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All Journal Indonesian Journal of Pharmaceutical Science and Technology Acta Pharmaceutica Indonesia Jurnal Mandala Pharmacon Indonesia ad-Dawaa : Journal of Pharmaceutical Sciences Proceeding of Mulawarman Pharmaceuticals Conferences Abdimas Indonesian Journal Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan
Angga Cipta Narsa
Research And Development Laboratory Of Farmaka Tropis, Faculty Of Pharmacy, Mulawarman University, Samarinda, Indonesia
Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Social Sciences

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Efek Antimikroba Sediaan Salep Kulit Berbahan Aktif Ekstrak Etil Asetat Daun Sungkai (Peronema Canencens Jack.) terhadap Bakteri Patogen Penginfeksi Luka Bakar Arsyik Ibrahim; Islamudin Ahmad; Angga Cipta Narsa; Yurika Sastyarina
Journal of Tropical Pharmacy and Chemistry Vol. 2 No. 3 (2013): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v2i3.58

Abstract

Research on the effects of skin ointment dosage active ingredient ethyl acetate leaf extract Sungkai (Peronema canencens Jack.) has be done burns infection against pathogens bacteria. This study aims to determine the effective concentration of the ethyl acetate extract antimicrobial in skin ointment preparations against pathogens skin burns infection. Test material obtained by fractionation of the methanol extract of leaves Sungkai, further formulated into an ointment base, was tested to determine the effective concentration of activity. The results obtained by the concentration of effective skin ointment preparation with the active ingredient ethyl acetate leaf extract Sungkai is 4% for gram-positive bacteria: B. subtilis and S. aureus, dankonsentrasi 2% for gram-negative bacteria: P. aeruginosa and Str. mutans. Key words: P. canencens Jack, Formulation, Antimicrobials, B. subtilis, S. aureus, P. aeruginosa, Str. Mutans ABSTRAK Telah dilakukan penelitian efek sediaan salep kulit berbahan aktif ekstrak etil asetat daun sungkai (Peronema canencens Jack.) terhadap bakteri patogen penginfeksi luka bakar. Penelitian ini bertujuan mengetahui konsentrasi efektif antimikroba ekstrak etil asetat dalam sediaan salep kulit terhadap bakteri patogen penginfeksi luka bakar. Bahan uji diperoleh dengan fraksinasi ekstrak metanol daun sungkai, selanjutnya formulasikan ke dalam basis salep, diuji aktivitasnya untuk menentukan konsentrasi efektif. Hasil penelitian diperoleh konsentrasi efektif sediaan salep kulit dengan bahan aktif ekstrak etil asetat daun Sungkai adalah 4 % untuk bakteri gram positif: B. subtilis dan S. aureus, dankonsentrasi 2% untuk bakteri gram negatif: P. aeruginosa dan Str. Mutans. Kata kunci : P. canencens Jack, Formulasi, Antimikroba, B. subtilis, S. aureus, P. aeruginosa, Str. mutans.
Aktivitas Gel Mulut Berbahan Aktif Ekstrak Daun Sirih Hitam Kalimantan sebagai Antimikroba Penyebab Radang Gusi (Gingivitis) dan Gigi Berlubang (Caries) Fajar Prasetya; Angga Cipta Narsa
Journal of Tropical Pharmacy and Chemistry Vol. 2 No. 3 (2013): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v2i3.60

