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All Journal Indonesian Journal of Pharmaceutical Science and Technology Acta Pharmaceutica Indonesia Jurnal Mandala Pharmacon Indonesia ad-Dawaa : Journal of Pharmaceutical Sciences Proceeding of Mulawarman Pharmaceuticals Conferences Abdimas Indonesian Journal Journal of Tropical Pharmacy and Chemistry Jurnal Sains dan Kesehatan
Angga Cipta Narsa
Research And Development Laboratory Of Farmaka Tropis, Faculty Of Pharmacy, Mulawarman University, Samarinda, Indonesia
Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Social Sciences

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Aktivitas Antioksidan Ekstrak Etanol Daun Kelapa Sawit (Elaeis guineensis Jacq.): Antioxidant Activity of Oil Palm Leaf Ethanol Extract (Elaeis guineensis Jacq.) Masrurotin Zumaro; Hifdzur Rashif Rija’i; Angga Cipta Narsa; Riski Sulistiarini; Helmi Helmi
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (289.534 KB) | DOI: 10.25026/mpc.v14i1.566

Abstract

Indonesia is a country with abundant natural wealth and almost all types of plants can grow in the territory of this country. One of them is oil palm leaf (Elaeis guineenis Jacq.) containing terpenoid compounds, steroids, alkaloids, flavonoids, glycosides, tannins and saponins and also this plant among the community has benefits that can be used for the treatment of skin infections. Purpose of this study was to determine the yield obtained as well as the antioxidant activity of ethanol extract of oil palm leaves. Oil palm leaves were extracted using 96% ethanol as solvents and using the maceration method. Testing the antioxidant activity of the ethanol extract of oil palm leaves was carried out using the DPPH method (2,2-diphenyl-1-picrylhydrazyl), where the absorbance was measured at max 515 nm using a UV-vis spectrophotometer. The results showed that the yield of oil palm leaf ethanol extract obtained as much as 5.44 % and obtained that the ethanolic extract of oil palm leaves had antioxidant activity against DPPH radicals with an IC50 value of 133.58 ppm. It could be concluded that the ethanolic extract of oil palm leaves (Elaeis guineensis Jacq.) had antioxidant activity in the moderate category because the IC50 value was between 100- 150 ppm.
Pengaruh Trietanolamin pada Basis Krim Minyak dalam Air yang Berbahan Dasar Asam Stearat dan Setil Alkohol: Effect of Triethanolamine on Oil-in-Water Cream Base Based on Stearic Acid and Cetyl Alcohol Novita Sari; Erwin Samsul; Angga Cipta Narsa
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (254.394 KB) | DOI: 10.25026/mpc.v14i1.573

Abstract

The cream is a semi-solid preparation with one or more ingredients dispersed in two types of emulsions, water-in-oil (W/O) and oil-in-water (O/W) type creams. Oil-in-water type cream has a high water content so that it can provide a hydration effect that can increase the penetration of the active substance. Triethanolamine in topical preparations is used as an emulsifier and alkalizing agent to form a homogeneous and stable cream. The purpose of this research was to determine the effect of triethanolamine on an oil-in-water cream base based on stearic acid and cetyl alcohol. Making the base is done by making preparations using four concentrations of triethanolamine 0.5% (F1), 1% (F2), 1.5% (F3), and 2% (F4). The cream base was then evaluated for its physical properties including organoleptic, homogeneity, pH, viscosity, spreadability, adhesion, and phase separation test. The results showed that in the organoleptic test cream bases were white, had a characteristic aroma with a semisolid form. The cream base has a homogeneity dispersion with an average pH between 6.53-7.29, viscosity between 3.5792396-3.8001904 (Pa.s), spreadability between 5.43-5.78 cm, and adhesion between 4.47-6.25 seconds. The cream base did not have phase separation and was stable in storage for 4 weeks at room temperature.
Optimasi Konsentrasi VCO Terhadap Stabilitas Fisik Facewash dan Uji Antibakteri Ekstrak Daun Kelapa Sawit (Eleais Guineensis Jacq.) pada Bakteri Penyebab Jerawat: Optimization of VCO Concentration on Physical Stability of Facewash and Antibacterial Test of Oil Palm Leaf Extract (Eleais Guineensis Jacq.) on Acne-causing Bacteria Selin Cenora Aritonang; Wisnu Cahyo Prabowo; Angga Cipta Narsa; Riski Sulistiarini; Helmi Helmi
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (354.444 KB) | DOI: 10.25026/mpc.v14i1.586

