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All Journal Jurnal Sain Veteriner Jurnal Riset Kesehatan Jurnal Teknologi Laboratorium Jurnal SOLMA Klinikal Sains (Jurnal Analis Kesehatan) Jurnal Ilmu Kedokteran dan Kesehatan Jurnal Analis Medika Biosains (JAMBS) Medical Laboratory Analysis and Sciences Journal JURNAL ANALIS LABORATORIUM MEDIK Lumbung Farmasi : Jurnal Ilmu Kefarmasian Medicra (Journal of Medical Laboratory Science/Technology) Jurnal Mitra Kesehatan Journal of Indonesian Medical Laboratory and Science (JoIMedLabS) Decode: Jurnal Pendidikan Teknologi Informasi Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Pharmaqueous Jurnal Pengabdian Pancasila (JPP) Jurnal Laboratorium Khatulistiwa Jurnal Pengabdian Masyarakat (Jupemas) Jurnal Kesehatan Bakti Tunas Husada Jurnal Teknologi Laboratorium Medik Borneo Jurnal Pengabdian Masyarakat Mandira Cendikia (JPKM-MC) Jurnal Bioteknologi & Biosains Indonesia (JBBI) Indonesian Journal of Innovation Multidisipliner Research Jurnal Ilmiah Nusantara Jurnal Bioteknologi & Biosains Indonesia Klinik: Jurnal Ilmiah Kedokteran dan Kesehatan
Imam Agus Faizal
Program Studi Sarjana Terapan Teknologi Laboratorium Medis, Fakultas Farmasi Sains Dan Teknologi, Universitas Al Irsyad Cilacap, Jalan Cerme No.24, Wanasari, Sidanegara, Kec. Cilacap Tengah, Kabupaten Cilacap, Jawa Tengah, Indonesia. 53223
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health Social Sciences Veterinary Other

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Ekspresi TNF-α Histopatologi Ginjal Pada Tikus Model Sepsis Sebagai Efek Preventif Diberi Nanoemulsi Burdock Yang Diinduksi Bakteri MRSA Faizal, Imam Agus; Nugroho, Yusuf Eko; Fauziah, Rahma Shifa; Yunadi, Frisca Dwi; Swandari, Mika Tri Kumala
Jurnal Sain Veteriner Vol 44, No 1 (2026): April
Publisher : Faculty of Veterinary Medicine, Universitas Gadjah Mada bekerjasama dengan PB PDHI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jsv.107607

Abstract

One of the natural ingredients utilized as a traditional medicinal herb is Arctium lappa L. or commonly called burdock. This plant has roots, leaves, seeds that have been used to treat infections and various skin disorders. Burdock is used for anti-inflammatory, anti-cancer, infection-fighting, and anti-tumor regulating activities. The purpose of this research is to determine the effect of Arctium lappa L. root extract on renal histopathology and tumor necrosis factor-alpha (TNF-α) expression in white rat sepsis model after Methicillin-Resistant Staphylococcus aureus (MRSA) bacteria administration. Where in this research stage is divided into 5 groups of test animal treatment. Each group was injected with MRSA bacterial suspension with a standard MC Farland turbidity test of 0.5. The results of this research obtained that burdock root extract is able to inhibit inflammation of sepsis test animals caused by MRSA bacteria with the average value of TNF- α reaction presentation, namely K1 (-) (13.632; 14.756), K2 (+) (33.291; 29,568), K3 (150 mg/kg BW) (35,458; 33,273), K4 (300 mg/kg BW) (36,120; 28,731) K5 (450 mg/kg BW) (28,086; 228,084. So it can be stated that Arctium lappa L root extract is able to inhibit inflammation with the use of the most effective dose of 450 mg/kg BW.
Inovasi Pengolahan Limbah Cangkang Kepiting Berbasis Zero Waste sebagai Produk Pangan Bergizi untuk Mendukung Program Makan Bergizi Gratis di Desa Kutawaru, Cilacap Faizal, Imam Agus; Saptyani, Putri Maretyara; Riviani, Riviani
Jurnal SOLMA Vol. 15 No. 1 (2026)
Publisher : Universitas Muhammadiyah Prof. DR. Hamka (UHAMKA Press)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22236/solma.v15i1.22350

