universitas Airlangga

Dengue hemorrhagic fever is one infectious diseases that have high case fatality rate in Indonesia. The aim of this study was to descibe the antibody anti-dengue profile in dengue hemorrhagic fever patients at Dr. Soetomo Hospital Surabaya. This study was epidemiological descriptive study to aims prevalence primary and secondary infection of dengue hemorrhagic fever and its clinical appearances. This study used 85 samples by taking medical record data of IgM and IgG anti-dengue serologic test from Internal Medicine Department, Dr. Soetomo Hospital, Surabaya, between January to December 2010. The data were collected and analyzed in diagrams and tables. Result of this study showed 25 (29,4%) patients had positive IgM serologic test, 14 (16,4%) patients had positive IgG serologic test and 46 (54,2%) patients had positive IgM and IgG serologic test. In primary infections, the history of fever was 3.8±1.2 days; platelet counts 58,6±21,4/ml and bleeding sign 37% of 25 patients. In secondary infections, the history of fever was 4.28±1.15 days; platelet count was 44,17±24,2/ml and bleeding sign 52% of 60 patients. In conclusion, patients with secondary infection have higher prevalence than primary infection. Then in secondary infection had more severe clinical appearance than primary infection.

Progress In Knowledge Of Microscopic Tuberculosis Diagnosis Laboratory Training Participants Silvia Sutandhio; Ni Made Mertaniasih; Eko Budi Koendhori; Deby Kusumaningrum; Titiek Sulistyowati; Lindawati Alimsardjono; Pepy Dwi Endraswari; Manik Retno Wahyunitisari; Rebekah Juniati Setiabudi
JURNAL WIDYA MEDIKA Vol. 5 No. 2 (2019)
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v5i2.2202

Indonesia is the second highest tuberculosis (TB)-burden country in the world. TB affects men and women in productive ages. Early and accurate diagnosis of TB is crucial in TB management because it allows prompt treatment with appropriate regimen. Sputum smear microscopy is the most common method used in resource-limited laboratories. The aim of this study is to assess whether adult learning method with student-centered approach can improve knowledge in laboratory techniques in microscopic TB diagnosis. It was a quasi experimental research with one group pretest and posttest design. Pretest was conducted before the training started. During the training, participants attended lectures, discussion sessions, and hands-on laboratory activities. After training, participants were asked to respond to posttest. There were 33 participants of this training (n=33). Paired t-test analysis showed significant difference between pretest and posttest scores (p=6.5x10-9). Variance between pretest scores was 4.00 and variance between posttest scores were 1.34. Pearson correlation coefficient was 0.45. Regardless their level of knowledge before training, participants could achieve relatively equivalent results after training. Significant difference between pre- and post-training test scores indicated that the learning method was effective and the training could improve participants knowledge in laboratory techniques in microscopic TB diagnosis.

Fungemia in Tertiary Hospitals; An Overview Fungal Profile, Antifungal Resistance, and Antifungal Therapy Monita, Syafira Putri; Endraswari , Pepy Dwi; Bramantono; Asmarawati , Tri Pudy; Khanfar, Sarah Amjad Abdel-Raouf
Indonesian Journal of Tropical and Infectious Disease Vol. 13 No. 1 (2025)
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v13i1.66500

Fungemia is a bloodstream infection caused by fungal pathogen and commonly occurs in hospitalized patients with certain risk factors. Indonesia itself is a tropical country with middle income that makes the incidence rate of fungemia tend to be higher, namely10/1 0,000 people. A recent study about candidemia conducted in Dr. Soetomo General Academic Hospital stated that the most common species that caused candidemia is Candida albicans (33.96%) and the blood sample mostly collected from patients from high care unit and patient with diabetes. We conducted this study to provide a new overview of data on the profile of the causes of fungal infections, patterns of fungal resistance to antifungals, and antifungal therapy in patients with fungemia in hospitalized patients at Dr. Soetomo General Academic Hospital, Surabaya, for the period of January December 2023. This research is a descriptive study using the patient’s medical records. Variables observed in this study include; gender, age, care unit, risk factor, species distribution, resistance pattern, type of antifungal therapy, and duration of antifungal therapy. Mostly the blood cultures are collected from female patients aged 0-9 years old. This study also found that most blood cultures are collected from patients in intensive care unit with use of CVC. Most of the patients did not receive antifungal therapy The most frequent found species is Candida parapsilosis with highest resistance rate found in Amphotericin-B. The most common antifungal that is used is Fluconazole which is mostly given within the range of 8-14 days .

Co-Authors Abdul Khairul Rizki Purba Mustofa Indwiani Astuti ACHMAD RIFAI Afif Nurul Hidayati Afif Nurul Hidayati, Afif Nurul Alimsardjono, Lindawati Amanda Gracia Manuputty Andy Setiawan Aquaresta, Febriana Asmarawati, Tri Pudy Astindari Bernadya Yogatri Anjuwita Bramantono Bramantono, Bramantono BUDI UTOMO Budi Utomo Budipramana, Vicky Sumarki Cita Rosita Sigit Prakoeswa Damayanti Damayanti Deby Kusumaningrum Diah Mira Indaramaya Diah Mira Indramaya Dinda Rachma Harlisa Dwi Murtiastutik Dyah Ratri Anggarini Dyah Ratri Anggarini, Dyah Ratri Eko Budi Koendhori, Eko Budi Emma Hidayati Sasmito Esti Hendradi Evy Ervianti Faizah, Wardatun Faradina Sulistiyani Fikri Sasongko Widyatama Hari Sukanto, Hari Intan Primasari Iskandar Zulkarnain Juita, Liza Puspa Senja Asmara Juniastuti Juniastuti Kadariswantiningsih, Ika Kawilarang, Arthur Pohan Khanfar, Sarah Amjad Abdel-Raouf Langgeng A Waskito, Langgeng A Lestari, Aprilia Dwi Linda Astari, Linda Lindarto, Wira Widjaya M. Yulianto Listiawan ManikRetno Wahyunitisari Marwasyifa, Nuritsna Monita, Syafira Putri Muna, Nafdzu Makhmudatul Ni Made Mertaniasih Nurul Wiqoyah, Nurul Nuswantoro, Djohar Olivia Maheswari Soerjanto Paulus B Notopuro Priyo Budi Purwono Rahmadewi Rahmadewi Rahmadewi Ratna Sofaria Munir Rebekah Setiabudi, Rebekah S. Soedarsono Sardjono, Lindawati Alim Sarwendah Paramesti Sawitri Sawitri Sawitri Sawitri Sawitri Setiawan, Firman Silvia Sutandhio Sudjarwo Sudjarwo Tengku Riza Zarzani N Titiek Sulistyowati Vermasari, Naritha Wahyunitisari, Manik Retno Wardiana, Maya Wiyogo, Illona Okvita Yitijuatni Yuani Setiawati Yudayanti, Elprania Credo Yusuf Wibisono

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