Abstract

Palm oil leaves (Elaeis guineensis Jacq.) is a waste from oil palm plantations which contain flavonoid, steroid, and alkaloid compounds that function as an antibacterial that causes acne. The purpose of this research was to identify determine the concentration of ethanolic extract of oil palm leaves which is effective in inhibiting acne-causing bacteria and to determine the best formulation that can produce a facewash base that fulfill the requirements for stability of the preparation according to SNI. Antibacterial test of oil palm leaf extract was using the pitting method against acne-causing bacteria. The results of the antibacterial test showed that the extract concentration of 75% had antibacterial activity against the growth of acne-causing bacteria. The facewash base was obtained by varying the VCO with concentrations of 17.5%, 20%, and 22.5%. The results of the evaluation of the facewash base formula for 28 days, namely F2 (20%) produced good characteristics and stability, namely a distinctive aroma, cream color, semi-solid form, pH 6,25 – 6,37, viscosity 0,904 -2,700 Pa.s, high foam stability. 89% - 100% and good homogeneity. The three base formulas have fulfill requirements for facewash according to SNI.
Karakteristik Granul Gastroretentive Mukoadhesif Amoksisilin dengan menggunakan Kitosan-Alginat, Na.CMC dan HPMC: Characteristics of Gastroretentive Mucoadhesive Granules Amoxicillin using Chitosan-Alginate, Na.CMC and HPMC Siti Rofi’ah Febryani; Sabaniah Indjar Gama; Angga Cipta Narsa
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (300.296 KB) | DOI: 10.25026/mpc.v14i1.588

Abstract

Gastroretentive Drug Delivery System (GRDDS) is a slow-release preparation that can be bound to the surface of epithelial cells or gastric mucosa, while mucoadhesive is one of the mechanisms of action of the Gastroretentive Drug Delivery System (GRDDS), which is a drug delivery system in which the bio adhesive polymer is combined with the drug. designed to have a longer contact with the mucous membranes in the digestive tract. This study aims to see how the characteristics of the granules that are formulated in the form of mucoadhesive gastroretentive granules. The preparation method used was wet granulation using a mucoadhesive polymer, namely chitosan-alginate with the addition of HPMC and Sodium CMC. The results showed that the velocity test of the flow rate on the granule formula F1-F8 met the flow rate requirements, the results of the F9 velocity had a poor flow rate, while the results of the angle of repose measurement in the F1, F2 and F4 formulas had good flowability, which was below 30o, different with F3, F5, F6, F7, F8, and F9 which have a 30-40o angle of repose with good flowability. The results of the particle size distribution using the stratified sieve method showed that the formulas F1-F9 were mostly retained by a mesh number 20 sieve with a size of 426-850 m. The results of the test results of the gastroretentive mucoadhesive granule preparation of amoxicillin showed that the preparation met the requirements for making granules.
Penggunaan Soy wax dan Beeswax sebagai Basis Lilin Aromaterapi: Use of Soy wax and Beeswax as Aromatherapy Candle Base Theresia Fenny Oktarina; Wisnu Cahyo Prabowo; Angga Cipta Narsa
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 14 (2021): Proceeding of Mulawarman Pharmaceuticals Conferences
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (247.405 KB) | DOI: 10.25026/mpc.v14i1.589