Abstract

Background: Peningkatan ketahanan pangan dan pengelolaan limbah perikanan berkelanjutan selaras dengan Sustainable Development Goals (SDGs), terutama SDG 2 (Zero Hunger) dan SDG 12 (Responsible Consumption and Production). Tujuan: Kegiatan ini bertujuan mengembangkan model bisnis zero waste melalui pemanfaatan limbah cangkang kepiting menjadi pangan fungsional sekaligus penguatan pemasaran digital UMKM pesisir di Desa Kutawaru, Cilacap. Metode: Program dilaksanakan melalui pemetaan kebutuhan dan kesepakatan mitra, sosialisasi partisipatif, pelatihan serta pendampingan berbasis IPTEKS dengan penerapan good manufacturing practices (GMP), penguatan branding dan pengemasan, pengembangan website, serta evaluasi berkelanjutan secara deskriptif-kualitatif. Hasil: Hasil menunjukkan peningkatan pengetahuan mitra pada pemanfaatan limbah cangkang kepiting dalam kerangka zero waste dari 35,90% menjadi 90,00%, literasi gizi terkait stunting dari 15,70% menjadi 94,60%, dan kewirausahaan digital dari 45,60% menjadi 89,00%. Produk inovasi kaldu kering cangkang kepiting dari Scylla serrata memenuhi persyaratan keamanan pangan berdasarkan uji organoleptik dan mikrobiologi, serta didukung website UMKM sebagai media promosi dan katalog. Kesimpulan: Kegiatan ini efektif meningkatkan kapasitas produksi, literasi gizi, dan daya saing UMKM, sekaligus memperkuat ekonomi sirkular masyarakat pesisir melalui model bisnis zero waste.
IN SILICO EVALUATION OF FLAVONOIDS FROM ACALYPHA INDICA L. AS Α-GLUCOSIDASE INHIBITORS FOR THE TREATMENT OF DIABETES MELLITUS Lisa Savitri; Kharisul Ihsan; Fendy Prasetyawan; Yuneka Saristiana; Imam Agus Faizal; Meri Meri
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 13 No. 1 (2026)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Type 2 diabetes mellitus continues to pose a significant global health burden, highlighting the urgent need for safer and more effective therapeutic agents with minimal adverse effects. One promising strategy involves targeting α-glucosidase, a key enzyme in postprandial glucose regulation, using bioactive compounds derived from medicinal plants. Acalypha indica, a tropical species widely used in traditional medicine, contains diverse flavonoids with potential antidiabetic activity; however, their molecular mechanisms remain insufficiently explored. This study employed an in silico approach to systematically evaluate the α-glucosidase inhibitory potential of five flavonoids from A. indica—mauritanin, repandusinic acid, hesperetin, glucogalin, and acaindinin. Molecular docking analysis using AutoDock revealed that all compounds exhibited favorable binding affinities toward the α-glucosidase enzyme (PDB ID: 5NN8), indicating spontaneous interactions at the active site. Among them, mauritanin demonstrated the highest binding affinity (–10.3 kcal/mol), forming multiple stabilizing hydrogen bonds with critical catalytic residues, including ASP69, HIS279, and GLU411. Notably, both mauritanin and repandusinic acid showed stronger binding interactions compared to the standard inhibitor acarbose, suggesting superior inhibitory potential. Further interaction analysis using LigPlot+ and Discovery Studio Visualizer confirmed stable ligand–enzyme complex formation, while ADMET predictions using SwissADME indicated favorable pharmacokinetic properties, including good oral bioavailability, low toxicity risk, and absence of major cytochrome P450 inhibition. Overall, these findings identify mauritanin and repandusinic acid as promising lead compounds for α-glucosidase inhibition and support the therapeutic potential of A. indica as a natural source for antidiabetic drug development. This study provides a strong computational foundation for future experimental validation and drug design efforts.
IN SILICO EVALUATION OF FLAVONOIDS FROM ACALYPHA INDICA L. AS Α-GLUCOSIDASE INHIBITORS FOR THE TREATMENT OF DIABETES MELLITUS Lisa Savitri; Kharisul Ihsan; Fendy Prasetyawan; Yuneka Saristiana; Imam Agus Faizal; Meri Meri
Jurnal Bioteknologi & Biosains Indonesia (JBBI) Vol. 13 No. 1 (2026)
Publisher : BRIN - Badan Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Type 2 diabetes mellitus continues to pose a significant global health burden, highlighting the urgent need for safer and more effective therapeutic agents with minimal adverse effects. One promising strategy involves targeting α-glucosidase, a key enzyme in postprandial glucose regulation, using bioactive compounds derived from medicinal plants. Acalypha indica, a tropical species widely used in traditional medicine, contains diverse flavonoids with potential antidiabetic activity; however, their molecular mechanisms remain insufficiently explored. This study employed an in silico approach to systematically evaluate the α-glucosidase inhibitory potential of five flavonoids from A. indica—mauritanin, repandusinic acid, hesperetin, glucogalin, and acaindinin. Molecular docking analysis using AutoDock revealed that all compounds exhibited favorable binding affinities toward the α-glucosidase enzyme (PDB ID: 5NN8), indicating spontaneous interactions at the active site. Among them, mauritanin demonstrated the highest binding affinity (–10.3 kcal/mol), forming multiple stabilizing hydrogen bonds with critical catalytic residues, including ASP69, HIS279, and GLU411. Notably, both mauritanin and repandusinic acid showed stronger binding interactions compared to the standard inhibitor acarbose, suggesting superior inhibitory potential. Further interaction analysis using LigPlot+ and Discovery Studio Visualizer confirmed stable ligand–enzyme complex formation, while ADMET predictions using SwissADME indicated favorable pharmacokinetic properties, including good oral bioavailability, low toxicity risk, and absence of major cytochrome P450 inhibition. Overall, these findings identify mauritanin and repandusinic acid as promising lead compounds for α-glucosidase inhibition and support the therapeutic potential of A. indica as a natural source for antidiabetic drug development. This study provides a strong computational foundation for future experimental validation and drug design efforts.
PERBANDINGAN PERTUMBUHAN Aspergillus niger PADA MEDIA POTATO DEXTROSE AGAR (PDA) DAN MEDIA ALTERNATIF DARI SINGKONG, UBI JALAR, DAN BEKATUL Indah Lestari; Akhmad Mubarok; Imam Agus Faizal
Klinikal Sains : Jurnal Analis Kesehatan Vol. 12 No. 2 (2024): Desember
Publisher : LPPM Universitas Abdurrab

