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All Journal Saintika Medika: Jurnal Ilmu Kesehatan dan Kedokteran Keluarga. Jurnal Kedokteran Brawijaya Berkala Kedokteran Jurnal Ilmiah Kedokteran Wijaya Kusuma Majalah Kesehatan FKUB Journal of Information Technology and Computer Science Oceana Biomedicina Journal Majalah Patologi Indonesia Medika Teknika : Jurnal Teknik Elektromedik Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Malang Respiratory Journal Jurnal Klinik dan Riset Kesehatan Journal of General Procedural Dermatology and Venereology Indonesia Jurnal Ners dan Kebidanan (Journal of Ners and Midwifery)
Retnani, Diah Prabawati
Department Of Pathological Anatomy, Faculty Of Medicine, Universitas Brawijaya, Malang, Indonesia
Biochemistry, Genetics & Molecular Biology Computer Science & IT Control & Systems Engineering Dentistry Education Electrical & Electronics Engineering Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Other

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Lung Adenocarcinoma Metastases to Mediastinal with Malignant Pericardial Effusion Andri, Andri; Parsama Putra, Ngakan Putu; Sargowo, Djanggan; Erawati, Dini Rachma; Retnani, Diah Prabawati
Malang Respiratory Journal Vol. 3 No. 2 (2021): Vol. 3 No. 2
Publisher : Universitaas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (424.362 KB) | DOI: 10.21776/ub.mrj.2021.003.02.4

Abstract

Lung adenocarcinoma with malignant pericardial effusion and also metastases to mediastinum has great impact on morbidity and mortality of patient and it is rare case. Most adenocarcinoma in the mediastinum are metastases from the lung, gastrointestinal tract, pancreas, kidney or even the pituitary gland. Cardiac metastases in lung cancer may occur due to retrograde lymphatic spread or by hematogenous dissemination of tumour cells. Pericardium is frequently involved in direct cardiac invasion by adjacent lung cancer. Pericardial effusion, pericarditis, and tamponade are common and life threatening presentation in such cases. A 42-years-old male with superior mediastinal mass has malignant pericardial effusion, cytology shows adenocarcinoma. The patient undergo transthoracic fine needle aspiration biopsy. The result from biopsy is adenocarcinoma. This is a rare case, patient with primary lung adenocarcinoma and malignant pericardial effusion also metastases to mediastinum. To determine the diagnosis requires a comprehensive clinical evaluation and multidisciplinary approach.
Successful Therapy on Patients with Yolksac and Embrional Carcinoma by Surgery and Chemotherapy Prasetya, Fahmi Adhi; Djajalaksana, Susanthy; Retnani, Diah Prabawati; Isharanto, Artono; Normahayu, Indrastuti; Okta, Shinta
Malang Respiratory Journal Vol. 2 No. 01 (2020): Shape the Curves
Publisher : Universitaas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.mrj.2020.002.01.5

Abstract

Background: Malignant mixed germ cell tumors account for 13-25% of all non seminoma germ cell tumors, almost all cases were found in males (85%), increased in the third decade, and had an average survival rate of 40-45%. With modern management the average 5-year survival rate can be over 80%.Case Report: We reported a case report in Saiful Anwar Malang Hospital, Indonesia, a young man, 26 years old with an malignant epithelial tumor derived from mediastinal or lung. The CT scan of the chest showed an lobulated solid mass of iso-hipodens on the anterior superior mediastinum, mass encompassing the aortic arch, left pulmonalis artery, subclavian artery. The result from transthoracic FNAB with USG guidance showed an malignant epithelial tumor derived from mediastinal or lung, impression of an adeno squamous carcinoma. The AFP, LDH, and NSE serum level was elevated. Patient underwent a surgical sternotomy and tumor debulking. The biopsy showed an malignant mixed germ cell tumor (yolksac and embrional carcinoma). These were confirming the diagnosis of malignant mixed germ cell mediastinal tumor (yolksac and embrinonal carcinoma). Patient received a combination bleomycin, etoposid, cisplatin 3 series chemoteraphy  and evaluated.Conclusion: Some procedures like biopsy, tumor marker, could differentiate the subtype of mediastinal germ cell tumor. The multimodality treatment by combining surgical therapy (surgical sternotomy and tumor debulking) with chemotherapy could increase the survival rate of patients.
Serial Excision of a Nevus Sebaceous of Jadassohn on the Scalp Sugiatno, Belladikna Brillianty; Widiatmoko, Arif; Dani, Adinda Amalia; Retnani, Diah Prabawati
Journal of General - Procedural Dermatology and Venereology Indonesia Vol. 9, No. 1
Publisher : UI Scholars Hub

