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All Journal Jurnal Farmasi Klinik Indonesia JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA Universa Medicina AKSIOLOGIYA : Jurnal Pengabdian Kepada Masyarakat Abdimas Talenta : Jurnal Pengabdian Kepada Masyarakat Jurnal Ilmiah Manuntung Indonesian Journal of Medicine JFIOnline Jurnal Ners Indonesian Journal of Pharmaceutical and Clinical Research International Journal Of Science, Technology & Management (IJSTM) Unri Conference Series: Community Engagement JOURNAL LA MEDIHEALTICO Jurnal Ilmiah Manuntung: Sains Farmasi dan Kesehatan
Urip Harahap
Faculty Of Pharmacy, Universitas Sumatera Utara, Medan, Indonesia
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The Prevention of Pesticide Risk Toxicity among Farmers on Food Estate Humbang Hasundutan Eka Lestari Mahyuni; R. Hamdani Harahap; Urip Harahap; Nurmaini
ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat Vol. 7 No. 2 (2022): ABDIMAS TALENTA: Jurnal Pengabdian Kepada Masyarakat
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/abdimastalenta.v7i2.7809

Abstract

This PPM activity is one of the community empowerment activities to increase the capacity of farmers, especially increasing safety and health behavior while using pesticides. The prevention program carried out in the form of a community movement to reduce the risk of pesticide toxicity is called GEMPAR (Gerakan Masyarakat Petani Atasi Racun). GEMPAR consists of eight action activities as a farmer movement in reducing the risk of toxicity due to the use of pesticides. GEMPAR in the PPM activity was carried out as a prevention effort which was promoted through FGD activities, demonstrations, and brainstorming. Farmers in the Food Estate are classified as farmers who work with the company so that the pattern of pesticide use is included in the regular category in determining the dose and type of pesticide used. However, the application of pesticides is still classified as very dangerous where direct contact with pesticides is very high. GEMPAR as a health solution responded very well and increased awareness of Food Estate farmers to improve pesticide use patterns. Each farmer acts as an agent of change who can comprehensively expand GEMPAR information through the promotion of the message of the eight GEMPAR actions which are divided into primary, secondary, and tertiary prevention actions.
Immunomodulatory Effects of Phaleria macrocarpa Leaf Extract in Normal And Cyclophosphamides Induced in Wistar Rats Febriady, Andy; Harahap, Urip; Yuandani, Yuandani
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 5 No. 2 (2022): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v5i2.11271

Abstract

Abstract. Cyclophosphamide is an antineoplastic drug belonging to the alkylating agents commonly used in treating cancer. However, the use of cyclophosphamide causes a decrease in the body's immune system by reducing lymphocyte proliferation. The curent study was conducted to evaluate the immunomodulatory effect of ethyl acetate extracts of the leaf of the P. macrocarpa (EEADMD) and the ethanol extracts of the leaf of the P. macrocarpa (EEDMD) in normal and cyclophosphamide induced rats. This study used rats classified into two major groups: normal rats and rats induced by cyclophosphamide which were then given P. macrocarpa leaf extract until day 14. On day 4, the test animals were infected with 1% Staphylococcus aureus suspension in. Induced with cyclophosphamide 70 mg/kg BW was carried out on the 8th and 13th days, and then the immunomodulatory activity was tested using total leukocyte analysis, leukocyte differential, and delayed type hypersensitivity response. The results showed that EEDMD 400 mg/kg BW  in normal rats and EEDMD 100 mg/kg BW in cyclophosphamide induced rats could increase total leukocytes and leukocyte differential with a significant difference to the negative group (p <0.05). The results of the delayed hypersensitivity response test of EEADMD and EEDMD at a dose of 100 mg/kg BW with cyclophosphamide induction and normal rats could give an increase in rat paw volume with a significant difference to the negative group (p <0.05). This study shows that EEADMD and EEDMD have an immunomodulatory effect on increasing total and differential leukocytes and leukocyte differential and delayed type hypersensitivity response.
Antioxidant activity of 1.3-bis(p-hydroxyphenyl)urea by CUPRAC and FRAP methods Satria, Denny; Rifda Amaliya Ma’ruf; Syukur Berkat Waruwu; Urip Harahap; Hari Purnomo4
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 6 No. 1 (2023): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v6i1.17768

