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All Journal HAYATI Journal of Biosciences Jurnal Ilmu dan Teknologi Kelautan Tropis Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Jurnal Pengelolaan Sumberdaya Alam dan Lingkungan (Journal of Natural Resources and Environmental Management) Biota Jurnal Perlindungan Tanaman Indonesia Journal of Tropical Biodiversity and Biotechnology BERITA BIOLOGI Majalah Ilmiah Biologi BIOSFERA: A Scientific Journal Jurnal Perikanan Universitas Gadjah Mada JMM (Jurnal Masyarakat Mandiri) Indonesian Journal of Biology Education Biota Journal of Aquaculture and Fish Health JURNAL PERIKANAN TROPIS Borneo Journal of Medical Laboratory Technology Berkala Penelitian Hayati Biological Environment and Pollution Rumphius Pattimura Biological Journal Berkala Ilmiah Biologi
Bambang Retnoaji
Fakultas Biologi Universitas Gadjah Mada
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Energy Environmental Science Health Professions Immunology & microbiology Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Social Sciences Veterinary Other

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Journal : Biological Environment and Pollution

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Histopathological evaluation of hepatic tissue of yellow Rasbora (Rasbora lateristriata) exposed to paracetamol Septriani, Nur Indah; Saribu, Ruth Liananda Citra Dolok; Apriliyani, Tia; Karlina, Ina; Pusparini, Nur Ainun Oktavia; Zusrina, Laili Mufli; Sari, Ria Vinola Septhya; Allimi, Hayu Swari; Supraitno, Murtiadi Erlan; Saeed, Faisal; Simanungkalit, Eben Ezer; Paramita, Pradnya; Retnoaji, Bambang; Sofyantoro, Fajar; Wijayanti, Nastiti
Biological Environment and Pollution Vol. 3 No. 1 (2023)
Publisher : Association for Scientific Computing, Electronics, and Engineering (ASCEE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31763/bioenvipo.v3i1.595

Abstract

Excessive consumption of paracetamol may lead to hepatic necrosis, nephrotoxicity, extra-hepatic lesions, and even fatality in both humans and animals. The objective of this study was to examine the histological changes in the hepatocytes of yellow rasbora (Rasbora lateristriata) exposed to paracetamol. The fish were subjected to varying concentrations of paracetamol over a period of four days. Group I served as the control group without any paracetamol exposure. Groups II, III, and IV were exposed to 2, 3, and 4 mg/L of paracetamol, respectively. A total of six individuals were allocated to each of the four experimental groups. The histological analysis of the hepatic tissue following paracetamol exposure at concentrations of 2, 3, and 4 mg/L revealed hepatic damage characterized by picnosis, necrosis, and vacuolization. In summary, higher concentrations of paracetamol were associated with an increase in the severity of histopathological changes in the hepatic tissues of yellow rasbora.
The effect of Garcinia mangostana L. skin decoct exposure on Zebrafish embryo Danio rerio (Hamilton, 1822) Yunita, Neri; Retnoaji, Bambang
Biological Environment and Pollution Vol. 3 No. 1 (2023)
Publisher : Association for Scientific Computing, Electronics, and Engineering (ASCEE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31763/bioenvipo.v3i1.631

Abstract

Hypertension is one of the diseases with the highest prevalence in Indonesia and is the main cause of death in patients. Pregnant women have a risk of losing their baby due to hypertension or death. ACEI and ARB-type antihypertensive drugs are dangerous for pregnant women because they can cause fetal death. In ancient times, Indonesians have used plants as herbal medicines for generations. One of the plants that has medicinal properties is mangosteen skin (Garcinia mangostana L.) as an antihypertensive drug through its diuretic effects. However, the drugs consumed can have toxic effects if used in high concentrations. A teratogenic test is a toxic test that is specifically carried out to determine the presence of organ abnormalities in the fetus due to exposure to xenobiotic compounds. The zebrafish (Danio rerio) embryo was chosen as the research object because the chorion in the embryonic phase is transparent, so it is easy to observe. This study aimed to determine the effect of exposure to mangosteen rind decoction on zebrafish embryos' hatchability and spinal curvature. Observations were made using a Leica microscope with ANOVA data analysis. The observations showed that high treatment concentrations decreased heart rate, while high concentrations didn’t affect egg hatching rate, spine curvature, or pigment density.
Co-Authors Adelfiani, Adelfiani Aeniah, Siti Allimi, Hayu Swari Andi Gita Maulidyah Indraswari Suhri Anita Restu Puji Raharjeng Apriliyani, Tia Ardaning Nuriliani Arief Maulana Sabilillah Ariel Hananya Ariesti, Wiwin Ascarti Adaninggar Dafa, Maula Haqul Della Blatama Devi Anisa Suci Empra, Desi Eka Putri Fajar Sofyantoro Faulana, Arum Fahmi Febrina Nanda Arfiani Halim, Shuha Ma’muriyah Hayu Swari Alimi Hendry Saragih Hendry T.S.S.G. Saragih Hendry Tri Sakti Saragih Hendry Tri Sakti SG Saragih Hurul Ein Illiyin, Sirayya Jerizqa Ayu Fajar Nita Jessy Octavia Harahap Joko Nugroho Wahyu Karyadi Karlina, Ina Karunia Galih Permadani Khasanah, Luthfia Uswatun Khoiruddin Anshori Khoiruddin Anshori Laili Mufli Zusrina Laili Mufli Zusrina Larasshita Putri Adhitya Sani Lathief Al Umami M. Zainuddin Lubis Maharesi, Chesa Ekani Mayani, Olvita Muhammad Zuchri Zayzda Murtiadi Erlan Supraitno Mustamin, Yusdar Muthia Arrusyda Nastiti Wijayanti Nastiti Wijayanti Nurhidayat, Luthfi Nyan Hayu Widiastuti Oktaviana, Shintia Pertiwi, Anggita Endar Podhi, Felisitas Moli Pradnya Paramita Primahesa, Alfian Prissandi, Anthera Al Firdaus Pusparini, Nur Ainun Oktavia Rahayu, Sekar Rahmadian, Desti Rey, Juniman Ria Vena Septhay Sari Rohmah, Zuliyati Rumansara, Papuani Samparisna Ruth Liananda Citra Dolok Saribu Sadewo, Imran Saeed, Faisal Sandi Francisco Pratama Saragih, Hendry Saragih, Hendry T. S. S. G. Saragih, Hendry Tri Sakti SG Sari, Ria Vinola Septhya Saribu, Ruth Liananda Citra Dolok Septriani, Nur Indah Septriani, Nur Indah Shalihah, Fianicha Sih Kahono Simanungkalit, Eben Ezer Slamet Widiyanto Sofyantoro, Fajar Sri Pujiyati Sularsah, Sais Supraitno, Murtiadi Erlan Susilo Hadi, Susilo Tia Apriliyani Yunita, Neri Zulfadhli Zulfadhli Zuliyati Rohmah Zusrina, Laili Mufli