Abstract

This study aimed to test the activity of active ingredient mouth gel preparation of kalimantan black piper betle leaf extract with the main base of Hydroxy Ethyl Cellulose namely (HEC) as a mucoadhesive polymer that is able to increase the attractive forces between the active material with a layer of mucus that will extend the contact time with the active ingredient tissue targets, moreover would be increase the effectiveness of antimicrobial activity causes inflammation of the gums (gingivitis) and tooth decay (caries). Activities that have been implemented are mouth gel activity assays with Kalimantan black piper betle leaf extract as in- vitro using the agar diffusion method pitting. In testing with active oral gel preparation of black piper betle leaf extract with the main base of Hydroxy Ethyl Cellulose namely (HEC) as in vitro, it can be seen that the sample may provide the inhibitory effect of the fungus Candida albicans and the bacterium Streptococcus mutans in the presence of a clear zone indicated on the medium. Furthermore, at this stage of the dilution of the gel in twice causing decline in the effectiveness of the inhibition of both the fungus Candida albicans and the bacterium Streptococcus mutans. The results of in- vitro testing without dilution is 19.8 mm in bacteria Streptococcus mutans and 34.4 mm in the fungus Candida albicans. Keywords: antimicrobial, oral gel, black piper betle, gingivitis , cavities ABSTRAK Penelitian ini bertujuan untuk menguji aktivitas sediaan gel mulut berbahan aktif ekstrak daun sirih hitam Kalimantan dengan basis utama yakni Hydroxy Ethyl Cellulose (HEC) sebagai mucoadhesive polymer yang mampu meningkatkan gaya tarik menarik antara bahan aktif dengan lapisan mukus sehingga akan memperpanjang waktu kontak bahan aktif dengan jaringan target, selanjutnya akan meningkatkan efektivitas aktivitas antimikroba penyebab radang gusi (gingivitis) dan gigi berlubang (caries). Kegiatan yang telah dilaksanakan adalah pengujian aktivitas gel mulut berbahan aktif ekstrak daun sirih hitam Kalimantan secara in vitro dengan menggunakan metode difusi agar teknik sumuran. Pada pengujian sediaan gel mulut berbahan aktif ekstrak daun sirih hitam Kalimantan dengan basis utama yakni Hydroxy Ethyl Cellulose (HEC) secara in vitro, dapat diketahui bahwa sampel dapat memberikan efek penghambatan jamur Candida albicans dan bakteri Streptococcus mutans dengan ditunjukkan adanya zona bening pada agar. Namun pada tahap dua kali pengenceran terhadap gel terjadi penurunan efektivitas kerja penghambatan baik pada jamur Candida albicans maupun pada bakteri Streptococcus mutans. Hasil pengujian in-vitro tanpa pengenceran adalah 19.8 mm pada bakteri Streptococcus mutans dan 34.4 mm jamur Candida albicans. Kata kunci: antimkroba, gel mulut, sirih hitam, radang gusi, gigi berlubang
Formulation of Hand Sanitizer Gel Jatropha Sap (Jatropha curcas L) as Antiseptic Siswati Siswati; Fika Aryati; Angga Cipta Narsa
Journal of Tropical Pharmacy and Chemistry Vol. 6 No. 1 (2022): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v6i1.333

Abstract

Jatropha curcas (Jatropha curcas L) is a medicinal plant that is often used, especially its sap. Jatropha sap contains secondary metabolite compounds in the form of saponins, flavonoids, and tannins which have antibacterial activity. This study aims to determine the antibacterial activity of Jatropha sap against Escherichia coli and Staphylococcus aureus, to determine the antibacterial activity of jatropha hand sanitizer gel preparation against Escherichia coli and Staphylococcus aureus, and to find out the best formula for hand sanitizer gel from jatropha that has antibacterial effectiveness against Escherichia coli and Staphylococcus aureus. This research was conducted by formulating hand sanitizer gel from jatropha sap with various concentrations. Based on the research data, the best data obtained for the concentration of jatropha sap which has antibacterial activity against Escherichia coli and Staphylococcus aureus is 10% with inhibition values of 13,33 ± 0,57 and 12,86 ± 0,51 the best concentrations of gel preparations. Hand sanitizer from jatropha sap which has antibacterial activity against Escherichia coli and Staphylococcus aureus is 10% with inhibitory value of 12,63 ± 0,35 and 12,10 ± 0,17 and the best formula for hand sanitizer gel contains jatropha sap fence with a concentration of 5% with a diameter value of 6,36 cm, pH 4,89, a viscosity of 4,60 ± 0,14 Pa.S, a clear whitish color with a gel-shaped texture and a homogeneous preparation.
The Potency of the Genus Uncaria from East Borneo for Herbal Medicine Purposes: A Mini-review Maria Almeida; Supriatno Salam; Agung Rahmadani; Helmi Helmi; Angga Cipta Narsa; Sri Agung Fitri Kusuma; Sriwidodo Sriwidodo
Journal of Tropical Pharmacy and Chemistry Vol. 6 No. 2 (2022): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v6i2.457

