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Cangara, Husni
Department Of Anatomical Pathology, Medical Faculty Hasanuddin University, Makassar, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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PERBANDINGAN KARAKTERISTIK KLINIKOPATOLOGIS ANTARA ADENOKARSINOMA KOLOREKTAL MUCINOUS DAN NON-MUCINOUS DI MAKASSAR TAHUN 2021-2023 Rasyid, Nur Rahmah; Miskad, Upik Anderiani; Cangara, Muhammad Husni; Wahid, Syarifuddin; Achmad, Djumadi; Tawali, Suryani; Mardiati, Mardiati
Medika Alkhairaat: Jurnal Penelitian Kedokteran dan Kesehatan Vol 6 No 3 (2024): Desember
Publisher : Fakultas Kedokteran Universitas Alkhairaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31970/ma.v6i3.248

Abstract

ABSTRAK Adenokarsinoma kolorektal terdiri dari dua subtipe utama, yaitu mucinous dan non-mucinous, dengan karakteristik klinikopatologis yang berbeda. Memahami perbedaan ini penting untuk menentukan prognosis dan pendekatan terapi yang tepat. Penelitian ini bertujuan mengevaluasi perbedaan klinikopatologis, termasuk grading Tumor Infiltrating Lymphocytes (TILs), antara adenokarsinoma mucinous dan non-mucinous. Studi cross-sectional ini melibatkan 24 pasien adenokarsinoma kolorektal di Rumah Sakit Dr. Wahidin Sudirohusodo, Makassar (2021-2023). Sebanyak 12 pasien dengan adenokarsinoma mucinous dan 12 pasien dengan adenokarsinoma non-mucinous dianalisis. Uji Chi-square digunakan untuk menilai perbedaan grading TILs dan variabel klinikopatologis lainnya, dengan p < 0,05 dianggap signifikan. Grading TILs secara signifikan lebih tinggi pada adenokarsinoma non-mucinous dibandingkan mucinous (p = 0,002). Tidak terdapat perbedaan signifikan pada usia (p = 0,640), jenis kelamin (p = 0,667), invasi limfovaskular (p = 1,000), metastasis nodus limfatik (p = 0,372), tumor budding (p = 0,372), pT (p = 0,457), dan lokasi tumor (p = 0,148). Grading TILs yang lebih tinggi pada adenokarsinoma non-mucinous menunjukkan respons imun yang lebih kuat. Hasil ini dapat membantu personalisasi strategi terapi pada adenokarsinoma kolorektal. Kata Kunci: Adenokarsinoma kolorektal, mucinous, non-mucinous, Tumor Infiltrating Lymphocytes (TILs), klinikopatologi. ABSTRACT Colorectal adenocarcinoma consists of two main subtypes: mucinous and non-mucinous, with distinct clinicopathological characteristics. Understanding these differences is important for determining prognosis and appropriate therapeutic approaches. This study aims to evaluate the clinicopathological differences, including Tumor Infiltrating Lymphocytes (TILs) grading, between mucinous and non-mucinous colorectal adenocarcinoma. This cross-sectional study involved 24 colorectal adenocarcinoma patients at Dr. Wahidin Sudirohusodo Hospital, Makassar (2021-2023). Twelve patients with mucinous adenocarcinoma and 12 with non-mucinous adenocarcinoma were analyzed. Chi-square tests were used to assess differences in TILs grading and other clinicopathological variables, with p < 0.05 considered significant. TILs grading was significantly higher in non-mucinous adenocarcinoma compared to mucinous (p = 0.002). No significant differences were found in age (p = 0.640), gender (p = 0.667), lymphovascular invasion (p = 1.000), lymph node metastasis (p = 0.372), tumor budding (p = 0.372), pT classification (p = 0.457), and tumor location (p = 0.148). Higher TILs grading in non-mucinous adenocarcinoma indicates a stronger immune response. These findings may assist in personalizing therapeutic strategies for colorectal adenocarcinoma patients. Keywords: Colorectal adenocarcinoma, mucinous, non-mucinous, Tumor Infiltrating Lymphocytes (TILs), clinicopathological analysis.
Leptin Expression in High-grade Serous Ovarian Carcinoma: The Controversy of Leptin Paradox in Ovarian Cancer Ham, Jonathan; Masadah, Rina; Nasser, Andi Sitti Halija Diawanti; Rauf, Syahrul; Nelwan, Berti Julian; Cangara, Muhammad Husni; Miskad, Upik Anderiani; Mardiati; Tawali, Suryani
Indonesian Journal of Obstetrics and Gynecology Volume 13. No. 1 January 2025
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32771/inajog.v13i1.2373

