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All Journal VALENSI Pharmaciana: Jurnal Kefarmasian Media Farmasi : Jurnal Ilmu Farmasi (Journal Of Pharmaceutical Science) E-Dimas: Jurnal Pengabdian kepada Masyarakat Jurnal Kesehatan Bakti Tunas Husada ALCHEMY Jurnal Penelitian Kimia JMM (Jurnal Masyarakat Mandiri) JFL : Jurnal Farmasi Lampung Jurnal Kreativitas PKM JFIOnline Jurnal Pengabdian kepada Masyarakat Nusantara Jurnal Insan Farmasi Indonesia J-ABDIPAMAS (Jurnal Pengabdian Kepada Masyarakat) Jurnal Pengabdian Pada Masyarakat Riset Informasi Kesehatan Warta LPM Jurnal Pengabdian Masyarakat (Jupemas)
Tresna Lestari, Tresna
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Journal : JFIOnline

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Studi Interaksi Senyawa Turunan 1,3-Dibenzoiltiourea sebagai Ribonukleotida Reduktase Inhibitor Lestari, Tresna
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol 7, No 3 (2015)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

In this research, docking process was carried out from 1,3-dibenzoylthio- urea derivates compound to ribonucleotide reductase receptor. The receptor used was 2EUD with ligand GCQ (Gemsitabine Diphosphate) obtained from the website of protein data bank (PDB). The purpose of this research was to ????ind out the inter- action and toxicity of 1,3-dibenzoylthiourea derivates compound to ribonucleotide reductase receptor. All compounds was docked using ArgusLab 4.0.1 applications. The docking process performed by the method of ArgusDock. The validation of dock- ing used RMSD value gained < 2 that is 1, 704524 on calculate size X=16.5, Y=17.25 and Z=16.75. The analysis of docking result showed that 1,3-bis[(3-methylphenyl) carbonyl]thiourea compound can be predicted to have lowest free binding energy (ΔG) than comparative ligand and parent compound. From this research result can conclude that 1,3-bis[(3-methylphenyl)carbonyl]thiourea to inhibitor activity of ri- bonucleotide reductase receptor. Toxicity test accomplished using ToxTree applica- tion, with parameter such as Cramer Rules, Benigni / Bossa rulebase and Kroes TTC decision tree.  Key word: Docking, 1,3-dibenzoylthiourea, ribonucleotide reductase inhibitor, toxicity
Studi Interaksi Senyawa Turunan 1,3-Dibenzoiltiourea sebagai Ribonukleotida Reduktase Inhibitor Lestari, Tresna
Jurnal Farmasi Indonesia Vol 7, No 3 (2015)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (389.645 KB) | DOI: 10.35617/jfi.v7i3.183

Abstract

In this research, docking process was carried out from 1,3-dibenzoylthio- urea derivates compound to ribonucleotide reductase receptor. The receptor used was 2EUD with ligand GCQ (Gemsitabine Diphosphate) obtained from the website of protein data bank (PDB). The purpose of this research was to ô°ind out the inter- action and toxicity of 1,3-dibenzoylthiourea derivates compound to ribonucleotide reductase receptor. All compounds was docked using ArgusLab 4.0.1 applications. The docking process performed by the method of ArgusDock. The validation of dock- ing used RMSD value gained < 2 that is 1, 704524 on calculate size X=16.5, Y=17.25 and Z=16.75. The analysis of docking result showed that 1,3-bis[(3-methylphenyl) carbonyl]thiourea compound can be predicted to have lowest free binding energy (Î?G) than comparative ligand and parent compound. From this research result can conclude that 1,3-bis[(3-methylphenyl)carbonyl]thiourea to inhibitor activity of ri- bonucleotide reductase receptor. Toxicity test accomplished using ToxTree applica- tion, with parameter such as Cramer Rules, Benigni / Bossa rulebase and Kroes TTC decision tree.  Key word: Docking, 1,3-dibenzoylthiourea, ribonucleotide reductase inhibitor, toxicity
Co-Authors Ahadi, Ghany Ahmad Tantowi Jaohari Alifia, Fathia Putri Andriani, Yeni Yulia Anggi Agustira Anindita Tri Kusuma Pratita Anindita Tri Kusuma Pratita Anindita Tri Kusuma Pratita Anisa Pebiansyah Anna Yuliana, Anna Annazalia Rustandi Putri Annisa Pebiansyah APP, Ferrinda Yunisha Ardiansyah, Dandi Arisanti, Nisa Arman, Siti Alisa Asep Robby, Asep ayunda Azahra, Fildza Fathila Cahyati, Keni Ida Citra Dewi Salasanti Dewi Dewi Diana Sri Zustika Dimas Rahman Fauzi Ditha Rizqi Aulia Utami Dudi Nurmalik F, Alya Nisrina F, Syifa Nur Fadilah, Refi Tazhqiyatul FAJAR SETIAWAN Falya, Yuniarti Fathurohman, Mochamad Fauziarahma, Wulan Fikri Alatas Firmansya, Ardianes Fitriani, Vina Nurul Gatut Ari Wardani Gunawan, Cyndi Arwini Hafsah, Nadia Auliya Hartyana Sutarna, Titta Hendy Suhendy Heri Herdiana Ilham Alifiar Ilham Alifiar Ilham Alifiar Imam Mustaqim Garna Ira Rahmiyani Keni Idacahyati Keni Idacahyati Kharina, Elin Leli Siti Zaqiah Lilis Tuslinah Lilis Tuslinah Lilis Tuslinah Lilis Tuslinah, Lilis Lusi Nurdianti, Lusi M. Faturohman Maryam, Sinta Dewi Maryanto, Naida Ajeng MAULANA, RIZA Mentari, Putri Moch. Reza Pratama Mochamad Fathurahman Mochamad Fathurohman Muharam Priatna Muharam Priatna Nofianti, Tita Nofianti, Tita Nur Laili Dwi Hidayati Nur Rahayuningsih Nur Rahayuningsih, Nur Nurafia, Fitri Nurbaeti, Yulia Nurdianingsih, Sefi Nurlita, Putri Nurmalasari, Anisa Nurmalasari, Trisna Nurmalik, Dudi Nurmalik, Dudi Pikri Adit Praditya R Pratama, Moch. Reza Pratita, Anindita Tri Kusuma Putri Pratiwi Rahadian, Gio Handika Rahmi, Sulis Gina Renny Amelia Richa Mardianingrum Rissa Putri Aulia Yulianto Ruswanto, Ruswanto Saeful Amin Setyaningsih, Indah Shal Nurdinda Fauziah Sindi Lestari Sri Asih Suharyani, Ine Sutaryat, Lulu Dhamayanti Syafar, Ridho Mulya Tiara Permata Sari Tifa Nofianti Tita Nofianti Tita Nofianti Tita Nofianti Tita Nofianti Tita Nofianti Tita Nofianti Tita Nofianti, Tita Tuslinah, Lilis Tuslinah, Lilis Tussadiyah, Halimah Vera Nurviana Winda Trisna Wulandari, Winda Trisna Yayan Rizikiyan Yulia Salmini Yunia Amalia Zahara, Sita