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Abstract

Background: Nevus sebaceous of Jadassohn (NSJ) is a non-hereditary hamartoma of the skin’s adnexal structures. The incidence of NSJ in newborns is estimated at 0.1-0.3% with no gender or ethnic propensity. Surgical excision is a common treatment for NSJ, although there is no definite consensus on the timing or recommendations for the removal. This article aims to present the advantages of serial excision therapy in a case of NSJ. Case Illustration: A 14-year-old male presented with a complaint of a bump on the scalp since birth, which had progressively enlarged during puberty. Dermatological examination revealed a well-demarcated, yellow-orange verrucous plaque with irregular borders measuring 3x3.5 cm. The diagnosis was confirmed through dermoscopy and histopathology. The patient underwent a three-stage serial excision at 3-4-week intervals. Discussion: The excision technique for NSJ excision was selected based on the location and size of the lesion. Serial excision is a widely used and straightforward method. This method was chosen due to the lesion’s large area. However, NSJ excision on the scalp presents its own challenges due to limited soft tissue flexibility, hair-bearing skin, and a convex surface, which may affect reconstruction outcomes. Conclusion: The three-stage serial excision resulted in complete removal of the NSJ, minimal scarring without significant alopecia, and no recurrence during the 6-month follow-up.
Pengaruh Pemberian Extra Virgin Olive Oil terhadap Jumlah Sel Granulosa dan Kadar 17 β Estradiol Tikus yang di Papar Rhodamin B Fera Yuli Setiyaningsih; Pande Made Dwi Jayasa; Hidayat Sujuti; Diah Prabawati Retnani
Journal of Ners and Midwifery Vol 5 No 3 (2018)
Publisher : STIKes Patria Husada Blitar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26699/jnk.v5i3.ART.p241-248

Abstract

The use of dyes in food today is very apprehensive. Many foods contain dyes that are prohibited to be used in food. The addition of the dye will have an impact on health. The aim of this research was to know the effectiveness of the administration of extra virgin olive oil to the number of granulosa cell and 17β estradiol level of Rats exposed by rhodamin B. The design of this study was true experimental with post test approach of group design control. The subject of the study was 30 white mice Rattus novergicus in the age of 12 weeks weight average 220 grams and in healthy condition. Rats were divided into 5 groups. Control group without treatment, positive control treatment with rhodamine B 18 mg / 200gr. Treatment 1 administration of rhodamine B 18 mg / 200gr and EVOO (Extra Virgin Olive Oil) 1.5 ml / KgBB, treatment 2 rhodamine B 18 mg / 200gr and EVOO 3 ml / KgBB, treatment 3 rhodamine B 18 mg / 200gr and EVOO 4,5 ml / KgBB. The number of granulosa cells was determined by HE staining, the level of 17β estradiol with ELISA. The data was analyzed by Kruskal Wallis test, Spearman Rank and Simple Linear Regression with degree of significance α <0.05. The average number of granulosa cells and the lowest levels of 17β estradiol were found in the positive control group and the highest average was in the treatment group 3. There was one dose that could significantly increase granulosa cells and the beta estradiol levels compared with the treatment group the other with niali α <0.05. The administration of EVOO affected the number of granulosa cells and the levels of 17β estradiol in rats exposed by rhodamine B.
Laporan Kasus: LESI BULOSA ATIPIKAL PADA PSORIASIS PUSTULAR GENERALISATA: SEBUAH KASUS JARANG Yosephine, Septina; Prawitasari, Suci; Yuniaswan, Anggun Putri; Retnani, Diah Prabawati
Majalah Kesehatan Vol. 12 No. 4 (2025): Majalah Kesehatan
Publisher : Faculty of Medicine Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/majalahkesehatan.2025.012.04.9

