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All Journal Biota: Jurnal Ilmiah Ilmu-Ilmu Hayati Indonesian Journal of Cancer Chemoprevention Dharmakarya : Jurnal Aplikasi Ipteks Untuk Masyarakat Indonesian Journal of Pharmaceutical Science and Technology Jurnal Farmasi Klinik Indonesia The Indonesian Biomedical Journal Indonesian Journal of Chemical Science IDJP (Indonesian Journal of Pharmaceutics) Chimica et Natura Acta CARADDE: Jurnal Pengabdian Kepada Masyarakat Jurnal Inovasi Hasil Pengabdian Masyarakat (JIPEMAS) FITOFARMAKA: Jurnal Ilmiah Farmasi JURNAL FARMASI GALENIKA Jurnal Ilmiah Farmako Bahari Indonesian Journal of Biological Pharmacy Jurnal Sains dan Teknologi Farmasi Indonesia Jurnal Farmasi Galenika ETHOS: Jurnal Penelitian dan Pengabdian kepada Masyarakat
Diah Lia Aulifa
Padjadjaran University
Agriculture, Biological Sciences & Forestry Arts Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Economics, Econometrics & Finance Education Electrical & Electronics Engineering Engineering Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences Other

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In Silico Study of Hops Plant Compounds (Humulus lupulus L.) as Phytoestrogens for Insulin Resistance Siagian, Johanna Berliana; Hermansyah, Inas Fathinah; Pendy, Violent Irene; Wibowo, Mutia Amara Putri; Haq, Dhiya'Ul; Pramudita, Fransisca Widi; Aulifa, Diah Lia
Biota : Jurnal Ilmiah Ilmu-Ilmu Hayati Vol 10, No 3 (2025): October 2025
Publisher : Universitas Atma Jaya Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24002/biota.v10i3.12143

Abstract

Postmenopausal women often experience insulin resistance, a condition linked to declining estrogen levels. Structurally similar to endogenous estrogen, phytoestrogens derived from Humulus lupulus L. (hops) hold potential as natural agents in hormone replacement strategies. This research utilized a comprehensive in silico methodology to assess 20 bioactive hop-derived compounds for their ability to act as agonists of estrogen receptor alpha (ERα). The evaluation involved Lipinski’s Rule of Five, ADME-Tox profiling, pharmacophore-based screening, and molecular docking analyses. Seven compounds satisfied the pharmacophore model criteria. Among them, Isoxanthohumol and 8-prenylnaringenin displayed the most favorable binding affinities, while Desmethylxanthohumol and Naringenin showed interaction patterns closely aligned with those of the native ligand. Although the majority demonstrated favorable pharmacokinetic properties, a few compounds presentedpotential mutagenic or carcinogenic effects. Considering binding performance, interaction resemblance, and predicted safety, these four compounds emerge as strong phytoestrogen candidates for ERα modulation in insulin resistance. Experimental validation through biological studies is necessary to substantiate these computational findings.
Ternary Solid Dispersion Improves Anti-cancer Activity of Alpha-mangostin Against MCF-7 Breast Cancer Cells Budiman, Arif; Yunita, Ellen Nathania; Rusdin, Agus; Marcelino, Jeremy; Amaliah, Salma; Aulifa, Diah Lia
The Indonesian Biomedical Journal Vol 18, No 1 (2026)
Publisher : The Prodia Education and Research Institute (PERI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18585/inabj.v18i1.3938

Abstract

BACKGROUND: Alpha-mangostin (AM) exhibits potent anti-breast cancer activity but its therapeutic effectiveness is constrained due to low aqueous solubility and poor bioavailability. Ternary solid dispersions (TSDs) were developed by adding another excipient to address these challenges. Nevertheless, limited studies have systematically evaluated whether improvements in dissolution and stability achieved through TSD systems are translated into enhanced in vitro cytotoxicity of AM. Therefore, TSD system of AM with Eudragit (EUD) and Poloxamer (POL) was developed, and in vitro cytotoxicity activity was evaluated as a preliminary proof-of-concept in MCF-7 breast cancer cells.METHODS: TSD of AM was prepared by solvent evaporation and characterized by Power X-Ray Diffraction (PXRD), Differential Scanning Calorimetry (DSC), and Fourier Transform Infrared (FT-IR) Spectroscopy. The pharmaceutical properties were evaluated by in vitro dissolution test using a standard paddle apparatus, while physical stability was assessed under two relative humidity environments. The in vitro anticancer efficacy was examined in MCF-7 breast cancer cell using an MTT assay.RESULTS: Amorphization of TSD was confirmed by a halo pattern with PXRD measurements and the absence of an AM melting peak in the DSC curve. FT-IR analysis revealed hydrogen bond interactions between the carbonyl group of AM and EUD/POL protons. TSD system significantly improved the dissolution profile and enhanced cytotoxic effects, reducing cell viability to 1.17% at 16 µg/mL with an IC50 of 7.11 μg/mL (CI 95%: 6.626-7.591).CONCLUSION: The TSD system significantly improved dissolution profile and in vitro cytotoxicity in MCF-7 breast cancer cells, providing proof-of-concept for enhancing the biological performance of AM. KEYWORDS: alpha-mangostin, ternary solid dispersions, dissolution, MCF-7, cytotoxicity
Effects of Extraction Temperature on the Total Protein and Vitamin C Levels of Channa striata Water Extract Restiasari, Anggi; Aulifa, Diah Lia; Febrianti, Raden Maya; Rosdianto, Aziiz Mardanarian; Rukayadi, Yaya; Levita, Jutti; Diantini, Ajeng
Indonesian Journal of Pharmaceutical Science and Technology Vol 13, No 2 (2026)
Publisher : Indonesian Journal of Pharmaceutical Science and Technology

