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Muhammad Azmi, Muhammad
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Journal : Heart Science Journal

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Association between frontal QRS-T angle and thrombus burden in patients with ST-elevation myocardial infarction: A single-center cross-sectional study Azmi, Muhammad; Nasution, Ali Nafiah; Lubis, Hilfan Ade Putra; Siregar, Abdullah Afif; Habib, Faisal; Sitepu, Andika
Heart Science Journal Vol. 6 No. 4 (2025): The Pursuit of Precision: Navigating Risks, Refining Diagnosis, and Securing Lo
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.04.13

Abstract

BACKGROUND: ST-Elevation Myocardial Infarction (STEMI) is one of the leading causes of global morbidity and mortality, with burden of thrombus as an influential factor of clinical outcomes. OBJECTIVES: The purpose of this study was to evaluate the relationship between frontal QRS-T (fQRST) angle and thrombus burden in STEMI patients. METHODS: A cross-sectional study was carried out at Haji Adam Malik General Hospital, Medan, between January 2024 and July 2024. STEMI patients who underwent coronary angiography were included. The fQRST angle was measured using a 12-lead electrocardiogram (ECG), the thrombus burden was graded according to the Thrombolysis in Myocardial Infarction (TIMI) grading system. Statistical analysis included Spearman's correlation and Receiver Operating Characteristic (ROC) curve analysis. RESULTS: 108 STEMI patients were included in the study. The fQRST angle was strongly positively correlated with thrombus burden (r = 0.61–0.80, p < 0.05). Patients with more thrombus burden had larger fQRST angles compared to patients with less thrombus burden. Additionally, diabetes mellitus and symptom delay exceeding 12 hours were highly correlated with higher thrombus burden (p < 0.05), whereas infarct-related artery (IRA) location was not significantly associated (p > 0.05). ROC curve demonstrated that the fQRST angle had an AUC of 0.88 (p = 0.001) At the optimal cut-off value of 61°, the sensitivity and specificity were 88.3% and 87.5% (95% CI of 88.5%–98.2).
Co-Authors Abdul Aziz Abdul Latif Agustiansyah, Muhammad Rizki Agustiansyah, Muhammad Rizki Agustiansyah Agustina Hanafi Alhakeem, Reinalgy Azni Alpen, Joni Aminah Aminah Andri Ramadhan Anindito Purnowidodo Apriani, Leni Apriliani, Insani Apriliani, Resty Arief, M Rudyanto Arifin, Syaiful Asgara, Zidan Az-Zahra, Annisa Azharuddin Azharuddin, Azharuddin AZMI, AZMI Bie, Kalistowen Chairil Darmawati Darmawati Djono Djono Dona Budi Kharisma, Dona Budi Elisa Elisa Elisa Eva Darnila Evadila Evadila Firdausi, Karunia Imam Fitriani Fitriani Habib, Faisal Hakim, Ummi Hafilda Hamdani, Muhammad Ananda Rizki Hanema, Vanny Hening, Beta Tiva Ratu Herawati Herawati Herlianti, Aulia Ichsan, T. Ilmi, Muhammad Fahmi Isnanda, Rizki Puji Jaya, Mochamad Jazila, Muhammad Afwan Joyosemito, Ibnu Susanto Kurni, Raden Riski Maulana Al Kurniawan Kurniawan Kusumawijaya, Rizal Izmi Latifah, Ayu Lindawati, Ratna Lubis, Hilfan Ade Putra M. Hafizulloh Maryana Maryana Maulinda, Ade Azahra Meilani, Sophia Shanti Muhammad Eko Fitrianto, Muhammad Eko Muhammad Rikza Nashrulloh Muhammad Sopyan Munajat, Ikbal Nasution, Ali Nafiah Novabegawati, Novabegawati Nurul Husna Perdana Setiawan, Surya Puspita, Intan Imda Putri, Andi Nirmala Putri, Anisa Devisa Rahayu, Raden Erwin Gunadhi Rahuma, Aulia Ramdan, Galih Muhammad Raviko, Johansyah Rizal Izmi Kusumawijaya Rosmaliati, Rosmaliati Rousanfikr, Sava Arcadia Rusdan Rusdan RUSDIYAH RUSDIYAH Sabrila, Trifebi Shina Saeful Anam Ismail Safrizal Rahman, Safrizal Saputra, Yulian Sari, Desti Eka Setyawati, Meita Sholahudin, Hary Siregar, Abdullah Afif Sitepu, Andika Siti Marfuah, Siti Slamet Wahyudi Soeddijono, Bambang Sopyan, Muhammad Sri Banun, Sri Suharyono Suharyono Suliana, I Made Suyono Suyono Syahputra, Muhammad Ilham Tri Indrahastuti Ulwatunnisa, Marwah Willyon Ferrari Yanto, Syafri Yusran, Nurul Faizah Zakaria Wahab, Zakaria Zulfiansyah, Rezky