Abstract

Psoriasis Pustular Generalisata (PPG) merupakan varian psoriasis yang cukup jarang terjadi. Karakteristik penyakit ini berupa lesi pustular generalisata. Lesi bulosa merupakan lesi atipikal pada kasus PPG dan belum pernah dilaporkan sebelumnya. Tujuan laporan kasus ini untuk melaporkan kasus PPG dengan atipikal lesi bulosa. Seorang laki-laki usia 33 tahun dengan keluhan bintil berisi nanah di seluruh tubuh disertai demam yang muncul sejak 5 hari sebelumnya. Awalnya muncul bercak kemerahan pada seluruh tubuh setelah 2 hari mengonsumsi cefadroxil terkait keluhan sinusitisnya. Keluhan tersebut disertai gatal dengan VAS 6/10 dan nyeri VAS 7/10. Pemeriksaan status dermatologis di seluruh tubuh: pustul multipel di atas plak eritematosa, sebagian berkonfluens membentuk lake of pus dengan body surface area (BSA)  eritema 68%. Pada  regio scalp, alis, dan area retroauricula : skuama putih tipis kekuningan. Pada pemeriksaan mikroskopis didapatkan pustul steril dan laboratorium: leukositosis, eosinophenia, hipoalbuminemia, peningkatan C-reactive Protein (CRP). Perawatan hari ke 3 muncul lesi atipikal bula tegang pada beberapa area tubuh. Hasil histopatologi menunjukkan reaksi psoriasiform dengan microabses monroe dengan kesimpulan psoriasis vulgaris overlapping dengan PPG. Lesi atipikal bulosa yang muncul pada kasus ini menyulitkan dalam penegakkan diagnosis, sehingga pemeriksaan histopatologi sangat penting dilakukan. Hal ini dikarenakan PPG bersifat mengancam nyawa dan perbedaan dalam penatalaksanaannya dibandingkan dengan penyakit bulosa lainnya.
An Expert System for Early Risk Diagnosis of Breast Cancer Using Fuzzy Mamdani and Case-Based Reasoning Rumahorbo, Cicilia Angelica; Arief Andy Soebroto; Putra Pandu Adikara; Diah Prabawati Retnani
Journal of Information Technology and Computer Science Vol. 10 No. 3: Desember 2025
Publisher : Faculty of Computer Science (FILKOM) Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25126/jitecs.2025103854

Abstract

Breast cancer remains one of the leading causes of morbidity and mortality among women worldwide, making early detection essential to improve treatment outcomes. However, early-stage breast cancer symptoms are often subjective and non-specific, which complicates initial risk assessment. This study proposes an expert system for early breast cancer risk diagnosis by integrating Fuzzy Mamdani and Case-Based Reasoning (CBR). The Fuzzy Mamdani method is employed as the primary inference mechanism to model uncertainty in symptoms and risk factors using linguistic rules, while CBR is utilized as a decision support component by leveraging similarities with previously validated clinical cases. The dataset consists of 150 patient records, of which 123 cases are used as the case base and 27 cases are employed for system evaluation. Experimental results show that the proposed system achieves an accuracy of 92.59% compared to expert judgments. These findings indicate that the integration of Fuzzy Mamdani and Case-Based Reasoning provides an interpretable and adaptive approach for early breast cancer risk assessment and has potential as a screening support tool.  
Pola Ekspresi Vascular Endothelial Growth Factor (VEGF) Dikaitkan dengan Pertumbuhan Tumor dan Edema Peritumoral pada Astrositoma Diah Prabawati Retnani; Dyah Fauziah
Majalah Patologi Indonesia Vol. 22 No. 3, September 2013
Publisher : Perhimpunan Dokter Spesialis Patologi Anatomik Indonesia (PDSPA)

