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All Journal Jurnal Farmasi Klinik Indonesia JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Jurnal Farmasi Sains dan Komunitas Universa Medicina AKSIOLOGIYA : Jurnal Pengabdian Kepada Masyarakat Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Indonesian Journal of Medicine JFIOnline Jurnal Ners Indonesian Journal of Pharmaceutical and Clinical Research International Journal Of Science, Technology & Management (IJSTM) Unri Conference Series: Community Engagement JOURNAL LA MEDIHEALTICO Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Urip Harahap
Faculty Of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia
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EKSTRAK ETANOL DAUN SIRIH MERAH (Piper crocatum) MENURUNKAN KADAR GULA DARAH MENCIT DIABETES Ambali Azwar Siregar; Urip Harahap; Mardianto Mardianto
Jurnal Ilmiah Manuntung Vol 1 No 1 (2015): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v1i1.10

Abstract

Diabetes mellitus is one of desease that have a large population and trend to increase. sulfonylurea and biguanide are almost used treatment but have unexpected side effects. The research still necessary to seek alternative medicine, such as Piper crocatum.This study aimed to determine the effect of ethanol extract of red betel leaves on blood sugar levels and body weight of mice (Mus musculus L.) diabetes. This riset was started to produce simplicia and drilled become powders, continued extract with 70% ethanol. The extract was evaporated with rotary evaporator until obtaine crude extract. And then screen it that determine phytochemical. To continued test on tolerance of level of glucose then mice diabetes induced aloxan.In summary, extract of red betle ethanolic has contained alkaloid, quercetin flavonoid, steroid and fenolic compounds and decreased level of glucose in blood mice diabetes. Besides, it can reduce lose of weight symptom.
IbM Gerakan Masyarakat Petani Atasi Racun (GEMPAR) di Kabanjahe Kabupaten Karo Mahyuni, Eka Lestari; Harahap, R. Hamdani; Harahap, Urip; Nurmaini, Nurmaini
Aksiologiya: Jurnal Pengabdian Kepada Masyarakat Vol 6 No 4 (2022): November
Publisher : Universitas Muhammadiyah Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30651/aks.v6i4.6658

Abstract

Keracunan pestisida merupakan suatu kejadian yang perlu diperhatikan khususnya bagi petani yang menggunakan pestisida. Fenomena keracunan umumnya disebabkan karena perilaku penggunaan pestisida yang tidak sesuai prosedur dan berisiko. Kegiatan PPM ini merupakan salah satu kegiatan pemberdayaan masyarakat untuk mengurangi risiko keracunan pestisida melalui gerakan sosial yang disebut dengan GEMPAR (Gerakan Masyarakat Petani Atasi Racun). GEMPAR merupakan gerakan sosial yang terdiri dari delapan aksi sebagai gerakan petani untuk mengurangi risiko keracunan akibat penggunaan pestisida. Aksi GEMPAR meliputi bagaimana mengenali bahaya racun pestisida dan gejala keracunan; menggunakan pelindung diri yang lengkap selama menggunakan pestisida; memperhatikan arah angin selama menyemprot; menyimpan pestisida di tempat yang aman dan tertutup; membuang sisa wadah pestisida di tempat yang tertutup; melaporkan keluhan bila mengalami gejala keracunan; dan beralih menggunakan pestisida alami dan meninggalkan pestisida kimia sintetis. GEMPAR yang dilaksanakan dalam kegiatan PPM ini dilakukan sebagai peningkatan edukasi petani dan menjawab kendala penerapan GEMPAR melalui kegiatan talk show. Kegiatan ini mendukung promosi aksi GEMPAR yang dilakukan petani sehingga dapat menunjang kesejahteraan dan perekonomian petani. Disamping dapat menghindari risiko keracunan juga dapat menyehatkan masyarakat petani dengan produk pertanian yang bebas pestisida.
Formulasi Nanogel Kuersetin dan Evaluasi Stabilitas Fisik, Aktivitas Anti-Inflamasi Pada Tikus Yang Diinduksi Oleh Karagenan Isna, Arfayani; Arianto, Anayanti; Harahap, Urip
Jurnal Ners Vol. 9 No. 4 (2025): OKTOBER 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i4.50816

