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All Journal Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Jurnal Farmasi Klinik Indonesia JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA JSKK (Jurnal Sains Keolahragaan dan Kesehatan) Jurnal Respirologi Indonesia Jurnal Ilmu Kefarmasian Indonesia Jurnal Ners Narra J Indonesian Journal of Health Science Indonesian Journal of Cancer Pharmaceutical Sciences and Research (PSR) Eduvest - Journal of Universal Studies Jurnal Farmasetis Borneo Journal of Pharmacy Jurnal Kefarmasian Indonesia Malahayati International Journal of Nursing and Health Science Holistik Jurnal Kesehatan Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Rani Sauriasari, Rani
Departement Of Pharmacy, Faculty Of Pharmacy, Universitas Indonesia, Depok, West Java, 16424, Indonesia
Aerospace Engineering Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Cognitive Function in Type 2 Diabetes Mellitus Patients Taking Metformin and Metformin-Sulfonylurea Rachman, Abu; Sauriasari, Rani; Syafhan, Nadia Farhanah; Prawiroharjo, Pukovisa; Risni, Hindun Wilda
Kesmas Vol. 17, No. 4
Publisher : UI Scholars Hub

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Abstract

The most prescribed antidiabetic drugs in Indonesian primary health care are metformin or a combination of metformin and sulfonylurea. Studies on metformin have shown various impacts on cognitive decline in patients with type 2 diabetes mellitus, whereas sulfonylurea has been shown to reduce this impact. This study aimed to compare the impacts of metformin and metformin-sulfonylurea on cognitive function and determine what factors affected it. This cross-sectional study was conducted at Pasar Minggu Primary Health Care involving 142 type 2 diabetes mellitus patients taking metformin or metformin-sulfonylurea for > 6 months and aged > 36 years. Cognitive function was assessed using the validated Montreal Cognitive Assessment Indonesian version. The effects of metformin and metformin-sulfonylurea on cognitive decline showed no significant difference, even after controlling for covariates (aOR = 1.096; 95% CI = 0.523–2.297; p-value = 0.808). Multivariate analysis showed age (OR = 4.131; 95% CI = 1.271–13.428; p-value = 0.018) and education (OR = 2.746; 95% CI = 1.196–6.305; p-value = 0.017) affected cognitive function. Since a lower education and older age are likely to cause cognitive decline, health professionals are encouraged to work with public health experts to address these risk factors for cognitive function.
Treatment Adherence and Incidence of Coronary Heart Disease in Type 2 Diabetes Mellitus Patients Baniu, Ahmad Sahlan; Sauriasari, Rani; Riyadina, Woro; Soewondo, Pradana
Kesmas Vol. 17, No. 2
Publisher : UI Scholars Hub

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Previous studies showed that uncontrolled blood sugar and long-term use of several types of antidiabetic could increase the risk of coronary heart disease (CHD). This study aimed to compare the incidence of CHD in type 2 diabetes mellitus (T2DM) patients showing treatment adherence and non-adherence behavior over four years. This was a retrospective cohort study with data sets obtained from the Bogor Cohort Study of Non-Communicable Disease Risk Factors. All study subjects were not diagnosed with CHD at the beginning of the study. The sample was divided into two groups; one had adhered to treatment from health centers and followed the treatment instructions (adherent group), while the other had not followed the treatment instructions (non-adherent group). Of 5,690 subjects, 276 were eligible for this study (84 in the adherent and 192 in the non-adherent group). The incidence of CHD in the non-adherent group was 2.3% higher than in the adherent group (p-value = 0.564) and had a 1.7 times greater risk of developing CHD, but not statistically significant (adjusted HR = 1.739; 95% CI = 0.673-4.490). The non-adherent T2DM patients had a greater risk of developing CHD than adherent T2DM patients.
The Effectiveness and Safety of Favipiravir in COVID-19 Hospitalized Patients at Tertiary Referral Hospital, Bali, Indonesia Damayanti, Herni; Sajinadiyasa, I Gede K; Risni, Hindun Wilda; Sauriasari, Rani
Kesmas Vol. 16, No. 4
Publisher : UI Scholars Hub

