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All Journal Jurnal Farmasi Klinik Indonesia JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Farmasi Sains dan Komunitas Universa Medicina AKSIOLOGIYA : Jurnal Pengabdian Kepada Masyarakat Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Indonesian Journal of Medicine JFIOnline Jurnal Ners Indonesian Journal of Pharmaceutical and Clinical Research International Journal Of Science, Technology & Management (IJSTM) Unri Conference Series: Community Engagement JOURNAL LA MEDIHEALTICO Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Urip Harahap
Faculty Of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia
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Phytochemical Screening and Antibacterial Potential Ethanol Extract of Kemangi Leaves (Ocimum basilicum L.) Towards Staphylococcus aureus Angga Nugraha Sanjaya; Urip Harahap; Aminah Dalimunthe
International Journal of Science, Technology & Management Vol. 3 No. 6 (2022): November 2022
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v3i6.630

Abstract

An infectious disease is a disease with the highest prevalence in the world, with a great risk of transmission. Staphylococcus aureus is a pathogen that can cause several infectious diseases. The use of kemangi leaves as vegetables can be used as an invention in treating infections caused by bacteria. The purpose of this study was a phytochemical screening test to determine what metabolites are contained and their potential activity against Staphylococcus aureus. The research method is to carry out a qualitative phytochemical screening test using reagents and an antibacterial potential test against Staphylococcus aureus using the Kirby-Bauer method (diffusion agar) with varying concentrations. The results showed that kemangi leaves extract showed positive results on the secondary metabolite compounds, were alkaloids, flavonoids, saponins, tannins, glycosides, and steroids/triterpenoids. The diameter of the inhibition zone at a concentration of 500 mg/mL showed the diameter of the inhibition zone was 11.93 ± 0.25 mm with the strong category group. The conclusion is that the ethanolic extract of kemangi leaves shows the ethanolic extract of kemangi leaves has potential as an antibacterial.
Formulation and Evaluation of Sustained Release Microcapsule of Metronidazole Natassya Manda Leo; Hakim Bangun; Urip Harahap
International Journal of Science, Technology & Management Vol. 3 No. 6 (2022): November 2022
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v3i6.643

Abstract

The oral conventional metronidazole dosage forms have a short duration of action due to gastric emptying process, hence the treatment of ulcus pepticum using metronidazole become less effective. Due to retaining the dosage form in the stomach, a preparation form of sustained released drug delivery systems has been developed. The aim of this study was to developed a sustained released drug delivery systems of metronidazole using alginate and chitosan as polymers that could last longer in stomach. The formulation consisted of variatons in chitosan 0.5%, 0.75% and 1%. The drug released test was carried out using paddle method in simulated gastric medium pH 1.2 at 37°C. The dissolution test results showed that formula with 0.75% of chitosan giving the best sustained released effect and the kinetics drug realeased of microcapsule followed Higuchi order. Based on the results of the study, it can be concluded that microcapsules of metronidazole with a combination of alginate and chitosan can be prepared as sustained released formulation.
IbM Gerakan Masyarakat Petani Atasi Racun (GEMPAR) di Kabanjahe Kabupaten Karo Eka Lestari Mahyuni; R. Hamdani Harahap; Urip Harahap; Nurmaini Nurmaini
Aksiologiya: Jurnal Pengabdian Kepada Masyarakat Vol 6, No 4 (2022): November
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/aks.v6i4.6658

Abstract

Keracunan pestisida merupakan suatu kejadian yang perlu diperhatikan khususnya bagi petani yang menggunakan pestisida. Fenomena keracunan umumnya disebabkan karena perilaku penggunaan pestisida yang tidak sesuai prosedur dan berisiko. Kegiatan PPM ini merupakan salah satu kegiatan pemberdayaan masyarakat untuk mengurangi risiko keracunan pestisida melalui gerakan sosial yang disebut dengan GEMPAR (Gerakan Masyarakat Petani Atasi Racun). GEMPAR merupakan gerakan sosial yang terdiri dari delapan aksi sebagai gerakan petani untuk mengurangi risiko keracunan akibat penggunaan pestisida. Aksi GEMPAR meliputi bagaimana mengenali bahaya racun pestisida dan gejala keracunan; menggunakan pelindung diri yang lengkap selama menggunakan pestisida; memperhatikan arah angin selama menyemprot; menyimpan pestisida di tempat yang aman dan tertutup; membuang sisa wadah pestisida di tempat yang tertutup; melaporkan keluhan bila mengalami gejala keracunan; dan beralih menggunakan pestisida alami dan meninggalkan pestisida kimia sintetis. GEMPAR yang dilaksanakan dalam kegiatan PPM ini dilakukan sebagai peningkatan edukasi petani dan menjawab kendala penerapan GEMPAR melalui kegiatan talk show. Kegiatan ini mendukung promosi aksi GEMPAR yang dilakukan petani sehingga dapat menunjang kesejahteraan dan perekonomian petani. Disamping dapat menghindari risiko keracunan juga dapat menyehatkan masyarakat petani dengan produk pertanian yang bebas pestisida.
Toxic Effect Of The Compound {1,3 Bis (P-Hydroxyphenyl) Urea} On Triiodothyronine (T3) Hormone Levels In Pregnant White Rats (Rattus Norvegicus L.) Ziza Putri Aisyia Fauzi; Urip Harahap; Yuandani Yuandani; Syukur Berkat Waruwu; Hari Purnomo; Denny Satria
International Journal of Science, Technology & Management Vol. 4 No. 1 (2023): January 2023
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v4i1.719