Abstract

The continuous use of paraffin wax produces pollutants that have a negative impact on health and the environment. Soy wax and beeswax candles are environmentally friendly materials because they produce fewer pollutants. This study aims to determine the best formula in the manufacture of aromatherapy candle preparations. This research was conducted using an experimental method. Aromatherapy candles are made by melting soy wax, beeswax, and stearic acid. Apply optimization based on the ratio formula of 75%:25% (F1), 50%:50% (F2), 25%:75% (F3) by evaluating physical properties such as organoleptic, melting point test, and burning time test to get the base The best aromatherapy candles from the use of soy wax and beeswax ingredients with the addition of stearic acid. The results of optimization of soy wax based on an organoleptic test, F1 and F2 have an even color and do not crack, F3 has an uneven color and does not crack. The melting point of wax preparations is 48°C-52°C, burning time 373 minutes-463 minutes. On the basis of the organoleptic test beeswax, F1 and F2 had an even color and did not crack, F3 had an even color and cracks. The melting point of the basic wax is 53°C-54°C, and the burning time is 443 minutes-499 minutes. From the results, it was found that the best formulas, namely F1 and F2, met the standards according to SNI, namely the color was uniform and not cracked and the melting point ranged from 42°C-60°C.
Sifat Fisika Kimia Tulang Sotong (Sepia Sp.) dan Optimasi Basis Pasta Gigi: Physicochemical Properties of Cuttlefish Bone (Sepia Sp.) and Optimization the Toothpaste Base Dyah Ayu Puspo Rini; Maria Almeida; Angga Cipta Narsa
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 15 (2022): Proceeding of Mulawarman Pharmaceuticals Conferences (Proc. Mul. Pharm. Conf.)
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/mpc.v15i1.615

Abstract

Pengaruh Jenis Pelarut terhadap Aktivitas Antibakteri Penyebab Jerawat dari Ekstrak Daun Kelapa Sawit (Elaeis Guineensis Jacq.): Pengaruh Jenis Pelarut Terhadap Aktivitas Antibakteri Penyebab Jerawat Dari Ekstrak Daun Kelapa Sawit (Elaeis Guineensis Jacq.) Nur Aini; Maria Almeida; Angga Cipta Narsa
Proceeding of Mulawarman Pharmaceuticals Conferences Vol. 15 (2022): Proceeding of Mulawarman Pharmaceuticals Conferences (Proc. Mul. Pharm. Conf.)
Publisher : Fakultas Farmasi, Universitas Mulawarman, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/mpc.v15i1.632

Abstract

Formulasi Cookies dari Labu Kuning (Cucurbita moschata) dan Tepung Kulit Pisang Kepok (Musa acuminata x Musa balbisiana) untuk Penderita DM Tipe 2 Haerunnisa, Rima; Sinthary, Venna; Kuncoro, Hadi; Narsa, Angga Cipta
Indonesian Journal of Pharmaceutical Science and Technology 2024: Suppl. 6, No. 1 (Special Issue for Mulawarman Pharmaceutical Conference)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v6i1.53425