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Abstract

ABSTRAK Latar belakang Astrositoma adalah tumor dari sel astrosit dengan variasi derajat histopatologik, disertai ukuran edema peritumoral. Peningkatan derajat keganasan, ukuran tumor dan pembentukan edema peritumoral diperlukan proses angiogenesis. Vascular Endothelial Growth Factor (VEGF) adalah salah satu faktor penting dalam proses angiogenesis. VEGF diperlukan dalam proliferasi, survival dan migrasi sel endotel dan permiabilitas vaskuler. Peranan VEGF dalam pembentukan edema peritumoral masih dalam perdebatan. Penelitian ini bertujuan untuk menganalisis hubungan antara pola ekspresi VEGF dan peningkatan derajat histopatologik, ukuran tumor dan insiden edema peritumoral pada astrositoma. Metode Arsip histopatologik astrositoma derajat II, III, IV (Glioblastoma) dari RSUD Dr. Soetomo Surabaya selama kurun waktu Januari 2009 hingga Januari 2012 dikumpulkan. Pada tiga puluh kasus astrositoma yang memenuhi kriteria inklusi dilakukan pemeriksaan imunohistokimia dengan VEGF Rabbit. Hubungan pola ekspresi VEGF dan derajat histopatologik, ukuran tumor dan kejadian edema peritumoral dianalisis menggunakan uji Spearman. Hasil Sebanyak 29 dari 30 kasus menunjukkan ekspresi VEGF positif. Dari 29 kasus dengan ekspresi VEGF positif tersebut, 13 kasus adalah astrositoma derajat IV, 22 kasus dengan ukuran tumor > 2cm, dan 17 kasus disertai edema peritumoral. Analisis statistik ekspresi VEGF memiliki pengaruh terhadap peningkatan derajat histopatologik (p=0,023), rs=0,413) dan ukuran tumor (p=0,005, rs= 0,499) namun tidak berpengaruh terhadap kejadian edema peritumoral (p=0,273). Kesimpulan Penelitian ini mengungkapkan bahwa ekspresi VEGF dapat meningkatkan derajat histopatologik dan besar tumor, namun tidak berpengaruh terhadap pembentukan edema peritumoral pada astrositoma. Kata kunci: Astrositoma, VEGF, derajat histopatologik, edema peritumoral. ABSTRACT Background Astrocytoma is a glial tumor that derived from astrocyte cells with various tumor size, histopathologic grading and peritumoral edema. Angiogenesis plays role in tumor grading, tumor size and formation of peritumoral edema. VEGF is needed for proliferation, survival, migration of endothel cell and vascular permiability. The role of VEGF to regulate peritumoral edema in brain tumor is still debated. The purpose of this study was to analyze the relationship between VEGF expression and tumor size, histopathologic grading and peritumoral edema of astrocytoma. Methods Pathology archives of grade II, III and IV astrocytomas were retrieved at Dr Soetomo Hospital Surabaya between Januari 2009-Januari 2012. Thirty cases of astrocytomas that fulfilled the conclusion criteria were stained with VEGF rabbit monoclonal antibody (clone EP1176Y). Relationship between VEGF expression and histopathologic grading, tumor size and peritumoral edema were analyzed using Spearman correlation test. Results There were 29 of 30 cases of astrocytom showing positif VEGF expression, 13 cases of grade IV astrocytoma, 22 cases had tumor size more than 2 cm, and 17 cases showing peritumoral edema. Statistical analyzis revealed that VEGF expression had a significant association with histopathologic grading ( p=0.023; rs=0.413) and tumor size (p=0.005; rs=0.499). In contrast, VEGF expression had no significant assoiation with peritumoral edema (p=0.273). Conclusion This study revealed that VEGF plays role in increasing histopathologic grading and tumor size in astrocytoma but its role in peritumoral edema is not significant. Key words : astrocytoma, VEGF, histopathologic grading, peritumoral edema.
A Histopathological Approach to a Case of Recurrent Genital Molluscum Contagiosum Dwi Intan Yuniasih; Lita Setyowatie; Diah Prabawati Retnani
Berkala Kedokteran Vol 21, No 2 (2025)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v21i2.24497

