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All Journal Jurnal Delima Harapan JURNAL FARMASIMED (JFM) Jurnal Review Pendidikan dan Pengajaran (JRPP) Jurnal Analis Farmasi PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Peduli Masyarakat Jurnal Kesehatan Tambusai Jurnal Buana Farma JAF (Jurnal Analis Farmasi) JIFI (Jurnal Ilmiah Farmasi Imelda) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Sains dan Teknologi GALENICAL : Jurnal Kedokteran dan Kesehatan Mahasiswa Malikussaleh Duta Pharma Journal Proceeding of International Conference Health, Science And Technology (ICOHETECH) Prosiding Seminar Informasi Kesehatan Nasional International Journal of Health, Engineering and Technology Inovasi Jurnal Pengabdian Masyarakat (IJPM) Jurnal Riset Ilmu Kesehatan Umum dan Farmasi Jurnal Pengabdian Masyarakat dan Riset Pendidikan EduInovasi: Journal of Basic Educational Studies Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Anna Fitriawati
Universitas Duta Bangsa Surakarta
Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Formulasi dan Evaluasi Obat Kumur Fraksi Etil Asetat Daun Sirih Cina (Peperomia Pellucida (L.) Kunth) Dan Uji Aktivitas Antioksidan Dengan Metode DPPH Evania Yudya Prameswari, Ninda; Fitriawati, Anna; Riska Permata, Bangkit
GALENICAL : Jurnal Kedokteran dan Kesehatan Mahasiswa Malikussaleh Vol. 4 No. 6 (2025): GALENICAL : Jurnal Kedokteran dan Kesehatan Mahasiswa Malikussaleh - November 2
Publisher : Program Studi Kedokteran Fakultas Kedokteran Universitas Malikussaleh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29103/jkkmm.v4i6.23702

Abstract

Karies gigi disebabkan oleh berkembangnya lubang kecil sampai merusak bagian dalam gigi, sehingga dapat mengganggu aktifitas sehari-hari seperti mengunyah, menggigit, dan berbicara. Berdasarkan faktor risiko karies gigi tinggi yaitu menggunakan obat kumur sebagai perawatan tanpa operasi. Daun sirih cina (Peperomia pellucida (L.) Kunth) dapat digunakan sebagai antipiretik, antiinflamasi, gastroprotektif, antioksidan, dan antibakteri. Penelitian ini bertujuan untuk mengetahui pengaruh variasi konsentrasi terhadap mutu fisik, kategori IC50, dan uji hedonik formulasi dan evaluasi obat kumur fraksi etil asetat daun sirih cina (Peperomia pellucida (L.) Kunth) dalam menghambat kerusakan sel akibat radikal bebas. Penelitian ini dilakukan secara eksperimental laboratorium dengan metode DPPH (1,1-diphenyl-picrylhydrazyl). Hasil penelitian menunjukkan bobot jenis F1 diperoleh hasil yang melebihi syarat, dan uji pH pada F0 diperoleh hasil yang melebihi syarat, aktivitas antioksidan pada F0 (tanpa penambahan ekstrak) diperoleh IC50 581.972 ppm, F1 (8%) diperoleh IC50 159.303 ppm, F2 (10%) diperoleh IC50 123.941 ppm, dan F3 (12%) diperoleh IC50 73.1378 ppm. Berdasarkan uji hedonik panelis menyukai Formula 2. Hasil yang diperoleh menunjukkan bahwa F3 dengan konsentrasi 12% dapat digunakan sebagai alternatif penggunaan obat kumur dengan kategori antioksidan yang kuat.
PENDEKATAN COMPUTER-AIDED DRUG DESIGN TERHADAP TURUNAN CARYOPHYLLENE KEMANGI (OCIMUM X AFRICANUM) SEBAGAI INHIBITOR BCL-2 Krisnantari, Ni Luh Novelia; Listyani, Tiara Ajeng; Fitriawati, Anna
Jurnal Kesehatan Tambusai Vol. 7 No. 1 (2026): MARET 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v7i1.55133