Abstract

An imbalance in the number of free radicals produced in the body can result in oxidative stress. Excessive oxidative stress can lead to chronic inflammation, which in turn can lead to most chronic diseases. Inflammation is related to oxidation through increased reactive oxidative stress, which can target modulators associated with inflammation, such as inflammatory cytokines. Antioxidants can inhibit or stop oxidation by protecting the body and neutralizing free radicals. 1.3-bis(p-hydroxyphenyl)urea is a modification of p-aminophenol and has hepatotoxic side effects such as those caused by acetaminophen. This compound can relieve pain, is anti-inflammatory, and has fewer side effects. This research was conducted to evaluate the antioxidant activity of 1.3-bis(p-hydroxyphenyl)urea using the CUPRAC (Cupric Ion Reducing Antioxidant Capacity) method and the FRAP (Ferric Reducing Antioxidant Power) method. The results of the CUPRAC method research show that the 1.3-bis(p-hydroxyphenyl)urea compound has an IC50 value of 4.40 ± 0.07 μg/mL. Meanwhile, the FRAP method was 29.36 ± 1.20 μg/mL. Apart from suppressing inflammation, this compound has the potential to be an antioxidant compound.
Analysis of the Application of Pharmaceutical Service Standards and Patient Satisfaction with Accreditation Status and Types of Services Tarigan, Betharina Br; Dalimunthe, Aminah; Nasution, Azizah; Harahap, Urip; Khairunnisa, Khairunnisa
Journal La Medihealtico Vol. 4 No. 2 (2023): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v4i2.846

Abstract

Accreditation is a method to improve the quality of health services, so that it is expected that the services provided are in accordance with established regulations. This study aims the implementation of Pharmaceutical Service Standards (PCSs) and patient satisfaction on accreditation status and types of PHCs in Deli Serdang Regency, Sumatera Utara. This descriptive analytical cross-sectional study was conducted to analyze pharmacy services at PHCs (n=34) in Deli Serdang Regency. The reference used is the Checklist for PCSs based on direct observations and interviews with the person in charge of pharmacy and the Patient Satisfaction Questionnaire. The data obtained were analyzed using SPSS version 22. The results on the value of a total score PCSs showed 41-90, with the highest level of patient satisfaction is the very satisfied category is 65.90%.The correlation test was analyzed using the Chi-Square test with a significance limit of p<0.05, the correlation of accreditation status to the implementation of PCSs showed a value of p=0.304, the correlation of the type of service to the implementation of PCSs showed a value of p=0.591, the correlation of the accreditation status of PHCs to the level of satisfaction patient value showed a value of p=0.000. This study concluded that the accreditation status of the PHCs does not affect implementation of PCSs, the type of PHCs service does not affect implementation of PCSs and the accreditation status of the PHCs has an effect on the level of patient satisfaction in Deli Serdang Region, Sumatera Utara.
Anti-Acne Activity From Biocellulose Mask Formula Containing (Aloe Vera (L.) Burm.F) Essence Combined With Vitamin E Raissa Fitri; Julia Reveny; Urip Harahap; Hariyadi Dharmawan; Nasri
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 4 No. 1 (2021): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v4i1.5382

Abstract

Abstract. Biocellulose mask sheet is a new found pharmaceutical cosmetic design that widely commercial. Mostly due to it’s biodegradable properties, provide an eco-friendly waste. Combination of Aloe vera essence (AE) and Vit E to provide and determine it’s respective anti-acne properties in biocellulose mask form. Formulation of biocellulose mask with the help of Acetobacter xylinum bacteria varied with different formulae: F1 (Vitamin E 1%), F2 (E 2.5 %), F3 (AE 5%), F4 (AE 2.5%+Vit E 1%) and F5 (AE 5%+Vit E 1%) followed antimicrobials test with common acne bacteria by diffusion disk against Propionibacterium acne (PAC) ATCC 6919 and Pseudomonas aeruginosa (PAA) ATCC 27853. Study revealed that each formulae design F1; F2; F3; F4; F5 tested against PAC diffusion disk resulted 7.86; 11.67; 10.13; 112.10; 10.33 mm respectively. As for PAA diffusion disk resulted 7.76; 11.63; 10.33; 11.67; 11.00 mm respectively. Biocellulose mask containing combination of AE 2.5% and Vit E (F4) would provide the best anti-acne activity amongst other formulae.
Cytotoxic and Apoptotic Activities of Vernonia amygdalina Extract in HepG2 Cell Line Herman Syukur Harefa; Poppy Anjelisa Zaitun Hasibuan; Urip Harahap
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 5 No. 2 (2022): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v5i2.6350

