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Pemberian Jus Buah (Etlingera hemisphaerica) terhadap Pemulihan Eritrosit dan Leukosit Akibat Perlakuan Merkuri Klorida (HgCl2) pada Mencit (Mus musculus) Azzahrah, Fatimah; Ruyani, Aceng; Parlindungan, Deni; Listiono, Arsela Eko; Mayub, Afrizal
BIOEDUSAINS:Jurnal Pendidikan Biologi dan Sains Vol. 8 No. 5 (2025): Bioedusains: Jurnal Pendidikan Biologi dan Sains
Publisher : Institut Penelitian Matematika, Komputer, Keperawatan, Pendidikan dan Ekonomi (IPM2KPE)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31539/7ef7hb33

Abstract

This study aims to determine the effect of Etlingera hemisphaerica (honje) fruit juice on the recovery of erythrocyte and leukocyte counts in mice (Mus musculus) exposed to mercuric chloride (HgCl₂). The method used was an experimental design using male mice as test animals, divided into three groups: K1 (control), K2 (honje juice 0.3 mL/20 g BW for 3 days), and K3 (HgCl₂ 5 mg/kg BW + honje juice 0.3 mL/20 g BW for 3 days). The observed parameters were the number of erythrocytes and leukocytes before and after treatment. The results showed that honje juice administration increased the erythrocyte count in group K2, while in group K3, erythrocyte recovery was affected by mercury exposure, making the honje juice less effective, although the values remained within the normal range compared to the control group. In leukocyte count, group K2 showed a stabilizing effect, whereas group K3 experienced an increase due to HgCl₂ exposure. In conclusion, Etlingera hemisphaerica fruit juice has potential as a phytotherapy agent to repair hematological damage caused by heavy metal toxicity, although its effectiveness is influenced by the metabolic condition of the mice and the high concentration of mercury. Keywords: Etlingera hemisphaerica, Erythrocytes, Leukocytes, Mice, Mercuric Chloride
Effect honje forest fruit juice administration on hemoglobin levels following mercury chloride treatment in mice Iskandar, Aiza Sabina Putri; Ruyani, Aceng; Parlindungan, Deni; Johan, Henny; Mayub, Afrizal
JPBIO (Jurnal Pendidikan Biologi) Vol 10, No 2 (2025): November 2025
Publisher : STKIP Persada Khatulistiwa Sintang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31932/jpbio.v10i2.5561

Abstract

Exposure to mercury chloride (HgCl?) is known to induce oxidative stress, which negatively affects the hematological system, including a decrease in hemoglobin levels. This study aims to analyze the effect of honje fruit juice (Etlingera hemisphaerica), known for its high antioxidant content, on hemoglobin levels in mice (Mus musculus) exposed to mercury chloride. This study used an experimental method involving several groups of mice, namely group K1 (control), group K2 (given honje fruit juice), and group K3 (injected with mercury and given honje fruit juice). Hemoglobin levels were measured using a Sahli tube. The results showed that honje fruit juice significantly increased hemoglobin levels in mice exposed to mercury chloride compared to the control group. These findings indicate that the antioxidant content in honje fruit can help reduce the toxic effects of mercury chloride on the circulatory system. Therefore, honje fruit juice has the potential to be developed as a natural therapeutic agent in efforts to mitigate the toxic effects of mercury chloride.