Abstract

Uncaria is a genus of plants that are widely distributed in the tropics. There are about 5 of the 38 species of this genus growing in the tropical rain forests of East Borneo, Indonesia. For a long time, Uncaria is commonly used as a traditional medicine to treat various diseases by the Dayak tribe in Kalimantan, traditional people believe that Uncaria may be cured cancer, tumors, mioms, and cycts. Based on previous studies, the activity of the genus Uncaria has been widely reported such as cytotoxic, antimicrobial, antioxidant, antidiabetic, and thrombolytic activities. This article aims to summarize the potential of the Uncaria genus, focusing on 5 species from East Borneo, namely Uncaria nervosa, Uncaria longiflora, Uncaria gambir, Uncaria tomentosa and Uncaria cordata. The method used in this article is a literature study by collecting previous research articles related to the Uncaria genus. The results of the literature study show that the Uncaria genus in East Borneo has many secondary metabolites with diverse chemical structures that show good biological potential so that they can be used as broad and promising insights for drug discovery and development. This paper is also expected to provide input for the policy of conservation of medicinal plants in the forests of East Borneo.
Formulation and Stability Tests of Hair Tonic from Oil Palm (Elaeis guineensis Jacq.) Leaves Extract and Effectiveness in Protecting Hair Angga Cipta Narsa
Journal of Tropical Pharmacy and Chemistry Vol. 6 No. 2 (2022): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v6i2.524

Abstract

Hair loss is a condition that unavoidable process, where the hair is detached more than 100 strands per day that occurs continuously. Oil palm leaf with their compounds can be used to treat hair loss and damage. The purpose of this study was to formulate oil palm leaf extract into hair tonic preparations and evaluate the effectiveness in preventing hair damage. Hair tonic formula from oil palm leaf extract contains 96% ethanol, menthol, propylene glycol, phenoxyethanol, and aquades. The evaluation of hair tonic preparations included organoleptic, homogeneity, pH, and viscosity tests, as well as tests of antioxidant activity and effectiveness of hair tonic preparations. The results of the antioxidant activity test of oil palm leaf extract hair tonic showed the IC50 value at room temperature (25°C) indicating an average value of 37.2519±8.535 ppm, warm temperature (50°C) 40.5459±9.086 ppm, and cold temperature (4°C) 36.8257±6.928 ppm, which belongs to the category of very strong antioxidant activity, with the results of the evaluation of the oil palm leaf hair tonic slightly colored. greenish to dark green, has a distinctive menthol aroma, has a pH and viscosity that meets the requirements of a good hair tonic preparation, with pH between 3-7 and viscosity less than 5 cPs. Hair tonic preparations of oil palm leaf extract can prevent hair decolorization due to sun exposure at concentrations of 25 ppm to 200 ppm.
Aktivitas Hemaglutinasi dan Identifikasi Ekstrak Berbasis Green Solvent dari Akar Tapak Dara (Vinca rosea) dan Daun Kadamba (Mitragyna speciosa Korth. Havil) Menggunakan FTIR-Kemometrik: Hemagglutination Activity and Authentication of Extracts-Based Green Solvent from Vinca rosea and Mitragyna speciosa using FTIR - Chemometrics Risna Agustina; Iswahyudi Iswahyudi; Erwin Samsul; Noor Linda Febrianie; Wisnu Cahyo Prabowo; M. Arifuddin; Hadi Kuncoro; Angga Cipta Narsa; Azminah Azminah; Gemini Alam; Abdul Mun’im; Islamudin Ahmad
Jurnal Sains dan Kesehatan Vol. 4 No. 5 (2022): J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v4i5.1086

