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All Journal Jurnal Delima Harapan JURNAL FARMASIMED (JFM) Jurnal Review Pendidikan dan Pengajaran (JRPP) Jurnal Analis Farmasi PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Peduli Masyarakat Jurnal Kesehatan Tambusai Jurnal Buana Farma JAF (Jurnal Analis Farmasi) JIFI (Jurnal Ilmiah Farmasi Imelda) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Sains dan Teknologi Jurnal Pharmacopoeia Duta Pharma Journal Proceeding of International Conference Health, Science And Technology (ICOHETECH) Prosiding Seminar Informasi Kesehatan Nasional International Journal of Health, Engineering and Technology Jurnal An-Najat: Jurnal Ilmu Farmasi dan Kesehatan Inovasi Jurnal Pengabdian Masyarakat (IJPM) Jurnal Riset Ilmu Kesehatan Umum dan Farmasi Jurnal Pengabdian Masyarakat dan Riset Pendidikan EduInovasi: Journal of Basic Educational Studies Inovasi Kesehatan Global Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Sciences of Phytochemistry Galen: Jurnal Ilmu Farmasi dan Kesehatan Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Jurnal Pengabdian Ilmu Kesehatan Borneo Nursing Journal
Anna Fitriawati
Universitas Duta Bangsa Surakarta
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STUDI IN SILICO AKTIVITAS SENYAWA MINYAK ATSIRI DAUN KEMANGI (Ocimum basilicum L.) SEBAGAI INHIBITOR ENZIM N-acyl-glutamine aminoacylase DARI Corynebacterium sp. UNTUK MENGATASI BAU BADAN Effendi Nursalim; Tiara Ajeng Listyani; Anna Fitriawati
Jurnal Analis Farmasi Vol 11, No 1 (2026): JURNAL ANALIS FARMASI
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jaf.v11i1.25095

Abstract

Bau badan merupakan permasalahan umum yang disebabkan oleh aktivitas bakteri kulit, terutama Corynebacterium sp.,. Enzim N-acyl glutamine aminoacylase (N-AGA) berperan penting dalam proses tersebut, sehingga menjadi target potensial dalam pengendalian bau badan. Daun kemangi (Ocimum basilicum L.) mengandung minyak atsiri dengan berbagai senyawa bioaktif yang berpotensi menghambat aktivitas enzim bakteri. Penelitian ini bertujuan untuk menganalisis potensi senyawa minyak atsiri daun kemangi sebagai inhibitor enzim N-AGA dari Corynebacterium sp. menggunakan pendekatan in silico. Penelitian meliputi molecular docking terhadap senyawa minyak atsiri daun kemangi menggunakan PyRx-AutoDock Vina, analisis interaksi residu asam amino, serta prediksi parameter (ADME) dan toksisitas menggunakan SwissADME dan Toxtree. Triclosan digunakan sebagai kontrol positif. Hasil docking menunjukkan bahwa seluruh senyawa memiliki nilai energi bebas ikatan (ΔG) negatif yang menandakan afinitas pengikatan yang baik terhadap enzim N-AGA. Senyawa myrtenol menunjukkan hasil terbaik dengan nilai ΔG –6,2 kcal/mol serta nilai RMSD 1.215 dan berinteraksi dengan residu asam amino yang sama dengan kontrol positif. Prediksi ADME dan toksisitas menunjukkan bahwa myrtenol memiliki profil drug-likeness yang baik dan tingkat toksisitas rendah. Kesimpulannya, myrtenol berpotensi dikembangkan sebagai kandidat inhibitor alami enzim N-AGA untuk mengatasi bau badan.Kata kunci: atsiri, bau badan, docking, N-AGA, Ocimum
HUBUNGAN TINGKAT KEPATUHAN PENGGUNAAN OBAT TERHADAP KUALITAS HIDUP DAN OUTCOME TERAPI PASIEN DIABETES MELITUS TIPE 2 DI RSUD DR. MOEWARDI SURAKARTA Neha Azziza Cherrysha Alifia; Kharisma Jayak Pratama; Anna Fitriawati
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 9 No. 2 (2026): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v9i2.2035

