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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal Ilmu Farmasi dan Farmasi Klinik (Journal of Pharmaceutical Science and Clinical Pharmacy) Biomedical Journal of Indonesia Jurnal Ilmu Kefarmasian Indonesia Jurnal Pembelajaran Pemberdayaan Masyarakat (JP2M) Lumbung Farmasi : Jurnal Ilmu Kefarmasian Jurnal Ilmiah Jophus: Journal of Pharmacy UMUS Jurnal Insan Farmasi Indonesia Jurnal Abdimas Indonesia : Jurnal Abdimas Indonesia IJCOSIN : Indonesian Journal of Community Service and Innovation Jurnal Farmasi Klinik dan Sains PCJN Pharmaceutical and Clinical Journal of Nusantara Borneo Journal of Pharmacy
Danang Prasetyaning Amukti
Prodi Farmasi, Fakultas Farmasi, Universitas Ahmad Dahlan Yogyakarta, Indonesia
Religion Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Economics, Econometrics & Finance Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Materials Science & Nanotechnology Medicine & Pharmacology Neuroscience Nursing Physics Public Health Social Sciences Other

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Pemberian edukasi pada usia remaja terhadap penyakit hipertensi Amukti, Danang Prasetyaning; Humolungo, Dwi Tiva Widyanti Sidik; Ardilla, Mita; Bachri, Moch. Saiful; Ma'ruf, Muhammad
Jurnal Pembelajaran Pemberdayaan Masyarakat (JP2M) Vol. 5 No. 2 (2024)
Publisher : Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jp2m.v5i2.21600

Abstract

Prevalensi penderita hipertensi di dunia sebesar 22% dan negara di kawasan Asia Tenggara berada di peringkat ke 3 tertinggi di dunia mengalami hipertensi. Hasil Riskesdas 2018 menunjukkan sebanyak 34,11% penduduk Indonesia mengalami hipertensi dan 20,1% diantaranya merupakan kelompok usia 18-24 tahun. Hipertensi pada remaja menjadi tantangan besar bagi keluarga di Indonesia dan merupakan masalah kesehatan masyarakat yang serius, karena jika tidak terkendali akan berkembang dan menimbulkan komplikasi berbahaya yang menyebabkan stroke, jantung koroner dan kematian. maka perlu dilakukan kegiatan pengabdian kepada remaja sekolah dalam bentuk edukasi kesehatan dan pemeriksaan faktor risiko hipertensi sebagai upaya potensi pencengahan hipertensi.Kegiatan program pemberdayaan umat (PRODAMAT) menggunakan metode Participatory Action Research (PAR). Metode Participatory Action Research (PAR) digunakan untuk menekankan partisipasi dan kolaborasi dari berbagai pihak dalam mengelola penelitian action research. Dalam penelitian ini kami ada beberapa langkah-langkah yang akan di lakukan mulai dari solusi atau gagasan yang di tawarkan, pihak yang di pertimbangkan untuk implementasi gagasan, dan langkah strategis implementasi.Hasil yang didapatkan setelah dilakukan pretest sebesar 64%. Dimana dari hasil yang didapatkan bahwa pengetahuan siswa terhadap hipertensi belum begitu paham. Setelah itu kemudian dilakukan pemaparan materi tentang pengobatan dan pencengahan hipertensi kepada siswa SMK Kesehatan Bantul. Kemudian dilanjutkan dengan sesi posttest pada akhir materi. Hasil yang didapatkan setelah dilakukan posttest sebesar 74%. Hasil ini menunjukkan adanya peningkatan pengetahuan dan pemahaman dari edukasi pengobatan dan pencengahan hipertensi yang perlu diterapkan pada kehidupan sehari-hari untuk mencengah terjadinya hipertensi pada usia remaja.
Upaya promosi kesehatan dan pencegahan hipertensi pada masyarakat Sulistyorini, Sri; Amukti, Danang Prasetyaning; Akrom
Jurnal Pembelajaran Pemberdayaan Masyarakat (JP2M) Vol. 5 No. 3 (2024)
Publisher : Universitas Islam Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33474/jp2m.v5i3.21841

