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All Journal Jurnal Sain Veteriner Jurnal Riset Kesehatan Jurnal Teknologi Laboratorium Jurnal SOLMA Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Analis Medika Biosains (JAMBS) Medical Laboratory Analysis and Sciences Journal Lumbung Farmasi : Jurnal Ilmu Kefarmasian Medicra (Journal of Medical Laboratory Science/Technology) Jurnal Mitra Kesehatan Journal of Indonesian Medical Laboratory and Science (JoIMedLabS) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Pharmaqueous Jurnal Pengabdian Pancasila (JPP) Jurnal Laboratorium Khatulistiwa Jurnal Pengabdian Masyarakat (Jupemas) Jurnal Pengabdian Masyarakat Mandira Cendikia (JPKM-MC) Jurnal Bioteknologi & Biosains Indonesia (JBBI) Indonesian Journal of Innovation Multidisipliner Research Jurnal Ilmiah Nusantara Jurnal Bioteknologi & Biosains Indonesia
Imam Agus Faizal
Program Studi Sarjana Terapan Teknologi Laboratorium Medis, Fakultas Farmasi Sains Dan Teknologi, Universitas Al Irsyad Cilacap, Jalan Cerme No.24, Wanasari, Sidanegara, Kec. Cilacap Tengah, Kabupaten Cilacap, Jawa Tengah, Indonesia. 53223
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Inovasi Sedotan Edible Lokal Dan Pelatihan Pemasaran Digital Umkm Cilacap Untuk Reduksi Sedotan Plastik Faizal, Imam Agus; Susanti, Susanti; Yusuf, Dede; Nizam, Muhammad Farid Khoirun; Wulandari, Mei
Jurnal Pengabdian Masyarakat (Jupemas) Vol. 7 No. 1 (2026): Maret
Publisher : Universitas Bakti Tunas Husada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36465/jupemas.v7i1.1914

Abstract

Program pengabdian ini mengembangkan prototipe awal sedotan edible berbasis pati sukun (Artocarpus altilis) dengan penambahan ekstrak daun beluntas (Pluchea indica) sebagai inovasi bahan lokal untuk mendukung pengurangan sedotan plastik sekali pakai dan peningkatan daya saing UMKM di Cilacap. Kegiatan melibatkan 13 peserta dari mitra UMKM KPK Tri Usaha melalui (1) sosialisasi literasi lingkungan dan potensi bahan baku lokal serta (2) pelatihan pemasaran digital berbasis praktik. Formulasi laboratorium menghasilkan prototipe sedotan berwarna hijau alami dengan performa awal bertahan sekitar 1,5 jam pada minuman dingin dan 30 menit pada minuman panas, namun masih memerlukan uji ketahanan lanjutan dan pemenuhan legalitas pangan. Evaluasi pengetahuan dengan desain pra–pasca menunjukkan peningkatan secara deskriptif: pada prates mayoritas peserta berada pada kategori cukup–kurang (69,3%), sedangkan pada pascates 84,6% berada pada kategori baik–sangat baik. Pelatihan pemasaran digital membantu mitra membuat akun bisnis, mengunggah listing produk, dan menyusun konten promosi sederhana. Program ini menjadi langkah awal menuju inovasi produk berorientasi circular economy, dengan kebutuhan pendampingan lanjutan pada transfer produksi dan kepatuhan regulasi.
Subchronic Toxicity Test of Burdock Root (Arctium Lappa L.) Nanoemulsion Based on Histopathology on The Albino Rat Rattus noverticus (Wistar strain): Uji Toksisitas Subkronik Nanoemulsi Akar Burdock (Arctium Lappa L.) Berdasarkan Histopatologi pada Tikus Albino Rattus noverticus (strain Wistar) Imam Agus Faizal; Dini Puspodewi; Ajeng Puspo Aji
Indonesian Journal of Innovation Multidisipliner Research Vol. 2 No. 2 (2024): April - Juni
Publisher : Institute of Advanced Knowledge and Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.69693/ijim.v2i2.140