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36341/klinikal_sains.v12i2.4955

Abstract

Aspergillus niger is one of the fungi that can produce citric acid and is often used in some studies because of its resistance to very low acidic conditions. Potato Dextrose Agar medium is a common medium for culturing fungi in the laboratory. Alternative media are media that use materials from nature whose content is not yet known in detail. Rubber cassava has a carbohydrate content of 98.4674%. The carbohydrate content of white sweet potato is 28.78%. Rice bran has a carbohydrate content of 84.36%. The purpose of this study was to determine the comparison of the growth diameter of Aspergillus niger fungi on Potato Dextrose Agar (PDA) media and alternative media made from cassava, sweet potato, and rice bran. The research used a pure experimental method. Aspergillus niger isolates were observed microscopically, after which they were planted on PDA media and alternative media, incubated at 37°C for 72 hours, then the diameter of fungal growth was measured. The results showed that the alternative media that had the largest Aspergillus niger fungal growth diameter compared to PDA media as a control was alternative media from rice bran with the smallest diameter of 40 mm and the largest diameter of 80 mm.
Profil Biokimia Darah Akibat Pemberian Ekstrak Akar Burdock (Arctium lappa L.) pada Tikus Putih (Rattus norvegicus) Ika Aulia Fazrianti; Dini Puspodewi; Imam Agus Faizal
Jurnal Ilmiah Kedokteran dan Kesehatan Vol. 5 No. 1 (2026): Januari: Jurnal Ilmiah Kedokteran dan Kesehatan
Publisher : Lembaga Pengembangan Kinerja Dosen