Abstract

Hipertensi merupakan penyakit yang banyak diderita masyarakat Indonesia. Salah satu faktor yang mempengaruhi terjadinya hipertensi adalah kurangnya pengetahuan tentang hipertensi. Promosi kesehatan yang dilaksanakan di RST Bhakti Wira Tamtama ditujukan kepada seluruh pasien atau keluarga yang menunggu obat di ruang tunggu Instalasi Farmasi. Metode Penelitian Tindakan Partisipatif (PAR) digunakan dengan harapan dapat menarik partisipasi dan kolaborasi dari berbagai pihak dalam pengelolaan penelitian tindakan. Materi yang disampaikan terkait hipertensi meliputi pengertian, gejala, faktor risiko, pengobatan hipertensi, dan pencegahannya. Hasil yang diperoleh setelah melaksanakan pre test sebesar 72% peserta belum begitu memahami tentang hipertensi. Setelah pemberian materi hipertensi, sesi post test dilanjutkan di akhir materi. Hasil yang diperoleh adalah 90%. Hasil ini menunjukkan adanya peningkatan pengetahuan dan pemahaman tentang hipertensi, serta pencegahan Promosi Kesehatan. Sehingga nantinya hasil penelitian upaya promosi kehatan dan pencegahan hipertensi pada masyarkat dapat memberikan gambaran kepada masyarakat supaya untuk menjaga gaya hidup sehat dan menghindari faktor pemicu dari hipertensi.
Analisis Hubungan Kepatuhan Suplementasi Tablet Besi Dengan Karakteristik Ibu Melahirkan Bayi Berat Badan Lahir Rendah di RSUD Wonosari Yogyakarta Herlina, Tetie; Prillia, Wiwi Kustio; Amukti, Danang Prasetyaning; Suminingtyas, Ifa Aris; Kusumawardani, Nurul
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 7, No 1 (2026): Januari
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v7i1.34945

Abstract

Low birth weight (LBW) is a leading cause of neonatal mortality, especially in developing countries. Previous studies have not comprehensively assessed the role of maternal adherence to iron tablet consumption, gestational age, maternal age, and anemia status. This study aims to analyze the relationship between adherence to iron tablet consumption and the characteristics of mothers who gave birth LBW at Wonosari Regional Hospital, Yogyakarta. This is a retrospective analytical study with a cross-sectional design on 47 pregnant women who gave birth  LBW between October 2024 and March 2025. Data collection involved the use of an adherence questionnaire to assess adherence to iron supplementation, as well as secondary data obtained from patient medical records. Statistical analysis was performed using the chi-square test to determine the relationship between variables. The results showed no statistically significant association between adherence to iron supplementation (p=0.74), maternal age (p=0.34), or anemia status (p=0.36) with LBW. However, there was a strong and statistically significant association between gestational age and LBW (p < 0.001), which showed that preterm birth is a major risk factor for LBW. In conclusion, gestational age was significantly associated with LBW, while adherence to iron supplementation, maternal age, and anemia status were not. Preventing preterm birth should be a primary focus in strategies aimed at reducing the incidence of LBW.
Analysis of bioactive compounds, antioxidant activity, and acute toxicity test of black garlic (Allium sativum L.) Moch. Saiful Bachri; Muhammad Ma'ruf; Hasna Tsamarah; Daru Estiningsih; Prasasti, Dian; Danang Prasetyaning Amukti; Sapto Yuliani; Vivi Sofia
Pharmaciana Vol. 15 No. 3 (2025): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.12928/pharmaciana.v15i3.31393

Abstract

Black garlic is obtained through a controlled fermentation process that alters its color, aroma, and flavor while enhancing its concentration of bioactive compounds. This product is rich in phenolics, flavonoids, alkaloids, and organosulfur compounds such as S-allyl cysteine, which are known to exhibit antioxidant, anti-inflammatory, and antimicrobial properties. This study aimed to determine the total alkaloid, flavonoid, and phenolic content, antioxidant activity, and acute toxicity profile of black garlic. Black garlic samples were prepared by fermenting Solo garlic for 12 days at 60–70 °C. Alkaloid content was analyzed spectrophotometrically using Bromocresol Green reagent with quinine as the standard, flavonoid content was determined using quercetin, and total phenolic content was measured using the Folin–Ciocalteu method with gallic acid as the standard. Antioxidant activity was assessed using the DPPH method, while acute toxicity testing was conducted on male BALB/c mice at doses of 500–5.000 mg/kg BW following OECD/GHS guidelines. The results showed that black garlic contained 301.65 ± 3.436 mg QE/kg alkaloids, 2.190 ± 0.051 mg QE/g flavonoids, and 81.976 ± 1.179 mg GAE/g phenolics. Antioxidant activity was categorized as very strong with an IC₅₀ value of 9.94 ± 0.012 ppm, comparable to Vitamin C (9.92 ± 0.005 ppm). Acute toxicity tests revealed no toxic symptoms or mortality up to 5.000 mg/kg BW, classifying black garlic as practically non-toxic. In conclusion, black garlic is rich in bioactive compounds, demonstrates strong antioxidant activity, and is safe for consumption, making it a potential functional food and health supplement.
STANDARISASI EKSTRAK ETANOL BAWANG DAYAK (Eleutherine bulbosa (Mill.) Urb) MELALUI ANALISIS PARAMETER SPESIFIK DAN NON-SPESIFIK Shafala Rivani Aisyah; Moch. Saiful Bachri; Laela Hayu Nurani; Sapto Yuliani; Silmi Kaffah; Sri Rahmawati; Muhammad Ma'ruf; Danang Prasetyaning Amukti
Jurnal Insan Farmasi Indonesia Vol 8 No 2 (2025): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/276ecv08