Abstract

Objectives : To analyse the characteristics and expression patterns of Leptin in high-grade serous epithelial ovarian carcinoma (HGSC), and to compare them with the overall serous ovarian carcinoma population. Methods : This was a cross-sectional study. A total of 77 paraffin-embedded tissue samples were collected from patients at the Wahidin Sudirohusodo Hospital over a period of 3 years. Immunohistochemical staining was performed using a polyclonal Leptin antibody. Data were analyzed using SPSS version 22.0. Results: Among HGSC patients, the majority (64.3%) were over 50 years old, and a significant portion (39.3%) were obese. Leptin showed strong cytoplasmic expression in 69.6% of HGSC tumor cells and in 100% of LGSC tumor cells (p-value = 0.004). There was no correlation between lymphovascular space invasion and leptin expression. Interestingly, leptin expression in overall serous ovarian carcinoma patients exhibited a protective effect against metastasis (p-value = 0.047), suggesting a leptin paradox exists in this type of cancer. However, this association was no longer significant when the analysis excluded the LGSC group (p-value = 0.193). Conclusion : This study suggest that leptin expression may not be a significant prognostic factor in HGSC. The appearance of the pseudo-leptin paradox phenomenon in several previous studies was confounded by sample populations with heterogeneous tumor morphology. Keywords: high-grade serous carcinoma, leptin paradox, immunohistochemistry, leptin, obesity
Effect of administration of ajwa date extract on renal histopathological changes in meloxicam induced in rats Abdul Halim, Musdalifah; Arsyad, M Aryadi; Dwi Kesuma Sari; Sartini Natsir; Muhammad Husni Cangara; Yulia Yusrini Djabir
Jurnal Riset Veteriner Indonesia (Journal of The Indonesian Veterinary Research) VOLUME 7, No 2, JULY 2023
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/jrvi.v7i2.21785

Abstract

Objective: This study aimed to examine the nephroprotector effect of ajwa date extract on the kidneys of white rats induced by meloxicam. Methods: 25 male (Rattus norvegicus) rats weighing 200-300 g were divided into 5 groups (n = 5), namely group 1 healthy control without meloxicam and ajwa date extract, group 2 negative control with meloxicam 30mg/kgBB without ajwa dates, group 4 with ajwa date extract 150mg/kgBW and meloxicam 30mg/kgBW, and group 5 with ajwa date extract 300mg/kgBW and meloxicam 30mg/kgBW. The treatment was given for 14 days, on the 15th day a necropsy was performed to take kidney organs for microscopic evaluation or histipathological examination. Results: Meloxicam at a dose of 30mg/kgBW caused damage to the kidneys with observations of glomerular hemorrhage, tubular necrosis, hydropic degeneration and narrowing of the tubular lumen as well as narrowing of the capsular space with an average degree of damage reaching 75% while ajwa date extract doses of 150 and 300mg/kgBW has a nephroprotector effect against meloxicam induction. Conclusion: Ajwa date extract doses of 150 and 300mg/kgBW had a nephroprotector effect on meloxicam induction.
The Effect of Ajwa Date Fruit Extract (Phoenix Dactylifera L.) Against Liver Damage in White Rats (Rattus Norvegicus) Induced by Meloxicam Fatimah Mappanyompa; Arsyad, M Aryadi; Sari, Dwi Kesuma; Natsir, Sartini; Cangara, Muhammad Husni; Djabir, Yulia Yusrini
Jurnal Riset Veteriner Indonesia (Journal of The Indonesian Veterinary Research) VOLUME 7, No 1, JANUARY 2023
Publisher : Hasanuddin University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20956/jrvi.v7i1.21788