Abstract

Type 2 Diabetes Mellitus is a chronic disease that requires long-term and continuous management. One of the key factors influencing treatment success is patient adherence to medication. Good adherence can improve quality of life and optimize therapeutic outcomes, while poor adherence often leads to unfavorable outcomes, such as uncontrolled HbA1c levels. This study aimed to determine the relationship between medication adherence and both quality of life and therapeutic outcomes among Type 2 Diabetes Mellitus patients at Dr. Moewardi General Hospital in Surakarta. This study employed an observational design with a cross-sectional approach. A total of 98 patients were recruited using purposive sampling. The instruments used included the MMAS-8 questionnaire to measure medication adherence, the WHOQOL-BREF questionnaire to assess quality of life, and laboratory HbA1c data to evaluate therapeutic outcomes. Data were analyzed using Pearson correlation and chi-square tests. The results showed that most patients had moderate adherence (64,3%), moderate quality of life (100%), and uncontrolled therapeutic outcomes. There was a significant relationship between medication adherence and quality of life (p = 0.015; r = -0.246), but no significant relationship between adherence and HbA1c therapeutic outcomes (p = 0.524). Other factors such as lifestyle, complications, and social support also influence therapeutic success.
Optimasi Sediaan Lotion dan Uji Aktivitas Antioksidan Ekstrak Etanol Daun Belimbing Wuluh (Averrhoa bilimbi L) Della Puspita Ningrum; Anna Fitriawati; Bagas Ardiyantoro
Jurnal Analis Farmasi Vol 10, No 2 (2025): JURNAL ANALIS FARMASI
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jaf.v10i2.21940

Abstract

Penelitian Antioksidan dan Optimasi formula lotion
STUDI IN SILICO AKTIVITAS SENYAWA MINYAK ATSIRI DAUN KEMANGI (Ocimum basilicum L.) SEBAGAI INHIBITOR ENZIM N-acyl-glutamine aminoacylase DARI Corynebacterium sp. UNTUK MENGATASI BAU BADAN Effendi Nursalim; Tiara Ajeng Listyani; Anna Fitriawati
Jurnal Analis Farmasi Vol 11, No 1 (2026): JURNAL ANALIS FARMASI
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jaf.v11i1.25095

Abstract

Bau badan merupakan permasalahan umum yang disebabkan oleh aktivitas bakteri kulit, terutama Corynebacterium sp.,. Enzim N-acyl glutamine aminoacylase (N-AGA) berperan penting dalam proses tersebut, sehingga menjadi target potensial dalam pengendalian bau badan. Daun kemangi (Ocimum basilicum L.) mengandung minyak atsiri dengan berbagai senyawa bioaktif yang berpotensi menghambat aktivitas enzim bakteri. Penelitian ini bertujuan untuk menganalisis potensi senyawa minyak atsiri daun kemangi sebagai inhibitor enzim N-AGA dari Corynebacterium sp. menggunakan pendekatan in silico. Penelitian meliputi molecular docking terhadap senyawa minyak atsiri daun kemangi menggunakan PyRx-AutoDock Vina, analisis interaksi residu asam amino, serta prediksi parameter (ADME) dan toksisitas menggunakan SwissADME dan Toxtree. Triclosan digunakan sebagai kontrol positif. Hasil docking menunjukkan bahwa seluruh senyawa memiliki nilai energi bebas ikatan (ΔG) negatif yang menandakan afinitas pengikatan yang baik terhadap enzim N-AGA. Senyawa myrtenol menunjukkan hasil terbaik dengan nilai ΔG –6,2 kcal/mol serta nilai RMSD 1.215 dan berinteraksi dengan residu asam amino yang sama dengan kontrol positif. Prediksi ADME dan toksisitas menunjukkan bahwa myrtenol memiliki profil drug-likeness yang baik dan tingkat toksisitas rendah. Kesimpulannya, myrtenol berpotensi dikembangkan sebagai kandidat inhibitor alami enzim N-AGA untuk mengatasi bau badan.Kata kunci: atsiri, bau badan, docking, N-AGA, Ocimum
Uji Aktivitas Antibakteri Propionibacterium Acne ATCC 6919 Ekstrak Etanol Daun Si Kejut (Mimosa Pudica L) Anna Fitriawati; Annie Rahmatillah; Nurul Agustiningrum
INSOLOGI: Jurnal Sains dan Teknologi Vol. 4 No. 6 (2025): Desember 2025
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/insologi.v4i6.7080