Abstract

Inflamasi merupakan suatu respon jaringan terhadap rangsangan fisik atau kimiawi yang merusak. Rangsangan ini menyebabkan lepasnya mediator inflamasi yang menimbulkan reaksi radang berupa panas, nyeri, merah, bengkak dan disertai gangguan fungsi. Salah satu zat aktif yang dapat menghambat infiltrasi neutrofil dan mengurangi kadar plasma sitokin inflamasi adalah quersetin. Quercetin juga memiliki fungsi sebagai antioksidan. Dalam penelitian ini quersetin dibuat sediaan nanogel. Kelebihan nanogel lebih mudah penetrasi kedalam kulit sehingga efektivitas antiinflamasinya lebih baik. Untuk mengetahui konsetrasi quersetin dapat diformulasi menjadi nanogel dengan menggunakan karbopol 940 sebagai bahan pembentuk gel serta mennguji memenuhi syarat karakteristik dari gel dan menguji efektivitas anti-inflamasi pada kaki tikus yang diinduksi karagenan. Quersetin dengan konsentrasi 0,06%, 0,08%, dan 0,1% diformulasikan menjadi sediaan nanogel. Diuji aktivitas anti-inflamasi pada tikus yang diinjeksikan dengan karagenan 1% untuk mengetahui dosis topikal yang efektif. Tahap awal formulasi adalah pembuatan nanosuspensi dengan konsentrasi quersetin 0,06g (F1), 0,08g (F2), 0,1g (F3). Nanosuspensi ditambahkan kedalam basis gel dengan pengadukan menggunakan homogenizer untuk mendapatkan nanogel. Nanogel dievaluasi stabilitas fisik dengan penyimpanan pada berbagai suhu selama 12 minggu dan cycling test. Setelah itu diuji anti-inflamasinya pada tikus dibandingkan dengan voltaren emulgel. Nanogel quersetin stabil selama penyimpanan 12 minggu dari organoleptis, homogenitas, pH (4,5-6,0), viskositas (7031-9894 m.Pa.s), daya sebar (4,5-7,1 cm2), ukuran partikel (40-70nm). Efek anti-inflamasi nanogel F3 menunjukan adanya penghambat anti-inflamasi 80,87±3.70%. Berdasarkan hasi penelitian ini nanogel quersetin yang memiliki aktivitas anti -inflamasi pada tikus yang lebih efektif adalah pada konsetrasi quersetin 0,1% (F3) pada tikus dibanding F1 dan F2. kata kunci : quersetin, nanogel, anti-inflamasi Abstract Inflammation is a tissue response to damaging physical or chemical stimuli. This stimulus causes the release of inflammatory mediators, which cause an inflammatory reaction in the form of heat, pain, redness, swelling, and impaired function. One active substance that can inhibit neutrophil infiltration and reduce plasma levels of inflammatory cytokines is quercetin. Quercetin also functions as an antioxidant. In this study, quercetin was made into a nanogel preparation. The advantage of nanogel is that it penetrates the skin more easily, thus improving its anti-inflammatory effectiveness. To determine the concentration of quercetin that can be formulated into nanogel using carbopol 940 as a gel-forming agent and to test whether it meets the characteristics of the gel and to test the anti-inflammatory effectiveness on carrageenan-induced rat paws. Quercetin with concentrations of 0.06%, 0.08%, and 0.1% was formulated into nanogel preparations. Anti-inflammatory activity was tested in mice injected with 1% carrageenan to determine the effective topical dose. The initial stage of the formulation was the preparation of nanosuspensions with quercetin concentrations of 0.06g (F1), 0.08g (F2), 0.1g (F3). The nanosuspensions were added to the gel base with stirring using a homogenizer to obtain nanogels. The nanogels were evaluated for physical stability by storage at various temperatures for 12 weeks and cycling tests. After that, their anti-inflammatory properties were tested in mice compared to voltaren emulgel. Quercetin nanogel was stable during 12 weeks of storage from organoleptic, homogeneity, pH (4.5-6.0), viscosity (7031-9894 m.Pa.s), spreadability (4.5-7.1 cm2), particle size (40-70nm). The anti-inflammatory effect of F3 nanogel showed an anti-inflammatory inhibitor of 80.87±3.70%. Based on the results of this study, quercetin nanogel which has more effective anti-inflammatory activity in mice is at a quercetin concentration of 0.1% (F3) in mice compared to F1 and F2.
Prevention of Pesticide Toxicity Risk through the Farmer Community Movement to Resolve Toxicity Mahyuni, Eka Lestari; Harahap, R. Hamdani; Harahap, Urip; Nurmaini
ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat Vol. 5 No. 2 (2020): ABDIMAS TALENTA : Jurnal Pengabdian Kepada Masyarakat
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (756.861 KB) | DOI: 10.32734/abdimastalenta.v5i2.4889

