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All Journal Jurnal Kesehatan Masyarakat LINK Jurnal Riset Kesehatan MEDISAINS Jurnal Imejing Diagnostik Buletin Keslingmas Journal Of Vocational Health Studies Belitung Nursing Journal AcTion: Aceh Nutrition Journal Journal of Health Promotion and Behavior Proceedings of the International Conference on Applied Science and Health Global Health Management Journal International Journal of Nursing and Health Services (IJNHS) Unnes Journal of Public Health Jurnal Kesehatan Budi Luhur: Jurnal Ilmu-Ilmu Kesehatan Masyarakat, Keperawatan, dan Kebidanan Journal of Applied Health Management and Technology Journal of Telenursing (JOTING) MAHESA : Malahayati Health Student Journal Advance Sustainable Science, Engineering and Technology (ASSET) Jurnal Info Kesehatan Jurnal Kesehatan Masyarakat
M. Choiroel Anwar
Jurusan Kesehatan Lingkungan Purwokerto Politeknik Kesehatan Kemenkes Semarang
Biochemistry, Genetics & Molecular Biology Chemistry Computer Science & IT Control & Systems Engineering Dentistry Education Electrical & Electronics Engineering Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Medicine & Pharmacology Nursing Public Health Social Sciences

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Journal : MEDISAINS

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Red ginger (Zingiber officinale var. rubrum) nanoparticle extracts on reducing the blood pressure for postpartum hypertension Luthfiyah, Ummu; Runjati, Runjati; Anwar, M. Choiroel
MEDISAINS Vol 21, No 1 (2023)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v21i1.15165

Abstract

Background: Red ginger contains flavonoids, which can cause vasodilation and decreased cardiac output and pressure. Previous research on red ginger on blood pressure has been carried out and showed significant results. However, it has yet to be studied in nanoparticle extracts, where nanoparticles are the best drug carrier system, so it is necessary to research.Purpose: Making and testing red ginger nanoparticle administration (Zingiber officinale var. rubrum) to reduce blood pressure in hypertensive postpartum mothers.Methods: This is an experimental study with a pre-post control group design. The sample consisted of 40 postpartum hypertensive mothers divided into two groups, namely 20 interventions and 20 controls. The intervention group was given red ginger nanoparticles made using the bottom-up method with a dose of 300 mg and the antihypertensive drug nifedipine, while the control group was given the antihypertensive drug nifedipine alone; both were given for two weeks. Data analysis used the Independent t-test and reapeted ANOVA tests.Results: The systolic blood pressure in the intervention group decreased by 12.95 mmHg on the 7th and 28.4 mmHg on the 14th day (p<0.001) while the control group was 7.05 mmHg on the 7th day and 14.8 mmHg on the 14th day (p<0.001). Diastolic blood pressure in the intervention group decreased by 3.55 mmHg on the 7th day and 11.90 mmHg on the 14th day (p<0.001), while the control group was 2.88 mmHg on the seventh day (p<0.007) and fifth day 35 mmHg on day 14 (p<0.002).Conclusion: Giving red ginger nanoparticles can reduce blood pressure in postpartum hypertension
The effectiveness of red ginger compress to prevent breast engorgement, reduce breast pain and prostaglandin hormone levels in postpartum mothers Sari, Tatsa Putri Kumala; Wijayanti, Krisdiana; Anwar, M. Choiroel
MEDISAINS Vol 20, No 2 (2022)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v20i2.13587

Abstract

Background: The active ingredients of ginger, such as gingerol, shogaol, zingerone, and paradol, are compounds that play a significant role in anti-inflammatory and analgesic properties. Previous studies that have been carried out using red ginger showed significant results on the severity of breast engorgement; however, these studies have not measured the decrease in levels of the hormone prostaglandin, which is an indicator of engorgement and pain. Previous studies have also shown the impracticality of the intervention. This study has made red ginger "param" (medicinal powder to rub on the body), but the param formulation needs to be tested.Purpose: Analyze the effectiveness of red ginger compress in preventing breast engorgement and reducing breast pain and prostaglandin hormone levels in postpartum mothers.Methods: This is experimental research with a post-test only with a control group design. Respondents in this study were postpartum mothers. Respondents were randomly allocated into two groups, control groups (n=15) and intervention groups (n=15). The intervention group receives red ginger compresses twice daily for five consecutive days. The variables observed were breast engorgement, breast tenderness, and levels of prostaglandins. Data were analyzed using the independent T-test and Mann-Whitney test.Results: There was an effect of a red ginger compress to prevent breast engorgement (p<0.05) and reduce breast pain (p <0.05); however that is not significant reduce prostaglandin hormone levels (p>0.05).Conclusions: Red ginger compress effectively prevents breast engorgement and reduces breast pain, but not significant in reducing prostaglandin hormone levels.
In vitro study of potential antibacterial pometia pinnata leaf extract in Neisseria gonorrhoeae Widayani, Gandi Ari Savitri; Anwar, Muhammad Choiroel; Sudirman, Sudirman
MEDISAINS Vol 19, No 3 (2021)
Publisher : Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/medisains.v19i3.11907