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COVID-19 is a major public health problem, with still questionable specific cure. Favipiravir is a COVID-19 antiviral that is potentially a therapy for COVID-19. This study aimed to analyze its effectivity and safety in moderate to critical hospitalized patients. This study was a retrospective cohort in a tertiary referral hospital in Denpasar City, Bali Province, Indonesia, from August 2020 to January 2021. There was a total of 192 patients; 96 in the favipiravir group and 96in the non-favipiravir group (remdesivir/oseltamivir). Effectivity was measured by assessing the clinical condition at the end of the isolation period of 14 days. The favipiravir group showed better clinical conditions than the non-favipiravir group (79.2% vs. 56.3%; adjusted RR = 2.196; 95% CI = 1.084 – 4.451; p-value= 0.029), seen from being free of fever and respiratory problems. Stratification analysis demonstrated that the clinical improvement was significantly differentin the severe/critical group in favor of favipiravir (RR = 1.573; 95% CI = 1.139-2.172). The most common non-serious adverse events (AE) found in the use offavipiravir were gastrointestinal disturbances (12.5%). In brief, favipiravir is effective in severe/critical cases, and less serious AE were found in its use. Appropriate treatment is expected to help in reducing the public health burden.
Tingkat Kejadian Hipoglikemia pada Pasien Diabetes Melitus Tipe 2 Peserta JKN dan Non-JKN pada Masa Pandemi COVID-19 di Kalimantan Tengah Veryanti, Putu Rika; Sartika, Ratu Ayu Dewi; Sauriasari, Rani; Elya, Berna; Puspitasari, Rara Merinda
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 2 (2023): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i2.1477

Abstract

Community activity restrictions during the COVID-19 pandemic in Indonesia impact the quantity and quality of health services for type 2 diabetes (T2DM). This limitation could increase the risk of hypoglycemia in type 2 diabetes patients. The study aimed to compare the incidence rate of hypoglycemia between national (NHIP) and non-national health insurance participants (N-NHIP) with T2DM during the COVID-19 pandemic in Indonesia. The study used a cross-sectional design and was conducted at a government hospital in Central Borneo. Data was collected by consecutive sampling from September to November 2021. Sixty-two participants were divided into two groups (NHIP and N-NHIP groups). Each group consisted of 31 participants. They were interviewed regarding their experience with hypoglycemia in the last three months. The incidence rate of hypoglycemia in N-NHIP was higher than in NHIP (93.55% vs. 87.10%; p>0.05). Hypoglycemia is mostly presented in patients using a combination of short-acting and long-acting insulin. The incidence rate of hypoglycemia in T2DM during the COVID-19 pandemic in Central Borneo was relatively high. In future studies, it is necessary to analyse the factors that significantly affect the incidence of hypoglycemia in the population of T2DM patients in Indonesia.
Diabetic Foot Ulcers: Impact on Quality of Life and Instruments for Its Measurement Qomariyanti, Khairunisa; Sauriasari, Rani; Sartika, Ratu Ayu Dewi
Borneo Journal of Pharmacy Vol. 7 No. 2 (2024): Borneo Journal of Pharmacy
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/bjop.v7i2.6554

Abstract

Diabetic foot ulcers (DFUs) are a major complication of diabetes mellitus, significantly impacting patients' quality of life (QoL) due to the heightened risk of infection and amputation. Pharmacists play a crucial role in managing diabetes and its complications, and assessing QoL can be a valuable tool for monitoring treatment success and medication effectiveness. This review explores instruments used to measure QoL in patients with DFUs, encompassing both general and disease-specific tools. We examine the impact of DFUs on QoL and discuss various theoretical frameworks used to understand this complex relationship.
Efficacy and Safety of Glibenclamide Compared with Insulin in Gestational Diabetes Mellitus: A Systematic Review and Meta-analysis Haifa, Alifia Fauziyyah; Qomariyanti, Khairunnisa; Sartika, Ratu Ayu Dewi; Sauriasari, Rani
Pharmaceutical Sciences and Research Vol. 12, No. 2
Publisher : UI Scholars Hub