Abstract

Abstract Objective: This study was aimed to investigate the protective effect of Ajwa date palm extract (Phoenix Dactylifera L.) against liver damage in white rats (Rattus norvegicus) induced by Meloxicam. Methods: The samples used in this study were twenty five male white rats divided into five groups with body weight 200 – 300gr, namely a healthy control group, negative control given Meloxicam 30mg/kgBB, treatment group 1 was given Ajwa date fruit extract 75mg/kgBW and Meloxicam 30mg/kgBW, treatment group 2 was given Ajwa date fruit extract 150mg/kgBW and Meloxicam 30mg/kgBW, and treatment group 3 was given Ajwa date fruit extract 300mg/kgBW and Meloxicam 30mg/BW for 14 days. On the 15th day, the rats were anesthetized for blood tests and euthanized for liver organ observation. Results: The result showed by giving Ajwa date palm extract with higher doses and Meloxicam 30mg/kgBW, resulted a decrease in ALT and AST enzyme levels which were close to normal values ​​in rats. Histological observation showed extensive damage to liver cell tissue, with signs of inflammation, hemorrhage, necrosis, and hydropic degeneration. By giving high doses of Ajwa date palm extract and Meloxicam 30mg/kgBW, gave a view of a decrease degree on liver tissue damage. Conclusion: The extract of Ajwa date palm (Phoenix Dactylifera L.) can provide a protective effect against liver damage in white rats (Rattus Norvegicus) induced by Meloxicam with decreased levels of liver function enzymes which are Alananine Transaminase (ALT) and Aspartate Aminotransferase (AST), along in the changes of liver histopathological view which showed a decrease degree of liver cell tissue damage. Keywords: Ajwa date palm extract; Meloxicam; Liver tissue damage.
The Role of Tumor Budding as a Prognostic Factor in Colorectal Adenocarcinoma Rianti, Andi Marcha; Miskad, Upik Anderiani; Cangara, Muhammad Husni; Wahid, Syarifuddin; Achmad, Djumadi; Tawali, Suryani
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 11 No. 1 (2025)
Publisher : Faculty of Medicine, Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v11i1.1586

Abstract

Background: Colorectal cancer is one of the most prevalent malignancies worldwide. Tumor budding has emerged as a potential prognostic indicator in colorectal adenocarcinoma. Objective: This study aimed to analyze the relationship between tumor budding and histopathological grade, lymphovascular invasion, and lymph node metastasis in colorectal adenocarcinoma, and to assess the potential of tumor budding as a prognostic factor. Methods: A cross-sectional study was conducted using 93 colorectal adenocarcinoma samples. The association between tumor budding and histopathological grade, lymphovascular invasion, and lymph node metastasis was evaluated using the Chi-square and Mann-Whitney tests. Results: Among the 93 samples, a significant difference in tumor budding scores was found between cases with and without lymphovascular invasion (p = 0.003). However, no significant association was observed between tumor budding scores and histopathological grade (p = 0.685) or lymph node metastasis (p = 0.092). Additionally, a significant correlation was found between lymphovascular invasion and lymph node metastasis (p < 0.001). Conclusion: Tumor budding may serve as an important prognostic factor in colorectal adenocarcinoma, particularly in its association with lymphovascular invasion
Characteristics of ER, PR, HER2 and Ki67 Expression in Invasive Breast Cancer Patients at RSUP Dr. Wahidin Sudirohusodo, Makassar 2021-2023 Rahmawani, Surya; Nelwan, Berti J; Miskad, Upik Anderiani; Cangara, Muhammad Husni; Sungowati, Ni Ketut; Yamin, Amalia; Aslam, Muhammad; Mardiati, Mardiati
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 11 No. 1 (2025)
Publisher : Faculty of Medicine, Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22487/htj.v11i1.1589

Abstract

Background: Invasive breast carcinoma is the most common type of breast cancer among women globally, with high mortality. In Indonesia, it ranks first based on Globocan 2020 data. Objective: To determine the expression of prognostic and predictive markers—Estrogen Receptor (ER), Progesterone Receptor (PR), HER2, and Ki67—in breast cancer cases at RSUP Wahidin Sudirohusodo. Methods: A descriptive study was conducted on 71 samples from 2021–2023. Data on age, histopathologic grade, and marker expression (HER2, ER, PR, Ki67) were analyzed. Samples were stained and examined microscopically. Chi-square tests were performed using SPSS version 27. Results: Among the 71 samples, 47.89% were from patients aged < 50 years and 52.11% from those >/ 50. Grade 2 was most common (59.15%). HER2 expression was negative in 59.15% of samples, ER positive in 83.10%, PR positive in 67.61%, and Ki67 expression was low in 52.11%. Conclusion: Most cases showed negative HER2 and positive ER/PR expression with low Ki67, indicating the relevance of hormonal receptors and proliferation rate as prognostic indicators. These markers are crucial for prognosis and treatment planning in breast carcinoma.
Hepatic Alteration due to Formaldehyde Exposure on Wistar Rats (Rattus norvegicus) Makbul, Hidayat; Wedayani, Anak Agung Ayu Niti; Punagi, Abdul Qadar; Pieter, Nova Audrey Luetta; Cangara, Muhammad Husni; Lestarini, Ima Arum; Restuningdyah, Novia Andansari Putri
Jurnal Biologi Tropis Vol. 24 No. 1 (2024): Januari - Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i1.6455