Abstract

Proteksi terhadap infeksi seperti pandemik virus dapat dihasilkan dengan meningkatkan imunitas tubuh. Tanaman obat yang diolah dan digunakan dengan baik mampu berpotensi meningkatkan imunitas tersebut. Penelitian ini bertujuan untuk mengetahui aktivitas hemaglutinasi dan karakteristik ekstrak berbasis natural deep eutectic solvents (NADES) atau lebih dikenal dengan istilah green solvent dari akar Tapak Dara (Vinca rosea) dan daun Kadamba (Mitragyna speciosa Korth. Havil) untuk melihat aktivitas ekstrak tersebut dalam mempengaruhi kerja sistem imun dalam melawan antigen yang masuk kedalam tubuh. Proses ekstraksi dilakukan menggunakan metode ekstraksi non-konvensional NADES based microwave-assisted extraction (NADES-MAE) dengan kondisi ekstraksi yang sesuai. Uji hemaglutinasi dilakukan pada hewan coba mencit yang telah diinduksi sel darah merah kambing (SDMK) 1%, yang diukur berdasarkan jumlah titer. Karakterisasi ekstrak dilakukan menggunakan analisis ATR-FTIR dan kemometrik. Berdasarkan hasil penelitian menunjukkan bahwa ekstrak Ekstrak Tapak Dara berbasis NADES memiliki aktivitas hemaglutinasi, sehingga berpotensi meningkatkan sistem imun tubuh. Ekstrak NADES tersebut dapat digunakan sebagai kandidat obat berbasis bahan alam sebagai preventif ataupun supportif dari inveksi virus SARS-CoV2 dan mengurangi gejala setelah terinfeksi. Selain itu, hasil identifikasi ekstrak berbasis NADES menggunakan ATR-FTIR dan kemometrik menunjukkan spesifisitas masing-masing ekstrak yang dihasilkan berdasarkan berbagai komposisi NADES yang digunakan pada kedua tanaman tersebut
Laporan Kasus: Kajian Pengobatan CKD Stage 5 dengan Hiperkalemia Noviyanty Indjar Gama; Ferdian George Sarung Allo; Fahriani Istiqomah; Angga Cipta Narsa
Jurnal Sains dan Kesehatan Vol. 4 No. SE-1 (2022): Spesial Edition J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v4iSE-1.1684

Abstract

Gagal Ginjal Kronis adalah kondisi ketidaknormalan penurunan fungsi ginjal. Laporan Kasus ini berfokus pada kondisi pasien yang mengalami gagal ginjal kronis dengan kondisi hiperkalemia. Pasien mengalami hipertensi dengan tekanan darah 180/ 90 mmHg, saturasi oksigen 92%. Pasien mengeluhkan lemas, nyeri ulu hati, mual, tidak mau makan, kulit gatal dan bengkak pada kedua kaki. Hasil laboratorium darah diketahui nilai Leukosit yaitu 6,2×103/µl, Ureum 255 mg/dL, Kreatinin 7,2 mg/dl , Natrium 138 mmol/L , Kalium 7,0 mmol/L, serta Hemoglobin 6,3 g/dl dan diagnosa adalah CKD stage V.
Studi Kasus: Pasien Gagal Ginjal Kronis (Stage V) dengan Edema Paru dan Ketidakseimbangan Cairan Elektrolit: Case Study: Chronic Kidney Disease (Stage V) Patient with Pulmonary Edema and Fluid Electrolyte Imbalance Angga Cipta Narsa; Vina Maulidya; Dea Reggina; Wina Andriani; Hifdzur Rashif Rijai
Jurnal Sains dan Kesehatan Vol. 4 No. SE-1 (2022): Spesial Edition J. Sains Kes.
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jsk.v4iSE-1.1685

Abstract

Gagal Ginjal Kronik (GGK) merupakan kondisi gangguan fungsi ginjal yang progresif dan tidak dapat pulih kembali, dimana tubuh tidak mampu memelihara metabolisme dan gagal memelihara keseimbangan cairan dan elektrolit. Pada penelitian ini pengambilan data dilakukan secara retrospektif yang dilihat dari data rekam medik. Penelitian ini bertujuan untuk membahas pengkajian pengobatan pada pasien gagal ginjal kronik dengan komplikasi. Seorang pasien Ny. WN usia 42 tahun masuk rumah sakit dengan keluhan sesak nafas, dada berdebar, mual muntah, pusing, demam dan BAB encer. Dari hasil pemeriksaan fisik dan laboratorium diketahui diagnose pasien adalah gagal ginjal kronik (GGK) stage 5 disertai edema paru, dyspnea, hipokalsemia, hiponatremia dan hiperkalemia. Pasien memiliki riwayat Hipertensi yang merupakan salah satu faktor resiko terjadinya gagal ginjal kronik (GGK).Terapi yang telah diberikan pada studi kasus ini adalah terapi yang telah sesuai dengan asuhan kefarmasian pada pasien GGK stage 5.
Recent Updates on the Potential of Medicinal Plants from Indonesia as Anti-Atherosclerotic Agents Prasesti, Gayuk Kalih; Narsa, Angga Cipta; Rijai, Akhmad Jaizzur; Lestari, Kharina Septi; Zulkaida, Zulkaida
Ad-Dawaa: Journal of Pharmaceutical Sciences
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/djps.v7i2.52261