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Abstract

Gestational diabetes mellitus (GDM) is a prevalent pregnancy complication associated with an increased risk of maternal and neonatal complications compared with non-diabetic pregnancies. Pharmacological treatments, such as glibenclamide, are expected to provide optimal glycemic control and reduce these risks. However, concerns regarding its safety persist and some regulatory agencies have not approved glibenclamide for GDM treatment. This systematic review and meta-analysis aimed to synthesize the most recent evidence on the efficacy and safety of glibenclamide compared with insulin in the management of GDM, with a focus on maternal and neonatal outcomes based on the most recent RCT. The objective is to provide updated insight and strengthen the evidence based supporting the use of glibenclamide as treatment option for GDM. Relevant studies were identified from Pubmed, Scopus, and CENTRAL databases, resulting in 11 randomized controlled trials (RCTs) involving 2,019 participants. The pooled analysis found that glibenclamide significantly increases the risk of neonatal hypoglycemia [RR 1.65; 95% CI 1.23 to 2.22; p-value 0.0009] and significantly decreases the risk of neonatal respiratory distress syndrome (NRDS) [RR 0.56; 95% CI 0.33 to 0.95; p-value 0.03], compared to insulin. No significant differences were observed in other maternal and neonatal outcomes between the two treatments. In conclusion, glibenclamide demonstrated comparable efficacy and safety to insulin in the management of GDM, making it a viable treatment option alongside insulin.
Faktor Gaya Hidup sebagai Prediktor Kualitas Hidup pada Pasien Luka Kaki Diabetik: Studi Cross-Sectional di Indonesia Restu Anisa Putri; Rani Sauriasari; Atika Wahyu Puspitasari
Jurnal Ners Vol. 10 No. 1 (2026): JANUARI 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v10i1.53487

Abstract

Diabetic foot ulcers (DFUs) are a serious complication of diabetes mellitus (DM) that significantly impacts patients' quality of life. Lifestyle factors, particularly smoking status and physical activity, are important modifiable factors to support improvement of this condition. This study aims to analyze the relationship between these two factors and the quality of life of DFU patients in Indonesia. A predictive cross-sectional study was conducted on 70 patients undergoing treatment at six branches of the Diabetic Wound Care Home Clinic in the Greater Jakarta area during March–May 2025. Quality of life was measured using the Indonesian version of the Diabetic Foot Ulcer Scale-Short Form (DFS-SF). Analysis was performed using the chi-square test for bivariate associations and multivariate logistic regression, controlling for confounding variables. The results showed that most patients did not smoke (74.3%) and did not exercise regularly (70.0%). Smoking status was significantly associated with quality of life (p=0.042), while physical activity showed a trend towards significance (p=0.060). Multivariate analysis identified physical activity as a predictor of quality of life (OR=5.30; 95% CI: 0.96–29.14; p=0.055), with patients who did not exercise being 5.3 times more likely to experience low quality of life. Smoking status showed a paradoxical result (OR=0.12; 95% CI: 0.02–0.82; p=0.030), which requires cautious interpretation. Physical activity also significantly impacted the domains of dependency/activities of daily living (p=0.001) and physical health (p=0.002). These findings emphasize the importance of integrating physical activity promotion and healthy lifestyle interventions in the holistic management of patients with LKD to support improved quality of life.
Praktik pencegahan dan efektivitas vaksinasi influenza terhadap penyakit pernapasan pada jemaah haji: A systematic literature review Rina Novianti Siregar; Dian Yudianto; Rani Sauriasari
Hik Vol. 20 No. 1 (2026): Volume 20 Nomor 1
Publisher : Program Studi Ilmu Keperawatan-fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/hjk.v20i1.1779