Abstract

Kanker lambung menyebabkan sekitar 700.000 kematian setiap tahun di seluruh dunia dan menempati urutan kedua dalam hal frekuensi. Terapi konvensional menggunakan venetoclax memiliki efek yang spesifik sebagai inhibitor B-Cell Lymphoma (BCL-2), namun sering dilaporkan efek samping neurotropenia, trombositopenia, hingga risiko tumor lysis syndrome (TLS). Minyak atsiri tanaman kemangi (Ocimum x africanum) diketahui memiliki kandungan metabolit sekunder sebagai inhibitor BCL-2. Penelitian ini bertujuan untuk mengevaluasi potensi senyawa turunan caryophyllene minyak atsiri kemangi sebagai kandidat inhibitor BCL-2 pada kanker lambung secara in silico. Penelitian ini menggunakan metode komputasi molecular docking dengan PyRx-AutoDock Vina, visualisasi ikatan residu asam amino dengan BIOVIA Discovery Studio Visualizer, prediksi parameter absorpsi, distribusi, metabolisme, ekskresi (ADME) dengan SwissADME berdasarkan Lipinski’s Rules, dan prediksi toksisitas berdasarkan Cramer Rules dengan ToxTree. Desain senyawa obat baru dari caryophyllene menunjukkan hasil nilai binding affinity -6.4 kkal/mol, Root Mean Square Deviation (RMSD) 1.76 Å, ikatan asam amino yang serupa dengan ligan natif, prediksi ADME sesuai parameter Lipinski’s Rules dan toksisitas sesuai parameter Cramer Rules. Dari penelitian ini yaitu bahwa senyawa baru turunan caryophyllene dapat digunakan dalam pengembangan sebagai kandidat obat oral baru sebagai inhibitor BCL-2, tetapi diperlukan uji lebih lanjut.
Uji Aktivitas Antibakteri Propionibacterium Acne ATCC 6919 Ekstrak Etanol Daun Si Kejut (Mimosa Pudica L) Anna Fitriawati; Annie Rahmatillah; Nurul Agustiningrum
INSOLOGI: Jurnal Sains dan Teknologi Vol. 4 No. 6 (2025): Desember 2025
Publisher : Yayasan Literasi Sains Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55123/insologi.v4i6.7080

Abstract

Vulgaris acne is a chronic inflammatory condition commonly experienced by adolescents and young adults, with a prevalence reaching up to 85%. Propionibacterium acnes plays a significant role in the inflammatory process of acne, which is influenced by sebum production, hyperkeratinization, and the inflammatory immune response. Acne treatment often involves antibiotics, but resistance to antibiotics such as erythromycin and clindamycin has increased, creating serious challenges in dermatology. Therefore, the development of non-antibiotic therapies for acne is crucial. One promising alternative is the extract of Mimosa pudica L., also known as the sensitive plant, which is recognized for its antimicrobial activity. The extract of Mimosa pudica L. leaves has been shown to inhibit the growth of various pathogenic bacteria and has potential anti-inflammatory effects based on in silico studies, opening up significant opportunities for the development of plant-based treatments for acne and other inflammatory diseases. This study aims to evaluate the effectiveness of ethanol extract of Mimosa pudica L. leaves in inhibiting the growth of Propionibacterium acnes ATCC 6919. The results of the study show that the 30% ethanol extract can inhibit bacterial growth with an inhibition zone diameter of 11.537 mm, indicating the potential of this extract as a safer and more effective alternative treatment for acne.
Test In Silico Compounds Of Lime Leaves (Citrus Amblycarpa (Hassk.) Ochse) As Inhibitors Of Angiotensin Converting Enzyme (ACE) Causes Hypertension Fitrohrezky Akbar Maulana; Tiara Ajeng Listyani; Anna Fitriawati
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.646

