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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Indonesian Journal of Tropical and Infectious Disease Jurnal Mikologi Indonesia J-Dinamika: Jurnal Pengabdian Kepada Masyarakat Bioscientia Medicina : Journal of Biomedicine and Translational Research JUXTA: Jurnal Ilmiah Mahasiswa Kedokteran Universitas Airlangga Jurnal Abdi Insani Majalah Biomorfologi (Biomorphology Journal) Jurnal Layanan Masyarakat (Journal of Public Service) CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL Jurnal Kesehatan Tambusai Bioscientia Medicina : Journal of Biomedicine and Translational Research International Journal of Science and Society (IJSOC) Jurnal Widya Medika Folia Medica Indonesiana
Pepy Dwi Endraswari, Pepy Dwi
Departemen Clinical Microbiology, Faculty Of Medicine, Universitas Airlangga, Dr. Soetomo General Academic Teaching Hospital, Surabaya, Department Of Clinical Microbiology, Universitas Airlangga Teaching Hospital, Surabaya
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Bloodstream Infections Leading to Sepsis: Clinical and Microbiological Profiling of Bacteremia among Hospitalized Patients in Surabaya, Indonesia Marwasyifa, Nuritsna; Asmarawati, Tri Pudy; Setiawan, Firman; Endraswari, Pepy Dwi
Current Internal Medicine Research and Practice Surabaya Journal Vol. 6 No. 2 (2025): CURRENT INTERNAL MEDICINE RESEARCH AND PRACTICE SURABAYA JOURNAL
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/cimrj.v6i2.66675

Abstract

Introduction: Bacteremia poses a significant health risk due to its frequently atypical presentation and potential progression to sepsis. Understanding its clinical profiles and causative pathogens is essential for timely diagnosis and effective management. This study examined the characteristics of bacteremia cases in 2022 at Universitas Airlangga Hospital, Surabaya, Indonesia. Methods: A retrospective, descriptive observational study was conducted utilizing hospitalized bacteremia patients' medical records. A total of 107 patients met the inclusion criteria, which required positive blood cultures along with complete data on age (≥19 years), sex, comorbidities, clinical manifestations, bacterial infection diagnosis, outcomes, and pathogen characteristics. Medical records failing to meet these criteria were excluded. The data were categorized and analyzed by variables. Results: Bacteremia predominantly affected patients aged >65 years (36.4%), males (50.5%), and those with diabetes (54.2%) and with pneumonia (79.4%). Key symptoms included tachycardia (55.1%), tachypnea (55.1%), anemia (65.4%), and leukocytosis (71.0%), despite normal vitals observed in numerous cases. Gram-positive bacteria were most prevalent (69.7%), mainly Staphylococcus hominis (18.7%). Escherichia coli (9.3%) was the leading Gram-negative isolate, while extended-spectrum beta-lactamase (ESBL) strains (4.2%) were the primary multidrug-resistant organisms (MDRO). Sepsis and septic shock were equally prevalent (35.5%). Mortality (64.5%) occurred primarily due to septic shock (49.3%). Conclusion: Sepsis and septic shock frequently occur in older males with diabetes and pneumonia. Key symptoms include frequent tachycardia, tachypnea, anemia, and leukocytosis. Septic shock, the leading cause of death in bacteremia patients, frequently occurs alongside infections by Staphylococcus hominis and ESBL-producing Escherichia coli.   Highlights: 1. This study offers fresh perspectives on the clinical profiles of hospitalized bacteremia patients and the characteristics of causative bacteria at Universitas Airlangga Hospital, a topic that has been minimally explored in the Indonesian medical community. 2. It highlights the prevalence of bacteremia, its clinical manifestations, and outcomes to determine the mortality rate of hospitalized bacteremia patients. 3. This study provides valuable data that can help inform future infection control strategies to manage and prevent bloodstream infections, hence enhancing healthcare outcomes by emphasizing the importance of improving clinical data collection and monitoring.
PEMBERDAYAAN STAF TEKNISI LABORATORIUM FASYANKES DAN KADER KESEHATAN DI KABUPATEN PAMEKASAN UNTUK PENINGKATAN PERAN PADA TEMUAN DAN DIAGNOSIS PENYAKIT TUBERKULOSIS PARU Mertaniasih, Ni Made; Kusumaningrum, Deby; Endraswari , Pepy Dwi; Koendhori, Eko Budi
Jurnal Abdi Insani Vol 12 No 7 (2025): Jurnal Abdi Insani
Publisher : Universitas Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/abdiinsani.v12i7.2314