Abstract

Background: Respiratory diseases such as influenza and pneumonia are the leading causes of illness among Hajj pilgrims each year. This is due to the high density of pilgrims and inter-country mobility. Preventive measures such as influenza vaccination and good hygiene practices have been recommended by the World Health Organization (WHO) and the Ministry of Health of the Republic of Indonesia. However, in reality, not all Hajj pilgrims receive the vaccine and consistently practice preventive behaviors, resulting in suboptimal prevention outcomes. Purpose: To identify respiratory disease prevention practices and the effectiveness of influenza vaccination among Hajj pilgrims. Method: This was a systematic literature review (SLR) based on PRISMA guidelines, using data sources from PubMed, Scopus, and ScienceDirect. Articles meeting the inclusion criteria (2013–2024) were analyzed using a thematic synthesis approach and narrative summary. Of the 150 articles screened, 35 studies were eligible for further analysis, and 10 were selected for review. Results: The combination of influenza vaccination, mask use, handwashing, and health education can reduce the incidence of respiratory infections by 40–60%. Factors contributing to this include social support, behavior, and policies. Conclusion: Preventing respiratory diseases among Hajj pilgrims requires a multilevel approach that integrates medical and sociocultural interventions. Suggestion: Future researchers are encouraged to develop epidemiological data-driven predictive models to estimate potential respiratory disease outbreaks during the next Hajj season, as well as to evaluate the effectiveness of digital technology-based interventions, such as through pilgrim health apps.   Keywords: Hajj Pilgrims; Influenza; Respiratory Diseases; Vaccination.   Pendahuluan: Penyakit pernapasan seperti influenza dan pneumonia menjadi salah satu penyebab utama banyaknya jemaah haji yang jatuh sakit setiap tahun. Kondisi ini terjadi akibat tingginya tingkat kepadatan jemaah dan mobilitas antarnegara. Upaya pencegahan melalui vaksinasi influenza dan penerapan perilaku higienis telah direkomendasikan oleh World Health Organization (WHO) dan Kementerian Kesehatan Republik Indonesia. Namun, pada kenyataannya tidak semua jemaah haji mendapatkan vaksin dan menerapkan perilaku pencegahan secara konsisten, sehingga hasil pencegahannya belum optimal. Tujuan: Untuk mengidentifikasi praktik pencegahan penyakit pernapasan dan efektivitas vaksinasi influenza pada jemaah haji. Metode: Penelitian systematic literature review (SLR) berdasarkan pedoman PRISMA dengan sumber data dari PubMed, Scopus, dan ScienceDirect. Artikel yang memenuhi kriteria inklusi (periode 2013–2024) dianalisis menggunakan pendekatan thematic synthesis dan narrative summary. Dari 150 artikel yang disaring, 35 studi memenuhi syarat untuk dianalisis lebih lanjut dan didapatkan 10 artikel yang di review. Hasil: Kombinasi vaksinasi influenza, penggunaan masker, cuci tangan, serta edukasi kesehatan mampu menurunkan insiden infeksi pernapasan hingga 40–60%. Adapun faktor yang menyebabkan hal tersebut disebabkan oleh faktor sosial, perilaku, dan dukungan kebijakan. Simpulan: Pencegahan penyakit pernapasan pada jemaah haji membutuhkan pendekatan multilevel yang mengintegrasikan intervensi medis dan sosial budaya. Saran: Bagi peneliti selanjutnya, disarankan mengembangkan model prediksi berbasis data epidemiologi untuk memperkirakan potensi wabah pernapasan di musim haji berikutnya, serta mengevaluasi efektivitas intervensi berbasis teknologi digital, misalnya melalui aplikasi kesehatan jemaah.   Kata Kunci: Influenza; Jemaah Haji; Penyakit Pernapasan; Vaksinasi.
Development and Validation of an Indonesian Questionnaire for Assessing Paracetamol Self-Medication Knowledge, Attitude, and Practice Putri, Widyana Sagita; Sauriasari, Rani; Septyowati, Priharika
Kesmas Vol. 21, No. 2
Publisher : UI Scholars Hub

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Paracetamol is a widely used over-the-counter medicine for self-medication and is often perceived as completely safe. However, inappropriate use may result in hepatotoxicity and other adverse effects, particularly at high doses. This study aimed to develop and validate a questionnaire to assess the general Indonesian population’s knowledge, attitude, and practice (KAP) regarding paracetamol self-medication. The validation procedure consisted of three stages: content, face, and construct validation. Three experts assessed the relevance of the items using the Content Validity Index, and five respondents were interviewed to assess the linguistic clarity and comprehensibility of the questions. Construct validity and reliability were assessed in 30 participants using Pearson’s correlation and Cronbach’s alpha. All items obtained excellent relevance scores. The final questionnaire demonstrated acceptable validity and reliability after revising and removing two low-performing practice items (P3 and P4), with Pearson’s correlation coefficients exceeding the r-table threshold (0.361) and Cronbach’s alpha values of 0.766, 0.734, and 0.640 for the KAP domains, respectively. The final instrument, comprising 20 items (10 knowledge items, 6 attitude items, and 4 practice items), was deemed suitable for assessing public KAP regarding safe self-medication with paracetamol.
Development and PLS-SEM Validation of a Multidimensional Instrument for Medication Adherence in Indonesian T2DM Patients Ivans Panduwiguna; Rani Sauriasari; Ratu Ayu Dewi Sartika; Woro Riyadina
Jurnal Kefarmasian Indonesia VOLUME 16, NUMBER 1, JUNE 2026
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

