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All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. Jurnal Kedokteran Brawijaya Jurnal Ilmiah Kedokteran Wijaya Kusuma Majalah Kesehatan FKUB Journal of General Procedural Dermatology and Venereology Indonesia Oceana Biomedicina Journal Majalah Patologi Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Medika Teknika : Jurnal Teknik Elektromedik Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Malang Respiratory Journal Journal of General-Procedural Dermatology & Venereology Indonesia Jurnal Ners dan Kebidanan (Journal of Ners and Midwifery)

Retnani, Diah Prabawati

Department Of Pathological Anatomy, Faculty Of Medicine, Universitas Brawijaya, Malang, Indonesia

Author-ID : 794052

Biochemistry, Genetics & Molecular Biology Dentistry Education Electrical & Electronics Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

Published : 36 Documents Claim Missing Document

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Prototipe Lung Tumor e-mannequin untuk Pelatihan Keterampilan Fine Needle Aspiration Biopsy Diah Prabawati Retnani; Kenty Wantri Anita; Dwi Hadi Sulistyarini; Thareq Barasabha; Amelinda Natania Nurasih; Muhammad Agung Putra Yudha; Ariyanta Dafa Diputra; Andreas Putra Christiawan Purba
Medika Teknika : Jurnal Teknik Elektromedik Indonesia Vol 5, No 2 (2024): April
Publisher : Universitas Muhammadiyah Yogyakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mt.v5i2.21582

Kanker paru merupakan penyebab kematian nomer 2 setelah kanker payudara dengan insiden 11,4% dari penyakit keganasan. Pengambilan spesimen untuk menegakkan diagnosis kanker paru oleh dokter spesialis Patologi Anatomik dapat dilakukan melalui prosedur Fine Needle Aspiration Biopsy (FNAB) menggunakan jarum halus melalui tuntunan imaging dari USG atau CT scan. Berbasis integrasi teknologi 3D Printer dengan manekin berbasis elektronik peneliti melakukan penelitian eksperimental dengan tujuan membuat e-mannequin yang dilengkapi dengan tumor paru untuk pelatihan keterampilan prosedur FNAB oleh mahasiswa Pendidikan Dokter Spesialis Patologi Anatomik sebelum melakukan tindakan pada pasien. Pembuatan e-mannequin menggunakan bahan filamen, tumor berbahan Thermoplastic Polyurethane (TPU) diletakkan pada lokasi paru kiri dan kanan dengan konsistensi kenyal yang dapat dimasukkan jarum halus dan dipasang sensor lampu sebagai validator ketepatan tindakan FNAB pada tumor paru.

The Role of Surgical Resection as A Salvage Therapy and Immunohistochemical Stain to Confirm Mediastinal Yolk Sac Tumor Dwi Rosa Eka Agustina; Suryanti Dwi Pratiwi; Diah Prabawati Retnani; Artono Isharanto; Rachma Dini Erawati
Malang Respiratory Journal Vol. 2 No. 01 (2020): Shape the Curves
Publisher : Universitaas Brawijaya

Background: Mediastinal germ cell tumors are uncommon, representing less than 1% of all malignancies. They mostly occur in young men after puberty and have a poor prognosis with over all long term survival rate 42%. Case Report: We reported a case report in Saiful Anwar Malang Hospital, Indonesia, a young man, 26 years old with an anterior mediastinum tumor and VCSS The CT scan of the chest showed an anterosuperior mediastinal mass which compress the superior vena cava. The result from transthoracic FNAB with USG guidance showed an extragonadal germ cell tumor which resemble an Embryonal Carcinoma from mediastinum. The AFP serum level was elevated. Patient underwent a radiotherapy and a surgical debulking. The biopsy showed an Endodermal Sinus Tumor (Yolk Sac). Immunohistochemical stain for cytokeratin was positive in the tumor cells while stain for CD30 was negative. These were confirming the diagnosis of primary mediastinal yolk sac tumor. Patient received a combination chemotherapy for a total 6 cycles.Conclusion: Some procedures like biopsy, tumor marker, immunohistochemical stain, could differentiate the subtype of mediastinal germ cell tumor. The multimodality treatment by combining chemotherapy with surgical therapy or radiotherapy could increase the survival outcome of patients.