Abstract

Formaldehyde is a hazardous chemical substance that can be found commonly in the environment which has various effects on cellular functions and could induce the cellular oxidative stress. Oxidative stress has a direct impact on the hepatic condition and could induce the activation of inflammatory mediators, lipid peroxidation, proteosomal degradation, and mitochondrial dysfunction resulting in hepatocyte injury that could be marked by hepatic enzyme elevation and hepatic weight alterations. This research was conducted using 16 Wistar rats (Rattus norvegicus), divided into 4 groups each containing 4 Wistar rats. The first group was the control group, while the other groups were exposed to formaldehyde 10% by inhalation at doses of 20, 30, and 40 ppm formaldehyde persistently for 6 hours daily for about 16 weeks. The result of this study reveals that formaldehyde induction has a significant impact on hepatic weight elevations (p=0.007) and ALT enzyme elevations (p=0.000) in the treatment groups compared with the control group. Collectively, our results provide valuable information on the hazardous effects of formaldehyde inhalation, especially on the liver.
Inhaled Formaldehyde Induction Effect on Urea and Creatinine Levels of Wistar Rats (Rattus Norvegicus) Ramadhita, Nova Izza Salsa; Lestarini, Ima Arum; Wedayani, Anak Agung Ayu Niti; Punagi, Abdul Qadar; Pieter, Nova Audrey Luetta; Cangara, Muhammad Husni
Jurnal Biologi Tropis Vol. 24 No. 1 (2024): Januari - Maret
Publisher : Biology Education Study Program, Faculty of Teacher Training and Education, University of Mataram, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jbt.v24i1.6457

Abstract

Formaldehyde is a chemical substance that has the molecular formula H2-C=O. These chemicals are frequently present in the form of contaminants in the outdoor environment. Previous research has been undertaken to investigate the effects of formaldehyde inhalation on various organs such as the nasopharynx, upper respiratory tract, and lungs. The purpose of this study is to determine the effect of inhaled formaldehyde exposure on kidney function. The parameters of the kidney function tests that were measured were urea and creatinine levels in the rat's blood serum. For 16 weeks, 12 male Wistar rats were used in an experimental investigation with a post-test-only control group design. The rats were divided randomly control and treatment groups. Treatment group exposed to 10% formaldehyde levels as high as 40 ppm by inhalation. Blood serum samples were obtained through the retro orbit at week 16 and analyzed using a UV VIS spectrophotometer. According to data analysis utilizing the Independent T-test, there was a significant difference in the urea content test data (p < 0.05). Mann-Whitney analysis of creatine data revealed that there is no significant difference between the groups. From the statistical analysis, it can be concluded that formaldehyde exposure has an effect on increasing urea levels and has no effect on creatinine levels.
Snail Expression is Positively Correlated with Depth of Invasion in Colorectal Carcinoma Miskad, Upik Anderiani; Akil, Fardah; Cangara, Muhammad Husni; Dahlan, Haslindah; Hutasoit, Gina Andyka; Ilyasa, Muhammad Riza
The Indonesian Biomedical Journal Vol 16, No 6 (2024)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v16i6.3392

