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All Journal Pharmasipha Jurnal Mandala Pharmacon Indonesia Jurnal Kefarmasian AKFARINDO Jurnal Riset Kefarmasian Indonesia Medfarm: Jurnal Farmasi dan Kesehatan Jurnal Kesehatan Tambusai Jurnal Ilmiah Wahana Pendidikan Jurnal Buana Farma Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Proceeding ISETH (International Summit on Science, Technology, and Humanity) Jurnal Riset Rumpun Ilmu Kedokteran (JURRIKE) Urecol Journal. Part C: Health Sciences Prosiding University Research Colloquium JURNAL JAMU KUSUMA Duta Pharma Journal Proceeding of International Conference Health, Science And Technology (ICOHETECH) Cerdika: Jurnal Ilmiah Indonesia Prosiding Seminar Informasi Kesehatan Nasional International Journal of Health, Engineering and Technology Journal of Educational Innovation and Public Health Jurnal Ilmiah Kesehatan JURNAL FARMASI DAN KESEHATAN INDONESIA The International Science of Health Journal CERATA Usadha Journal of Pharmacy Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Aksi Nyata : Jurnal Pengabdian Sosial dan Kemanusiaan International Journal of Health and Medicine Klinik: Jurnal Ilmiah Kedokteran dan Kesehatan
Danang Raharjo
Pogram Studi Farmasi, Fakultas Kesehatan, Universitas Duta Bangsa, Surakarta
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Penetapan Kadar Flavonoid dan Uji Aktivitas Antioksidan Ekstrak Etanol 70%, Fraksi N-Heksana, Etil Asetat, dan Air dari Kubis Putih dan Kubis Ungu Menggunakan Metode Frap Santoso, Budi; Raharjo, Danang; Permatasari, Desy Ayu Irma
Cerdika: Jurnal Ilmiah Indonesia Vol. 2 No. 9 (2022): Cerdika: Jurnal Ilmiah Indonesia
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/cerdika.v2i9.441

Abstract

Cabbage contains various vitamins such as vitamin A, vitamin C and phytonutrient compounds that are natural antioxidants. Flavonoids are compounds with antioxidant activity that can protect the body from free radicals. This study aims to determine the flavonoid content and antioxidant activity of 70% ethanol extract, n-hexane fraction, ethyl acetate, and water from white cabbage (Brassica oleracea l.) and purple cabbage (Brassica oleracea l. Var. Capitata f. Rubra) FRAP method. This study was conducted experimentally including sample preparation, phytochemical screening, simplisia characterization, determination of total flavonoid content using colorimetric method with AlCl3 reagent and quercetin was used as a comparison. Antioxidant activity testing was carried out using the FRAP method with vitamin C as a comparison measured using a UV-Visible spectrophotometer. The results showed that the total flavonoid levels contained in white cabbage and purple cabbage were 5.664 mg QE/g sample and 10.145 mg QE/sample. Ethanol extracts of white cabbage and purple cabbage n-hexane, ethyl acetate and water fractions have antioxidant capacity of 71.534 mg AAE/ gram extract, 69.651 mg AAE/ gram extract, 93.781 mg AAE/ gram extract, 74.941 mg AAE/ gram extract and 78.08 mg AAE/ gram extract, 77.913 mg AAE/ gram extract, 99.145 mg AAE/ gram extract, 76.319 mg AAE/ gram extract. It can be concluded that the antioxidant activity of purple cabbage is higher than that of white cabbage.
FORMULASI SEDIAAN SERUM ANTIOKSIDAN DARI EKSTRAK ETANOL BUAH BELIMBING WULUH (Averrhoa bilimbi L.) Fatimah, Siti; Raharjo, Danang; Permata, Bangkit Riska
Usadha Journal of Pharmacy Vol. 3 No. 3 (2024): Agustus
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/ujp.v3i3.340

Abstract

Buah belimbing wuluh (Averrhoa bilimbi L.) merupakan tanaman yang mengandung senyawa saponin, pektin, vitamin C, flavonoid yang dapat menangkal radikal bebas penyebab kerusakan pada kulit. Tujuan penelitian ini adalah untuk mengetahui mutu fisik ektrak dan aktivitas antioksidan sediaan serum ekstrak etanol buah belimbing wuluh dengan konsentrasi 5%, 7,5%, dan 10%. Pengujian aktivitas antioksidan dengan metode DPPH (2,2-difenil-1-pikrilhidrazil). Uji mutu fisika meliputi uji pH, viskositas, organoleptis, daya lekat, dan daya sebar. Hasil pengujian mutu fisik sediaan serum yaitu pH sedian berkisar antara 4,26–4,74; viskositas berkisar antara 2007,00–2886,67 cPs; daya sebar berkisar antara 6,30–7,57 cm dan daya lekat berkisar antara 1,55–2,36 detik. Hasil pengujian antikoksidan didapatkan nilai IC50 masing-masing formula sebagai berikut: formula I 154,43 ppm; formula II 96,18 ppm dan formula III 49,58 ppm. Berdasarkan hasil penelitian dapat disimpulkan variasi konsentrasi kandungan ekstrak etanol buah belimbing wuluh mempengaruhi mutu fisik dan formula III dengan kandungan 10% ekstrak memberikan aktivitas antioksidan terkuat.
ANTIHYPERURESEMIA ACTIVITY OF ETHANOL EXTRACTS AND FRACTIONS OF NIPAH LEAF FRONDS (NYPA FRUTICANS. WURMB) Raharjo, Danang; Dwi S, Anita; Aminnulloh, Muhammad
Proceeding of the International Conference Health, Science And Technology (ICOHETECH) 2023: Proceeding of the 4th International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/icohetech.v4i1.3397