Abstract

Tuberkulosis (TB) merupakan masalah kesehatan global yang masih menjadi prioritas utama dalam upaya penanggulangan penyakit. Tingginya angka kesakitan dan kematian akibat TB memerlukan langkah-langkah strategis, terutama dalam hal deteksi dini dan pengobatan yang tepat. Diagnosis dini TB paru yang akurat dan cepat sangat bergantung pada deteksi bakteri patogen dalam dahak pasien, yang selanjutnya menentukan strategi pengobatan yang sesuai. Tes Cepat Molekuler (TCM) digunakan untuk diagnosis awal, sedangkan pemantauan hasil pengobatan dilakukan melalui pemeriksaan mikroskopis bakteri tahan asam (BTA). Tujuan kegiatan Pengmas adalah meningkatkan pemahaman dan keterampilan staf teknisi laboratorium dalam mendiagnosis TB sesuai dengan standar kompetensi.  Serta memperkuat peran kader kesehatan dalam penanggulangan TB di masyarakat. Tim Dosen Departemen Mikrobiologi Kedokteran Fakultas Kedokteran Universitas Airlangga bersama mahasiswa dan alumni Program Studi Spesialis Mikrobiologi Klinik melaksanakan kegiatan ceramah mengenai TB paru, meliputi aspek diagnosis, pengobatan, dan pencegahan penularan kepada 17 kader kesehatan serta pelatihan pemeriksaan mikroskopis BTA bagi  16 staf teknisi laboratorium dari berbagai fasilitas kesehatan masyarakat dan RSUD di Kabupaten Pamekasan. Evaluasi pasca pelatihan menunjukkan peningkatan yang signifikan dalam pemahaman dan keterampilan para kader kesehatan terkait temuan kasus TB di masyarakat, diagnostik, serta upaya pencegahan penularan. Seluruh staf laboratorium mengalami peningkatan kompetensi dalam pemeriksaan BTA, termasuk pembuatan dan pembacaan sediaan sesuai standar nasional (IUATLD). Kegiatan pengabdian kepada masyarakat oleh tim akademisi efektif dalam pemberdayaan kader kesehatan sebagai ujung tombak deteksi dini TB serta meningkatkan keterampilan diagnosis mikroskopis staf laboratorium. Pelatihan ini berkontribusi pada peningkatan kualitas diagnosis dan pengobatan TB.
ESKAPE Pathogens in Hospitalized Patients: A Comprehensive Profiling of Infections and Characteristics at Universitas Airlangga Hospital, Surabaya, Indonesia Dinda Rachma Harlisa; Tri Pudy Asmarawati; Firman Setiawan; Pepy Dwi Endraswari
Majalah Biomorfologi Vol. 35 No. 2 (2025): Majalah Biomorfologi
Publisher : Universitas Airlangga, Surabaya, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/mbiom.v35i2.2025.103-112

Abstract

Highlights This study found that ESKAPE pathogenic infections at Universitas Airlangga Hospital were dominated by Gram-negative bacteria, particularly Klebsiella pneumoniae, with sputum as the most commonly collected specimen providing valuable data for infection control strategies. Most patients exhibited significant clinical manifestations involving neurological disorders, with the respiratory system being the most affected information that may enhance the effectiveness of patient management in the hospital.   ABSTRACT Background: Infections pose a significant threat in Indonesia, particularly in healthcare settings where healthcare-associated infections (HAIs) are prevalent. At a hospital in Jakarta, the prevalence of ESKAPE pathogens was reported to be 69.8%. However, detailed data on the infection profiles of these pathogens remain scarce. This underscores the importance of studying ESKAPE pathogenic bacteria to better understand their characteristics. Objective: This study aimed to determine the infection profile of ESKAPE pathogens in hospitalized patients at Universitas Airlangga Hospital, Surabaya, Indonesia in 2022. Material and Method: This descriptive observational study employed a retrospective design using secondary data from non-ICU inpatients at Universitas Airlangga Hospital infected with ESKAPE pathogens in 2022. Total sampling was applied to eligible medical records. Result: The study included 119 specimens from inpatients infected with ESKAPE pathogens that met the inclusion and exclusion criteria. Of these, 78% were Gram-negative bacterial infections, with Klebsiella pneumoniae being the most prevalent (29%). Sputum was the most commonly collected specimen (49%). Most patients were male (57%), aged 56–65 years (29%), and had no comorbidities (46%). Additionally, 63% of patients had used invasive devices during hospitalization. The majority were admitted to low-care inpatient wards. The primary clinical features were neurological complaints (29%) and respiratory disorders (37%), predominantly associated with Klebsiella pneumoniae. Conclusion: ESKAPE infections were primarily caused by Klebsiella pneumoniae, a Gram-negative bacterium, most frequently identified in sputum samples. The predominant clinical manifestations were decreased consciousness and respiratory disorders. Affected patients were mainly male, aged ≥56 years, hospitalized in low-care wards, with a history of invasive device use and no comorbidities.
Profil Spesies Candida Dan Pola Kepekaan Antijamur Pada Pasien Candidemia Darah di Unit Mikrobiologi Klinik RSUD Dr.Soetomo periode 2020-2023 Faizah, Wardatun; Wiqoyah, Nurul; Ervianti, Evy; Endraswari, Pepy Dwi
Jurnal Kesehatan Tambusai Vol. 5 No. 1 (2024): MARET 2024
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v5i1.23799