Abstract

Molluscum contagiosum (MC) is a harmless, viral skin infection with a high transmission risk. The Molluscum contagiosum virus (MCV) has two primary forms: type 1 and type 2. Sexually transmitted MC affects the anogenital region, encompassing external genital organs, inner thighs, inguinal folds, and suprapubic areas. The likelihood of MC recurring after treatment can reach up to 35 percent. Transmission primarily occurs through direct physical contact. A 29-year-old man who complained of bumps on the pubis and penile shaft for 3 months accompanied by itching. Venerological examination revealed multiple, round, dome-shaped erythematous papules with and central umbilication on the pubis and penile shaft. On punch biopsy, the epidermis appears with hyperplastic squamous cell epithelium with a cup shape containing Handerson-Peterson bodies. The condition of recurrent, atypical, and mimicking lesions with condyloma lata lesions means that diagnosis in this patient requires a histopathological examination.
Co-Authors Aina Angelina Amelinda Natania Nurasih Andrea Aprilia Andreas Putra Christiawan Purba Andri Andri Anggie Sasmita Kharisma Putri Anggun Putri Yuniaswan Anugrah Putri, Deka Miftalia Arief Andy Soebroto Arif Widiatmoko Ariyanta Dafa Diputra Barasabha, Thareq Berlian Anggraeni Putri Boco Pranowo, Tri Pradesa Christiawan Purba, Andreas Putra Dani, Adinda Amalia Dewi, Rose Khasana Diah Prabawati Dini Rachma Erawati Diputra, Ariyanta Dafa Djajalaksana, Susanthy Djanggan Sargowo Dwi Hadi Sulistyarini Dwi Intan Yuniasih Dwi Jayasa, Pande Made DYAH FAUZIAH, DYAH Eka Agustina, Dwi Rosa Ekasari, Dhany Prafita Ervina, Rita Eviana Norahmawati Eviana Norahmawati Fadli, Muhammad Luqman Fitria Mayasari Hamka Muhammad Nasir Laitupa Hanggara, Dian Sukma Hardika, Arif Satria hardiyanto, frenky Harun Al Rasyid Harun Al Rasyid Harun Al Rasyid Hendy Setyo Yudhanto Herman Saputra hermanto, djoko heri Herwinda Brahmanti Hery Susilo Hidayat Sujuti Holipah Holipah Ihda Dian Kusuma Ihda Dian Kusuma Indrastuti Normahayu, Indrastuti Isharanto, Artono Karyono Mintaroem Kenty Wantri Anita Kenty Wantri Anita, Kenty Wantri Larasaty, Nanda Shaskia Lilasari, Sekar Puspita Lita Setyowatie Lita Setyowatie Lita setyowatie Lita Setyowatie, Lita Lucky Pratama Muhammad Agung Putra Yudha Nurasih, Amelinda Natania Okta, Shinta Pande Made Dwi Jayasa Parsama Putra, Ngakan Putu Pinahayu, Griesinta Trianty Andria Prasetya, Fahmi Adhi Pratiwi, Suryanti Dwi Prawitasari, Suci Pudjo, Herwindo Putra Pandu Adikara Putra Yudha, Muhammad Agung Putri Rachma Safitri Putri, Anggie Sasmita Kharisma Putri, Berlian Anggraeni RA Rose Khasana Dewi Rachmad Sarwo Bekti Rahmadiani, Nayla Rahmawati, Yustian Devika Rumahorbo, Cicilia Angelica Safitri, Putri Rachma Setiyaningsih, Fera Yuli Shinta Oktya Wardhani, Shinta Oktya Sugiatno, Belladikna Brillianty Susilo, Hery Tazakka, Achmad Aidil Thareq Barasabha Widiatmoko, Arif Widiatmoko, Arif Yosephine, Septina Yudanto, Hendy Setyo Yudhanto, Hendy Setyo Yulian, Inneke Yuniaswan, Anggun Putri Yustian Devika Rahmawati