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All Journal Medula Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Wiyata : Penelitian Sains dan Kesehatan Diklabio: Jurnal Pendidikan dan Pembelajaran Biologi Jurnal Teknologi Sistem Informasi dan Aplikasi PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Dunia Farmasi J-HESTECH (Journal Of Health Educational Science And Technology) PREPOTIF : Jurnal Kesehatan Masyarakat Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS) Medfarm: Jurnal Farmasi dan Kesehatan Jurnal Insan Farmasi Indonesia JOURNAL OF COMMUNITY ENGAGEMENT AND EMPOWERMENT Jurnal Farmasi Indonesia Jurnal Bisnis dan Ekonomi Media Farmasi Conference Proceedings International Conference on Education Innovation and Social Science International Journal of Contemporary Sciences (IJCS)
Evi Kurniawati, Evi
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Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Law, Crime, Criminology & Criminal Justice Library & Information Science Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Veterinary Other

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Perbandingan Aktivitas Antioksidan Ekstrak Kentos Kelapa (Cocos nucifera L.) Yang Diekstraksi Dengan Metode Berbeda Kurniawati, Evi
Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS) Vol 5 No 02 (2024): HERCLIPS VOL 05 NO 02
Publisher : Universitas Muhammadiyah Gresik

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30587/herclips.v5i02.7369

Abstract

Kentos kelapa (Cocos nucifera L.) merupakan bagian dalam dari buah kelapa yang sudah cukup matang, kentos kelapa memiliki senyawa bioaktif seperti alkaloid, flavonoid, terpenoid, steroid, saponin dan tanin yang dapat bermanfaat sebagai antioksidan. Antioksidan merupakan suatu senyawa yang digunakan untuk menetralisir dan mencegah kerusakan yang terjadi dalam tubuh akibat dari radikal bebas. Penelitian ini bertujuan untuk mengetahui adanya perbandingan aktivitas antioksidan pada kentos kelapa apabila dilakukan dengan metode ekstraksi yang berbeda. Metode penarikan senyawa dilakukan dengan menggunakan metode ekstraksi maserasi, perkolasi dan sokletasi, kemudian dilanjutkan dengan uji aktivitas antioksidan dengan metode FRAP (Ferric Reducing Antioxidant Power) yang diukur menggunakan spektrofotometer visible pada panjang gelombang 595 nm. Data yang diperoleh diolah menggunakan uji Kruskal-Wallis. Hasil penelitian menunjukkan adanya senyawa bioaktif berupa alkaloid, flavonoid, terpenoid, steroid, saponin dan tanin pada kentos kelapa. Aktivitas antioksidan tertinggi diperoleh ekstrak etanol kentos kelapa yang diekstraksi dengan metode perkolasi. Uji Kruskal-Wallis meunjukkan Sig. 0,027<0,05 sehingga dapat disimpulkan dari ketiga metode ekstraksi terdapat perbedaan aktivitas antioksidan yang bermakna. Kata kunci :kentos kelapa, ekstraksi, antioksidan, FRAP
Factors Affecting Potentially Inappropriate Medications (PIMs) Based on STOPP/START Criteria in Geriatric Patients at RSUD Dr. Soedomo Trenggalek: Faktor-Faktor yang Mempengaruhi Potentially Inappropriate Medications (PIMs) Berdasarkan Kriteria STOPP/START pada Pasien Geriatri di RSUD Dr. Soedomo Trenggalek Widyaningrum, Esti Ambar; Fitriani, Marina; Irawati, Reny Nur Satya; Fajriyah, Shofiatul; Kurniawati, Evi; Lestari, Tri Puji
Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) Vol. 10 No. 2 (2024): (October 2024)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/j24428744.2024.v10.i2.16641