Abstract

Hyperuresemia is a metabolite syndrome characterised by high levels of uric acid in the blood. Hyperuresmia in advanced stages can cause gout or pyrexia (a disease that affects the joints and causes joint damage), kidney stones, kidney damage, and hypertension. The nipah plant (Nypa fruticans. Wurmb) is traditionally used in the treatment of stomach pain, diabetes, fever, toothache, uric acid reduction and headache medicine. In general, the content of secondary metabolite compounds from nipah plants includes flavonoids, phenols, tannins, terpenois, steroids, alkaloids and saponins. The purpose of this study was to determine the xanthine oxidase inhibitory activity of ethanol extracts and fractions of nipah leaves (Nypa fruticans. Wurmb). Extraction process using maceration method with 96% ethanol solvent, fractionation using liquid-liquid partition method with separating funnel. . Testing the inhibition of xanthine oxidase enzyme activity in vitro using UV/VIS spectrophotometer. The results showed that ethanol extract, water fraction, ethyl acetate fraction and n-hexane fraction showed inhibitory activity of xanthine oxidase enzyme with IC50 values of 47.558 ± 2.862; 18.755 ± 3.821; 3.543 ± 1.440 and 110.213 ± 1.577 ppm, respectively. From the results of the study it can be concluded that ethanol extracts and fractions of nipah leaf fronds (Nypa fruticans.Wurmb) can inhibit the activity of xanthine oxidase enzyme with ethyl acetate fraction giving the highest inhibitory activity with IC50 value of 3,543±1,440 ppm.
Antioksidan Ekstrak Etanol Daun Pedada (Sonneratia ovata Backer) Raharjo, Danang; Fitriawati, Anna; Aminulloh, Muhammad
Proceeding of the International Conference Health, Science And Technology (ICOHETECH) 2024: Proceeding of the 5th International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/icohetech.v5i1.4194

Abstract

Free radicals are reactive oxygen compounds that are known to be compounds that have free or unpaired electrons. Free radicals will look for new partners so that they will easily bind to other substances such as proteins, fats, and DNA in the body, resulting in cell damage and causing various degenerative diseases. To overcome the negative effects of free radicals, a substance that acts as an antioxidant is needed. Sonneratia Ovata or often called pedada by coastal communities is often used to treat various diseases including diabetes, ulcers, analgesic diarrhea, inflammation, pain and accelerate wound healing. This study aims to examine the levels of flavonoid compounds in the ethanol extract of S. ovata leaves using the colorimetric method and antioxidant activity using the ABTS method (2,2 azinobis (3-ethylbenzothiazolin-6- sulfonic acid) and DPPH (2,2-diphenyl-1-picrylhydrazyl) on the ethanol extract of S. ovata leaves. The research process began with the extraction of S. ovata leaves with 96% ethanol, followed by determination of total flavonoid levels and antioxidant testing. From the results of the determination of total flavonoid levels, it was found that the ethanol extract of S. ovata leaves had a flavonoid content of 38,248 ± 0.142 mgQE/gram. In measuring antioxidant activity using the DPPH and ABTS methods, the IC50 values were 31.785 ± 0.047 ppm and 28.303 ± 0.558 ppm, respectively. Based on these results, the ethanol extract of S. ovata provided very strong antioxidant activity with an IC50 value of less than 50 ppm.
Antioxidant Activity of Mangrove Sonneratia caseolaris L using the FRAP Method Raharjo, Danang; Haryoto, H
Proceeding ISETH (International Summit on Science, Technology, and Humanity) 2019: Proceeding ISETH (International Summit on Science, Technology, and Humanity)
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/iseth.1435