The Role of CD3, CD20, CD30, and Ki67 Immunohistochemistries in Establishing Mediastinal Gray Zone Lymphoma Diagnosis in 24-years-old Female Patient frenky hardiyanto; Suryanti Dwi Pratiwi; Dini Rachma Erawati; Artono Isharanto; Diah Prabawati Retnani; Herwindo Pudjo
Malang Respiratory Journal Vol. 2 No. 02 (2020)
Publisher : Universitaas Brawijaya

Title: The Role of CD3, CD20, CD30, and Ki67 Immunohistochemistries in Establishing Â Mediastinal Gray Zone Lymphoma Diagnosis in 24-years-old Female PatientAuthor: Frenky Hardiyanto, MD. Pulmonology and Respiratory Medicine Department, Brawijaya University, Malang, Indonesia. Supervisor: Suryanti Dwi Pratiwi, MD, Pulmonologist Consultant, Artono I, MD, Cardiovascular and Thorax Surgeon, Dini Rachma Erawati, MD, Radiologist Consultant, Diah Prabawati R, MD, Patology Anatomy Specialist, Herwindo P, MD, Internal Medicine Specialist.Introduction:. A woman with complaints of shortness of breath, cough, fever, night sweating, decrease of body weight and swelling in face, neck and right arm. Chest x-rays and ct thorax revealed a mass in mediastinum.Case Description: Patient is a 24 years old female with complaints of shortness of breath, cough, fever, night sweating, decrease of body weight and swelling in face, neck and right arm. Chest x rays and CT thorax revealed a mass in mediastinum. Open biopsy on right neck mass and transthoracic FNAB resulting of chronic inflammation, so the patient was diagnosed with glandular tuberculosis and Mediastinal Tumor. Patient was getting worse after one month consuming OAT. Patient was consulted to Cardiovascular and thorax Surgery Department. Patient was performed thoracotomy and debulking. Anatomical pathology was examined from debulking mass, the result of immunohistochemistry was found nodular mediastinal gray zone lymphoma.Discussion: this case it is very difficult to enforce the diagnosis. Patients have done neck FNAB, transthoracic FNAB, open biopsy right neck mass and FOB have not been able to establish diagnosis. Until finally done thoracotomy and debulking in this patient, from immunohistochemistry results obtained nodular sclerosis Hodgkin lymphoma. Collaboration from pulmonologist, radiologist, cardiovascular and thorax surgeon, and patology anatomy specialistÂ is needed to confirm the diagnosis in these patients.Keywords: mediastinal tumor, mediastinal gray zone lymphoma

Lung Adenocarcinoma Metastases to Mediastinal with Malignant Pericardial Effusion Andri Andri; Ngakan Putu Parsama Putra; Djanggan Sargowo; Dini Rachma Erawati; Diah Prabawati Retnani
Malang Respiratory Journal Vol. 3 No. 2 (2021): Vol. 3 No. 2
Publisher : Universitaas Brawijaya

Lung adenocarcinoma with malignant pericardial effusion and also metastases to mediastinum has great impact on morbidity and mortality of patient and it is rare case. Most adenocarcinoma in the mediastinum are metastases from the lung, gastrointestinal tract, pancreas, kidney or even the pituitary gland. Cardiac metastases in lung cancer may occur due to retrograde lymphatic spread or by hematogenous dissemination of tumour cells. Pericardium is frequently involved in direct cardiac invasion by adjacent lung cancer. Pericardial effusion, pericarditis, and tamponade are common and life threatening presentation in such cases. A 42-years-old male with superior mediastinal mass has malignant pericardial effusion, cytology shows adenocarcinoma. The patient undergo transthoracic fine needle aspiration biopsy. The result from biopsy is adenocarcinoma. This is a rare case, patient with primary lung adenocarcinoma and malignant pericardial effusion also metastases to mediastinum. To determine the diagnosis requires a comprehensive clinical evaluation and multidisciplinary approach.