Abstract

Hypertension is a global health problem with high prevalence and is a major risk factor for cardiovascular disease. One of the main mechanisms of hypertension is increased Angiotensin Converting Enzyme (ACE) activity. The use of synthetic ACE inhibitors often causes side effects, such as nausea, hyperkalaemia, headaches, swelling of the lower skin, coughing, taste disturbances, and angioneurotic edema. Therefore, natural-based alternatives are needed. Lime leaves (Citrus amblycarpa) are known to contain various bioactive compounds that have the potential to act as ACE inhibitors. This study aims to analyze the interaction of active compounds in lime leaves with ACE through molecular docking, as well as to predict their ADME profile and toxicity. The study was conducted in silico using PyRx–AutoDock Vina for molecular docking, PyMOL and BIOVIA Discovery Studio for interaction visualization, SwissADME for ADME prediction, and ToxTree for toxicity analysis. Method validation was performed based on an RMSD value < 2Å. The results of the study indicate that 1,3-benzenedicarboxamide is the best compound with an RMSD value of 1.998 Å and a bond free energy (ΔG) of −6.4 kcal/mol, forming specific amino acid residue bonds similar to the native captopril ligand. ADME predictions meet Lipinski's Rule of Five criteria and fall into the low toxicity category (Class I) based on Cramer's rules. The compound 1,3-benzenedicarboxamide has the potential to be developed as a candidate ACE inhibitor for hypertension therapy.
Antibacterial Activity Test Of Extract, N-Hexane Fraction, Ethyl Acetate And Water Of Kesum Leaves (Polygonum Minus H) Against Escherichia Coli ATCC 25922 Bacteria Wahana Ayu Saputri; Tatiana Siska Wardani; Anna Fitriawati
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.663

Abstract

Diarrheal disease caused by Escherichia coli is a serious health problem in Indonesia, especially in toddlers, with increasing antibiotic resistance. Kesum leaves (Polygonum minus H.) have antibacterial potential because they contain flavonoids, phenols, alkaloids, and saponins. To evaluate the antibacterial activity of 70% ethanol extract and fractions of n-hexane, ethyl acetate, and kesum leaf water against E. coli ATCC 25922, to identify effective concentrations, and to determine the MIC and MBC of the most active fraction. Laboratory experimental study with 70% ethanol maceration extraction and liquid-liquid fractionation. E. coli ATCC 25922 population, 7 kg of simplex samples from Sambas, West Kalimantan. Instruments include an incubator, SPSS 25. Analysis techniques: disc diffusion, liquid/solid dilution, ANOVA.  The ethyl acetate fraction was the most effective (inhibition zone 12.36 mm, at a concentration of 40%, strong category), followed by the extract (inhibition zone 11.31 mm, at a concentration of 30%, medium category), n-hexane (10.46 mm), water (8.86 mm). MIC and MBC of the ethyl acetate fraction were 30%. The extract and fraction of kesum leaves have moderate to strong antibacterial activity against E. coli ATCC 25922, supporting the development of anti-diarrhea herbal medicine.
Formulation Of Antifungal Solid Soap From 96% Ethanol Extract Of Neem Leaves (Azadirachta Indica A.Juss) Against Malassezia Furfur ATCC 14251 Diyah Nurayuni; Anna Fitriawati; Annie Rahmatillah
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.667

Abstract

Fungal skin infections are still a health problem in tropical regions, especially those caused by Malassezia furfur, so alternative natural skin cleansing preparations are needed that are safe and effective. Neem leaves (Azadirachta indica A. Juss) are known to have antifungal activity and have the potential to be developed into solid soap preparations. This study aims to formulate an antifungal solid soap made from 96 percent ethanol extract of neem leaves, evaluate the physical quality of the preparation, and test its antifungal activity against Malassezia furfur. This study is a laboratory experimental study with a pretest-posttest only control group design. The study population was neem leaves obtained from Mount Pati District, Semarang, with simplicia samples selected using a purposive sampling technique. The research instruments included formulation equipment, physical quality tests based on SNI 3532:2016, and antifungal activity tests using the well diffusion method, while data analysis was carried out using nonparametric statistical tests. The results showed that all soap formulas met the physical quality requirements, and the formulation with a 10 percent extract concentration produced the largest inhibition zone diameter against Malassezia furfur, although it was still relatively weak. The conclusion of this study is that neem leaf extract solid soap has potential as a natural skin cleanser with antifungal activity, but further development and optimization of the formulation are needed to increase its effectiveness.
Evaluation Of The Antioxidant Activity Of Lotion Containing Ethanolic Extract Of Matoa Leaves (Pometia Pinnata J.R.Forst, & G.Forst.) Mei Vita Rachma Pertiwi; Anna Fitriawati; Annie Rahmatillah
International Journal of Health Engineering and Technology Vol. 4 No. 6 (2026): IJHET MARCH 2026
Publisher : CV. AFDIFAL MAJU BERKAH