Abstract

Candida spp fungal infections. can attack the circulatory system (can be known as candidemia or blood infection by the fungus Candida spp.). Patients in the intensive care unit (ICU) or emergency unit (IGD) with long-term air-conditioned conditions resulting in Candida spp. can grow more easily and increase the risk of fungal infections. This study aims to evaluate the profile of Candida spp. as well as patterns of sensitivity to antifungals in patients with blood candidemia in the Clinical Microbiology Unit of Dr. RSUD. Soetomo during the 2020-2023 period. This research method involves analysis of medical record data of patients diagnosed with blood candidemia, with a retrospective descriptive research type. The research samples were isolate data, used were clinical specimens that can cause candidiasis in the vagina, oral cavity and urogenital tract. The sample size in this study was as large as the data from isolates originating from a total of clinics in the time period. The results of this study provide a comprehensive picture regarding the distribution of Candida spp. the most commonly encountered, as well as the pattern of sensitivity to certain antifungals in patients with blood candidemia in the Dr. Hospital environment. Soetomo. It is hoped that the information obtained from this study will provide better guidance in the management and selection of appropriate therapy for patients affected by blood candidemia in the future.
Antibody anti-dengue profile in dengue hemorrhagic fever patients at dr. Soetomo hospital, surabaya Waskito, Langgeng A; Notopuro, Paulus B; Endraswari, Pepy Dwi
Folia Medica Indonesiana Vol. 51, No. 3
Publisher : Folia Medica Indonesiana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Dengue hemorrhagic fever is one infectious diseases that have high case fatality rate in Indonesia. The aim of this study was to descibe the antibody anti-dengue profile in dengue hemorrhagic fever patients at Dr. Soetomo Hospital Surabaya. This study was epidemiological descriptive study to aims prevalence primary and secondary infection of dengue hemorrhagic fever and its clinical appearances. This study used 85 samples by taking medical record data of IgM and IgG anti-dengue serologic test from Internal Medicine Department, Dr. Soetomo Hospital, Surabaya, between January to December 2010. The data were collected and analyzed in diagrams and tables. Result of this study showed 25 (29,4%) patients had positive IgM serologic test, 14 (16,4%) patients had positive IgG serologic test and 46 (54,2%) patients had positive IgM and IgG serologic test. In primary infections, the history of fever was 3.8±1.2 days; platelet counts 58,6±21,4/ml and bleeding sign 37% of 25 patients. In secondary infections, the history of fever was 4.28±1.15 days; platelet count was 44,17±24,2/ml and bleeding sign 52% of 60 patients. In conclusion, patients with secondary infection have higher prevalence than primary infection. Then in secondary infection had more severe clinical appearance than primary infection.
Co-Authors Abdul Khairul Rizki Purba Mustofa Indwiani Astuti ACHMAD RIFAI Afif Nurul Hidayati Afif Nurul Hidayati, Afif Nurul Alimsardjono, Lindawati Amanda Gracia Manuputty Andy Setiawan Aquaresta, Febriana Asmarawati, Tri Pudy Astindari Bernadya Yogatri Anjuwita Bramantono Bramantono, Bramantono BUDI UTOMO Budi Utomo Budipramana, Vicky Sumarki Cita Rosita Sigit Prakoeswa Damayanti Damayanti Deby Kusumaningrum Diah Mira Indaramaya Diah Mira Indramaya Dinda Rachma Harlisa Dwi Murtiastutik Dyah Ratri Anggarini Dyah Ratri Anggarini, Dyah Ratri Eko Budi Koendhori, Eko Budi Emma Hidayati Sasmito Esti Hendradi Evy Ervianti Faizah, Wardatun Faradina Sulistiyani Fikri Sasongko Widyatama Hari Sukanto, Hari Intan Primasari Iskandar Zulkarnain Juita, Liza Puspa Senja Asmara Juniastuti Juniastuti Kadariswantiningsih, Ika Kawilarang, Arthur Pohan Khanfar, Sarah Amjad Abdel-Raouf Langgeng A Waskito, Langgeng A Lestari, Aprilia Dwi Linda Astari, Linda Lindarto, Wira Widjaya M. Yulianto Listiawan ManikRetno Wahyunitisari Marwasyifa, Nuritsna Monita, Syafira Putri Muna, Nafdzu Makhmudatul Ni Made Mertaniasih Nurul Wiqoyah, Nurul Nuswantoro, Djohar Olivia Maheswari Soerjanto Paulus B Notopuro Priyo Budi Purwono Rahmadewi Rahmadewi Rahmadewi Ratna Sofaria Munir Rebekah Setiabudi, Rebekah S. Soedarsono Sardjono, Lindawati Alim Sarwendah Paramesti Sawitri Sawitri Sawitri Sawitri Sawitri Setiawan, Firman Silvia Sutandhio Sudjarwo Sudjarwo Tengku Riza Zarzani N Titiek Sulistyowati Vermasari, Naritha Wahyunitisari, Manik Retno Wardiana, Maya Wiyogo, Illona Okvita Yitijuatni Yuani Setiawati Yudayanti, Elprania Credo Yusuf Wibisono