Abstract

Tanaman burdock (Arctium lappa L.) merupakan tanaman herbal yang berkhasiat sebagai penambah darah (hemoglobin dan hematokrit) pada penderita anemia defisiensi besi. Sebanyak 15 ekor tikus (Rattus norvegicus) strain Wistar, jantan dan betina dibagi menjadi 3 kelompok secara random sampling yaitu Kelompok 1 Kontrol negatif (KN) tidak diberi A. lappa L. nanoemulsion. Kelompok Dosis 1 (KD1) diberi A. lappa L. nanoemulsion dengan dosis 150 mg/kgBB/hari. Kelompok Dosis 2 (KD2) diberikan A. lappa L. nanoemulsion dengan dosis 450 mg/kgBB/hari (selama 14 hari dimulai hari ke 8). Indikator penelitian ini dilihat kadar pemeriksaan biokimia kadar darah. Organ hati dan ginjal dinilai menggunakan Hematoxylin-Eosin (HE). Hasil pemeriksaan biokimia darah relatif normal. Sedangkan pewarnaan HE pada kelompok KD1 dan KD2 terjadi perubahan pada sel organ ginjal dan hati, menunjukkan bahwa sediaan nanoemulsi akar burdock bersifat toksik, namun terdapat faktor pengganggu yaitu ditemukan cacing parasit Taenia taeniaeformis, sehingga interpretasi hasilnya terganggu.
Ekspresi TNF-α Histopatologi Ginjal Pada Tikus Model Sepsis Sebagai Efek Preventif Diberi Nanoemulsi Burdock Yang Diinduksi Bakteri MRSA Faizal, Imam Agus; Nugroho, Yusuf Eko; Fauziah, Rahma Shifa; Yunadi, Frisca Dwi; Swandari, Mika Tri Kumala
Jurnal Sain Veteriner Vol 44, No 1 (2026): April
Publisher : Faculty of Veterinary Medicine, Universitas Gadjah Mada bekerjasama dengan PB PDHI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jsv.107607

Abstract

One of the natural ingredients utilized as a traditional medicinal herb is Arctium lappa L. or commonly called burdock. This plant has roots, leaves, seeds that have been used to treat infections and various skin disorders. Burdock is used for anti-inflammatory, anti-cancer, infection-fighting, and anti-tumor regulating activities. The purpose of this research is to determine the effect of Arctium lappa L. root extract on renal histopathology and tumor necrosis factor-alpha (TNF-α) expression in white rat sepsis model after Methicillin-Resistant Staphylococcus aureus (MRSA) bacteria administration. Where in this research stage is divided into 5 groups of test animal treatment. Each group was injected with MRSA bacterial suspension with a standard MC Farland turbidity test of 0.5. The results of this research obtained that burdock root extract is able to inhibit inflammation of sepsis test animals caused by MRSA bacteria with the average value of TNF- α reaction presentation, namely K1 (-) (13.632; 14.756), K2 (+) (33.291; 29,568), K3 (150 mg/kg BW) (35,458; 33,273), K4 (300 mg/kg BW) (36,120; 28,731) K5 (450 mg/kg BW) (28,086; 228,084. So it can be stated that Arctium lappa L root extract is able to inhibit inflammation with the use of the most effective dose of 450 mg/kg BW.
Inovasi Pengolahan Limbah Cangkang Kepiting Berbasis Zero Waste sebagai Produk Pangan Bergizi untuk Mendukung Program Makan Bergizi Gratis di Desa Kutawaru, Cilacap Faizal, Imam Agus; Saptyani, Putri Maretyara; Riviani, Riviani
Jurnal SOLMA Vol. 15 No. 1 (2026)
Publisher : Universitas Muhammadiyah Prof. DR. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/solma.v15i1.22350

