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All Journal Medula MPI (Media Pharmaceutica Indonesiana) Jurnal Manajemen Pendidikan Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) Jurnal Wiyata : Penelitian Sains dan Kesehatan Diklabio: Jurnal Pendidikan dan Pembelajaran Biologi Jurnal Teknologi Sistem Informasi dan Aplikasi JKM (Jurnal Kebidanan Malahayati) PengabdianMu: Jurnal Ilmiah Pengabdian kepada Masyarakat Jurnal Dunia Farmasi J-HESTECH (Journal Of Health Educational Science And Technology) PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Riset Kefarmasian Indonesia Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS) Medfarm: Jurnal Farmasi dan Kesehatan Jurnal Insan Farmasi Indonesia JOURNAL OF COMMUNITY ENGAGEMENT AND EMPOWERMENT Jurnal Farmasi Indonesia Media Farmasi Conference Proceedings International Conference on Education Innovation and Social Science International Journal of Contemporary Sciences (IJCS)
Evi Kurniawati, Evi
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Penetapan Kadar dan Uji Stabilitas Senyawa Stigmasterol pada Obat Herbal Peluruh Batu Ginjal yang Mengandung Ekstrak Keji Beling (Strobilanthes crispus) menggunakan Metode KCKT Purwani, Asih Imulda Hari; Aryantini, Dyah; Kurniawati, Evi; Wahyuni, Dwi; Pramasari, Nadia
MPI (Media Pharmaceutica Indonesiana) Vol. 8 No. 1 (2026): JUNE
Publisher : Fakultas Farmasi, Universitas Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24123/mpi.v8i1.7774

Abstract

Nefrolitiasis atau batu ginjal merupakan salah satu gangguan saluran kemih yang prevalensinya terus meningkat di berbagai negara, termasuk Indonesia. Penggunaan tanaman obat sebagai terapi alternatif telah banyak dilakukan, salah satunya Strobilanthes crispus (keji beling) yang secara empiris memiliki efek peluruh batu ginjal. Efektivitas tanaman ini berkaitan dengan keberadaan senyawa aktif salah satunya adalah stigmasterol. Penetapan senyawa marker menjadi aspek penting dalam proses standardisasi untuk menjamin kualitas dan konsistensi produk herbal. Metode analisis berbasis kromatografi, seperti Kromatografi Cair Kinerja Tinggi (KCKT), banyak digunakan dalam identifikasi, uji stabilitas dan penetapan kadar senyawa marker. Hasil penelitian menunjukkan stabilitas senyawa aktif stigmasterol pada produk kapsul herbal dalam rentang waktu 0–24 jam, terdapat penurunan area pada larutan standar kurang dari 2% dan pergeseran waktu retensi (tR) juga kurang dari 2%. Hasil pengujian diperoleh persen kadar stigmasterol sebesar 16,07% dengan nilai Vxo 3,48%. Nephrolithiasis, or kidney stone disease, is one of the most common urinary tract disorders, with a prevalence that continues to increase worldwide, including in Indonesia. The use of medicinal plants as alternative therapies has been widely explored, one of which is Strobilanthes crispus, which is empirically known for its diuretic and lithotriptic effects. The effectiveness of this plant is associated with the presence of bioactive compounds, particularly stigmasterol. The determination of marker compounds is a crucial aspect of the standardization process to ensure the quality and consistency of herbal products. Chromatography-based analytical methods, such as High-Performance Liquid Chromatography (HPLC), are commonly employed for compound identification, stability testing, and quantification of marker compounds. The results of this study demonstrated that stigmasterol exhibited good stability in herbal capsule formulations within a time range of 0–24 hours, with a decrease in standard solution area of less than 2% and a retention time (tR) shift was below 2%. The stigmasterol content was determined to be 16.07%, with a Vxo value of 3.48%.
Co-Authors Afandi Ali Ikhwan Anis Akhwan Dhafin Ardianto, Dimas Asih Imulda Hari Purwani Dewy Resty Basuki, Dewy Resty Dwi Wahyuni Dyah Aryantini, Dyah Eko Sri Wahyuni Esti Ambar Widyaningrum Esti Ambar Widyaningrum Faisal Akhmal Muslikh Fendy Prasetyawan Fita Sari, Fita Fitriani, Marina Giska Tri Putri Hardini, Pri Hardini Herlinda Mawardika Hety, Dyah Siwi Ida Kristianingsih Ika Yuni Susanti, Ika Yuni Intanri Kurniati Irawati, Renny Nur Satya Irawati, Reny Nur Satya Ismunanto, Aziza Regina Kinasih Jezmy, Beby Kelidia Kharisma, Krisna KRISNA KHARISMA PERTIWI Lestari, Tri Puji Ma'arif, Burhan Mawarni, Agrintya Indah Mita Riandini, Hanifa Nadia Pramasari Nandang Nandang Ninis Yuliati, Ninis Putri, Morica Angellia Shyama Rachma Nurhayati Rachmawati, Siti Dewi Rasmi Zakiah Oktarlina Ratna Dewi Puspita Sari Rilawati, Fentyana Dwi Rizky, Fara Nikhmatul Safitri, Citra Adityarini Salmasfattah, Novyananda Shofiatul Fajriyah Shoviantari, M.Farm., Apt., Fenita Sony Andika Saputra Sugiyartono, Sugiyartono Susianti Susianti Tri Puji Lestari Zenmas, Syendriva Zeptyan