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/klinik.v5i1.5307

Abstract

Burdock (Arctium lappa L.) is a medicinal plant that contains active compounds such as flavonoids, lignans, and phenolic acids, which act as antioxidants, anti-inflammatory agents, and hepatoprotective substances. This study aimed to evaluate the blood biochemical profile following the administration of burdock root extract in white rats (Rattus norvegicus). The study was conducted experimentally using eight male and female rats, divided into four groups: a negative control group (aquadest) and three treatment groups receiving doses of 150, 300, and 450 mg/kgBB orally for 28 days. Blood biochemical parameters were examined on day 36, including albumin, total protein, globulin, glucose, urea, amylase, cholesterol, ALT, ALP, total bilirubin, creatinine, and creatine kinase. The results showed that most biochemical parameters remained within the normal range, although significant changes were observed in some groups. Urea, amylase, and total bilirubin levels remained stable, while total protein, globulin, and ALP levels tended to be higher in female rats. Elevated glucose, cholesterol, and ALT levels in most treatment groups indicated potential disturbances in carbohydrate and lipid metabolism, while increased creatinine levels in some groups suggested possible nephrotoxic effects. Administration of burdock root extract influenced the biochemical blood profile, particularly related to glucose and lipid metabolism as well as liver function. Further studies are needed to explore the underlying mechanisms and evaluate the long-term safety of burdock root extract.
KORELASI KADAR GLUKOSA DARAH DENGAN HITUNG JENIS LEUKOSIT PADA PASIEN DIABETES MELITUS TIPE 2 DI RSUD BAHTERAMAS KOTA KENDARI SULAWESI TENGGARA Wa Ode Surida; Imam Agus Faisal; Ira Pangesti
Jurnal Analis Laboratorium Medik Vol 10 No 2 (2025): JURNAL ANALIS LABORATORIUM MEDIK
Publisher : UNIVERSITAS SARI MUTIARA INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Latar belakang: Diabetes melitus tipe 2 adalah penyakit metabolik kronis yang ditandai dengan hiperglikemia akibat resistensi insulin. Hiperglikemia kronis memicu peradangan sistemik yang memengaruhi sistem kekebalan tubuh. Oleh karena itu, pengukuran glukosa darah dan jumlah leukosit sangat penting untuk menilai status metabolik dan imunologi pasien. Tujuan: Penelitian ini bertujuan untuk mengetahui korelasi antara kadar glukosa darah dengan hitung jenis leukosit pada penderita DM tipe 2 di RSUD Bahteramas Kota Kendari Sulawesi Tenggara. Metode: Penelitian ini bersifat deskriptif analitik dengan pendekatan cross-sectional dengan menggunakan data sekunder dari 53 pasien DMT2 di RSUD Bahteramas Kota Kendari. Data berupa hasil pemeriksaan glukosa darah dan hitung jenis leukosit dari rekam laboratorium. Analisis dilakukan dengan uji Shapiro-Wilk dan korelasi Spearman Rank menggunakan SPSS. Hasil: Hasil penelitian ini menunjukkan bahwa sebagian besar pasien memiliki kadar glukosa darah ≥200 mg/dL. Jumlah neutrofil rata-rata lebih tinggi dibandingkan jenis leukosit lainnya. Hasil uji Spearman menunjukkan bahwa akumulasi neutrofil berkorelasi positif signifikan dengan kadar glukosa darah (r = 0,413; p = 0,002), sementara akumulasi eosinofil berkorelasi negatif signifikan (r = -0,290; p = 0,035). Kesimpulan: Terdapat hubungan yang signifikan antara kadar glukosa darah dengan beberapa jenis leukosit.
POTENSI AKAR BURDOCK SEBAGAI BENTUK PROTEKTIF RADIKAL BEBAS PADA SALURAN PERNAPASAN PEROKOK AKTIF STUDY IN-VIVO PADA TIKUS JANTAN Imam Agus Faizal; Frinsisca Octaviany; Ira Pangesti; Dini Puspodewi; Arina Lis Sa'adah
Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Vol 11 No 1 (2026): Jurnal Ilmiah Ibnu Sina
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jiis.v11i1.2561