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijpst.v13i2.65682

Abstract

Channa striata are a freshwater fish, popularly known as snakehead fish in Indonesia, belonging to the family Channidae. The fish are usually consumed for their protein and their medicinal properties in treating wounds and pain. Previous study showed that the protein in C. striata can be extracted using water at 50 °C for 60 minutes, and using acetone at 4°C for 24 hours. Considering all, this work aims to investigate the effects of temperature on the protein and vitamin C content of the water extract from C. striata fish collected in Rancaekek, West Java. The meat was extracted with water at 55-60 °C for 10 and 30 minutes, compared to the cold extraction at room temperature for 60 minutes. The resulting extracts were subjected to the qualitative Biuret color test and quantitative protein analysis using the Kjeldahl Method. The study revealed that cold extraction of C. striata meat for 60 minutes resulted in the highest protein content (0.29% in the residue and 0.35% in the supernatant). Moreover, the vitamin C levels, determined using the iodometric method, in the homogenate, supernatant, and residue were 60.64 mg/100 g, 60.82 mg/100 g, and 43.38 mg/100 g respectively.
In Silico Study of Licorice Compounds (Glycyrrhiza inflata BAT.) on PPAR-γ Receptor as Antidiabetic Nababan, Roger Rinaldi; Amri, Rahma Emilya; Wijaya, Nabila Qonita; Abdah, Bintang Mutya; Haq, Dhiya’ Ul; Pramudita, Fransisca Widi; Aulifa, Diah Lia
Indonesian Journal of Biological Pharmacy Vol 5, No 2 (2025): IJBP (Agustus)
Publisher : Department of Biological Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/ijbp.v5i2.67342

Abstract

Diabetes melitus tipe 2 (DMT2) merupakan penyakit metabolik ditandai dengan hiperglikemia kronis akibat resistensi atau kekurangan insulin. Peroxisome proliferator-activated gamma (PPAR-y) adalah reseptor yang berperan pada metabolisme glukosa dan lipid sehingga dapat menjadi target terapi antidiabetes. Penelitian ini bertujuan menguji dan mengevaluasi potensi 18 senyawa kalkon dari Glycyrrhiza inflata Bat. sebagai agonis PPAR-γ melalui pendekatan in silico. Sebagian besar senyawa memenuhi kriteria drug-likeness. Hasil prediksi ADMET menunjukkan 14 senyawa memiliki penyerapan usus yang baik (HIA < 70%) dengan permeabilitas dan toksisitas yang bervariasi. Pemodelan farmakofor menunjukkan senyawa isoliquiritigenin memiliki nilai fit score (42,18) menunjukkan kesesuaian struktur terhadap kantong pengikatan PPAR-y tertinggi sedangkan hasil docking menunjukkan DTM memiliki afinitas pengikatan energi tertinggi. DTM membentuk ikatan hidrogen dan interaksi hidrofobik penting dengan residu asam amino seperti HIS323, TYR473, SER289, dan HIS449.  Temuan ini menunjukkan DTM berpotensi sebagai agonis alami PPAR-y dengan aktivitas antidiabetes yang menjanjikan dan layak diteliti secara in vitro maupun in vivo.
Ternary Solid Dispersions for Improved Dissolution Profile of Poorly Water-Soluble Drugs: Insights from Recent Studies Amaliah, Salma; Aulifa, Diah Lia; Budiman, Arif
Indonesian Journal of Pharmaceutics Vol 7, Issue 2, May - August 2025
Publisher : Universitas Padjadjaran (Unpad)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/idjp.v7i2.63625