Abstract

Background: Peningkatan ketahanan pangan dan pengelolaan limbah perikanan berkelanjutan selaras dengan Sustainable Development Goals (SDGs), terutama SDG 2 (Zero Hunger) dan SDG 12 (Responsible Consumption and Production). Tujuan: Kegiatan ini bertujuan mengembangkan model bisnis zero waste melalui pemanfaatan limbah cangkang kepiting menjadi pangan fungsional sekaligus penguatan pemasaran digital UMKM pesisir di Desa Kutawaru, Cilacap. Metode: Program dilaksanakan melalui pemetaan kebutuhan dan kesepakatan mitra, sosialisasi partisipatif, pelatihan serta pendampingan berbasis IPTEKS dengan penerapan good manufacturing practices (GMP), penguatan branding dan pengemasan, pengembangan website, serta evaluasi berkelanjutan secara deskriptif-kualitatif. Hasil: Hasil menunjukkan peningkatan pengetahuan mitra pada pemanfaatan limbah cangkang kepiting dalam kerangka zero waste dari 35,90% menjadi 90,00%, literasi gizi terkait stunting dari 15,70% menjadi 94,60%, dan kewirausahaan digital dari 45,60% menjadi 89,00%. Produk inovasi kaldu kering cangkang kepiting dari Scylla serrata memenuhi persyaratan keamanan pangan berdasarkan uji organoleptik dan mikrobiologi, serta didukung website UMKM sebagai media promosi dan katalog. Kesimpulan: Kegiatan ini efektif meningkatkan kapasitas produksi, literasi gizi, dan daya saing UMKM, sekaligus memperkuat ekonomi sirkular masyarakat pesisir melalui model bisnis zero waste.
IN SILICO EVALUATION OF FLAVONOIDS FROM ACALYPHA INDICA L. AS Α-GLUCOSIDASE INHIBITORS FOR THE TREATMENT OF DIABETES MELLITUS Lisa Savitri; Kharisul Ihsan; Fendy Prasetyawan; Yuneka Saristiana; Imam Agus Faizal; Meri Meri
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 13 No. 1 (2026)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Type 2 diabetes mellitus continues to pose a significant global health burden, highlighting the urgent need for safer and more effective therapeutic agents with minimal adverse effects. One promising strategy involves targeting α-glucosidase, a key enzyme in postprandial glucose regulation, using bioactive compounds derived from medicinal plants. Acalypha indica, a tropical species widely used in traditional medicine, contains diverse flavonoids with potential antidiabetic activity; however, their molecular mechanisms remain insufficiently explored. This study employed an in silico approach to systematically evaluate the α-glucosidase inhibitory potential of five flavonoids from A. indica—mauritanin, repandusinic acid, hesperetin, glucogalin, and acaindinin. Molecular docking analysis using AutoDock revealed that all compounds exhibited favorable binding affinities toward the α-glucosidase enzyme (PDB ID: 5NN8), indicating spontaneous interactions at the active site. Among them, mauritanin demonstrated the highest binding affinity (–10.3 kcal/mol), forming multiple stabilizing hydrogen bonds with critical catalytic residues, including ASP69, HIS279, and GLU411. Notably, both mauritanin and repandusinic acid showed stronger binding interactions compared to the standard inhibitor acarbose, suggesting superior inhibitory potential. Further interaction analysis using LigPlot+ and Discovery Studio Visualizer confirmed stable ligand–enzyme complex formation, while ADMET predictions using SwissADME indicated favorable pharmacokinetic properties, including good oral bioavailability, low toxicity risk, and absence of major cytochrome P450 inhibition. Overall, these findings identify mauritanin and repandusinic acid as promising lead compounds for α-glucosidase inhibition and support the therapeutic potential of A. indica as a natural source for antidiabetic drug development. This study provides a strong computational foundation for future experimental validation and drug design efforts.