Abstract

Background: Geriatric patients often have multiple comorbidities and decreased physiological function, leading to polypharmacy and potential exposure to inappropriate medications (PIMs). Objectives: This study investigates geriatric inpatients' characteristic profiles, evaluates PIMs using STOPP/START criteria, and explores factors influencing PIM incidence. Method: This study employed a retrospective observational analytical approach. The sampling technique was purposive sampling. The sample involved in this study was 312 patients. Results: The geriatric patients involved in this study had the following characteristics: 62% male and 38% female; 69% youngest-old (65-74 years), 30% middle-old (75-90 years), and 1% oldest-old (>90 years); 87% with BPJS service type and 13% with general service type; main diagnosis groups of the patients were gastrointestinal of 9%, cardiovascular of 31%, respiratory of 3%, neurological of 1%, infection of 11%, endocrine of 13%, genitourinary of 15%, immune an malignant of 1%, blood of 11%, musculoskeletal of 2%, eyes of 2% and skin of 1%; 13% patients had one disease, 43% had two diseases, 25% had three diseases, and 19% had ≥ four diseases;29% had 15 drugs, 50% had 6-10 drugs, 17% had 11-15 drugs, 3% had 20 drugs, and 1% had ≥ 20 drugs. There were 72 PIMs based on STOPP/START criteria. The results of the analysis using the C contingency coefficient test showed the following factors, such as gender (p-value of 0.894), age (p-value of 0.470), type of service (p-value of 0.166), main diagnosis (p-value of 0.042), number of illness (p-value of 0.106), and number of drugs (p-value of 0.182). Conclusion: There is a correlation between the main diagnosis factor and PIMs with a p-value of 0.042 (p-value < 0.05).
Uji Perbandingan Pelarut Metanol dan Etanol 96% Terhadap Hasil Kromatografi Lapis Tipis Flavonoid pada Tanaman Daun Patikan Kebo (Euphorbia hirta L.) Hari Purwani, Asih Imulda Asih; Sari, Fita; Kharisma, Krisna; Nurhayati, Rachma; Kurniawati, Evi
Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS) Vol 6 No 01 (2024): HERCLIPS VOL 06 NO 01
Publisher : Universitas Muhammadiyah Gresik

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30587/herclips.v6i01.8226

Abstract

Daun patikan kebo merupakan tanaman yang mengandung senyawa metabolit sekunder golongan flavonoid, terpenoid, tanin dan fenolik. Penelitian ini bertujuan untuk mengetahui uji perbandingan pelarut metanol dan etanol 96% terhadap hasil kromatografi lapis tipis flavonoid pada tanaman daun patikan kebo (Euphorbia hirta L.). Metode daun patikan kebo diekstraksi dengan maserasi dengan pelarut yang digunakan yaitu metanol dan etanol 96%. Skrining dilakukan menggunakan reagen Pb Asetat 10% dan NaOH 20%. Kromatografi lapis tipis (KLT) menggunakan fase gerak n-butanol : asam asetat glasial : air (4:1:5) dan fase diam plat silika gel G60 F254. Hasil skrining fitokimia yaitu negatif pada penambahan reagen Pb Asetat 10% dan hasil positif pada penambahan reagen NaOH 20%. Pada hasil penelitian dianalisis terjadi perubahan warna pada plat KLT dari biru menjadi fluoresensi nyala biru muda. Kesimpulan didapatkan nilai Rf ekstrak metanol empat bercak flavonoid dengan nilai Rf 033, 0,47, 0,61 dan 0,88, sedangkan ekstrak etanol 96% terdapat tiga bercak flavonoid dengan nilai Rf 0,29, 0,46 dan 0,59. Kata kunci : Daun Patikan Kebo, Skrining Fitokimia, KLT
Analisis Faktor-Faktor yang Mempengaruhi Kejadian Potentially Inappropriate Medications (PIMs) pada Pasien Geriatri Rawat Inap RSUD Dr. Soedomo Trenggalek Widyaningrum, Esti Ambar; Rizky, Fara Nikhmatul; Irawati, Renny Nur Satya; Fajriyah, Shofiatul; Rilawati, Fentyana Dwi; Kurniawati, Evi; Lestari, Tri Puji
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 17 No. 1 (2025): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfionline.v17i1.271

