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All Journal Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Jurnal Farmasi Klinik Indonesia JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA JSKK (Jurnal Sains Keolahragaan dan Kesehatan) Jurnal Respirologi Indonesia Jurnal Ilmu Kefarmasian Indonesia Jurnal Ners Narra J Indonesian Journal of Health Science Indonesian Journal of Cancer Pharmaceutical Sciences and Research (PSR) Eduvest - Journal of Universal Studies Jurnal Farmasetis Borneo Journal of Pharmacy Jurnal Kefarmasian Indonesia Malahayati International Journal of Nursing and Health Science Holistik Jurnal Kesehatan Jurnal Farmasi Sains dan Terapan (Journal of Pharmacy Science and Practice) Kesmas: Jurnal Kesehatan Masyarakat Nasional (National Public Health Journal)
Rani Sauriasari, Rani
Departement Of Pharmacy, Faculty Of Pharmacy, Universitas Indonesia, Depok, West Java, 16424, Indonesia
Aerospace Engineering Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Dentistry Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences Veterinary Other

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Effects of L-Carnitine on blood pressure, VO2 max, and endurance in athletes: Systematic Review Annisa Lazuardi Larasati; Rani Sauriasari; Arry Yanuar
Eduvest - Journal of Universal Studies Vol. 4 No. 11 (2024): Journal Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v4i11.1419

Abstract

When playing sports, athletes are required to always maintain their health to provide maximum results in their performance. Supplements are products intended to complement nutritional needs, maintain, enhance and/or improve health functions and have nutritional value and/or physiological effects. L-Carnitine is a health supplement that is widely consumed by athletes. L-Carnitine has many effects on the body and the main effects are seen on blood pressure and VO2 max. The aim of this review is to look at the effects of L-Carnitine on blood pressure and VO2 max. It was found that L-Carnitine had more effect on a person's diastolic than systolic at doses of more than 2 grams/day. Meanwhile, the effect on VO2 max was seen in long-term use of 2 grams for 24 weeks and found a significant increase in VO2 max (p<0.05). L-Carnitine does influence blood pressure, VO2 max and is also correlated with endurance, but until now there is still a need for more research to show that the effects produced by L-Carnitine are significant both on blood pressure and VO2 max in athletes.
Socioeconomic and Clinical Profile of Diabetic Foot Ulcer Patients with National Health Insurance during Pandemic COVID-19 in Indonesia Fitrianingsih Fitrianingsih; Rani Sauriasari; Em Yunir; Agusdini Banun Saptaningsih
Jurnal Kefarmasian Indonesia VOLUME 15, NUMBER 1, FEBRUARY 2025
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

During the COVID-19 pandemic, the mandatory lockdown and government policy in prioritizing COVID-19 patients affected patients with diabetic foot ulcers (DFU). Most DFU patients experienced difficulties visiting hospitals and covering the cost of treatment, which led to changes in patient characteristics, poor clinical outcomes, and higher total costs. This study aimed to determine the sociodemographic and clinical outcomes profile of DFU patients under National Health Insurance (NHI-DFU) during the COVID-19 pandemic and their effect on the total direct medical cost. This cross-sectional study enrolled all JKN-DFU hospitalized patients at the National Referral Hospital, Cipto Mangunkusumo Hospital (RSCM), Jakarta, Indonesia, during COVID-19 pandemic (March 2nd, 2020, to December 2022). We used electronic health records, electronic billing, and foot registry systems. Participants were over 18 years old in a single admission period. Statistical analysis used Mann-Whitney and Kruskal-Wallis; Post hoc used the Mann-Whitney test. There were 158 JKN-DFU patients with predominated criteria: female patients (55.1%), aged over 60 years old (55.1%) with a mean age of 59.3 ± 11.0 years, unemployed (63.9%), intermediate educated (41.8%), Jakarta residents (68.4%), and mostly severe infection (63.3%). The total cost was much higher than INA-CBG’s coverage. The occupation (p=0.048), length of stay (LOS) (p=0.001), and amputation status (p<0.001) significantly affected total cost. Civil servants, longer LOS, and major amputation status leading higher total costs.
Analysis of adverse drug reactions in remdesivir therapy using the Naranjo Algorithm Afifah Fauziyyah; Rani Sauriasari; Ratika Rahmasari; Hindun Wilda Risni; Puji Astuti
Indonesian Journal of Health Science Vol 6 No 1 (2026)
Publisher : PT WIM Solusi Prima

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54957/ijhs.v6i1.2049

Abstract

Research on the safety of remdesivir in Indonesian subjects for COVID-19 therapy is still limited and has yielded different results. None of these studies have used the Naranjo algorithm to analyze the causality of remdesivir safety. This study aimed to evaluate the safety of remdesivir in patients with severe COVID-19. Data were collected using medical records of patients with severe COVID-19 at Cengkareng Regional Hospital, Indonesia. The study was conducted retrospectively with a cohort study design. Subjects consisted of the remdesivir group (n=80) and the non-remdesivir group (n=80). Adverse drug reactions (ADRs) were observed, and causality analysis of ADRs was performed using the Naranjo algorithm. The study found 10 ADRs experienced by patients during treatment. ADRs were more common in the remdesivir group than in the non-remdesivir group (58.8% vs 53.8%; p=0.633). Significant events with a high proportion in the remdesivir group were increased ALT (p=0.037) and lymphopenia (p=0.01). Hepatotoxic reactions associated with remdesivir use were associated with P-glycoprotein (P-gp) inhibitor interactions. Decreased lymphocyte counts were closely related to the clinical condition of the study subjects, namely patients with severe COVID-19, and this condition was associated with a poor prognosis. Increased blood triglycerides, lymphopenia, and decreased estimated glomerular filtration rate (eGFR) were categorized as probable. Meanwhile, nausea, melena, QT interval prolongation, increased ALT, increased AST, hyperuricemia, and neutrophilia were categorized as quite possible. The results of this study can be concluded that remdesivir causes liver dysfunction manifested by increased ALT values ​​and decreased lymphocyte counts, which worsen the condition of patients with severe COVID-19.
Effectiveness and implementation challenges of short-course all-oral BPaL and BPaLM regimens for drug-resistant tuberculosis: A systematic literature review Fikria Adiputri; Rani Sauriasari; Dewi Danawati
Malahayati International Journal of Nursing and Health Science Vol. 8 No. 11 (2026): Volume 8 Number 11
Publisher : Program Studi Ilmu Keperawatan-fakultas Ilmu Kesehatan Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/minh.v8i11.1998