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are among the most commonly prescribed drugs for pregnant women to treat fever, pain and inflammation. Specific NSAIDs can displace thyroid hormone from its protein binding sites, causing thyroid hormone measurement problems. {1,3 bis (p-Hydroxyphenyl)urea} is a modified p-aminophenol compound with potent analgesic and anti-inflammatory activity and less toxicity. This study is a follow-up to previous research to observe the toxic effect on triiodothyronine hormone levels after administration of {1,3 bis(p-Hydroxyphenyl)urea} compound in pregnant white rats. The toxic effect test was carried out by giving the test preparation to pregnant rats, which had been divided into five groups, namely the normal control group (CMC-Na 0.5%), the positive control (Gabapentin 50 mg/kg BW), Compound {1.3 bis (p- Hydroxyphenyl)urea} at a dose of 50 mg/kg BW, 500 mg/kg BW and 1000 mg/kg BW. Mice were given the test preparation every day from the 6th to the 15th day of pregnancy. Blood was taken on the 16th day, and T3 hormone levels were measured using the ELISA method. The results showed that the T3 hormone levels in the {1,3 bis(p-Hydroxyphenyl)urea group had no significant difference from the normal control group, so it was concluded that {1,3 bis(p-Hydroxyphenyl)urea) did not have a significant effect on the hormone T3.
Phytochemical Screening Of Ethanol Extract Of Temu Kunci (Boesenbergia Rotunda (L.) Mansf) Rhizome Extract And Testing Of Bilirubin Levels In Male White Mice Mawandha Sari Harahap; Urip Harahap; Panal Sitorus
International Journal of Science, Technology & Management Vol. 4 No. 3 (2023): May 2023
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v4i3.819

Abstract

Liver Disease Is A Deadly Disease That Has Attacked Many People. Liver Disease Is A Disease That Occurs As A Result Of An Unhealthy Lifestyle. Usually, The Patient Will Consume Drugs With Chemical Compounds To Overcome The Problem Of This Disease. The Long-Term Use Of Chemical Drugs Will Certainly Cause Side Effects Or, Even Worse, Cause New Diseases. Therefore, The Latest Treatment Methods Must Be Developed To Minimize Side Effects, Namely The Use Of Traditional Medicines. The Purpose Of This Study Was To Determine The Use Of Temu Kunci Rhizome As An Alternative To Reduce Total Bilirubin Levels In Rats As Experimental Animals. This Study Used Rats As Experimental Animals, Which Were Divided Into 6 Test Groups, Namely Group 1 Without Treatment, Group 2 With 0.5% CMC Suspension, Group 3 With 200 Mg Acetylcysteine, Group 4 With 250 Mg/Kg BW Ethanol Extract Of Temukunci, Group 5 Treated With A 500 Mg/Kg BW Dose Of Ethanol Extract Of Temukunci, And Group 6 With A 750 Mg/Kg BW Ethanol Extract Of Temukunci. From The Results Of The Research Conducted, The Ethanol Extract Of Temu Kunci At A Dose Of 750 Mg/Kg BW Was The Best Treatment For Reducing Total Bilirubin Levels In Rats As Experimental Animals.
Phytochemical and FTIR Analysis Of Coriander Leaf Infusion As An Active Pharmaceutical Ingredient Suci Wulandari; Siti Morin Sinaga; Urip Harahap
International Journal of Science, Technology & Management Vol. 4 No. 4 (2023): July 2023
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v4i4.878