Abstract

Background: Geriatric patients are elderly patients with multiple diseases. Geriatric patients have more comorbidities and often receive polypharmacy prescriptions. PIMs have been identified in many elderly patients. One of the explicit criteria that can be used to identify the incidence of PIMs in geriatric patients is the Beers Criteria. Objective: To determine the frequency of PIMs and the factors that can influence the occurrence of PIMs based on the Beers Criteria in hospitalized geriatric patients at RSUD Dr. Soedomo Trenggalek. Method: This research uses a type of research with a retrospective observational analytical approach. The sampling technique used was purposive sampling with a total sample of 312 medical records.  Inclusion criteria: age ≥ 65 years and exclusion: incomplete medical record data. Results: The most common characteristic profiles were male gender (62%), elderly (65-74 years) 69%, type of BPJS service (87%), main disease with the cardiovascular system (31%), number of diseases 2 (43%) and the number of drugs 6-10 drugs (50%). There was an incidence of PIMs of 78.53%. The factors gender, age, type of service, main diagnosis have a p value ≥ 0.05, while the number of diseases and medications have a p value ≤ 0.05. Conclusion: There is an incidence of PIMs in hospitalized geriatric patients of 78.53% with the number of diseases and number of medications influencing the incidence of PIMs in hospitalized geriatric patients.
Skrining Fitokimia Kualitatif Ekstrak Etanol 96% dan H-Heksana Kulit Batang Bakau Lindur (Bruguiera gymnorrhiza) Ismunanto, Aziza Regina Kinasih; Kurniawati, Evi; Putri, Giska Tri; Susianti, Susianti
Medula Vol 15 No 1 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i1.1253

Abstract

Lindur mangrove plants (Bruguiera gymnorrhiza) are known to contain secondary metabolite compounds which function as antibacterials. These secondary metabolite compounds include alkaloids, flavonoids, tannins, phenols, saponins, terpenoids and steroids. The design of this research was experimental, carried out to determine and compare the phytochemical components contained in 96% ethanol extract and n-hexane of Bruguiera gymnorrhiza mangrove bark. Bruguiera gymnorrhiza mangrove bark was taken at KPH Gunung Balak, East Lampung, then 4.5 kg of wet mangrove bark was obtained and dried for 7 days, then the extract was made using the maceration method for 3x24 hours using 2 types of solvents, namely 96% ethanol and n-hexane with a ratio of 1:10 between simplicia and solvent. Thick extracts were obtained from the two types of solvents which were then carried out qualitative phytochemical tests.  The results of this study showed that 96% ethanol extract and n-hexane of Bruguiera gymnorrhiza mangrove bark positively contained secondary metabolite compounds. The 96% ethanol extract of Bruguiera gymnorrhiza mangrove bark contains all types of secondary metabolite compounds, namely alkaloids, flavonoids, tannins, phenols, saponins, terpenoids and steroids, while the n-hexane extract contains secondary metabolite compounds, namely alkaloids, flavonoids, tannins, phenols, terpenoids, steroid but does not contain saponins. The conclusion of this research is that the 96% ethanol extract of Bruguiera gymnorrhiza mangrove bark contains more secondary metabolite compounds than the n-hexane extract of Bruguiera gymnorrhiza mangrove bark.
Tinjauan Pustaka: Pengaruh Hipertensi Kronis pada Ibu Hamil terhadap Kejadian Preeklampsia Putri, Morica Angellia Shyama; Kurniati, Intanri; Putri, Giska Tri; Kurniawati, Evi
Medula Vol 15 No 1 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i1.1458

Abstract

Chronic hypertension in pregnant women is a medical condition that can significantly affect maternal and fetal health. Chronic hypertension is defined as high blood pressure that has been present before pregnancy or diagnosed before 20 weeks of gestation. Risk factors that affect this condition include older maternal age, obesity, family history of hypertension, and an unhealthy lifestyle. The pathophysiology of chronic hypertension that progresses to preeclampsia involves endothelial dysfunction, which causes vasoconstriction and decreased placental perfusion, leading to placental hypoxia and increased oxidative stress, which further triggers activation of systemic inflammatory pathways causing damage to target organs such as the kidneys (proteinuria) and liver (elevated liver enzymes). The prevalence of chronic hypertension in pregnant women in Indonesia is quite high. According to data from the Lampung Provincial Health Office in 2018, hypertension in pregnancy caused 15.16% of maternal deaths. In addition, data from Riskesdas 2018 shows that the prevalence of hypertension in pregnant women in Indonesia is 6.18%, with the highest prevalence in West Java Province at 10.57%. The purpose of this article is to provide a better understanding of the effect of chronic hypertension in pregnant women on the incidence of preeclampsia. This article will discuss the association of chronic hypertension with the risk and underlying mechanisms of preeclampsia.
PENGARUH EKSTRAK DAUN RANDU (Ceiba pentandra) TERHADAP PROSES PENYEMBUHAN LUKA SAYAT PADA MENCIT (Mus musculus L) Jezmy, Beby Kelidia; Oktarlina, Rasmi Zakiah; Sari, Ratna Dewi Puspita; Kurniawati, Evi
Medula Vol 15 No 2 (2025): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v15i2.1607