Abstract

Vulgaris acne is a chronic inflammatory condition commonly experienced by adolescents and young adults, with a prevalence reaching up to 85%. Propionibacterium acnes plays a significant role in the inflammatory process of acne, which is influenced by sebum production, hyperkeratinization, and the inflammatory immune response. Acne treatment often involves antibiotics, but resistance to antibiotics such as erythromycin and clindamycin has increased, creating serious challenges in dermatology. Therefore, the development of non-antibiotic therapies for acne is crucial. One promising alternative is the extract of Mimosa pudica L., also known as the sensitive plant, which is recognized for its antimicrobial activity. The extract of Mimosa pudica L. leaves has been shown to inhibit the growth of various pathogenic bacteria and has potential anti-inflammatory effects based on in silico studies, opening up significant opportunities for the development of plant-based treatments for acne and other inflammatory diseases. This study aims to evaluate the effectiveness of ethanol extract of Mimosa pudica L. leaves in inhibiting the growth of Propionibacterium acnes ATCC 6919. The results of the study show that the 30% ethanol extract can inhibit bacterial growth with an inhibition zone diameter of 11.537 mm, indicating the potential of this extract as a safer and more effective alternative treatment for acne.
Formulation Of Antifungal Solid Soap From 96% Ethanol Extract Of Neem Leaves (Azadirachta Indica A.Juss) Against Malassezia Furfur ATCC 14251 Diyah Nurayuni; Anna Fitriawati; Annie Rahmatillah
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.667

Abstract

Fungal skin infections are still a health problem in tropical regions, especially those caused by Malassezia furfur, so alternative natural skin cleansing preparations are needed that are safe and effective. Neem leaves (Azadirachta indica A. Juss) are known to have antifungal activity and have the potential to be developed into solid soap preparations. This study aims to formulate an antifungal solid soap made from 96 percent ethanol extract of neem leaves, evaluate the physical quality of the preparation, and test its antifungal activity against Malassezia furfur. This study is a laboratory experimental study with a pretest-posttest only control group design. The study population was neem leaves obtained from Mount Pati District, Semarang, with simplicia samples selected using a purposive sampling technique. The research instruments included formulation equipment, physical quality tests based on SNI 3532:2016, and antifungal activity tests using the well diffusion method, while data analysis was carried out using nonparametric statistical tests. The results showed that all soap formulas met the physical quality requirements, and the formulation with a 10 percent extract concentration produced the largest inhibition zone diameter against Malassezia furfur, although it was still relatively weak. The conclusion of this study is that neem leaf extract solid soap has potential as a natural skin cleanser with antifungal activity, but further development and optimization of the formulation are needed to increase its effectiveness.
Evaluation Of The Antioxidant Activity Of Lotion Containing Ethanolic Extract Of Matoa Leaves (Pometia Pinnata J.R.Forst, & G.Forst.) Mei Vita Rachma Pertiwi; Anna Fitriawati; Annie Rahmatillah
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.672

Abstract

Skin exposure to environmental stress produces free radicals and ROS that accelerate aging and skin damage, while antioxidant Lotions from natural extracts such as Matoa leaves (Pometia pinnata) offer protection. This experimental study aimed to evaluate the antioxidant activity of ethanol extracts, the effect of concentration (0.5-6%) on the physical quality of Lotions, and the DPPH scavenging ability of the final Lotion. The population of all Matoa leaf extract Lotion formulations; a sample of 2 kg of fresh leaves from Matesih, Karanganyar was purposively selected. Instruments included a UV-Vis spectrophotometer (517 nm), a Brookfield viscometer, a pH meter; SPSS 28.0 was analyzed by ANOVA, regression for IC50. The extract was very potent (IC50 43.07 ppm) containing flavonoids, alkaloids, saponins, tannins; All Lotions met the standards (homogeneous, pH 5.22-6.34, viscosity 10,100-12,740 cP, spreadability 5-6.5 cm), FV (6%) was optimal (IC50 66.30 ppm, strong). High concentrations increased inhibition but increased viscosity, decreased spreadability (p<0.05). The findings confirm that Matoa Lotion is effective for herbal skin care; further in vivo and stability testing is recommended.
Karakterisasi Stabilitas Warna dan Sifat Fisik Loose Powder Blush dengan Ekstrak Kayu Secang (Caesalpinia Sappan L.) pada Berbagai Konsentrasi Trianita Septiana; Anna Fitriawati; Bagas Ardiyantoro
An-Najat Vol. 4 No. 3 (2026): Agustus: An-Najat: Jurnal Ilmu Farmasi dan Kesehatan
Publisher : STIKes Ibnu Sina Ajibarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59841/an-najat.v4i3.3937