Successful Therapy on Patients with Yolksac and Embrional Carcinoma by Surgery and Chemotherapy Fahmi Adhi Prasetya; Susanthy Djajalaksana; Diah Prabawati Retnani; Artono Isharanto; Indrastuti Normahayu; Shinta Okta
Malang Respiratory Journal Vol. 2 No. 01 (2020): Shape the Curves
Publisher : Universitaas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mrj.2020.002.01.5

Background: Malignant mixed germ cell tumors account for 13-25% of all non seminoma germ cell tumors, almost all cases were found in males (85%), increased in the third decade, and had an average survival rate of 40-45%. With modern management the average 5-year survival rate can be over 80%.Case Report: We reported a case report in Saiful Anwar Malang Hospital, Indonesia, a young man, 26 years old with an malignant epithelial tumor derived from mediastinal or lung. The CT scan of the chest showed an lobulated solid mass of iso-hipodens on the anterior superior mediastinum, mass encompassing the aortic arch, left pulmonalis artery, subclavian artery. The result from transthoracic FNAB with USG guidance showed an malignant epithelial tumor derived from mediastinal or lung, impression of an adeno squamous carcinoma. The AFP, LDH, and NSE serum level was elevated. Patient underwent a surgical sternotomy and tumor debulking. The biopsy showed an malignant mixed germ cell tumor (yolksac and embrional carcinoma). These were confirming the diagnosis of malignant mixed germ cell mediastinal tumor (yolksac and embrinonal carcinoma). Patient received a combination bleomycin, etoposid, cisplatin 3 series chemoteraphy Â and evaluated.Conclusion: Some procedures like biopsy, tumor marker, could differentiate the subtype of mediastinal germ cell tumor. The multimodality treatment by combining surgical therapy (surgical sternotomy and tumor debulking) with chemotherapy could increase the survival rate of patients.

Laporan Kasus: GAMBARAN HISTOPATOLOGI HODGKIN LIMFOMA KLASIK MENYERUPAI KARSINOMA PARU Yudanto, Hendy Setyo; Retnani, Diah Prabawati; Ervina, Rita; Wardhani, Shinta Oktya; Hermanto, Djoko Heri
Majalah Kesehatan Vol. 10 No. 3 (2023): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/majalahkesehatan.2023.010.03.6

Limfoma Hodgkin merupakan neoplasma limfoid berasal dari sel B dengan ciri-ciri adanya sel Reed-Sternberg dengan latar belakang sel-sel radang, Limfoma Hodgkin yang melibatkan organ paru terjadi sekitar 15% hingga 40% kasus. Angka kejadian Limfoma Hodgkin ekstra nodal khususnya paru sekitar 3,6%. Seorang pasien wanita usia 31 tahun dengan keluhan batuk lama dan sakit tenggorokan selama satu tahun, dan telah mendapatkan pengobatan rutin, didapatkan penurunan berat badan disertai benjolan pada ketiak kanan berukuran 5 cm, dan dilanjutkan dengan pemeriksaan penunjang radiologi thorak, computed tomography (CT) dengan mengesankan terdapat massa pada paru kanan, kemudian dilanjutkan dengan biopsi dan pulasan imunohistokimia dan di simpulkan sebagai Limfoma Hodgkin, serta pasien menjalani kemoterapi. Biopsi jarum halus atau Fine Needle Aspiration Biopsy (FNAB) pada aksila dapat mengetahui adanya metastasis karsinoma, sarkoma atau Limfoma. Pemeriksaan histopatologi pada sediaan biopsi paru dan dilanjutkan dengan pulasan immunohistokimia Cytokeratin (-), CD45 (-), CD20 (-), CD3 (-) pada sel tumor, Ki67 low proliferation index, CD30 (+), dan PAX5 (+), sehingga didapatkan gambaran Limfoma Hodgkin. Limfoma Hodgkin merupakan neoplasma limfoid berasal dari sel B yang sering mengenai nodul limfoid, mengandung sel mononuklear displastik besar dan sel-sel Multinucleated Reed-Sternberg cells yang dikelilingi oleh sel-sel radang campuran non neoplastik, seperti limfosit kecil, eosinophil, netrofil, histiosit dan sel plasma. Dari kasus ini disimpulkan bahwa Limpoma Hodgkin ekstranodul yang melibatkan organ paru merupakan kasus yang jarang terjadi, dengan open biopsy dan perlu dipertimbangkan pemeriksaan immunohistokimia merupakan cara definitif untuk menegakkan diagnosis Limfoma Hodgkin.