Abstract

Wound causes mechanical bleeding, inducing a response of the body to fix itself which undergoes a wound healing process through a few phases; hemostasis, inflammation, proliferation, and maturation or remodelling. Wound healing is a complex process due to biocellular and biochemistry activities occuring continously. One of the natural treatments is the administration of randu (Ceiba pentandra) leaf, a Spermatophyte which has been identified and used for its healing properties. This study was an experimental study with a post-test-only control group design, and datas were analyzed using a non-parametric Kruskal Wallis test. Treatments were given randu (Ceiba pentandra) leaf extract, grouped into 4: (K1): a negative control group, (P1): 40 ml of randu (Ceiba pentandra) leaf extract, (P2): 60 ml of randu (Ceiba pentandra) leaf extract, and (P3): 80 ml of randu (Ceiba pentandra) leaf extract. Through this study, randu (Ceiba pentandra) leaf extracts were rated based on the its wound healing rate and showed results of 80 ml, 60 ml, and 40 ml respectively. There is an effect of administration of randu (Ceiba pentandra) leaf extract on cut wound healing in mice (Mus musculus L) (p=0,037)  
Phytochemical Composition of 70% Ethanol Extract of Noni Fruit (MorindacitrifoliaL.) Using Ultrasound-Assisted Extraction Method and LC-MS Q-ToF Kurniawati, Evi; Lestari, Tri Puji; Kristianingsih, Ida; Purwani, Asih Imulda Hari; Nurhayati, Rachma
MEDFARM: Jurnal Farmasi dan Kesehatan Vol 14 No 1 (2025): Medfarm: Jurnal Farmasi dan Kesehatan
Publisher : LPPM Akafarma Sunan Giri Ponorogo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.48191/medfarm.v14i1.573

Abstract

Noni (Morinda citrifolia L.) is a traditional medicinal plant that is widely used in the treatment of various degenerative diseases. However, scientific data regarding the composition of its bioactive compounds are still limited, especially those analyzed using a high-precision instrument approach. This study aims to identify the phytochemical composition in 70% ethanol extract of noni fruit using Liquid Chromatography-Mass Spectrometry (LC-MS) method. Extraction was performed by Ultrasound-Assisted Extraction (UAE) method and compound analysis using Q-ToF type LC-MS instrument with positive ionization mode. The results showed that noni extract contained 28 compounds, with 13 compounds successfully identified consisting of 7 alkaloids, 3 glycosides, 1 phenolic, 1 amino acid, and 1 aminoglycoside. The major compound identified was Methyl (5R)-2,3,4-tris-O-(methoxymethyl)-5-{2-[(2R,3R,4R,5R,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-piperidinyl]ethyl}-α-D-xylopyranoside, belonging to the glycoside group with a molecular weight of 485.25 g/mol. These results indicate that noni fruit contains diverse secondary metabolite compounds with the dominance of alkaloid and glycoside compounds. This study contributes to providing primary data based on LC-MS technology on the chemical composition of Indonesian natural ingredients and can be a scientific basis for the development of medicinal plant-based pharmaceutical preparations with noni active ingredients.
Pemetaan Sistematis Topik Nature Of Science Berdasarkan Analisis Bibliometrik Menggunakan VOSViewer Kurniawati, Evi; Afandi; Eko Sri Wahyuni
Diklabio: Jurnal Pendidikan dan Pembelajaran Biologi Vol 7 No 1 (2023)
Publisher : UNIB Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33369/diklabio.7.1.38-48