Abstract

Atherosclerosis is one of the causes of problems in the cardiovascular system. This condition can be prevented by using natural products, one of which is medicinal plants. This review collects data on medicinal plants that are easily found in Indonesia that can reduce or improve atherosclerosis conditions. There are 10 plants reviewed that have a high level of safety and potential to be developed as medicine. The plant parts used are fruit and leaves. Some are commonly used as cooking spices such as turmeric and garlic which are found to be useful for improving atherosclerosis conditions. In the context of modern drug development, Indonesia holds significant potential for exploring these plants as sources of active compounds for pharmaceutical applications. Scientific studies of these natural materials are crucial for identifying bioactive components and understanding their mechanisms of action. With the right approach, Indonesia's natural resources could form the basis for developing new, safer, and more effective drugs. Additionally, Indonesia has a considerable opportunity in the global market for natural health products, including nutraceuticals and dietary supplements, as global interest in natural health solutions continues to grow.
Penyuluhan Pembuatan Gummy Candy Wortel dan Tomat sebagai Upaya Pencegahan Stunting pada Anggota Pengajian Langgar At-Taubah Kelurahan Bukuan Samarinda Narsa, Angga Cipta; Bahar, Zulhaerana; Badawi, Satriani; Pamungkas, Barolym Tri; Irfan, Muhammad
Abdimas Indonesian Journal Vol. 4 No. 2 (2024)
Publisher : Civiliza Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59525/aij.v4i2.505

Abstract

This activity aims to improve the knowledge and skills of mothers who are members of the Langgar At-Taubah study group, Bukuan Village, Samarinda, East Kalimantan regarding making gummy candy to prevent stunting in children. The method of implementing this service uses interactive counseling. The evaluation instruments for this service are pre-test and post-test. The results of this service show that the knowledge and skills of most mothers have increased, as evidenced by the presence of 76% of mothers in the post-test who managed to answer all questions correctly, previously in the pre-test only 45%.
Co-Authors Abdul Mun’im Almeida, Maria Arifah Aidah Salman Arsyik Ibrahim Asyarie, Sukmadjaja Ayu Rahmawatiani Ayu Wulan Dari Azminah Azminah Badawi, Satriani Bahar, Zulhaerana Boesro Soebagio Dea Reggina Dewi Mayasari Dyah Ayu Puspo Rini Erwin Samsul Erwin Samsul Fahriani Istiqomah Fajar Prasetya Fajar Prasetya Ferdian George Sarung Allo Fika Aryati Fika Aryati Gemini Alam Hadi Kuncoro Hadi Kuncoro Haerunnisa, Rima Harra Ismi Farah Helmi Helmi Hifdzur Rashif Rijai Hifdzur Rashif Rija’i Indah Silvia Sugiyamin Islamudin Ahmad Iswahyudi Iswahyudi Lestari, Kharina Septi Lisna Meylina M. Arifuddin Masrurotin Zumaro Mauludin, Rachmat Muhammad Fauzi Zainal Abidin Muhammad Irfan Mukti Priastomo Noor Linda Febrianie Nova Mega Handayani Novita Sari Noviyanty Indjar Gama Nur Ainah Nur Aini Nur Masyithah Zamruddin Pamungkas, Barolym Tri Prasesti, Gayuk Kalih Putri , Novita Eka Kartab Rachmat Mauludin Rahmadani, Agung Ratna A. Utami Reca Indiyen Rijai, Akhmad Jaizzur Risma Dwi Novianti Risna Agustina Risna Agustina Ronaldo, Leo Selin Cenora Aritonang Sinthary, Venna Siswati Siswati Siti Rofi’ah Febryani Sri Agung Fitri Kusuma Sriwidodo Sriwidodo Sriwidodo Sriwidodo Sukmadjaja Asyarie Sulistiarini, Riski Supriatno Salam Theresia Fenny Oktarina Utami, Ratna A. Vina Maulidya Wina Andriani Wisnu Cahyo Prabowo Wisnu Cahyo Prabowo Wisnu Cahyo Prabowo Yurika Sastyarina Yurika Sastyarina Zulkaida, Zulkaida