Abstract

Pesticide toxicity is a phenomenon that needs to be prevented, which is generally caused by the risky behavior of using pesticides. This PPM activity is one of the community empowerment activities to reduce the risk of pesticide toxicity through the GEMPAR (Gerakan Masyarakat Petani Atasi Racun) action. GEMPAR consists of eight farmer movements to prevent the risk of toxicity due to pesticides used. The eight GEMPAR actions were applied by farmers with promotional and educational methods through the GEMPAR demonstration activities. The demonstration implementation method is presented by the farming community which is divided into three areas in Sumber Mufakat Village, namely Berhala, Simpang Sumbul, and Pasar Sumbul. Demonstrations from these three areas were contested as a form of appreciation for the community so that they could motivate the community to participate in preventing the risk of pesticide toxicity. The demonstration that displayed the messages of the eight GEMPAR movements was carried out well. Each demonstration gives special characteristics either through songs or slogans related to preventing the risk of toxicity. The community became very enthusiastic about the demonstration which could increase the participation of the farming community to use better and healthier pesticides sustainably.
The Prevention of Pesticide Risk Toxicity among Farmers on Food Estate Humbang Hasundutan Mahyuni, Eka Lestari; Harahap, R. Hamdani; Harahap, Urip; Nurmaini
ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat Vol. 7 No. 2 (2022): ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/abdimastalenta.v7i2.7809

Abstract

This PPM activity is one of the community empowerment activities to increase the capacity of farmers, especially increasing safety and health behavior while using pesticides. The prevention program carried out in the form of a community movement to reduce the risk of pesticide toxicity is called GEMPAR (Gerakan Masyarakat Petani Atasi Racun). GEMPAR consists of eight action activities as a farmer movement in reducing the risk of toxicity due to the use of pesticides. GEMPAR in the PPM activity was carried out as a prevention effort which was promoted through FGD activities, demonstrations, and brainstorming. Farmers in the Food Estate are classified as farmers who work with the company so that the pattern of pesticide use is included in the regular category in determining the dose and type of pesticide used. However, the application of pesticides is still classified as very dangerous where direct contact with pesticides is very high. GEMPAR as a health solution responded very well and increased awareness of Food Estate farmers to improve pesticide use patterns. Each farmer acts as an agent of change who can comprehensively expand GEMPAR information through the promotion of the message of the eight GEMPAR actions which are divided into primary, secondary, and tertiary prevention actions.
The Farmer’s Personal Hygiene Improvement Through the Use of Hand Soap Gel Extract of Acem Acem Leaf Mahyuni, Eka Lestari; Harahap, Urip
ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat Vol. 8 No. 1 (2023): ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/abdimastalenta.v8i1.7810

Abstract

Pesticide exposure due to poor personal hygiene is very high because farmers generally contact soil, fertilizers, and pesticides which are synthetic chemicals that are harmful to health. The leaves of acem acem are a type of wild plant that is often used by farmers in Tanah Karo as a medium for cleaning hands after applying pesticides. Based on the results of laboratory tests, this leaf has properties as a pesticide cleaner so that it can be used to improve the personal hygiene of farmers. This activity is carried out by empowering the behaviour of washing hands using hand soap gel acem acem leaf extract. Farmers' awareness to improve personal hygiene begins with socialization and training provided as personal hygiene education to improve public health. Education accompanied by the movement of washing hands with hand soap gel acem acem leaf extract has given a positive contribution and appreciation and can increase the enthusiasm of farmers to improve public health.
The Formulation of Effervescent Granules with Oxalis dehradunensis Raizada Ethanol Extract as an Antioxidant Mahyuni, Eka Lestari; Harahap, Urip
Jurnal Farmasi Sains dan Komunitas (Journal of Pharmaceutical Sciences and Community) Vol 21, No 1 (2024)
Publisher : Sanata Dharma University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24071/jpsc.004492

Abstract

Antioxidants and their health implications are widely studied related to their benefits in reducing free radical exposure. Oxalis dehradunensisRaizada is a type of wild mountain clover containing flavonoids and polyphenols. These contents allow the leaves to be consumed in a more practical, effective, and efficient way by processing the extract into effervescent granules. This experimental study used samples of Oxalis dehradunensisRaizadaethanol extract formulated in the form of effervescent granules. The content included citric acid, tartrate acid, lactose and sodium bicarbonate. The antioxidant activity assays were conducted by DPPH methods including testing the total phenol and flavonoid contents for the extracts and forms of effervescent granules. The total phenol content analysis used the Folin-Ciocalteu method while the total flavonoid content used the colorimetry method. The results identified the extract as the hygroscopic extract which had increasing IC50 for upgraded content of the formula but looked wet and was not stable. The experiment for the formula of effervescent granules was fulfilled by adding povidone, aspartame and polyethylene glycol. It required angle of repose which was 200-400 with a flow time not exceeding 10 seconds. The tap density also fulfilled the requirements, with the smaller the granule tap density, the greater the compression volume. The extract has a good antioxidant with IC50 value which reached near moderate to high levels. Although the formula 4 of effervescent granules was the best, it did not have the best antioxidant activity. Based on the results from the antioxidant activity assays, the extract has good antioxidant activity but it decreased when made into effervescent granules. 
The Significance of Troponin and Ck-Mb in Association with Q-Wave Myocardial Infarction Harahap, Urip; Margata, Linda
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 1 No. 1 (2018): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (746.21 KB) | DOI: 10.32734/idjpcr.v1i1.199