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Abstract

There are several instruments available to assess adherence levels, most have not comprehensively measured the determinants that influence patient behavior, especially in the context of the Indonesian culture. This study aims to develop and test the psychometric validity of a new instrument that can measure the determinants of medication adherence in T2DM patients in Central Bogor, Indonesia. This Study using the development method borg and gall method and expert panel, the instrument was tested for content validity using the content validity ratio (CVR) and content validity index (CVI). The population consisted of patients enrolled in the Noncommunicable Disease Risk Factors Study in Bogor City, based on data from the Health Development Policy Agency. Using purposive sampling of 170 patients with type 2 diabetes (T2DM) in Central Bogor. Structural model evaluation was performed using the partial least squares structural equation modeling (PLS-SEM) approach. The final instrument consisted of 7 constructs and 40 items. All items had adequate factor loading values (≥0.678), and all constructs showed good reliability (α = 0.678−0.975; CR > 0.8; AVE > 0.5). The results of the structural analysis showed significant relationships between the constructs and compliance. For example, perceived barriers played a negative role in compliance (β = −0.573; p < 0.001). The model fit index also showed adequate results (SRMR = 0.061; RMSEA = 0.047; NFI = 0.914). The developed instrument has strong psychometric characteristics and its use is feasible for the identification of factors that influence medication adherence in T2DM patients in Indonesia.
Co-Authors Abu Rachman Adisa Swastika Adisa Swastika, Adisa Afifah Fauziyyah Agusdini Banun Saptaningsih Ahmad Sahlan Baniu Anna Rozaliyani Annisa Azka Hikmawati Aulia Annisa Azka Hikmawati Aulia, Annisa Azka Hikmawati Annisa Lazuardi Larasati Arifianti, Ayun Ariska Deffy Anggarany, Ariska Deffy Arry Yanuar Atika Wahyu Puspitasari Baniu, Ahmad Sahlan Berna Elya Damayanti, Herni Dewi Danawati Dian Yudianto Dodi Sudiana Em Yunir, Em Evi Martha Fauziyyah, Afifah Fikria Adiputri Fitrianingsih Fitrianingsih Fonny Cokro Hadijah Tahir Haifa, Alifia Fauziyyah Hayatun Nufus Herni Damayanti Hindun W. Risni Hindun Wilda Risni Hindun Wilda Risni Hindun Wilda Risni I Gede Ketut Sajinadiyasa Indah Kusumawati Susanti Irianti Bahana Maulida Irianti Bahana Reyaan Ivans Panduwiguna Ivans Panduwiguna July Makau, Juliann Nzembi Marina Ika Irianti Maryati Kurniadi Maryati Kurniadi Maulida, Irianti Bahana Muh Ronike Yunus Muhammad Alkaff Muhammad Alkaff Muhareva Raekiansyah Nadia Farhanah Syafhan Novita Sari Nurwijayanti Oriza Satifa Panduwiguna, Ivans Paramita, Diana Pradana Soewondo Puji Astuti Pukovisa Prawiroharjo Pukovisa Prawiroharjo, Pukovisa Puspitasari, Rara Merinda Putri Ayuningtyas Putri Ayuningtyas Putri, Risani Andalasia Putri, Widyana Sagita Qamar, Muhammad Qomariyanti, Khairunisa Qomariyanti, Khairunnisa Rachman, Abu Radoti Merlin Rahmasari, Ratika Ratika Rahmasari Ratu Ayu D Sartika Ratu Ayu Dewi Sartika Renaldi, Fransiskus Samuel Restu Anisa Putri Rina Novianti Siregar Risni, Hindun Wilda Rizki Oktarini RR. Ella Evrita Hestiandari Sagala, Radoti Merlin Sajinadiyasa, I Gede K Sarah Almira Septyowati, Priharika Sesilia Keban Sesilia Keban, Sesilia Soraya, Indana Ayu Syahdi, Rezi Riadhi Tahapary, Dicky L. Takhwifa, Famila Veryanti, Putu Rika Vincent Pratama Wawaimuli Arozal Woro Riyadina Woro Riyadina Woro Riyadina Woro Riyadina Woro Riyadina Woro Riyadina