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Journal : Jurnal NERS

The Relationship of Ns1 Antigen Profi Le and Days of Illness in Children with Dengue Virus Infection Dwiyanti Puspitasari; Saraswati Dewi; Aryati Aryati
Jurnal Ners Vol. 8 No. 1 (2013): April 2013
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (275.654 KB) | DOI: 10.20473/jn.v8i1.3867

Abstract

Introduction: Dengue NS1 Antigen (NS1 Ag) detection or quantification has become a specific diagnostic tool for dengue virus infection, but has variable sensitivity. Previous research reported NS1 Ag level can be detected up to the 7th–10th day of fever, others stated the sensitivity was decreased after four days of fever. We performed this research to analyze the NS1 Ag profile and its relationship with the day of illness.Methods: This study was a prospective cohort study on 39 children hospitalized at Dr. Soetomo Hospital Surabaya since November 2009 to May 2010. Inclusion criteria were acute fever less than 72 hours, bleeding tendency denoted at least by positive tourniquet test, age between 1–14 years, and confirmed by positive dengue IgM/IgG on the 5th day of fever. We performed daily quantitative dengue NS1 Ag tests until defervescence day, and its relationship with the day of illness were analyzed.Results: NS1 Ag was positive in 19/39 samples. Secondary infection occurred in 14/19 of Dengue Fever and 17/20 of Dengue Hemorrhagic Fever cases. Positivity of NS1Ag was higher in primary (6/8 cases) than secondary infection (12/31 cases). Mean level of NS1 Ag was highest on the 2nd day, decreased afterwards and undetected on the 5th day of fever. There was significant relationship between NS1 Ag positivity (P=0.037, rs=-0.9) and level (P<0.001, rs=-1) with the day of illness.Conclusion: Dengue NS1 Ag positivity and level were highest during the acute phase of fever and decreased afterwards.The Relationship of Ns1 Antigen Profi Le and Days of Illness in Children with Dengue Virus Infection
Clinical Features of Children with Diphtheria on Soetomo Hospital Dwiyanti Puspitasari; Erna Supatmini; Dominicus Husada
Jurnal Ners Vol. 7 No. 2 (2012): Oktober 2012
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (214.679 KB) | DOI: 10.20473/jn.v7i2.4012

Abstract

Introduction: Diphtheria is an important disease in children that could lead to fatal disease. East Java Province was declared to have Diphtheria outbreak in 2011 with increasing morbidity and mortality, including on Soetomo Hospital. Our paper aimed to describe the profi le of diphtheria cases in children admitted at dr Sutomo Hospital.Method: This descriptive study reviewed all medical records of diphtheritic patients admitted to Dr. Soetomo Hospital, January 2004–December 2010, of concerns were clinical presentations, age, sex, immunizations status, complications, and outcomes.Result: From 148 diphtheria cases, 22.3% were bacteriologically proven; 53.4% were male with sex ratio 1.1:1. The age proportion of ≤ 5 years old, 5- ≤ 10 years old, and > 10 years old were 61.5%, 31.8%, and 6.7%. Fever occurred in 99% cases, sore throat, stridor and bullneck occurred respectively in 62.2%, 39.9%, and 29.7% cases. There were 56.8% severe and 41.9% moderate diphtheria. Subjects were immunized in 84%, but none of them have adequate immunization. Myocarditis, being one of the commonest complications occurred in 11.4% cases and tracheostomy was the second (4.0%). All of the death cases (7.9%) were unvaccinated and in severe form.Discussion: The mostly prevalent clinical manifestations in diphtheria children were fever and sore throat. Half of the cases came with severe diphtheria and most cases were inadequately vaccinated. Death occurred in the unvaccinated and severe form.
Co-Authors A.A.W., I Wayan Putra Abu Rohiman Alifadiningrat, Dianira Hanum Febia Alpha Fardah Athiyyah Amanah Fatmadani Suwarno Amor Peraten Ginting Andy Darma Annisa Fira Salsabila Arguni, Egi Arina Setyaningtyas Aris Wiji Utami Aryati Aryati Atika Atika Auliya, Arsya Ayu Citra Gestari AYU WULANSARI Ayuningtyas, Jayanti Febry Ayush Khangai Baiduri, Senja Bangkit Putrawan Basuki, Setio Catarina Rani Desy Primayani Devi Maya Arista Dewi, Maharani Sita Dharmawati, Ira Dhasih Afiat Dwi Pawestri Dominicus Husada Edward Adijaya Rusli Egi Arguni Elfrida A. Rachmah Erna Supatmini Ernawati Ernawati Esti Yunitasari Eveline Irawan Ferisca Maya Kurnia Wardhani Firdaus, Hema Rizkyana Hammam Izza Rofiqi Hanik, Elya Umi Haq, Arini Hartono Kahar, Hartono Hilwana, Lutifta Husada, Dominicius I Gusti Made Reza Gunadi Ranuh Ida Fitriawati Ida Safitri Laksanawati Inna Fairuuza Firdaus Innayah, Reza Nidaul Irwanto Irwanto Ismoedijanto Januarti, Catur Ifda Juniastuti Juniastuti Jusak Nugraha Kartina, Leny Kevin Sastra Dhinata Khadijah Rizky Sumitro Khadijah Rizky Sumitro Kristina Marbun Kuntaman Kuntaman Linda Astari, Linda Lutfi Dewanda Nugroho Maesarah Maesarah ManikRetno Wahyunitisari Medhi Denisa Alinda, Medhi Denisa Mohammad Sjaifullah Noer Muhammad Faizi Muhammad Faizi, Muhammad Muhammad Miftahussurur Mustikasari, Rahma Ira Mutahhar, Alif Nadya Khuswatun Khasanani Nesa, Ni Nyoman Metriani Ni Nyoman Metriani Nesa Ni Nyoman Metriani Nesa Ningrum, Astika Gita Ninik Asmaningsih Soemyarso Ninik Darsini Parwati S. Basuki Parwati Setiono Basuki Perwitasari, Yulinda Ayu Prastiya Indra Gunawan Pratiwi, Maurin Pudji Lestari Purnama Sari, Yulia Purwanta, Marijam Puspa Wardhani Putri, Ardelia Savinka Anandrian Raissa Manika Purwaningtias Ratni Indrawanti Rebekah Setiabudi, Rebekah Regitha Adit Pramesty Reza Gunadi Ranuh Reza Gunadi Ranuh Risa Etika, Risa Risky Vitria Prasetyo Riza Noviandi Rizkiya Candra Sari Rochmanti, Maftuchah Rochmanti Rokhmah Ayu Suliasih Rusli, Musofa Sacharissa Zerlina Tsarwah Thirafi Safitri, Emilia Samira - Assegaf Saraswati Dewi Sari, Gadis Meinar Sri Utami Sri Utami Steven Christian Susianto Steven Christian Susianto Steven Christian Susianto Sudarmo, Subijanto Marto Sulistiawati Sulistiawati Sulistiawati Sulistiawati Sumitro, Khadijah Rizky Sunny Mariana Samosir Susianto, Steven Christian Tirthaningsih, Ni Wajan Tri Yeni Fahmawati Tuksin Jearanaiwitayakul Wahyu, Agung Dwi Wahyul Anis Wahyuni Mahmud Date Widati Fatmaningrum Widodo Darmowandowo Winni Aprillia Putri Woro Setia Ningtyas Yetti Hernaningsih Yuni Hisbiiyah Zaky Firmawan El-Hakim