Abstract

Latar belakang: Bawang dayak (Eleutherine bulbosa (Mill.) Urb) merupakan bahan alami yang diolah menjadi ekstrak etanol dari umbi tanaman, dan sangat memerlukan proses standardisasi guna menjamin kualitas, keamanan, serta efektivitasnya secara konsisten bagi konsumen. Penelitian ini bertujuan untuk menilai mutu ekstrak etanol bawang dayak yang diperoleh dari wilayah Sintang, Kalimantan Barat melalui pengujian terhadap parameter spesifik dan nonspesifik. Metode: Pengujian dilakukan dengan mengukur parameter non spesifik dan parameter spesifik. Hasil: Uji laboratorium dilakukan dengan mengukur kadar air (6,31%), abu total (2,27%), dan sari larut etanol (10,84%) sebagai indikator nonspesifik yang merefleksikan stabilitas dan tingkat kemurnian bahan. Sementara itu, parameter spesifik menunjukkan kandungan flavonoid total sebesar 8,416 mgQE/g dan fenolik total sebesar 75,026 mgGAE/g, yang mengindikasikan potensi tinggi terhadap aktivitas antioksidan dan manfaat farmakologis. Kesimpulan: Berdasarkan hasil tersebut, ekstrak etanol bawang dayak dinilai telah memenuhi standar mutu dan berpotensi untuk dikembangkan sebagai bahan baku obat herbal, meskipun kajian lanjutan tetap diperlukan guna mengoptimalkan penerapannya dalam formulasi farmasi yang lebih luas.
Identifikasi Mutu Simplisia dan Ekstrak Serta Uji Aktivitas Antioksidan Ekstrak Daun Sungkai (Peronema canescens Jack) Ma'ruf, Muhammad; Febrianti, Dwi Rizki; Kumalasari, Eka; Amukti, Danang Prasetyaning; Santoso, Blegoh Iwan
Jurnal Farmasi Klinik dan Sains Vol 5, No 2 (2025): Jurnal Farmasi Klinik dan Sains
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas Muhammadiyah Gombong