Abstract

Penggunaan pewarna alami dalam kosmetik dekoratif semakin berkembang sebagai alternatif terhadap pewarna sintetis. Kayu secang (Caesalpinia sappan L.) berpotensi sebagai sumber pewarna alami karena mengandung pigmen merah, termasuk brazilin/brazilein dan senyawa terkait antosianin. Penelitian ini bertujuan mengetahui pengaruh variasi konsentrasi ekstrak kayu secang terhadap karakteristik sifat fisik loose powder blush, mengevaluasi stabilitas warna dan fisik setelah cycling test, mengetahui tingkat kesukaan panelis, serta menentukan formula terbaik. Penelitian eksperimental laboratorium ini menggunakan empat formula, yaitu F0 (0%), F1 (1%), F2 (3%), dan F3 (5%) ekstrak kayu secang. Evaluasi meliputi organoleptik, homogenitas, pH, kadar air, ukuran partikel, sifat alir, iritasi, dan hedonik. Stabilitas dipercepat dilakukan selama enam siklus pada suhu 4 °C dan 40 °C, sedangkan kadar antosianin total dianalisis dengan metode diferensial pH menggunakan spektrofotometri UV-Vis. Seluruh formula homogen, memiliki kadar air rendah, menunjukkan sifat alir yang baik, dan tidak menimbulkan iritasi pada 20 panelis. F3 memperoleh skor hedonik tertinggi serta kadar antosianin total tertinggi sebesar 39,07 mg/L. Karakteristik organoleptik dan homogenitas tetap terjaga selama cycling test, sedangkan formula yang mengandung ekstrak mempertahankan pH pada rentang yang digunakan dalam evaluasi kosmetik kulit. Secara keseluruhan, formula F3 dengan ekstrak kayu secang 5% memberikan kombinasi paling baik antara mutu fisik, intensitas warna, stabilitas, dan penerimaan panelis.
Utilization of Simplex Lattice Design to Optimize the Sunscreen Cream Formula Containing Tamarind Peel Extract Endriyatno, Nur Cholis; Fuadhiya, Arina; Efrilia, Erin; Saad, Muhammad; Fitriawati, Anna
Sciences of Phytochemistry Volume 5 Issue 2 (2026)
Publisher : ETFLIN

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphy0502533

Abstract

The tamarind peel (Tamarindus indica L.) extract contains flavonoids that have the ability to provide photoprotection. An optimal cream formulation is required to achieve a high-quality dosage form. This study aimed to determine the total flavonoid content (TFC), to obtain the optimal cream formula, and to measure its photoprotective activity. This research was conducted experimentally and optimized using the Simplex Lattice Design (SLD) method using factors (stearic acid and triethanolamine) and responses (pH, viscosity, spreadability, and adhesiveness). In vitro photoprotective activity determination test using sun protection factor (SPF), erythema transmission percentage (%Te), and pigmentation transmission percentage (%Tp) parameters. The TFC is 47.7018±1.68 mg QE/g. The optimization results showed that variations in stearic acid and trietanolamine concentrations affected pH, viscosity, spreadability, and adhesiveness. The optimization produced a desirability value of 0.967 with predicted factors of 16.078% stearic acid and 3.922% triethanolamine. The predicted responses included pH (4.933), viscosity (247.32 dPas), spreadability (7.07 cm), and adhesiveness (7.37 seconds). A one-sample t-test showed no significant difference between the predictions and the actual results, as indicated by the calculated t-value (pH 0.002, viscosity 0.049, spreadability 0.000, and adhesion 0.000) < t-table (4.303). The cream containing tamarind peel extract exhibits photoprotective activity, with an SPF value of 13.63 ± 1.01, a %Te of 4.64 ± 1.19, and a %Tp of 12.37 ± 1.89. Photoprotective parameters show that the cream is quite good and has the potential for further development. In conclusion, this study shows that the optimized tamarind peel extract cream has photoprotective activity.
Formulasi dan Uji Antibakteri Sediaan Sabun Padat Kombinasi Ekstrak Etanol Daun Pepaya Jepang (Cnidoscolus Aconitifolius) dan Minyak Serai Wangi (Cymbopogon Nardus L.) terhadap Bakteri Staphylococcus Aureus ATCC 25923 Chofifatun Mubarokah; Anna Fitriawati; Bagas Ardiyantoro
Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 2 (2026): Galen: Jurnal Riset Ilmu Farmasi dan Kesehatan Bulan Oktober
Publisher : PT Pustaka Cendekia Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.71417/galen.v2i2.298