Abstract

BACKGROUND: Colorectal carcinoma ranks as the second deadliest and third most prevalent cancer globally. The depth of tumor invasion and the presence of tumor-infiltrating lymphocytes (TILs) are linked to survival rates in this disease. Meanwhile, Snail expression is positively correlated with tumor grade, recurrence, metastasis and poor prognosis in various tumors. However, not many studies discuss the correlation of Snail expression with invasion depth and TILs in Indonesia. Therefore, this study was conducted to investigate the correlation between Snail expression and both the depth of invasion and TIL scoring in colorectal carcinoma.METHODS: A cross-sectional study was conducted to evaluate 70 paraffin-embedded blocks of colorectal carcinoma patients. Snail expression was measured with immunohistochemistry using Snail rabbit polyclonal antibody. Stromal TILs were assessed on a single full-face hematoxylin and eosin (H&E) slide, and classified into high, intermediate, and low TILs.RESULTS: The results showed that the most invasion was to the muscularis propria (42.9%) and the least invasion was to the submucosa (4.3%). In scoring TILs, the most samples with intermediate TILs (58.6%) and the least samples with low TILs (4.3%). The analysis employing a Spearman Rank coefficient shows significant positive correlation between the expression of Snail with depth of invasion (r=0.273; p=0.022) but there was no significant correlation with TILs scoring (p=0.892).CONCLUSION: Even though, there is no significant correlation between Snail expression with TILs, there is, however, a significant positive correlation between Snail expression with depth of invasion in colorectal carcinoma. Therefore, Snail expression might be potentially used as a prognostic factor in colorectal carcinoma.KEYWORDS: Colorectal, carcinoma, Snail, depth of invasion and TILs
Cardioprotective of Ethanol Extract of Black Turmeric (Curcuma Caesia Roxb) on Doxorubicin Induced Rats Pratiwi, Nadya; Wahyudin, Elly; Cangara, Muhammad Husni
Jurnal Ilmiah Kesehatan (JIKA) Vol. 6 No. 2 (2024): Volume 6 Nomor 2 Agustus 2024
Publisher : Sarana Ilmu Indonesia (salnesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36590/jika.v6i2.496

Abstract

Discovery of black turmeric's anti-radical, anti-inflammatory properties and ability to inhibit the growth of tumor cells. This study aimed to evaluate the cardioprotective effects and identity the effect of black turmeric (Curcuma caesia Roxb) ethanol extract in preventing cardiac damage in mice induced by doxorubicin. The experimental design employed is a pre-post test control group design. The study used male Wistar rats weighing between 150-200 grams, divided into 6 groups, with each group consisting of 4 rats. The first group, serving as the normal group, was only provided with food and water. The second group received Na-CMC as a negative control, while the third group was given Vitamin E as a positive control. The fourth, fifth, and sixth groups were administered suspensions of black turmeric extract at doses of 100, 300, and 500 mg/kg BW, respectively. The rats were induced with doxorubicin at a dose of 5 mg/kg BW once a week for 3weeks. On the final day of treatment, the rats were fasted for 18 hours, anesthetized, and blood samples were taken for analysis. The rats were also secured on a surgical board. Following induction, CKMB and LDH levels were measured again, and histopathological observations were conducted. The results showed CKMB levels indicated significant differences between groups with p<0,05 (0,025), while LDH levels did not show significant differences with p-value>0,05 (0,225). Histopathological examination of the heart revealed improvements in function and structure in the group IV.
Co-Authors A Endang Kusuma Intan Abdul Halim, Musdalifah Abdul Qadar Punagi Achmad, Djumadi Amir, Muzakkir Anak Agung Ayu Niti Wedayani Andi Alfian Zainuddin Ariyandy, Andi Arsyad, M Aryadi Arsyad, Muhammad Aryadi Arsyadi, Gunawan Aslam, Muhammad Cahyono Kaelan, Cahyono Christinahadi, Agnes Dyah Dahlan, Haslindah Desi Dwirosalia Suparman Djabir, Yulia Yusrini Djimahit, Tarsisia Truly Dwi Kesuma Sari Elly Wahyudin Fardah Akil Fatimah Mappanyompa Gina Andyka Hutasoit Ham, Jonathan Ika Yustisia Ilhamjaya Patellongi Ilyasa, Muhammad Riza Ima Arum Lestarini Juniarsih, Juniarsih Makbul, Hidayat Mardiati Mardiati Mardiati Marinati A Manggau Miskad, Upik Nasser, Andi Sitti Halija Diawanti Natsir, Sartini Nelwan, Berti J Nelwan, Berti Julian Ni Ketut Sungowati, Ni Ketut Pieter, Nova Audrey Luetta Pratiwi, Nadya Rahmawani, Surya Ramadhita, Nova Izza Salsa Rasyid, Nur Rahmah Restuningdyah, Novia Andansari Putri Rianti, Andi Marcha Rina Masadah Rosdiana Natsir Sakinah, Andi Irhamnia Sartini Natsir Solly Aryza Sudin, Asmirani Syahrul Rauf Syamsiar, Syamsiar Syarifuddin Wahid talawo, Vivi Yuniarti Tawali, Suryani UPIK ANDERIANI MISKAD, UPIK ANDERIANI Yamin, Amalia Yulia Yusrini Djabir