Tinjauan Literatur: KORIOKARSINOMA GESTASIONAL: ETIOPATOGENESIS, MANIFESTASI KLINIS RADIOLOGIS, SERTA TEMUAN MAKROSKOPIK DAN MIKROSKOPIK Rahmadiani, Nayla; Retnani, Diah Prabawati; Fadli, Muhammad Luqman
Majalah Kesehatan Vol. 11 No. 3 (2024): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/majalahkesehatan.2024.011.03.8

Koriokarsinoma gestasional merupakan tumor ganas yang berasal dari komponen sinsitiotrofoblas, trofoblas intermediate, dan sitotrofoblas, yang kejadiannya terkait dengan kehamilan. Koriokarsinoma merupakan jenis neoplasma trofoblastik gestasional tersering, dengan insiden yang tinggi di negara-negara Asia Tenggara. Entitas ini penting untuk didiagnosis dan diterapi dengan tepat, karena ditemukan adanya metastasis pada lebih dari 50% kasus yang tidak tertangani. Pada kajian literatur ini, akan dibahas mengenai aspek diagnosis patologis menurut literatur-literatur terbaru. Secara klinis, gejala dan tanda yang dapat ditemukan antara lain perdarahan pervaginam dengan cairan tampak berwarna kecoklatan bercampur darah, serta kadar hCG serum dan urin yang sangat tinggi. Kriteria diagnosis patologisnya menurut WHO yakni adanya pola bifasik khas, dengan sitotrofoblas villous mononuklear dan trofoblas intermediate yang dikelilingi oleh sinsitiotrofoblas berinti banyak yang ganas. Imunohistokimia dapat membantu pada kasus di mana pola klasik tidak terlalu nampak, dan pemeriksaan genotip dapat dilakukan bila tersedia.

PROFIL KLINIKOPATOLOGI KARSINOMA SEL BASAL DI RSUD DR. SAIFUL ANWAR MALANG TAHUN 2016-2021 Retnani, Diah Prabawati; Anugrah Putri, Deka Miftalia; Putri, Berlian Anggraeni
Majalah Kesehatan Vol. 11 No. 3 (2024): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/majalahkesehatan.2024.011.03.4

Karsinoma sel basal (KSB) merupakan karsinoma keratinosit dengan insiden tertinggi, terutama pada populasi kulit putih. Insiden karsinoma jenis ini meningkat setiap tahun. Penelitian epidemiologi tentang profil klinikopatologi kasus KSB di RSUD dr. Saiful Anwar Malang belum pernah dilakukan. Tujuan penelitian ini adalah untuk mengetahui profil klinikopatologi kasus KSB di RSUD dr. Saiful Anwar Malang periode tahun 2016 sampai dengan tahun 2021. Penelitian ini merupakan penelitian deskriptif untuk mengetahui jumlah kasus KSB di RSUD dr. Saiful Anwar selama tahun 2016 sampai dengan tahun 2021. Data diperoleh dari rekam medis biopsi spesimen dari Instalasi Patologi Anatomi RSUD dr. Saiful Anwar Malang. Data biopsi spesimen tersebut meliputi jenis kelamin, usia, lokasi, dan tipe histopatologi serta tingkat rekurensi yang dibagi menjadi rendah dan tinggi. Terdapat 66 kasus biopsi kulit yang terdiri dari 35 laki-laki dan 31 perempuan. Rentang usia yang memiliki kejadian KSB tertinggi adalah antara usia 61-70 tahun. Area predileksi kanker yang paling banyak adalah hidung. Tipe histopatologi terbanyak yang ditemukan pada kelompok dengan angka rekurensi rendah adalah tipe nodular, dan pada kelompok dengan angka rekurensi tinggi adalah tipe basosquamous.