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55227/ijhet.v4i6.672

Abstract

Skin exposure to environmental stress produces free radicals and ROS that accelerate aging and skin damage, while antioxidant Lotions from natural extracts such as Matoa leaves (Pometia pinnata) offer protection. This experimental study aimed to evaluate the antioxidant activity of ethanol extracts, the effect of concentration (0.5-6%) on the physical quality of Lotions, and the DPPH scavenging ability of the final Lotion. The population of all Matoa leaf extract Lotion formulations; a sample of 2 kg of fresh leaves from Matesih, Karanganyar was purposively selected. Instruments included a UV-Vis spectrophotometer (517 nm), a Brookfield viscometer, a pH meter; SPSS 28.0 was analyzed by ANOVA, regression for IC50. The extract was very potent (IC50 43.07 ppm) containing flavonoids, alkaloids, saponins, tannins; All Lotions met the standards (homogeneous, pH 5.22-6.34, viscosity 10,100-12,740 cP, spreadability 5-6.5 cm), FV (6%) was optimal (IC50 66.30 ppm, strong). High concentrations increased inhibition but increased viscosity, decreased spreadability (p<0.05). The findings confirm that Matoa Lotion is effective for herbal skin care; further in vivo and stability testing is recommended.
HUBUNGAN TINGKAT KEPATUHAN PENGGUNAAN OBAT TERHADAP KUALITAS HIDUP DAN OUTCOME TERAPI PASIEN DIABETES MELITUS TIPE 2 DI RSUD DR. MOEWARDI SURAKARTA Alifia, Neha Azziza Cherrysha; Pratama, Kharisma Jayak; Fitriawati, Anna
JIFI (Jurnal Ilmiah Farmasi Imelda) Vol. 9 No. 2 (2026): JIFI (Jurnal Ilmiah Farmasi Imelda)
Publisher : Universitas Imelda Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52943/jifarmasi.v9i2.2035

Abstract

Type 2 Diabetes Mellitus is a chronic disease that requires long-term and continuous management. One of the key factors influencing treatment success is patient adherence to medication. Good adherence can improve quality of life and optimize therapeutic outcomes, while poor adherence often leads to unfavorable outcomes, such as uncontrolled HbA1c levels. This study aimed to determine the relationship between medication adherence and both quality of life and therapeutic outcomes among Type 2 Diabetes Mellitus patients at Dr. Moewardi General Hospital in Surakarta. This study employed an observational design with a cross-sectional approach. A total of 98 patients were recruited using purposive sampling. The instruments used included the MMAS-8 questionnaire to measure medication adherence, the WHOQOL-BREF questionnaire to assess quality of life, and laboratory HbA1c data to evaluate therapeutic outcomes. Data were analyzed using Pearson correlation and chi-square tests. The results showed that most patients had moderate adherence (64,3%), moderate quality of life (100%), and uncontrolled therapeutic outcomes. There was a significant relationship between medication adherence and quality of life (p = 0.015; r = -0.246), but no significant relationship between adherence and HbA1c therapeutic outcomes (p = 0.524). Other factors such as lifestyle, complications, and social support also influence therapeutic success.
Formulasi Gel dan Karakterisasi Mutu Fisik Ekstrak Etanol Daun Dadap Serep (Erythrina subumbrans) dengan Variasi Gelling Agent HPMC dan Carbopol Danang Raharjo; Ones Kotouki; Anna Fitriawati
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 6 No. 2 (2026): Juli: Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v6i2.11021