Abstract

Antioxidants are compounds that have an important role in maintaining health because they can ward off free radicals that inhibit oxidation reactions in the body that cause various diseases. Antioxidant compounds are many flavonoid compounds found in mangrove plants. The purpose of this study was to determine the antioxidant activity of red pidada leaves (Sonneratia caseolaris L) using the Ferric Reduction Antioxidant Power (FRAP) method with vitamin C as a comparison. The research process begins with the extraction of red pidada (Sonneratia caseolaris L) leaves with ethanol. The extraction process was carried out by maceration method for 3 x 24 hours @ 24 hours and continued with fractionation. The maserate obtained was then evaporated with a rotary evaporator at a temperature of 40 - 60OC obtained a thick extract, then the fractions obtained were non-polar, semi-polar and polar fractions. The results showed antioxidant activity; ethanol extract, non-polar, semi-polar and polar fractions were 6.37; 5,35; 6.59 and 5.96 mgAAE / g.
Antihiperglikemia Postprandial Dari Ekstrak Daun Nipah (Nypa fruticans. Wurmb) Terhadap Tikus Normoglikemia Permata, Bangkit Riska; Raharjo, Danang
Jurnal Mandala Pharmacon Indonesia Vol. 11 No. 2 (2025): Jurnal Mandala Pharmacon Indonesia 
Publisher : Program Studi Farmasi Universitas Mandala Waluya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35311/jmpi.v11i2.1043

Abstract

Pemanfaatan Serbuk Tempe Non-Lemak sebagai Pangan Fungsional melalui Pemberdayaan Kader PKK Desa Baturan Danang Raharjo; Vivin Marwiyati Rohmana; Kharisma Jayak Pratama
Aksi Nyata : Jurnal Pengabdian Sosial dan Kemanusiaan Vol. 3 No. 1 (2026): Januari : Aksi Nyata : Jurnal Pengabdian Sosial dan Kemanusiaan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.62383/aksinyata.v3i1.2865

Abstract

Regarding the Utilization of Non-Fat Tempeh Powder as a Functional Food Based on Local Potential. The activity was conducted in Baturan Village, Colomadu District, Karanganyar Regency, involving 55 members of the PKK (Family Welfare Empowerment) cadre. The community service method employed a Community-Based Research (CBR) approach combined with Asset-Based Community Development (ABCD). The activities included participatory counseling, group discussions, and evaluation through pre-tests and post-tests. The results demonstrated an increase in knowledge, a shift in attitudes, and a growing awareness among the PKK cadre regarding the importance of functional food based on non-fat tempeh. Furthermore, the cadre emerged as peer educators with the potential to drive program sustainability at the community level. This community service proves that community-based counseling is effective in fostering initial social transformation towards healthier and more self-reliant food consumption patterns.
Analisis Kadar Hidrokuinon pada Day cream yang Beredar di Kecamatan X Kabupaten Sukoharjo Kharisma Riskiana; Danang Raharjo
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 5 No. 1 (2026): April: Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v5i1.8501

Abstract

The use of cosmetics, especially day creams, is increasing along with the high public interest in facial skin care. However, day cream products are still found to potentially contain hydroquinone, a skin whitening agent whose use is restricted because it can cause harmful side effects on skin health. This study aims to identify the presence and determine the levels of hydroquinone in day cream products circulating in District X, Sukoharjo Regency, and to assess their compliance with the regulations of the Food and Drug Monitoring Agency (BPOM). This study was a descriptive analytical study using a purposive sampling technique. A total of 15 day cream products were analyzed, consisting of 8 BPOM-registered products and 7 products not registered with BPOM. Qualitative analysis was conducted using color reaction tests with FeCl₃, Benedict’s, and o-phenanthroline reagents. Furthermore, quantitative analysis was performed using the High Performance Liquid Chromatography (HPLC) method to accurately and specifically confirm the presence and determine the levels of hydroquinone. The results showed that the color reaction test has limitations in specifically identifying hydroquinone. HPLC confirmation revealed the presence of hydroquinone in several day cream samples, with concentrations ranging from 0.024% to 0.150%. These findings indicate the need for stricter monitoring of day cream distribution to ensure the safety of cosmetic products for the wider public.
Deteksi dan Kuantifikasi Hidrokuinon pada Sampel Night Cream di Kecamatan X Sukoharjo Retno Kurnia Dewi; Danang Raharjo; Bagas Ardiyantoro
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 5 No. 1 (2026): April: Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v5i1.8503