IN SILICO EVALUATION OF FLAVONOIDS FROM ACALYPHA INDICA L. AS Α-GLUCOSIDASE INHIBITORS FOR THE TREATMENT OF DIABETES MELLITUS Lisa Savitri; Kharisul Ihsan; Fendy Prasetyawan; Yuneka Saristiana; Imam Agus Faizal; Meri Meri
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 13 No. 1 (2026)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Type 2 diabetes mellitus continues to pose a significant global health burden, highlighting the urgent need for safer and more effective therapeutic agents with minimal adverse effects. One promising strategy involves targeting α-glucosidase, a key enzyme in postprandial glucose regulation, using bioactive compounds derived from medicinal plants. Acalypha indica, a tropical species widely used in traditional medicine, contains diverse flavonoids with potential antidiabetic activity; however, their molecular mechanisms remain insufficiently explored. This study employed an in silico approach to systematically evaluate the α-glucosidase inhibitory potential of five flavonoids from A. indica—mauritanin, repandusinic acid, hesperetin, glucogalin, and acaindinin. Molecular docking analysis using AutoDock revealed that all compounds exhibited favorable binding affinities toward the α-glucosidase enzyme (PDB ID: 5NN8), indicating spontaneous interactions at the active site. Among them, mauritanin demonstrated the highest binding affinity (–10.3 kcal/mol), forming multiple stabilizing hydrogen bonds with critical catalytic residues, including ASP69, HIS279, and GLU411. Notably, both mauritanin and repandusinic acid showed stronger binding interactions compared to the standard inhibitor acarbose, suggesting superior inhibitory potential. Further interaction analysis using LigPlot+ and Discovery Studio Visualizer confirmed stable ligand–enzyme complex formation, while ADMET predictions using SwissADME indicated favorable pharmacokinetic properties, including good oral bioavailability, low toxicity risk, and absence of major cytochrome P450 inhibition. Overall, these findings identify mauritanin and repandusinic acid as promising lead compounds for α-glucosidase inhibition and support the therapeutic potential of A. indica as a natural source for antidiabetic drug development. This study provides a strong computational foundation for future experimental validation and drug design efforts.
Co-Authors Adilla Putri Az-Zahra Afrilla, Rananda Agung Dwi Wahyu Widodo Ajeng Puspo Aji Alifah Alifah Alifah Arelliza, Fatma Sheilla Ayuningtyas Ayuningtyas BUDIYANTO Dede Yusuf, Dede Denih Agus Setia Permana Dian Novita Dini Puspodewi Elfred Rinaldo Kasimo, Elfred Rinaldo Farabi, Meka Faizal Fariza Yulia Kartika Sari Faulia wijayanti Fauziah, Rahma Shifa Fendy Prasetyawan Frisca Dewi Yunadi Frisca Dewi Yunadi Haryanti, Anik Hayati, Defi Nurul Ihsan, Kharisul Ira Pangesti Jusak Nugraha Kharisul Ihsan Kusumawati, Dhiah Dwi Lailiya Ramadhanti Lisa Savitri Ma’rifah, Solihatul Meri Meri Mika Tri Kumala Swandari Mika Tri Kumala Swandari, Mika Tri Kumala Ningrum, DM Ningrum, Windi Nisa, Dwi Faizatun Nizam, Muhammad Farid Khoirun Nugrahaeni, Dian Rahma Nugroho, Yusuf Eko Nur Ariska Nugrahani Octaviany, Frinsisca Pangesti, Ira Permana, Denih agus Setia Priyanto, Anggih Purwati, Rina Putri Maretyara Saptyani Ramadhan, Fahri Riviani Riviani, Riviani Saputri, Ratna Dwi Sa’adah, Arina Lis Sodikin Sodikin Susanti Susanti Utami, Tri Fitri Yana Wigati, Atika Nur Wulandari, Mei Yayuk Mundriyastutik Yulianto, Asep Nurrahman yunadi, frisca dewi Yunadi, Frisca Dwi Yuneka Saristiana