Abstract

Dadap serep leaves (Erythrina subumbrans) contain flavonoid compounds with antioxidant and anti-inflammatory activities, thus have potential to be developed as topical gel preparations. This study aimed to formulate and characterize the physical quality of ethanol extract gel of dadap serep leaves with variations of HPMC and Carbopol 940 as gelling agents and to determine the best formula. The extract was obtained by maceration method using 96% ethanol. Gels were prepared in five formulas with variations in HPMC and Carbopol 940 concentrations: F I (HPMC 2%), F II (Carbopol 0.5% + HPMC 1.5%), F III (Carbopol 2%), F IV (Carbopol 1% + HPMC 1%), and F V (Carbopol 1.5% + HPMC 0.5%). Physical quality evaluation included organoleptic, homogeneity, pH, viscosity, spreadability, and adhesion tests. Data were analyzed using one-way ANOVA followed by Tukey's post-hoc test (α=0.05). The results showed that variations in gelling agents significantly affected pH (p<0.05), viscosity (p<0.001), spreadability (p<0.05), and adhesion (p<0.001). The higher the Carbopol concentration, the viscosity and adhesion increased but spreadability decreased. All formulas had brownish-green color, characteristic extract odor, thick consistency, good homogeneity, and pH within the range of 4.5-6.5. Formula I had adhesion of 3.1 seconds which did not meet the requirement (>4 seconds). Formula II (Carbopol 0.5% + HPMC 1.5%) was selected as the best formula because it met all requirements with pH 5.62, viscosity 12,670 cPs, spreadability 6.2 cm, and adhesion 4.2 seconds, showing an optimal balance between ease of spreading and adhesive ability. Further research is recommended including long-term stability tests, pharmacological activity tests, and safety tests of the preparation.
Co-Authors Abdul Wahab Sabrina, Azimah Adhe Wibawa Mahardika Putra Agustiningrum, Nurul Alifia, Neha Azziza Cherrysha Alya Atla Lidya Aminnulloh, Muhammad Aminnulloh, Muhhamad Aminulloh, Muhammad Anisa Fadilah Kumala Putri Bagas Ardiyantoro Bangkit Riska P Bryan Dwi Multi Danang Raharjo Diyah Nurayuni Dwi S, Anita Emin Karoba Endang Suciati Evania Yudya Prameswari, Ninda Fitrohrezky Akbar Maulana Hasna Afifah, Diyana Hendra, Naufal Dhuha Indi yatno, Aurora Shalfa Alkhariza Karim Karim, Karim Kharisma Jayak P Krisnantari, Ni Luh Novelia Kusumaningrum, Indah Mega Lestari, Vera Fuji Listyani, Tiara Ajeng Luthfiyanti, Niken Mei Vita Rachma Pertiwi Muhammad Abdul Azis Nia Kurniati Ningrum, Della Puspita ningsih, endang wahyu Nurul Agustiningrum Nurul Fatimah Olga Nordeka, Marcela Ones Kotouki P, Kharisma Jayak Peni Indrayudha Permata, Bangkit Riska Pradina Arifah Nurcahyani Pratama, Kharisma Jayak Prity, Intan Qurrota'Ain, Rusyda Raden Rara Anteng Pujowati Rahmad Adji, Alenda Rahmat Hidayat Rahmatillah, Annie Riska P, Bangkit Riska Permata, Bangkit Riztiandi Ardiansyah Rochayati, Popiy Eko Sari, Cantyka Eka Viemala Sari, Sindy Avita Septian Maulid W Septian Maulid Wicahyo siska, Tatiana Tanoyo, William Toyang, Gresilia Wahana Ayu Saputri Wahyu, Rizka Wardani, Lydia Puspita Wardani, Tatiana Siska Wulandari, Diana