Abstract

Nature of science merupakan model pembelajaran yang berlandaskan pada pemahaman konstruktivisme dengan pendekatan inkuiri. Penelitian ini memiliki tujuan untuk mengetahui pemetaan sistematis jurnal internasional terkait topik nature of science berdasarkan analisis bibliometrik menggunakan VOSViewer. Penelitian ini menggunakan metode deskriptif dengan pendekatan kuantitatif. Dalam mengumpulkan data, digunakan aplikasi Publish or Perish dengan keywords berupa background readings, case study discussions, inquiry lessons, inquiry labs, historical studies, dan multiple assessments. Pengolahan dan analisis data menggunakan aplikasi mendeley dan VOSViewer. Hasil penelitian menunjukkan bahwa dari 777 artikel jurnal internasional yang dipublikasi, jumlah publikasi tertinggi terjadi pada tahun 2020 sebesar 108 artikel jurnal yaitu sebesar 13,90%. Jurnal yang paling banyak mempublikasi artikel adalah Science and Education. Peneliti yang paling produktif mempublikasikan sebanyak 14 artikel. Sitasi terbanyak pada sebuah artikel adalah sebesar 731 sitasi. Pemetaan visualisasi jaringan terbagi menjadi 2 clusters, dimana case study discussions menjadi topik yang sering dikutip pada tahun 2014-2018. Topik selanjutnya yang paling banyak dikutip adalah historical studies, inquiry lessons, inquiry labs, multiple assessments, nature of science, background readings.
Edukasi Penggunaan Suplemen Selama Pandemi Covid-19 pada Kader Kesehatan di Wilayah Kerja Puskesmas Karangan Kabupaten Trenggalek: Education on the Use of Supplements During the Covid-19 Pandemic for Health Cadres in the Work Area of the Karangan Health Center Trenggalek Regency Widyaningrum, Esti Ambar; Kurniawati, Evi; Lestari, Tri Puji; Pertiwi, Krisna Kharisma
PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Vol. 8 No. 6 (2023): PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat
Publisher : Institute for Research and Community Services Universitas Muhammadiyah Palangkaraya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33084/pengabdianmu.v8i6.5547

Abstract

Several ways can be used to boost the immune system, one of which is by using supplements that can be obtained through a doctor's recommendation or pharmacist consultation. Low immunity in humans will make it easy to be exposed to diseases or viruses, including quickly exposure to Covid-19. This is why many people take supplements: they think the amount of minerals and vitamins they get from their food is insufficient to keep their immune system healthy. One of the considerations for taking supplements is knowledge of their benefits. Even though supplements are not drugs, their use must also be rational. Individuals with adequate knowledge, especially about supplements, will tend to choose and use supplements according to conditions and benefits for the body. To find out the effectiveness of counseling in increasing knowledge of the use of supplements to increase body immunity during the Covid-19 pandemic for health cadres in the Karangan Health Center, Trenggalek Regency working area. This community service is conducted through lectures and question-and-answer method counseling. The number of participants in this activity was 33 health workers in the work area of the Karangan Health Center, Trenggalek Regency. Results: There was an increase in knowledge of the use of immunity-boosting supplements in health cadres in the work area of the Karangan Health Center, Trenggalek Regency, from the majority of sufficient knowledge (pre-test) to good (post-test). Education on using supplements can increase the knowledge of health cadres in the work area of the Karangan Health Center.
Co-Authors Afandi Ali Ikhwan Anis Akhwan Dhafin Ardianto, Dimas Arief, Muhtosim Asih Imulda Hari Purwani Dewy Resty Basuki, Dewy Resty Eko Sri Wahyuni Esti Ambar Widyaningrum Esti Ambar Widyaningrum Faisal Akhmal Muslikh Fendy Prasetyawan Fita Sari, Fita Fitriani, Marina Giska Tri Putri Herlinda Mawardika Ida Kristianingsih Intanri Kurniati Irawati, Renny Nur Satya Irawati, Reny Nur Satya Ismunanto, Aziza Regina Kinasih Jezmy, Beby Kelidia Kharisma, Krisna KRISNA KHARISMA PERTIWI Lestari, Tri Puji Ma'arif, Burhan Mawarni, Agrintya Indah Mita Riandini, Hanifa Ninis Yuliati, Ninis Putri, Morica Angellia Shyama Rachma Nurhayati Rasmi Zakiah Oktarlina Ratna Dewi Puspita Sari Riadi, Refren Rilawati, Fentyana Dwi Rizky, Fara Nikhmatul Salmasfattah, Novyananda Shofiatul Fajriyah Shoviantari, M.Farm., Apt., Fenita Sony Andika Saputra Sugiyartono, Sugiyartono Susianti, Susianti Tri Puji Lestari Zenmas, Syendriva Zeptyan