Abstract

Diabetes mellitus (DM) merupakan penyakit yang ditandai dengan tingginya kadar gula dalam darah. Pemberian makanan yang tinggi serat diketahui dapat mengontrol kadar gula darah pada penderita diabetes mellitus. Buah labu kuning dan kulit pisang kepok merupakan salah satu pangan pilihan dengan kandungan serat tinggi sehingga bisa menjadi alternatif makanan selingan bagi penderita diabetes mellitus melalui olahan cookies. Penelitian ini bertujuan untuk mengetahui formulasi cookies yang optimal serta mengetahui evaluasi yakni kadar air, kadar abu, kadar serat, organoleptik dan hedonik. Hasil yang diperoleh yaitu didapatkan 3 formulasi yang berbeda FI (0,5:1,5 labu kuning:kulit pisang kepok); F2 (1:1 labu kuning:kulit pisang kepok); F3 (1,5:0,5 labu kuning:kulit pisang kepok) dengan nilai kadar air berturut-turut yaitu 0,289%; 0,375 dan 0,306%. Nilai kadar abu berturut-turut yaitu 1,974%; 1,990% dan 1,965%. Nilai Kadar serat berturut-turut yaitu 33,8%; 35,08% dan 50,525%. Nilai uji hedonik terbaik yaitu pada F2 dengan persentase nilai yaitu 72,67% dengan karakteristik organoleptik berwarna coklat, sedikit beraroma kulit pisang dan sedikit beraroma labu kuning, berasa manis dan memiliki tekstur renyah. Hal ini menunjukkan bahwa formula cookies yang dibuat dapat menjadi makanan selingan karena memenuhi nilai kadar serat dan nilai uji hedonik (kesukaan).
Pengaruh Propilen Glikol terhadap Laju Difusi Krim Natrium Diklofenak dengan Basis Hidrofobik Secara Invitro Angga Cipta Narsa; Boesro Soebagio; Sriwidodo Sriwidodo
Journal of Tropical Pharmacy and Chemistry Vol. 1 No. 1 (2010): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v1i1.2

Abstract

ABSTRACT The research on effect of propylene glycol in diffusion of cream diclofenac sodium from hydrophobic base with in-vitro. The research has been used for concentrations propylene glycol (0, 3, 5, and 7%). The stability test included organoleptic, pH, viscosity, consistency, flow type for 56 days of storge, and diffusion test used diffusion franz cell and membrane spangler. The result showed that formula diclofenac sodium cream contained propylene glycol 7% was the one best in diffusion of 0.0203 ppm/menit. Key words : Propylene glycol, diffusion, hydrophobic base ABSTRAK Telah dilakukan penelitian mengenai pengaruh propilen glikol terhadap laju difusi krim natrium diklofenak basis hidrofobik secara invitro. Dalam penelitian ini dibuat formula dengan variasi konsentrasi propilen glikol yaitu 0, 3, 5, dan 7%. Pengujian stabilitas fisik sediaan krim meliputi organoleptis, pH, viskositas, konsistensi, dan uji sifat aliran selama 56 hari penyimpanan, serta uji difusi menggunakan alat difusi Franz dan membran spangler. Dari hasil penelitian ini didapat bahwa formula krim natrium diklofenak yang mengandung propilen glikol 7% memiliki laju difusi paling baik yaitu 0,0203 ppm/menit. Kata kunci : Propilen glikol, laju difusi, basis hidrofobik
Peningkatan Kelarutan Ketokonazol dengan Teknik Dispersi Padat Menggunakan Eudragit® E 100 Angga Cipta Narsa
Journal of Tropical Pharmacy and Chemistry Vol. 2 No. 1 (2012): J. Trop. Pharm. Chem.
Publisher : Faculty of Pharmacy, Universitas Mulawarman, Samarinda, Indonesia, 75117, Gedung Administrasi Fakultas Farmasi Jl. Penajam, Kampus UNMUL Gunung Kelua, Samarinda, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25026/jtpc.v2i1.42