Prototipe Lung Tumor e-mannequin untuk Pelatihan Keterampilan Fine Needle Aspiration Biopsy Retnani, Diah Prabawati; Anita, Kenty Wantri; Sulistyarini, Dwi Hadi; Barasabha, Thareq; Nurasih, Amelinda Natania; Putra Yudha, Muhammad Agung; Diputra, Ariyanta Dafa; Christiawan Purba, Andreas Putra
Medika Teknika : Jurnal Teknik Elektromedik Indonesia Vol. 5 No. 2 (2024): April
Publisher : Universitas Muhammadiyah Yogyakarta, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mt.v5i2.21582

Mohs Micrographic Surgery for Morpheaform Type Basal Cell Carcinoma: A Case Report Larasaty, Nanda Shaskia; Widiatmoko, Arif; Retnani, Diah Prabawati
Jurnal Kedokteran Brawijaya Vol. 33 No. 3 (2025)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2025.033.03.9

Morpheaform basal cell carcinoma (BCC) is an infiltrative and destructive type of BCC with a high recurrence, necessitating effective and minimally invasive management. Mohs Micrographic Surgery (MMS) is a treatment option for BCC with high conservation results of the entire tumor wall with minimal removal of surrounding healthy tissue, and the lowest recurrence rate compared to other treatment options. In this study, we report a 48-year-old woman with dark spots on the left cheek area that had enlarged over the past year. Dermatological examinations showed hyperpigmentation patches with indistinct borders, irregular edges, and telangiectasis. Fine Needle Aspiration Biopsy (FNAB) confirmed BCC, and the patient underwent Mohs Micrographic Surgery (MMS) for tumor removal. The post-procedural follow-up showed a good outcome.

Co-Authors Aina Angelina Amelinda Natania Nurasih Andreas Putra Christiawan Purba Andri Andri Anggie Sasmita Kharisma Putri Anggun Putri Yuniaswan Anugrah Putri, Deka Miftalia Aprilia, Andrea Arif Widiatmoko Ariyanta Dafa Diputra Artono Isharanto Artono Isharanto Barasabha, Thareq Berlian Anggraeni Putri Boco Pranowo, Tri Pradesa Christiawan Purba, Andreas Putra Dewi, Rose Khasana Dini Rachma Erawati Diputra, Ariyanta Dafa Djanggan Sargowo Dwi Hadi Sulistyarini Dwi Jayasa, Pande Made Dwi Jayasa, Pande Made Dwi Rosa Eka Agustina DYAH FAUZIAH, DYAH Ekasari, Dhany Prafita Ervina, Rita Eviana Norahmawati Eviana Norahmawati Fadli, Muhammad Luqman Fahmi Adhi Prasetya Fitria Mayasari frenky hardiyanto Hamka Muhammad Nasir Laitupa Hanggara, Dian Sukma Hardika, Arif Satria Harun Al Rasyid Harun Al Rasyid Harun Al Rasyid Hendy Setyo Yudhanto Herman Saputra hermanto, djoko heri Herwinda Brahmanti Herwindo Pudjo Hery Susilo Hidayat Sujuti Holipah Holipah Ihda Dian Kusuma Ihda Dian Kusuma Indrastuti Normahayu Karyono Mintaroem Kenty Wantri Anita Kenty Wantri Anita, Kenty Wantri Larasaty, Nanda Shaskia Lilasari, Sekar Puspita Lita Setyowatie Lita setyowatie Lita Setyowatie, Lita Lucky Pratama Muhammad Agung Putra Yudha Ngakan Putu Parsama Putra Nurasih, Amelinda Natania Pande Made Dwi Jayasa Pinahayu, Griesinta Trianty Andria Putra Yudha, Muhammad Agung Putri Rachma Safitri Putri, Berlian Anggraeni RA Rose Khasana Dewi Rachma Dini Erawati Rachmad Sarwo Bekti Rahmadiani, Nayla Rahmawati, Yustian Devika Safitri, Putri Rachma Setiyaningsih, Fera Yuli Shinta Okta Shinta Oktya Wardhani, Shinta Oktya Suryanti Dwi Pratiwi Suryanti Dwi Pratiwi Susanthy Djajalaksana Susilo, Hery Tazakka, Achmad Aidil Thareq Barasabha Widiatmoko, Arif Widiatmoko, Arif Yudanto, Hendy Setyo Yudhanto, Hendy Setyo Yulian, Inneke Yuniaswan, Anggun Putri Yustian Devika Rahmawati

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