Abstract

Exposure to cigarette smoke is known to trigger oxidative stress and trigger an inflammatory response in lung tissue. Lung organs are highly susceptible to damage due to continuous exposure to pollutants, especially free radicals. This condition has the potential to cause pathological changes in the structure of lung cells. This study aimed to evaluate the difference in histological changes in rat lungs between the group not exposed to conventional cigarette smoke (control group) and the group exposed to cigarette smoke accompanied by the administration of burdock root extract, ethanol solvent, methanol, and vitamin E. Exposure was carried out 7 times for 14 days, using one cigarette for each treatment session. The results of the observation showed that all the groups that received exposure had lung tissue damage. Based on the average histopathological score, the rate of lung damage was grouped as follows: K1 (negative control) of 4.6; K2 (positive control) of 7; P1 (treatment with ethanol) of 5.6; P2 (treatment with methanol) of 8.6; and P3 (treatment with vitamin E) by 6.6. The group with the highest level of damage was P2 (methanol) which fell into the severe damage category, while the lowest level of damage was found in P1 (ethanol), which fell into the light category.
Toxicity Test Of Burdock (Arctium lappa L) Root Extract On Renal Histopathological Profile And Granulocyte Response In Wistar Rats : Uji Toksisitas Ekstrak Akar Burdock (Arctium lappa L) Terhadap Profil Histopatologi Ginjal Dan Respon Granulosit Tikus Wistar Dwi Faizatun Nisa; Imam Agus Faizal; Dini Puspodewi
Medicra (Journal of Medical Laboratory Science/Technology) Vol. 8 No. 2 (2025): December
Publisher : Universitas Muhammadiyah Sidoarjo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21070/medicra.v8i2.1790

Abstract

Burdock (Arctium lappa L) is a medicinal plant widely used in traditional therapy due to its active compounds, including arctigen, and phenolic acids, which possess antioxidant and anti inflammatory pro penties. The study aims to investigate the histopatholohical profile of the kidneys and granulocyte levels in wistar rats after administration of burdock root extract. This study employed an experimental method using 8 male and female wistar rats divided into four groups, an negative control group and treatment groups whith doses 0f 150 mg/kgBB, 300 mg/kgBB, and 450 mg/kgBB. The extract was orally for 28 days. Was performed using Periodic Acid Schiff (PAS) sataining, and granulocyte counts were using a hematology analyzer. The results of kidney tissue examination showed no significant histopatological damage in all treatment groups, some sampeles showed the presence of adipocytes, but without indication of kidey damage. PAS staining showed no glycogen or mucopolysaccharides, which indicate tissue damage. Granulocyte levels in the treatment groups showed varying changes, depending on dose and gender, whit a significant increase in high doses in females. It can be mucopolysaccharides indicating tissue damage. Granulocyte counts in the treatment groups showed varying changes depending on dose and gender, whit a significant increase at high doses in famales. It can be concluded that burdock root extrack dose not cause histopathological kidey tissue damage and is relativeky safe use at low to high doses, but it affects granulocyte counts in a dose and sex dependent manner. 
Analisis Mutu Sediaan Dan Pembacaan Mikroskopis Tuberkulosis Di Cilacap Tahun 2024 : Quality Of Tuberculosis Smear Preparation And Reading In Cilacap, 2024 Fitria Nur Kartika; Imam Agus Faizal; Ira Pangesti; Meka Faizal Farabi
Jurnal Kesehatan Bakti Tunas Husada: Jurnal Ilmu-ilmu Keperawatan, Analis Kesehatan dan Farmasi Vol 26 No 2 (2026)
Publisher : LPPM Universitas Bakti Tunas Husada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36465/jkbth.v26i2.1932