Abstract

Liver cancer is a malignant tumor originating from the development of chronic hepatitis or cirrhosis and is responsible for damage to the shape and function of the liver. The loss of the ability of conventional chemotherapy to inhibit the growth of cancer cells is a major focus in the world. Natural ingredients are the solution to this problem, for example the use of Vernonia amygdalina leaves. Vernonia amygdalina contains flavonoids, cardiac glycosides, and steroids/triterpenoids which are reported to have anticancer properties. This study aims to examined the activity of these plants as anticancer liver through cytotocix and apoptotic activity. Vernonia amygdalina ethanol extract (VAEE), Vernonia amygdalina ethyl acetate extract (VAEAE), and Vernonia amygdalina n-hexane extract (VAHE) were obtained from a multistage maceration process. The extracts were tested for cytotoxic activity by the MTT method on HepG2 cells. VAEAE had the best inhibitory concentration 50 (IC50) value of 19.91 ± 0.24 µg/mL. Apoptosis test was performed using double staining method. Subjective observations were made using a fluorescence microscope. It was seen that Vernonia amygdalina ethyl acetate extract was able to trigger apoptosis in HepG2 cells.
Antidiarrheal Effect of Lactobacillus fermentum Isolated from Dengke Naniura on Escherichia coli-induced Rats Nasri Nasri; Urip Harahap; Jansen Silalahi; Denny Satria
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 5 No. 1 (2022): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v5i1.6478

Abstract

Diarrhea is discharge of abnormal and liquid stool with a frequency of 3-4 daily which caused by pathogenic organisms such as Escherichia coli, and other. Dengke Naniura is a traditional Batak Toba food that can produce probiotics (Lactobacillus fermentum). Probiotics are defined as live microorganisms that confer a health benefit on the host. Nutritional supplements combined between probiotics and prebiotics are called synbiotics, The purpose of this study was to analyze the preventive effect of diarrhea in rats given L.fermentum for 21 days. The preventive effect of diarrhea test begins with the giving of L.fermentum from day 1 to day 21. From day 7 to day 14 rats were induced with E.coli. Weight of the rats, stool consistency, onset of diarrhea, frequency of diarrhea, and duration of diarrhea were observed. The results of the observation that weight of rats in the L.fermentum group increased compared to group 1 (p<0.05). Consistency stool is soft (massless). Onset of diarrhea on day 1 after induced of E.coli in the group 1. Frequency of diarrhea increased to 9.25 ± 0.50 times on day 14 (group 1). And diarrhea occurs for 10 days. Conclusion L.fermentum showed a preventive effect of diarrhea in rats induced E.coli.
Patient Satisfaction on Covid-19 Handling in Primary Health Centers Yustika Wirda Ningsih; Azizah Nasution; Urip Harahap
Indonesian Journal of Pharmaceutical and Clinical Research Vol. 5 No. 1 (2022): Indonesian Journal of Pharmaceutical and Clinical Research
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/idjpcr.v5i1.7416

Abstract

Primary health centers play important roles in preventing, detecting, and helping people to cope with the problems associated with the COVID-19 infection. Therefore, it is necessary to strengthen and optimize the role of primary health center, including pharmaceutical care. This prospective descriptive study aimed to evaluate the level of patient satisfaction on COVID-19 handling in seven primary health centers Medan, Sumatera Utara, Indonesia period January to April 2021. A self-designed questionnaire was distributed to a total of 617 patients admitted to the 7 primary health centers to assess the characteristics of the patients and the required data about patient satisfaction about nine-item pharmaceutical services provided, supporting facilities, and infrastructures. The patient satisfaction was assessed using a 4-point Likert scale categorized into very dissatisfied, dissatisfied, satisfied and very satisfied. The obtained data were analyzed using descriptive and Chi-Square analyses. Most (67%) of the respondents were females. The present study indicated that most respondents satisfied with the services provided.
Cardio Protective Effect of Ethanolic Extract Vernonia Amygdalina Delile on Rats Induced L-NAME Harahap, Rizki Doli Hartama; Harahap, Urip; Dalimunthe, Aminah
Jurnal Ners Vol. 9 No. 1 (2025): JANUARI 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i1.30981