Abstract

Background: Drug-resistant tuberculosis (TB-RO), including MDR and XDR forms, remains a major global health burden due to prolonged, toxic, and often ineffective conventional regimens. The introduction of short-course all-oral therapies BPaL (bedaquiline, pretomanid, linezolid) and BPaLM (with moxifloxacin) has offered a promising alternative, with evidence of superior efficacy, safety, and patient adherence. However, implementation across countries continues to face challenges, including limited access to pretomanid, insufficient laboratory capacity, and scarce evidence for special populations. Purpose: To synthesize global evidence on the effectiveness, implementation challenges, and supporting factors associated with BPaL and BPaLM regimens for drug-resistant tuberculosis. Method: A Systematic Literature Review (SLR) following the PRISMA protocol was conducted to identify, screen, and include relevant studies published from 2016–2024. Data sources consisted of clinical trials, operational studies, cost-effectiveness analyses, bibliometric reviews, and qualitative stakeholder assessments. Thematic analysis was applied to summarize findings on treatment outcomes, adverse effects, operational barriers, and socio-economic influences that shape implementation across different health system contexts. Results: Regimens BPaL and BPaLM demonstrated high treatment success rates ranging from 84% to 97.6%, with rapid sputum culture conversion. Linezolid-related toxicities—such as neuropathy and myelosuppression—were common but manageable through dose adjustment and active monitoring. Cost-effectiveness analyses indicated up to a 25% reduction in per-patient expenditure compared with conventional regimens. Supporting factors included patient-centred care, psychosocial support, strengthened pharmacovigilance, and international technical collaboration. Key barriers comprised limited pretomanid access, inadequate laboratory capacity for drug-susceptibility testing, variable readiness of health systems, and limited evidence in special populations (children, pregnant women, and extrapulmonary TB cases). Conclusion: The global adoption of BPaL and BPaLM regimens marks a significant advancement in the treatment of drug-resistant tuberculosis by enabling shorter, safer, and more cost-effective therapy with consistently high treatment success and improved operational feasibility across diverse settings.
Co-Authors Abu Rachman Adisa Swastika Adisa Swastika, Adisa Afifah Fauziyyah Agusdini Banun Saptaningsih Ahmad Sahlan Baniu Anna Rozaliyani Annisa Azka Hikmawati Aulia Annisa Azka Hikmawati Aulia, Annisa Azka Hikmawati Annisa Lazuardi Larasati Arifianti, Ayun Ariska Deffy Anggarany, Ariska Deffy Arry Yanuar Atika Wahyu Puspitasari Baniu, Ahmad Sahlan Berna Elya Damayanti, Herni Dewi Danawati Dian Yudianto Dodi Sudiana Em Yunir, Em Evi Martha Fauziyyah, Afifah Fikria Adiputri Fitrianingsih Fitrianingsih Fonny Cokro Hadijah Tahir Haifa, Alifia Fauziyyah Hayatun Nufus Herni Damayanti Hindun W. Risni Hindun Wilda Risni Hindun Wilda Risni Hindun Wilda Risni I Gede Ketut Sajinadiyasa Indah Kusumawati Susanti Irianti Bahana Maulida Irianti Bahana Reyaan Ivans Panduwiguna Ivans Panduwiguna July Makau, Juliann Nzembi Marina Ika Irianti Maryati Kurniadi Maryati Kurniadi Maulida, Irianti Bahana Muh Ronike Yunus Muhammad Alkaff Muhammad Alkaff Muhareva Raekiansyah Nadia Farhanah Syafhan Novita Sari Nurwijayanti Oriza Satifa Panduwiguna, Ivans Paramita, Diana Pradana Soewondo Puji Astuti Pukovisa Prawiroharjo Pukovisa Prawiroharjo, Pukovisa Puspitasari, Rara Merinda Putri Ayuningtyas Putri Ayuningtyas Putri, Risani Andalasia Putri, Widyana Sagita Qamar, Muhammad Qomariyanti, Khairunisa Qomariyanti, Khairunnisa Rachman, Abu Radoti Merlin Rahmasari, Ratika Ratika Rahmasari Ratu Ayu D Sartika Ratu Ayu Dewi Sartika Renaldi, Fransiskus Samuel Restu Anisa Putri Rina Novianti Siregar Risni, Hindun Wilda Rizki Oktarini RR. Ella Evrita Hestiandari Sagala, Radoti Merlin Sajinadiyasa, I Gede K Sarah Almira Septyowati, Priharika Sesilia Keban Sesilia Keban, Sesilia Soraya, Indana Ayu Syahdi, Rezi Riadhi Tahapary, Dicky L. Takhwifa, Famila Veryanti, Putu Rika Vincent Pratama Wawaimuli Arozal Woro Riyadina Woro Riyadina Woro Riyadina Woro Riyadina Woro Riyadina Woro Riyadina