Abstract

Background: Gonorrhea cases experiencing antibiotic resistance are increasing due to inadequate treatment or failure to contribute to an increase in antibiotic resistance cases; WHO suggests adding herbal therapy treatment methods is expected to minimize the occurrence of drug resistance as much as possible. Previous studies that have been carried out using other herbal plants have not shown any potential to inhibit the growth of Neisseria gonorrhoeae bacteria, seen from the amount of extract concentration and the dosage and content of the compounds in the contents monitoring the time.Objective: To analyze the difference in the effect of various concentrations of Matoa Leafs Extract (Pometia Pinnata) compared to 500mg Levofloxacin on the increase in the growth inhibition of Neisseria gonorrhoeae.Methods: This is true-experimental research with a post-test-only control group with a randomized design. The sample in this study was the microorganism Neisseria gonorrhoeae obtained through vaginal swabs in 2 females (FSW) positive for Gonorrhea by gram staining and microscopic examination and culture on Chocolate Agar Plant (CAP) media. The culture was then suspended in CAP media. Matoa Leaf extract concentration of 100%, 80%, 60%, 40%, 20%, positive control with Levofloxacin 500 mg and negative control with distilled water with four replications and monitoring in 24 hours, 48 hours, 72 hours, and 96 hours. Data analysis used Kruskal-Wallis, Mann-Whitney, and cohen's test. Result: Levofloxacin 500mg in inhibiting Neisseria Gonorrhoeae bacteria is very effective, and Matoa Leaf extracts 60% and 40% P=0,026 have a strong enough potential to inhibit the growth of Neisseria gonorrhoeae bacteria with the same potential strength. The cohen's test 1.4 effect the levofloxacin 500mg provides a significant influence inhibiting Neisseria Gonorrhoeae.Conclusion: Matoa Leaf extract 60%, and 40% have solid antibacterial potential, although not as strong as Levofloxacin 500mg.
Co-Authors A.A. Ketut Agung Cahyawan W Adi Septian Agung Nugroho Setiawan Agus Subagiyo Amaliah, Nurul Anak Agung Aris Diartama Ari Suwondo Ari Suwondo Ari Suwondo Ariawan Soejoenoes Ariawan Soejoenoes Arif Widyanto Aris Santjaka Aris Santjaka Bedjo Santoso Belliya Yulis Rahmadani Budi Triyantoro Budi Utomo Chatarina Umbul Wahyuni Darmini Darmini Darmini Devi Farah Ghina Devi Ratna Yuliani Devi Ratna Yuliani Dewi Rahayu Dewi, Mariza Mustika Dewi, Putri Sitronela Dian Apri Nelyanti Diartama, Anak Agung Aris Dina Adelia Djamaluddin Ramlan, Djamaluddin Djamil, Masrifan Donny Kristanto Mulyantoro Donny Kristanto Mulyantoro Donny Kristanto Mulyantoro Faisal Amri Faisal Amri Faisal Amri Fatimah Fauzan Ma’aruf Fitria, Candra Tyas Nur Frisian Lutfi Intan Risqita Gatot Murti Wibowo Gatot Murti Wibowo, Gatot Murti Ghina, Devi Farah Hamdiah Hamdiah Hani, Umu Hari Rudijanto I.W Hari Rudijanto Indro Wardono Hari Santoso Hermawan Pamot, Hermawan Husnul Yusmianti, Siti Nur Intan Risqita, Frisian Lufti Irma Nadziroh Irwan Irwan Irwan Katili Jannah, Marichatul Jannah, Marichatul Jaya Maulana Krisdiana Wijayanti Kun Aristiati Susiloretni Leny Latifah Leny Latifah Leny Latifah Luthfiyah, Ummu M.Pd S.T. S.Pd. I Gde Wawan Sudatha . Ma'ruf, Fauzan Makruf, Fauzan Mardiyono Mardiyono Mardiyono, Mardiyono Marsum Marsum Mayu Sanlia Samadani Mela Firdaust Melyana Nurul Widyawati Mohamad Ilham Maulana Latif Mohammad Alif Nur Fathoni Muliadi Muliadi Nabiha, Puteri Inandin Nela Maghfirotul Ilmi Nilam Safitri Ariani Nisa, Alfiana Ainun Nor Istiqomah Novita, Dhea Nur Fathoni, Mohammad Alif Nur Lu’lu Fitriyani Nyoman Supriyani Oktari, Ida Ayu Pranandya, Brian Ilham Priantoro, Win Priantoro, Win Prima Selvia Megawati Priyo Sulistiyono Pujiastuti, Rr Sri Endang Puteri Inandin Nabiha Putri Intan Pertiwi Rahayu, Umi Margi Rahma Widiantari Reni Nuraeni Rihardini Okvitasari Rintan Rizkiya Mufidah Ristiawati Rr. Sri Endang Pujiastuti Rr.Sri Endang Pujiastuti Runjati Saifudin Sari, Tatsa Putri Kumala Selasih Putri Isnawati Hadi Septiani, Ainishfi Laili septiwiyarsi, septiwiyarsi Slamet Budiyanto Sri Sumarni Sri Widiyati Sri Widiyati, Sri Sudirman Sudirman Sudiyono Sudiyono Sudiyono Sudiyono Sudiyono Sudiyono Sudiyono SUGIYANTO Sugiyanto - Sugiyanto Sugiyanto Sugiyanto Sugiyanto Sunarto Sunarto Sunarto Sunarto Sunaryo Sunaryo Susy Suswaty Susy Suswaty Susy Suswaty Sutopo Patria Jati Tauleka, Abdul Rohim Ta’adi Ta’adi Titha Yuda Pratiwi Tjahjono Kuntjoro Tri Cahyono Tri Cahyono Triana Sri Hardjanti Triana Sri Hardjanti, Triana Sri Utomo, Nur Wahyu Putriyantari Widayani, Gandi Ari Savitri Win Priantoro Win Priantoro Wiwit Estuti Yudastuti, Ririh Yuni Sulistiawati Zaeni Budiono, Zaeni