Abstract

This study aimed to analyse the effects of ethanol extract of African leaves (Vernonia Amygdalina Del.) on the levels plasma renin, IL-6 and cardiac histopathology in L-NAME-induced rats. This research stage includes the preparation of ethanol extract of African leaves, standardization of extracts and testing the effectiveness of African leaves on rat heart damage. Data were analysed using one-way ANOVA with p<0.05. testing the cardioprotective effectiveness of ethanol extract of African leaves in hypertension model rats and then examining heart histopathology using HE staining and analysing parameters, namely plasma renin and IL-6 levels. This study used 6 groups, each group consisted of 5 male rats, namely the normal group, negative control by administering L-NAME 40 mg/kgBB, positive control by administering L-NAME plus lisinopril 2.5 mg/kgBB, EEDA 100 mg/kgBB, EEDA 300 mg/kgBB and EEDA 500 mg/kgBB. L-NAME responds to heart damage such as degeneration and necrosis of heart cells. In the negative group, plasma renin levels were 40.60 ± 9.98 ng/mL while the EEDA group with a dose of 500 mg/kgBB experienced the highest decrease in plasma renin compared to other EEDA groups and positive controls, namely 13.80 ± 1.30 ng/mL. The positive control group obtained plasma renin levels of 14.20 ±1.79 ng/mL. In the negative group, IL-6 levels were 4.80 ± 1.30 pg/mL while the group given EEDA, the group with a dose of 500 mg/kgBB experienced a decrease in IL-6, namely 1.52 ±0.96 ng/mL. The positive control group experienced a decrease in IL-6 levels of 0.77 ± 0.20 ng/mL. The result can be concluded that EEDA reduces plasma renin, IL-6 levels, improves the condition of cardiac cell degeneration and necrosis.
EKSTRAK ETANOL DAUN SIRIH MERAH (Piper crocatum) MENURUNKAN KADAR GULA DARAH MENCIT DIABETES Ambali Azwar Siregar; Urip Harahap; Mardianto Mardianto
Jurnal Ilmiah Manuntung Vol 1 No 1 (2015): Jurnal Ilmiah Manuntung
Publisher : jurnal ilmiah manuntung sekolah tinggi ilmu kesehatan samarinda

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.51352/jim.v1i1.10

Abstract

Diabetes mellitus is one of desease that have a large population and trend to increase. sulfonylurea and biguanide are almost used treatment but have unexpected side effects. The research still necessary to seek alternative medicine, such as Piper crocatum.This study aimed to determine the effect of ethanol extract of red betel leaves on blood sugar levels and body weight of mice (Mus musculus L.) diabetes. This riset was started to produce simplicia and drilled become powders, continued extract with 70% ethanol. The extract was evaporated with rotary evaporator until obtaine crude extract. And then screen it that determine phytochemical. To continued test on tolerance of level of glucose then mice diabetes induced aloxan.In summary, extract of red betle ethanolic has contained alkaloid, quercetin flavonoid, steroid and fenolic compounds and decreased level of glucose in blood mice diabetes. Besides, it can reduce lose of weight symptom.
Co-Authors Ade Sri Rohani Ambali Azwar Siregar Aminah Dalimunthe Angga Nugraha Sanjaya Azmi Sarriff Dasopang, Eva S. Delyuzar, Delyuzar Denny Satria Denny Satria, Denny dharma Lindarto, dharma Edy Fachrial Eka Lestari Mahyuni Eka Lestari Mahyuni Eka Lestari Mahyuni Embun Suci Nasution Eva S. Dasopang Febriady, Andy Hakim Bangun* Harahap, Rizki Doli Hartama Hari Purnomo Hari Purnomo4 Hariyadi Dharmawan Hasibuan, Poppy Anjelisa Zaitun Herman Syukur Harefa Husori, Dadang Irfan Jansen Silalahi Julia Reveny Julia Reveny Khairunnisa Khairunnisa Khairunnisa Khairunnisa Khairunnisa Khairunnisa Khairunnisa Lokot Donna Lubis Mahyuni, Eka Lestari Mardianto Mardianto Mardianto Mardianto Mawandha Sari Harahap Nadroh br Sitepu Nasri Nasri Nasri Nasution, Azizah Nasution, Salli Roseffi Nasution, Salli Roseffi Natassya Manda Leo Nurmaini Nurmaini Nurmaini Panal Sitorus* R. Hamdani Harahap R. Hamdani Harahap R. Hamdani Harahap Raissa Fitri Ricke Loesnihari Rifda Amaliya Ma’ruf Rumanda Nurhasanah Siahaan, Jekson Martiar Siregar, Ambali Azwar Siti Morin Sinaga Sri Wahyuni Suci Wulandari Sunarti Sunarti Syukur Berkat Waruwu Syukur Berkat Waruwu Tanjung, Hari Ronaldo Tarigan, Betharina Br Tri Widyawati Yuandani Yustika Wirda Ningsih Ziza Putri Aisyia Fauzi Zulmai Rani