Abstract

Enhancing the dissolution of poorly water-soluble drugs remains a major challenge in drug development. Binary solid dispersions (BSDs), composed of a drug and a hydrophilic polymer, have been employed to improve solubility primarily through amorphization. However, many BSD systems suffer from limited wettability and suboptimal dispersion, which reduce their effectiveness in promoting rapid and consistent drug release. Ternary solid dispersions (TSDs) introduce a functional third component, such as an additional polymer, surfactant, co-former, or other excipient, to overcome these limitations and further enhance dissolution performance. This review provides a concise summary of current advancements in TSD systems and their underlying mechanisms for improving drug dissolution. Relevant studies published between 2020 and 2025 were retrieved from Scopus, Google Scholar, and PubMed using the keywords "ternary solid dispersion" and "dissolution." Critical formulation strategies, excipient combinations, and manufacturing techniques were summarized to elucidate how TSDs improve dissolution by stabilizing the amorphous state, inhibiting nucleation and crystal growth, enhancing wettability, and preventing particle agglomeration. The selected preparation method was determined to significantly affect dissolution behavior. The compiled evidence supports TSD systems as a versatile and efficient strategy for improving the dissolution characteristics of poorly water-soluble drugs, offering substantial potential for advancing oral drug delivery.
Co-Authors Abdah, Bintang Mutya Ajeng Diantini, Ajeng Al Shofwan, Adnan Aly Almattin, Bilqis Na'ilah Alya Puteri Agustina Pribadi Amaliah, Salma Amirah, Siti Rafa Amri, Rahma Emilya Angela Alysia Elaine Anggi, Joseph Fide Anisa Pebiansyah Arif Budiman Audry Rahma Dewayani Augustina, Yeni Ayodduki, Zahra Noor Silmi Hermawan Ayu Permatasari Bernap Dwi Putra Sitinjak Diffa Hauna F. Pakhrul Diki Prayugo Wibowo Elaine, Angela Alysia Emamia, Evelyn Stepania Febriani, Yessi Febrianti, Raden Maya Firman Firman Firman Firman Fitriansyah, Sani Nurlaela Guspira, Yunitasya Hadiwijaya, Nathannael Adrya Halwa Aulia Nurdin Haq, Dhiya'Ul Haq, Dhiya’ Ul Hartono, Sugianto Ayudha Helmi, Nyai Ayu Sylfia Stannia Puspitasari Hermansyah, Inas Fathinah Hesti Riasari Husna Muharram Ahadi Hutapea, Ezra Calista Izzaturrahmi, Ahda Salsabila Jhoni, I Made Jutti Levita Kamaludin, Asilla Mauri Ramdini Karim, Bilqisti Kanzabila Kevin Gabriel Liawardi, Petra Pahlawanda Chrisanto Maharani, Devita Salsa Marcelino, Jeremy Maria Selviana Rendo Maya Andani, Maya Mei, Kaila Keyshia Muchtaridi Muchtaridi Mulyadi, Ananda Putri Aulia Muntashir, Ilham Mohammad Nababan, Roger Rinaldi Nahariyah, St. Rohmani Natashya Parameswari Natasya Prameswari Nursuhud Nurulaini, Siti Nunung Nurviana, Destawesty Nyi Mekar Saptarini Parameswari, Natashya Pauziah, Ai Syipa Ulfah Pendy, Violent Irene Permatasari, Ayu Pramudita, Fransisca Widi Pratomo, Muhammad Fadhil Priana, Diva Dhaifina Mazaya Pribadi, Alya Puteri Agustina Puspitasari, Citra Dewi Ramadhiany, Ziyan Zulfah Redjeki, Sarah Gustia Resmi Mustarichie Restiasari, Anggi Riasari, Hesti Richa Mardianingrum Riezki Amalia Riki - Nugraha Rini Hendriani Rizky Prasiska Wulandari Rosandi, Nurul Fauziah Rosdianto, Aziiz Mardanarian Rusdin, Agus Sabetta, Oktavia Sabiq Salmandhiya Harits Salsabil Ghaliya Sani nurlaela fitriansyah Sani Nurlaela Fitriansyah Setyawati, Luthfi Utami Siagian, Johanna Berliana Siti Uswatun Hasanah Sitinjak, Bernap Dwi Putra Sitinjak, Gloria Maharyani Lastiar Sudirman, Virgiana Keisha Rajabi Johni Sunani, Sunani Swarga, Kirana Fayruz Tsamarah, Dinda Firanitha Virliana, Amrina Wibowo, Mutia Amara Putri Wijaya, Nabila Qonita Winingsih, Wiwin Wiwin Winingsih YAYA RUKAYADI Yeni Augustina Yessi - Febriani Yessi Febriani Yunita, Ellen Nathania Zahira, Annisa