Abstract

Ketoconazole is an antifungal azole synthetic which derivatived from imidazole. Ketoconazole is practically insoluble in water and its bioavailability depend on pH condition of the gastrointestinal tract. The purpose of the research is to increase the solubility of ketoconazole by solid dispersion method using Eudragit® E 100, PEG 6000, and glycerol. Solid dispersion was evaluated with respect to solubility, cristalinity, complexation and morphology of solid dispersion. The optimum formulation with the highest solubility was resulted by solid dispersion with ratio ketoconazole - Eudragit® E 100 - glycerol of 1:8:0.5. X-ray diffraction test revealed the change of crystalline ketoconazole and similar to Eudragit® E 100. This result was also supported by spectrum of infrared and endothermic peak of differential scanning calorimetry. Based on scanning electron microscopy morphology of pure Eudragit® E 100 and solid dispersion was similar. Solid dispersion of ketoconazole with Eudragit® E 100 and glycerol improved solubilty. Keywords : ketoconazole, solid dispersion, Eudragit® E 100 ABSTRAK Ketokonazol merupakan zat antijamur sintetik golongan azol yang merupakan turunan imidazol.Ketokonazol praktis tidak larut dalam air dan ketersediaan hayati melalui rute oral sangat beragam tergantung dari kondisi pH saluran pencernaan.Penelitian ini bertujuan untuk meningkatkan kelarutan ketokonazol dengan cara pembuatan dispersi padat mengunakan Eudragit® E 100, PEG 6000, serta gliserol. Dispersi padat di evaluasi dengan uji kelarutan jenuh, kristalinitas, kompleksasi, dan morfologinya.Formula optimal dengan peningkatan kelarutan tertinggi dihasilkan oleh perbandingan dispersi padat ketokonazol - Eudragit® E 100 - gliserol 1:8:0,5. Pengujian difraksi sinar-X menunjukkan adanya perubahan kristalinitas ketokonazol yaitu sama seperti Eudragit® E 100.Hasil ini juga didukung oleh hasil pengujian spetkrofotometer infra merah dan puncak endotermik differential scanning calorimetry.Berdasarkan hasil scanning electrom microscopyterlihat morfologi dari Eudragit® E 100 murni dan dispersi padatnya yang hampir sama..Pembentukan dispersi padat ketokonazol dengan Eudragit® E 100 dan gliserol dapat meningkatkan kelarutan. Kata Kunci : ketokonazol, dispersi padat, Eudragit® E 100
Co-Authors Abdul Mun’im Almeida, Maria Arifah Aidah Salman Arsyik Ibrahim Asyarie, Sukmadjaja Ayu Rahmawatiani Ayu Wulan Dari Azminah Azminah Badawi, Satriani Bahar, Zulhaerana Boesro Soebagio Dea Reggina Dewi Mayasari Dyah Ayu Puspo Rini Erwin Samsul Erwin Samsul Fahriani Istiqomah Fajar Prasetya Fajar Prasetya Ferdian George Sarung Allo Fika Aryati Fika Aryati Gemini Alam Hadi Kuncoro Hadi Kuncoro Haerunnisa, Rima Harra Ismi Farah Helmi Helmi Hifdzur Rashif Rijai Hifdzur Rashif Rija’i Indah Silvia Sugiyamin Islamudin Ahmad Iswahyudi Iswahyudi Lestari, Kharina Septi Lisna Meylina M. Arifuddin Masrurotin Zumaro Mauludin, Rachmat Muhammad Fauzi Zainal Abidin Muhammad Irfan Mukti Priastomo Noor Linda Febrianie Nova Mega Handayani Novita Sari Noviyanty Indjar Gama Nur Ainah Nur Aini Nur Masyithah Zamruddin Pamungkas, Barolym Tri Prasesti, Gayuk Kalih Putri , Novita Eka Kartab Rachmat Mauludin Rahmadani, Agung Ratna A. Utami Reca Indiyen Rijai, Akhmad Jaizzur Risma Dwi Novianti Risna Agustina Risna Agustina Ronaldo, Leo Selin Cenora Aritonang Sinthary, Venna Siswati Siswati Siti Rofi’ah Febryani Sri Agung Fitri Kusuma Sriwidodo Sriwidodo Sriwidodo Sriwidodo Sukmadjaja Asyarie Sulistiarini, Riski Supriatno Salam Theresia Fenny Oktarina Utami, Ratna A. Vina Maulidya Wina Andriani Wisnu Cahyo Prabowo Wisnu Cahyo Prabowo Wisnu Cahyo Prabowo Yurika Sastyarina Yurika Sastyarina Zulkaida, Zulkaida