Abstract

Latar Belakang: Staphylococcus aureus merupakan bakteri penyebab infeksi kulit yang umum dijumpai. Bahan alam seperti minyak atsiri serai wangi (Cymbopogon nardus L.) dan ekstrak etanol daun pepaya Jepang (Cnidoscolus aconitifolius) berpotensi dikembangkan sebagai antibakteri dalam sediaan sabun padat. Tujuan: Penelitian ini bertujuan memformulasikan kombinasi ekstrak etanol daun pepaya Jepang dan minyak atsiri serai wangi dalam sediaan sabun padat, mengevaluasi mutu fisik, serta mengetahui aktivitas antibakterinya terhadap S. aureus ATCC 25923. Metode: Penelitian eksperimental laboratorium dilakukan dengan ekstraksi daun pepaya Jepang menggunakan metode maserasi etanol 70% dan perolehan minyak atsiri serai wangi melalui destilasi uap. Kombinasi bahan aktif diformulasikan menjadi tiga formula (F1, F2, dan F3). Evaluasi meliputi organoleptik, homogenitas, pH, tinggi busa, kadar air, asam lemak bebas, bahan tak larut etanol, lemak total, iritasi, dan hedonik. Aktivitas antibakteri diuji menggunakan metode difusi cakram. Hasil: Seluruh formula memenuhi persyaratan mutu fisik berdasarkan SNI dan menunjukkan aktivitas antibakteri. Formula dengan konsentrasi bahan aktif tertinggi menghasilkan daya hambat terbesar. Kesimpulan: Kombinasi kedua bahan aktif berhasil diformulasikan menjadi sabun padat yang memenuhi persyaratan mutu fisik dan memiliki aktivitas antibakteri terhadap S. aureus ATCC 25923.
Co-Authors Abdul Wahab Sabrina, Azimah Adhe Wibawa Mahardika Putra Agustiningrum, Nurul Alya Atla Lidya Aminnulloh, Muhammad Aminnulloh, Muhhamad Aminulloh, Muhammad Andini Natasya Anisa Fadilah Kumala Putri Annie Rahmatillah Bagas Ardiyantoro Bangkit Riska P Bryan Dwi Multi Chofifatun Mubarokah Danang Raharjo Della Puspita Ningrum Diyah Nurayuni Dwi S, Anita Effendi Nursalim Efrilia, Erin Emin Karoba Endang Suciati Fuadhiya, Arina Hendra, Naufal Dhuha Indi yatno, Aurora Shalfa Alkhariza Karim Karim, Karim Kharisma Jayak P Kharisma Jayak Pratama Krisnantari, Ni Luh Novelia Kusumaningrum, Indah Mega Lestari, Vera Fuji Listyani, Tiara Ajeng Mei Vita Rachma Pertiwi Mel Rinda Nurdilanda Muhammad Abdul Azis Muhammad Saad, Muhammad Neha Azziza Cherrysha Alifia Nia Kurniati Niken Luthfiyanti ningsih, endang wahyu Nur Cholis Endriyatno Nurul Agustiningrum Nurul Fatimah Olga Nordeka, Marcela Ones Kotouki P, Kharisma Jayak Peni Indrayudha Permata, Bangkit Riska Pradina Arifah Nurcahyani Pratama, Kharisma Jayak Prity, Intan Puguh Ika Listyorini Qurrota'Ain, Rusyda Raden Rara Anteng Pujowati Rahmad Adji, Alenda Rahmat Hidayat Rahmatillah, Annie Rendy Satya Febriansyah Riska P, Bangkit Riztiandi Ardiansyah Rochayati, Popiy Eko Rohmana, Vivin Marwiyati Sari, Cantyka Eka Viemala Sari, Sindy Avita Septian Maulid W Septian Maulid Wicahyo siska, Tatiana Siwi Hastuti Tanoyo, William Tatiana Siska Wardani Toyang, Gresilia Trianita Septiana Wahyu, Rizka Wardani, Lydia Puspita Wardani, Tatiana Siska Wulandari, Diana