Abstract

This study reported that the sample used in the study was an infusion using fresh coriander leaves samples taken in the Lubuk Pakam area. Several studies have shown that the active components of coriander seeds are essential oils such as sabiene, myrcene, alphaterpine, ocimene, linalool, graniol, decanal, desilaldehyde, trantridecen, petroselinic acid, octadesenic acid, d-mannite, scopoletin, psimena, kamfena and felandren. These components cause coriander to have a good effect as a medicinal component. In previous studies, Linalool is believed to have antioxidant, anxiety, antibacterial (especially gram-positive) and antifungal effects. This activity is suspected because coriander contains secondary metabolites such as alkaloids, saponins, flavonoids, tannins, steroids, triterpenoids, glycosides. So this research was conducted to determine the content of secondary metabolites in coriander leaves by phytochemical screening. Phytochemical screening is a test to determine the class of chemical compounds present in coriander leaf infusion samples. Fourier transform infrared spectroscopy (FTIR) analysis was performed to find the isolating compounds in coriander leaves. The results showed that one secondary metabolite compound was negative in examining steroid secondary metabolites. The results of extract assistance with FTIR showed the presence of saponins with a molecular weight of 873.0 g/mol at a retention time of 19,287 minutes, but the peaks produced were not dominant.
Immunomodulatory Effects of Phaleria macrocarpa Leaf Extract in Normal And Cyclophosphamides Induced in Wistar Rats Febriady, Andy; Harahap, Urip; Yuandani, Yuandani
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 5 No. 2 (2022): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v5i2.11271

Abstract

Abstract. Cyclophosphamide is an antineoplastic drug belonging to the alkylating agents commonly used in treating cancer. However, the use of cyclophosphamide causes a decrease in the body's immune system by reducing lymphocyte proliferation. The curent study was conducted to evaluate the immunomodulatory effect of ethyl acetate extracts of the leaf of the P. macrocarpa (EEADMD) and the ethanol extracts of the leaf of the P. macrocarpa (EEDMD) in normal and cyclophosphamide induced rats. This study used rats classified into two major groups: normal rats and rats induced by cyclophosphamide which were then given P. macrocarpa leaf extract until day 14. On day 4, the test animals were infected with 1% Staphylococcus aureus suspension in. Induced with cyclophosphamide 70 mg/kg BW was carried out on the 8th and 13th days, and then the immunomodulatory activity was tested using total leukocyte analysis, leukocyte differential, and delayed type hypersensitivity response. The results showed that EEDMD 400 mg/kg BW  in normal rats and EEDMD 100 mg/kg BW in cyclophosphamide induced rats could increase total leukocytes and leukocyte differential with a significant difference to the negative group (p <0.05). The results of the delayed hypersensitivity response test of EEADMD and EEDMD at a dose of 100 mg/kg BW with cyclophosphamide induction and normal rats could give an increase in rat paw volume with a significant difference to the negative group (p <0.05). This study shows that EEADMD and EEDMD have an immunomodulatory effect on increasing total and differential leukocytes and leukocyte differential and delayed type hypersensitivity response.
Antioxidant activity of 1.3-bis(p-hydroxyphenyl)urea by CUPRAC and FRAP methods Satria, Denny; Rifda Amaliya Ma’ruf; Syukur Berkat Waruwu; Urip Harahap; Hari Purnomo4
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 6 No. 1 (2023): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v6i1.17768

Abstract

An imbalance in the number of free radicals produced in the body can result in oxidative stress. Excessive oxidative stress can lead to chronic inflammation, which in turn can lead to most chronic diseases. Inflammation is related to oxidation through increased reactive oxidative stress, which can target modulators associated with inflammation, such as inflammatory cytokines. Antioxidants can inhibit or stop oxidation by protecting the body and neutralizing free radicals. 1.3-bis(p-hydroxyphenyl)urea is a modification of p-aminophenol and has hepatotoxic side effects such as those caused by acetaminophen. This compound can relieve pain, is anti-inflammatory, and has fewer side effects. This research was conducted to evaluate the antioxidant activity of 1.3-bis(p-hydroxyphenyl)urea using the CUPRAC (Cupric Ion Reducing Antioxidant Capacity) method and the FRAP (Ferric Reducing Antioxidant Power) method. The results of the CUPRAC method research show that the 1.3-bis(p-hydroxyphenyl)urea compound has an IC50 value of 4.40 ± 0.07 μg/mL. Meanwhile, the FRAP method was 29.36 ± 1.20 μg/mL. Apart from suppressing inflammation, this compound has the potential to be an antioxidant compound.
Analysis of the Application of Pharmaceutical Service Standards and Patient Satisfaction with Accreditation Status and Types of Services Tarigan, Betharina Br; Dalimunthe, Aminah; Nasution, Azizah; Harahap, Urip; Khairunnisa, Khairunnisa
Journal La Medihealtico Vol. 4 No. 2 (2023): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v4i2.846