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26753/jfks.v5i2.1862

Abstract

Sungkai (Peronema canescens Jack.) merupakan salah satu tanaman yang telah lama dimanfaatkan oleh masyarakat sebagai obat tradisional untuk berbagai jenis penyakit. Tanaman ini khususnya pada bagian daun diketahui mengandung flavonoid alkaloid saponin tanin dan terpenoid atau steroid yang berperan sebagai antioksidan. Namun data terkait variasi mutu simplisia dan ekstrak daun sungkai masih terbatas sehingga berpotensi memengaruhi konsistensi aktivitas dan kualitas produk herbal. Penelitian ini bertujuan untuk mengetahui kandungan kimia dalam simplisia dan ekstrak daun sungkai, serta menguji kemampuan antioksidannya dengan metode DPPH. Penelitian ini diawali dengan pengambilan daun sungkai segar yang kemudian diolah menjadi simplisia dan diekstraksi menggunakan etanol 96% melalui metode maserasi. Karakterisasi simplisia dan ekstrak dilakukan melalui uji organoleptik, penetapan parameter spesifik dan nonspesifik, serta skrining fitokimia. Uji aktivitas antioksidan dilakukan dengan metode DPPH menggunakan vitamin C sebagai pembanding serta mengacu pada kriteria klasifikasi nilai IC₅₀ untuk menentukan tingkat kekuatan aktivitas antioksidan. Hasil penelitian ini menunjukkan bahwa simplisia dan ekstrak daun sungkai mengandung alkaloid, flavonoid, saponin, tanin, serta terpenoid/steroid. Parameter mutu simplisia memenuhi standar Farmakope Herbal Indonesia. Uji DPPH menghasilkan nilai IC₅₀ vitamin C sebesar 7,80 ppm dan ekstrak daun sungkai sebesar 14,55 ppm. Keduanya termasuk kategori aktivitas antioksidan sangat kuat, meskipun ekstrak daun sungkai sedikit lebih rendah dibanding vitamin C. Temuan ini menunjukkan bahwa daun sungkai berpotensi dikembangkan sebagai sumber antioksidan alami serta menjadi dasar dalam upaya standardisasi bahan baku dan pengembangan sediaan herbal.
KRT23 SEBAGAI BIOMARKER PROGNOSTIK PADA ADENOKARSINOMA REKTAL: ANALISIS BIOINFORMATIKA BERBASIS UALCAN: KRT23 sebagai Biomarker Prognostik pada Adenokarsinoma Rektal: Analisis Bioinformatika Berbasis UALCAN Danang Prasetyaning Amukti; Mitha Dwi Puspitasari; Ari Widhiarso; Bayu Bakti Angga Santoso; Ria Indah Pratami
Jurnal Ilmiah JOPHUS : Journal Of Pharmacy UMUS Vol. 7 No. 2 (2026): Februari
Publisher : Program Studi Farmasi, Universitas Muhadi Setiabudi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46772/jophus.v7i2.1836

Abstract

 Introduction: Colorectal cancer, including READ, is one of the leading causes of cancer death worldwide. Recent studies have shown the involvement of the KRT23 gene, a member of the type I keratin family, in various malignant processes, including tumor cell proliferation, migration, and invasion. Although KRT23 expression has been studied in several types of cancer, its role in rectal cancer remains poorly understood. This study aimed to evaluate the relationship between KRT23 expression and patients' clinical characteristics and their survival. Methods: KRT23 expression data in rectal cancer patients were obtained from the UALCAN platform, which included subgroups based on race, sex, and weight status. Analysis was performed to evaluate the relationship between KRT23 expression levels and patients' clinical characteristics and their effects on survival using Kaplan-Meier curves and log-rank statistical analysis. Results: KRT23 expression was significantly increased in rectal cancer tissues compared to normal tissues. Survival analysis showed that race significantly affected the relationship between KRT23 expression and patient prognosis (p < 0.0001), especially in the Caucasian and African-American racial groups. In contrast, there was no significant difference based on gender (p = 0.97) and weight status (p = 0.64). Conclusion: High KRT23 expression is associated with better prognosis in certain racial subgroups, making it a potential candidate prognostic biomarker for rectal cancer. However, further studies with larger sample sizes are needed to strengthen these findings and understand the underlying biological mechanisms.
Decoding Genetic Risk: A Genome-Wide Association and Functional Analysis of Variants Linked to Liver Cancer Susceptibility: Analysis of Variants Linked to Liver Cancer Susceptibility amukti, danang prasetyaning; Daru Estiningsih; Tetie Herlina; Latifa Amalia; Ifa Aris Suminingtyas; Moch. Saiful Bachri; Ria Indah Pratami; Imam Akbar; Muhammad Ma’ruf
Jurnal Ilmu Farmasi dan Farmasi Klinik Vol. 23 No. 1 (2026): Jurnal Ilmu Farmasi dan Farmasi Klinis (JIFFK)
Publisher : Universitas Wahid Hasyim Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31942/jiffk.v23i1.14048