Abstract

Abstract. Acute myocardial infarction (AMI) is the global main cause of morbidity and mortality. AMI describes the process of cell death due to prolonged ischemia identified by the appearance of pathological Q-wave in electrocardiogram (ECG). Myocardial cell death does not occur directly after the onset of myocardial ischemia, however, it occurs more than 6 hours after the onset. Thus, certain cardiac markers, such as cardiac troponin and creatinine kinase-MB (CK-MB) which formed in myocardial cell damage, play a vital role in diagnosing AMI. Keywords: Cardiac Biomarker, CK-MB, Diagnosis, Q-wave Myocardial Infarction, Troponin
The Role Of hs-CRP In Predicting The Likelihood Of Coronary Heart Disease Sitepu, Nadroh Br; Harahap, Urip
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 3 No. 1 (2020): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v3i1.4015

Abstract

Coronary Heart Disease (CHD) is a disorder of the cardiovascular system, characterized by atherosclerotic lesions. Inflammation is a strong predictor for coronary heart disease. High sensitivity C-Reactive Protein (hs-CRP) is an important biomarker, synthesized in the liver, can predict the severity of CHD. If the hs-CRP level is found to be low 3 mg / L, a person has the potential for severe vascular risk. Therefore, hs-CRP can be used as a predictor of primary CHD prevention, especially if the hs-CRP level is still low.
Anti-Acne Activity From Biocellulose Mask Formula Containing (Aloe Vera (L.) Burm.F) Essence Combined With Vitamin E Fitri, Raissa; Reveny, Julia; Harahap, Urip; Dharmawan, Hariyadi; Nasri
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 4 No. 1 (2021): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v4i1.5382

Abstract

Abstract. Biocellulose mask sheet is a new found pharmaceutical cosmetic design that widely commercial. Mostly due to it’s biodegradable properties, provide an eco-friendly waste. Combination of Aloe vera essence (AE) and Vit E to provide and determine it’s respective anti-acne properties in biocellulose mask form. Formulation of biocellulose mask with the help of Acetobacter xylinum bacteria varied with different formulae: F1 (Vitamin E 1%), F2 (E 2.5 %), F3 (AE 5%), F4 (AE 2.5%+Vit E 1%) and F5 (AE 5%+Vit E 1%) followed antimicrobials test with common acne bacteria by diffusion disk against Propionibacterium acne (PAC) ATCC 6919 and Pseudomonas aeruginosa (PAA) ATCC 27853. Study revealed that each formulae design F1; F2; F3; F4; F5 tested against PAC diffusion disk resulted 7.86; 11.67; 10.13; 112.10; 10.33 mm respectively. As for PAA diffusion disk resulted 7.76; 11.63; 10.33; 11.67; 11.00 mm respectively. Biocellulose mask containing combination of AE 2.5% and Vit E (F4) would provide the best anti-acne activity amongst other formulae.
Co-Authors Ade Sri Rohani Ambali Azwar Siregar Aminah Dalimunthe Angga Nugraha Sanjaya Arianto, Anayanti Azmi Sarriff Dasopang, Eva S. Delyuzar, Delyuzar Denny Satria Denny Satria, Denny dharma Lindarto, dharma Dharmawan, Hariyadi Edy Fachrial Eka Lestari Mahyuni Embun Suci Nasution Eva S. Dasopang Febriady, Andy Fitri, Raissa Hakim Bangun* Harahap, Rizki Doli Hartama Harefa, Herman Syukur Hari Purnomo Hari Purnomo4 Hasibuan, Poppy Anjelisa Zaitun Husori, Dadang Irfan Isna, Arfayani Jansen Silalahi Julia Reveny Julia Reveny Julianti, Maelani Khairunnisa Khairunnisa Khairunnisa Khairunnisa Khairunnisa Khairunnisa Khairunnisa Linda Margata Lokot Donna Lubis Mahyuni, Eka Lestari Mardianto Mardianto Mardianto Mardianto Mawandha Sari Harahap Nadroh br Sitepu Nasri Nasri Nasri, Nasri Nasution, Azizah Nasution, Salli Roseffi Nasution, Salli Roseffi Natassya Manda Leo Nurmaini Nurmaini Panal Sitorus R. Hamdani Harahap R. Hamdani Harahap Ricke Loesnihari Rifda Amaliya Ma’ruf Rumanda Nurhasanah Siahaan, Jekson Martiar Siregar, Ambali Azwar Siti Morin Sinaga Sri Wahyuni Suci Wulandari Sunarti Sunarti Syukur Berkat Waruwu Syukur Berkat Waruwu Tanjung, Hari Ronaldo Tarigan, Betharina Br Tri Widyawati Yuandani Yustika Wirda Ningsih Ziza Putri Aisyia Fauzi Zulmai Rani