Abstract

Accreditation is a method to improve the quality of health services, so that it is expected that the services provided are in accordance with established regulations. This study aims the implementation of Pharmaceutical Service Standards (PCSs) and patient satisfaction on accreditation status and types of PHCs in Deli Serdang Regency, Sumatera Utara. This descriptive analytical cross-sectional study was conducted to analyze pharmacy services at PHCs (n=34) in Deli Serdang Regency. The reference used is the Checklist for PCSs based on direct observations and interviews with the person in charge of pharmacy and the Patient Satisfaction Questionnaire. The data obtained were analyzed using SPSS version 22. The results on the value of a total score PCSs showed 41-90, with the highest level of patient satisfaction is the very satisfied category is 65.90%.The correlation test was analyzed using the Chi-Square test with a significance limit of p<0.05, the correlation of accreditation status to the implementation of PCSs showed a value of p=0.304, the correlation of the type of service to the implementation of PCSs showed a value of p=0.591, the correlation of the accreditation status of PHCs to the level of satisfaction patient value showed a value of p=0.000. This study concluded that the accreditation status of the PHCs does not affect implementation of PCSs, the type of PHCs service does not affect implementation of PCSs and the accreditation status of the PHCs has an effect on the level of patient satisfaction in Deli Serdang Region, Sumatera Utara.
Cardio Protective Effect of Ethanolic Extract Vernonia Amygdalina Delile on Rats Induced L-NAME Harahap, Rizki Doli Hartama; Harahap, Urip; Dalimunthe, Aminah
Jurnal Ners Vol. 9 No. 1 (2025): JANUARI 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i1.30981

Abstract

This study aimed to analyse the effects of ethanol extract of African leaves (Vernonia Amygdalina Del.) on the levels plasma renin, IL-6 and cardiac histopathology in L-NAME-induced rats. This research stage includes the preparation of ethanol extract of African leaves, standardization of extracts and testing the effectiveness of African leaves on rat heart damage. Data were analysed using one-way ANOVA with p<0.05. testing the cardioprotective effectiveness of ethanol extract of African leaves in hypertension model rats and then examining heart histopathology using HE staining and analysing parameters, namely plasma renin and IL-6 levels. This study used 6 groups, each group consisted of 5 male rats, namely the normal group, negative control by administering L-NAME 40 mg/kgBB, positive control by administering L-NAME plus lisinopril 2.5 mg/kgBB, EEDA 100 mg/kgBB, EEDA 300 mg/kgBB and EEDA 500 mg/kgBB. L-NAME responds to heart damage such as degeneration and necrosis of heart cells. In the negative group, plasma renin levels were 40.60 ± 9.98 ng/mL while the EEDA group with a dose of 500 mg/kgBB experienced the highest decrease in plasma renin compared to other EEDA groups and positive controls, namely 13.80 ± 1.30 ng/mL. The positive control group obtained plasma renin levels of 14.20 ±1.79 ng/mL. In the negative group, IL-6 levels were 4.80 ± 1.30 pg/mL while the group given EEDA, the group with a dose of 500 mg/kgBB experienced a decrease in IL-6, namely 1.52 ±0.96 ng/mL. The positive control group experienced a decrease in IL-6 levels of 0.77 ± 0.20 ng/mL. The result can be concluded that EEDA reduces plasma renin, IL-6 levels, improves the condition of cardiac cell degeneration and necrosis.
Co-Authors Ade Sri Rohani Ambali Azwar Siregar Aminah Dalimunthe Angga Nugraha Sanjaya Arianto, Anayanti Azmi Sarriff Dasopang, Eva S. Delyuzar, Delyuzar Denny Satria Denny Satria, Denny dharma Lindarto, dharma Dharmawan, Hariyadi Edy Fachrial Eka Lestari Mahyuni Embun Suci Nasution Eva S. Dasopang Febriady, Andy Fitri, Raissa Hakim Bangun* Harahap, Rizki Doli Hartama Harefa, Herman Syukur Hari Purnomo Hari Purnomo4 Hasibuan, Poppy Anjelisa Zaitun Husori, Dadang Irfan Isna, Arfayani Jansen Silalahi Julia Reveny Julia Reveny Julianti, Maelani Khairunnisa Khairunnisa Khairunnisa Khairunnisa Khairunnisa Khairunnisa Khairunnisa Linda Margata Lokot Donna Lubis Mahyuni, Eka Lestari Mardianto Mardianto Mardianto Mardianto Mawandha Sari Harahap Nadroh br Sitepu Nasri Nasri Nasri, Nasri Nasution, Azizah Nasution, Salli Roseffi Nasution, Salli Roseffi Natassya Manda Leo Nurmaini Nurmaini Panal Sitorus R. Hamdani Harahap R. Hamdani Harahap Ricke Loesnihari Rifda Amaliya Ma’ruf Rumanda Nurhasanah Siahaan, Jekson Martiar Siregar, Ambali Azwar Siti Morin Sinaga Sri Wahyuni Suci Wulandari Sunarti Sunarti Syukur Berkat Waruwu Syukur Berkat Waruwu Tanjung, Hari Ronaldo Tarigan, Betharina Br Tri Widyawati Yuandani Yustika Wirda Ningsih Ziza Putri Aisyia Fauzi Zulmai Rani