Abstract

Liver cancer is one of the leading causes of cancer death worldwide. Genetic factors play a role in determining a person's susceptibility to this disease. Genome-Wide Association Studies (GWAS) have identified several genetic variants associated with liver cancer, but their functional mechanisms still need to be further explored. Therefore, this study aims to identify genetic variants that contribute to liver cancer, evaluate their functional effects on proteins, analyze allele frequencies across global populations, and examine gene expression in various human tissues. This study used a bioinformatics approach to identify genetic variations associated with liver cancer from the GWAS Catalog. Five selected missense variants were analyzed using SIFT and PolyPhen-2 to assess their functional impact. Allele distributions in the global population were analyzed using 1000 Genomes Project data, and gene expression was analyzed using the GTEx Portal. The analysis identified 77 candidate genes with significant associations with liver cancer, based on p-values meeting the threshold (p < 5 × 10⁻⁸). Five genes in the Missense Variant category showed a strong association with liver cancer: IFNL3, SLC30A10, PNPLA3, OSMR, and CMTR2. In the analysis using SIFT and PolyPhen-2, the rs3096380 variant (CMTR2) was deleterious, and rs738409 (PNPLA3) and rs188273166 (SLC30A10) were deleterious and probably damaging, with the potential to disrupt protein function and contribute to the pathogenesis of liver cancer. Conclusion: Genetic variations rs738409 (PNPLA3) and rs188273166 (SLC30A10) are deleterious and probably damaging, potentially disrupting protein function and contributing to liver cancer pathogenesis.
Adherence and blood pressure control in hypertensive patients: a cross-sectional study Larasati, Intan Sukma; Nurinda, Eva; Wulandari, Ari Susiana; Kusumawardani, Nurul; Indrayana, Sofyan; Amukti, Danang Prasetyaning
JURNAL ILMU KEFARMASIAN INDONESIA Vol. 24 No. 1 (2026): JIFI In Press
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v24i1.1641

Abstract

In 2023, the prevalence of hypertension in the Special Region of Yogyakarta was  31.8%, with 24% of patients inconsistent adherence to therapy. This study was a cross-sectional study which examined the link between adherence to medication and lifestyle changes with blood pressure control among 120 hypertensive patients in the Hypertension Class Program at Bambanglipuro Primary Health Center using an adherence questionnaire. Most participants exhibited low adherence to both medication (54.2%) and lifestyle interventions (73.3%). The cut-off point for grouping respondents into low and high adherence is based on the median value of the respondents' questionnaire scores (because the data is not normally distributed). Uncontrolled blood pressure was prevalent, with a mean systolic pressure of 151.95±11.45 mmHg and a mean diastolic pressure of 87.14±10.45 mmHg. Spearman's rho analysis revealed a statistically significant relationship between adherence and blood pressure control (p<0.001), with a strong negative correlation observed for medication adherence (r = -0.530) and a moderate negative correlation for lifestyle adherence (r = -0.404). Furthermore, low adherence was associated with a substantially increased risk of uncontrolled blood pressure, with odds ratios of 11.30 (95% CI: 4.70–27.21) for medication adherence and 6.82 (95% CI: 2.77–16.80) for lifestyle adherence. These findings underscore the critical importance of improving patient adherence to both pharmacological and non-pharmacological management strategies to achieve optimal blood pressure control.
Co-Authors Ainiyah, Nadia Putri Akrom Akrom Akrom Akrom Akrom, Akrom Andre, Muhamad Ardilla, Mita Ari Widhiarso Bachri, Mochammad Saiful Bayu Bakti Angga Santoso Daru Estiningsih Dian Prasasti Dwi Tiva Widyanti S. Humolungo Dwi Tiva Widyanti S. Humolungo Eka Kumalasari Evelin Febrianti, Dwi Rizki Gustinanda, Rizky Handaningrum, Karunia Nining Hasna Tsamarah Herlina, Tetie Humolungo, Dwi Tiva Widyanti Sidik Ifa Aris Suminingtyas Iis Wahyuningsih Imam Akbar Indrayana, Sofyan Ismyama, Dian Farida Kaffah, Silmi Kusumawardani, Nurul Laela Hayu Nurani Laela Hayu Nurani Lalu Muhammad Irham Larasati, Intan Sukma Latifa Amalia Liani, Fega Ma'ruf, Muhammad Mita Ardila Mita Ardila Mitha Dwi Puspitasari Moch Saiful Bachri Moch. Saiful Bachri Moch. Saiful Bachri Muhammad Ma'ruf Muhammad Ma'ruf Muhammad Ma’ruf Muhammad Yusron Maulana El-Yunusi Nina Salamah Ningsih, Novita Fitria Nurdevi, Aldise Indah Nurfaizah, Eka Nurinda, Eva Nurshintya, Agnes Panduwinata, Revina Pratami, Ria Indah Prillia, Wiwi Kustio Puspitasari, Ade Ramadhan, Muhammad Marwan Ria Indah Pratami Ria Indah Pratami Ria Indah Pratami Santoso, Blegoh Iwan Sapto Yuliani Sapto Yuliani Shafala Rivani Aisyah Silmi Kaffah Sri Rahmawati Sri Sulistyorini, Sri Suminingtyas, Ifa Aris Tetie Herlina Vivi Sofia Wahyu Widyaningsih Wahyuningtyas, Nurma Wirawan Adikusuma Wulandari, Ari Susiana