Abstract

Hydroquinone is a skin lightening agent that effectively inhibits melanogenesis, but its use in cosmetics is restricted due to the potential for serious side effects. Although banned in over-the-counter cosmetics, hydroquinone is still found in unregistered night cream products. This study aims to detect the presence, determine the levels of hydroquinone, and evaluate its safety risks in night cream products sold in District X, Sukoharjo Regency. The study was conducted experimentally in a laboratory using a purposive sampling technique on 15 night cream samples consisting of 8 BPOM-registered products and 7 non-BPOM products. Qualitative analysis was carried out using FeCl₃, Benedict's, and o-phenanthroline color reaction tests, while quantitative analysis used the HPLC method with a C18 column and a UV-Vis detector at a wavelength of 280 nm. The results showed that all BPOM-registered samples did not contain hydroquinone, while several non-BPOM samples were detected to contain hydroquinone at levels ranging from 0.0688%–0.2043%. These findings indicate a higher safety risk in non-BPOM products. The implications of this research emphasize the importance of strengthening regulatory oversight and increasing public literacy in choosing safe and legal cosmetic products.
In-Vitro Antioxidant, Antihyperlipidemic, and Antihypertensive Activities of Ethanol Extract of Pedada Stem Bark (Sonneratia caseolaris L.) Haryoto, Haryoto; Raharjo, Danang
Urecol Journal. Part C: Health Sciences Vol. 5 No. 2 (2025): August-Dec
Publisher : Konsorsium LPPM Perguruan Tinggi Muhammadiyah 'Aisyiyah (PTMA) Koordinator Wilayah Jawa Tengah - DIY

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Pedada (Sonneratia caseolaris) is one type of mangrove from the genus Sonneratia with high flavonoid content that has the potential as an antioxidant. Flavonoids as antioxidants can improve blood lipid profiles by lowering total cholesterol, triglycerides, and LDL, and increasing HDL. In addition, flavonoids can inhibit the activity of Angiotensin-converting enzyme (ACE) so that it has the potential as an antihypertensive. This study aims to examine the potential of kedabu leaf extract as an antioxidant, antihypertensive and antihyperlipidemia agent tested in vitro. Antioxidant testing was carried out using the ABTS (2,2-azinobis-3-ethylbenzothiazoline-6sulfonate) method, antihypertensive testing was carried out by inhibiting Angiotensin converting enzyme and antihyperlipidemia was carried out by inhibiting the lipase enzyme. The results of the study showed that the total flavonoid content was 24.827 ± 0.327 mgQE / g mgQE / g with an antioxidant capacity with an IC50 value of 54.166 ± 0.558 ppm. From the Angiotensin converting enzyme inhibition test and lipase enzyme inhibition, the IC50 values ??were 33.843±0.157 ppm and 63.709±0.819 ppm, respectively. Based on these results, the pedada bark extract showed antihypertensive and antihyperlipidemic activity by inhibiting the activity of Angiotensin converting enzyme and lipase enzyme.
Co-Authors Addawiyyah, Muniroh Adiyantoro, Bagas Aini, Riszki Nur Aminnulloh, Muhammad Aminnulloh, Muhhamad Aminulloh, Muhammad Anita Dwi Septiarini Anita Dwi Septiarini S Anna Fitriawati Apriliawan, Hidayah apriliyanti, laela intan Bagas Ardiyantoro Bangkit Riska Permata Bangkit Riska Permata Bangkit Riska Permata Desy Ayu Irma Permatasari Diana Nurrah Ashari Dwi Bagus Pambudi Dwi Bagus Pambudi Dwi Budi Santoso Dwi Nurul Khotimah Dwi S, Anita Eny Wijayanti Fadilla, Fitri Hansa Fatimah Azzahro Febriyani, Rima Fevi Indri Oktaviani Fitriwati, Anna Gusmao, Nandito Manuel Ximenes Haryoto Haryoto Haryoto, H Hidayat, Allif Nur Ika Dwi Ningrum Ilham Zikri Kharisma Jayak Pratama Kharisma Riskiana kristian saputra, samuel Kusumaningtyas Siwi Artini Listyani, Tiara Ajeng Lisyani, Tiara Ajeng Luthfia Dhiyaul Amalia Lydia Fitriana Musniati, Musniati Nafiah, Azidatun Niken Luthfiyanti Nuniek Nizmah Fajriyah Nurcahyani, Dona Agustin NURUL HIDAYAH Oktafia Nur Fatimah Pambudi, Dwi Bagus Permata, Bangkit Riska Permatasari, Desy Ayu Irma Pratama, Kharisma Jayak Rafidah Hanifah Rahardian Ariana Putri Raharjo, Oktavia Wijaya Rahmat Hidayat Retno Kurnia Dewi Riska Amelia Rohmana, Vivin Marwiyati Rusmiati Rusmiati Salsabila Khoerunniyssa Sania, Sania Septian Maulid Wicahyo Setyaningrum, Fidya Shafi Surya Donar E K Siska Wardani, Tatiana Siti Fatimah Siti Fatimah Siwi Artini, Kusumaningtyas Sya'bania, Muti' Tiara Ajeng L Tiara Ajeng L. Vinkasari, Elriza Wardani , Tatiana Siska Wardani, Tatiana Siska Wulandari, Nia Isa Yuliya Rahma