Abstract

Pemeriksaan mikroskopis Basil Tahan Asam (BTA) merupakan metode yang tetap digunakan dalam pemantauan pengobatan tuberkulosis (TBC) di fasilitas pelayanan kesehatan yang belum memiliki akses ke Tes Cepat Molekuler (TCM). Kualitas pemeriksaan sangat dipengaruhi oleh mutu pembuatan dan pembacaan sediaan. Penelitian ini bertujuan untuk mengevaluasi kualitas sediaan mikroskopis TBC di Kabupaten Cilacap tahun 2024 berdasarkan enam indikator standar, serta menilai akurasi pembacaan melalui uji silang sebagai bagian dari Pemantapan Mutu Eksternal (PME). Penelitian menggunakan desain deskriptif evaluatif menggunakan pendekatan evaluasi program secara retrospektif. Data uji silang triwulan I–IV dianalisis secara deskriptif kuantitatif. Hasil menunjukkan tingkat partisipasi yang tinggi (91,67–97,92%), peningkatan kualitas spesimen, serta akurasi pembacaan yang sangat tinggi (99,23–100% tanpa kesalahan besar). Namun, indikator ketebalan, ukuran, dan kerataan masih belum optimal pada sebagian fasilitas. Kesimpulannya, mutu pembuatan dan pembacaan sediaan mikroskopis TBC di Kabupaten Cilacap telah memenuhi standar nasional, namun masih diperlukan peningkatan kompetensi teknis dan penguatan pembinaan serta pemantapan mutu untuk menjaga konsistensi hasil pemeriksaan.
Co-Authors Adilla Putri Az-Zahra Afrilla, Rananda Agung Dwi Wahyu Widodo Ajeng Puspo Aji Akhmad Mubarok Alifah Alifah Alifah Arelliza, Fatma Sheilla Arina Lis Sa'adah Ayuningtyas Ayuningtyas BUDIYANTO Dede Yusuf Dede Yusuf, Dede Denih Agus Setia Permana Dian Novita Dini Puspodewi Dwi Faizatun Nisa Elfred Rinaldo Kasimo, Elfred Rinaldo Fariza Yulia Kartika Sari Faulia wijayanti Fauziah, Rahma Shifa Fendy Prasetyawan Fitria Nur Kartika Frinsisca Octaviany Frisca Dewi Yunadi Frisca Dewi Yunadi Haryanti, Anik Hayati, Defi Nurul Ihsan, Kharisul Ika Aulia Fazrianti Indah Lestari Ira Pangesti Ira Pangesti Ira Pangesti Ira Pangesti Jusak Nugraha Kharisul Ihsan Kusumawati, Dhiah Dwi Lailiya Ramadhanti Lisa Savitri Ma’rifah, Solihatul Meka Faizal Farabi Meri, Meri Mika Tri Kumala Swandari Mika Tri Kumala Swandari, Mika Tri Kumala Ningrum, DM Ningrum, Windi Nizam, Muhammad Farid Khoirun Nugrahaeni, Dian Rahma Nugroho, Yusuf Eko Nur Ariska Nugrahani Permana, Denih agus Setia Pramudiatmoko Priyanto, Anggih Purwati, Rina Putri Maretyara Saptyani Ramadhan, Fahri Riviani Riviani, Riviani Saputri, Ratna Dwi Sa’adah, Arina Lis Setiawan Ardi Wijaya Sodikin Sodikin Susanti Susanti Tri Stiyo Famuji Utami, Tri Fitri Yana Wa Ode Surida Wigati, Atika Nur Wulandari, Mei Yayuk Mundriyastutik Yulianto, Asep Nurrahman yunadi, frisca dewi Yunadi, Frisca Dwi Yuneka Saristiana Yusuf Eko Nugroho Yusuf Eko Nugroho