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All Journal Jurnal Delima Harapan JURNAL FARMASIMED (JFM) Jurnal Review Pendidikan dan Pengajaran (JRPP) Jurnal Analis Farmasi PREPOTIF : Jurnal Kesehatan Masyarakat Jurnal Peduli Masyarakat Jurnal Kesehatan Tambusai Jurnal Buana Farma JAF (Jurnal Analis Farmasi) JIFI (Jurnal Ilmiah Farmasi Imelda) Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan Jurnal Sains dan Teknologi GALENICAL : Jurnal Kedokteran dan Kesehatan Mahasiswa Malikussaleh Duta Pharma Journal Proceeding of International Conference Health, Science And Technology (ICOHETECH) Prosiding Seminar Informasi Kesehatan Nasional International Journal of Health, Engineering and Technology Inovasi Jurnal Pengabdian Masyarakat (IJPM) Jurnal Riset Ilmu Kesehatan Umum dan Farmasi Jurnal Pengabdian Masyarakat dan Riset Pendidikan EduInovasi: Journal of Basic Educational Studies Obat: Jurnal Riset Ilmu Farmasi dan Kesehatan Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Anna Fitriawati
Universitas Duta Bangsa Surakarta
Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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FORMULASI DAN EVALUASI MASKER GEL PEEL-OFF EKSTRAK ETANOL BUAH MERAH PAPUA (PANDANUS CONOIDEUS LAMK) DAN UJI AKTIVITAS ANTIBAKTERI PROPIONIBACTERIUM ACNES ATCC 6919 Emin Karoba; Anna Fitriawati; Bangkit Riska P
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 8 No. 2 (2024): AGUSTUS 2024
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v8i2.28470

Abstract

Jerawat dapat disebabkan oleh faktor genetik, hormon, kondisi kulit, makanan, psikis, cuaca, infeksi bakteri Staphylococcus aureus pekerjaan, kosmetika dan bahan kimia lain. Bakteri penyebab jerawat terdiri dari Propionibacterium acnes, Staphylococcus aureus dan Staphylococcus epidermidis. Masker dalam bentuk gel yang memiliki beberapa keuntungan diantaranya mudah dalam penggunaan, serta mudah untuk dibersihkan karna setelah kering mudah untuk dikelupas biasa dikenal masker gel peel-off. Buah merah (Pandanus conoideus Lamk) merupakan tumbuhan endemik papua yang memiliki kandungan flavonoid, tanin, dan saponin yang dapat menghambat pertumbuhan bakteri. Tujuan penelitian ini untuk memformulasikan masker gel peel-off dari ekstrak buah merah (Pandanus conoideus Lamk) dan melihat evaluasi mutu fisiknya. Metode penelitian ini dari eksperimental yang terdiri dari membuat ekstrak buah merah dengan metode maserasi menggunakan pelarut etanol 96%. Masker gel peel-off dibuat menjadi empat formulasi yaitu F0, FI, FII dan FIII masing-masing ekstrak buah merah 30%, 40% dan 50%. Hasil penelitian menunjukkan formula masker yang memiliki sifat fisik paling baik adalah formula III dengan konsentrasi ekstrak buah merah sebanyak 50% karena memenuhi ketentuan fisik masker gel peel-off meliputi uji organoleptis, uji visikositas, uji homogenitas, uji daya sebar, uji waktu sediaan mengering, uji pH dan uji aktivitas antibakteri propionibacterium acne ATCC 6919.
FORMULASI MOUTHWASH EKSTRAK ETANOL DAUN KECOMBRANG (ETLINGERA ELATIOR (JACK) R.M.SM.) DAN UJI AKTIVITAS ANTIBAKTERI TERHADAP BAKTERI LACTOBACILLUS ACIDOPHILUS ATCC 4356 Prity, Intan; Fitriawati, Anna; Riska P, Bangkit
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 8 No. 2 (2024): AGUSTUS 2024
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v8i2.28474

Abstract

Karies gigi merupakan infeksi penyakit gigi dan mulut yang disebabkan oleh bakteri Lactobacillus acidophilus. Daun kecombrang (Etlingera elatior (Jack) R.M.Sm.) memiliki efek antibakteri yaitu senyawa flavonoid, saponin, tanin, dan triterpenoid/steroid. Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri dari ekstrak dan sediaan mouthwash terhadap bakteri Lactobacillus acidophilus. Daun kecombrang (Etlingera elatior (Jack) R.M.Sm.) diekstraksi dengan pelarut etanol 96%, kemudian diuapkan dengan rotary vacuum evaporator dan waterbath. Uji aktivitas antibakteri menggunakan metode difusi agar dalam konsentrasi perlakuan yaitu 10% b/v, 15% b/v dan 20% b/v. Clorhexidin 0,2% sebagai kontrol positif dan aquadest sebagai kontrol negatif. Pengujian antibakteri ditandai dengan adanya zona bening di sekitar kertas cakram. Kemudian ekstrak dibuat mouthwash dengan formula F1 10%, F2 15%, dan F3 20%. Hasil data sediaan mouthwash akan dibuat dalam bentuk tabel dan diameter zona hambat dianalisis menggunakan metode SPSS dan uji One Way ANOVA. Ekstrak daun kecombrang (Etlingera elatior (Jack) R.M.Sm.) dapat diformulasikan menjadi sediaan mouthwash secara fisik ditinjau dari hasil uji organoleptis, pH, viskositas, kejernihan dan homogenitas. Hasil pengujian antibakteri ekstrak daun kecombrang memiliki diameter zona hambat pada konsentrasi 10% sebesar 9,33 mm, konsentrasi 15% sebesar 11,18 mm dan konsentrasi 20% sebesar 14,65 mm dapat menghambat pertumbuhan Lactobacillus acidophilus. Pada diameter zona hambat formula F1 sebesar 8,91 mm, formula F2 sebesar 10,03 mm dan formula F3 sediaan mouthwash memiliki aktivitas antibakteri tertinggi dengan diameter zona hambat 11,06 mm dalam menghambat pertumbuhan Lactobacillus acidophilus.
UJI EFEK TONIKUM SEDUHAN HERBAL KOMBINASI JAHE MERAH (ZINGIBER OFFICINALE VAR. RUBRUM) DAN DAUN KAYU MANIS (CINNAMOMUM BURMANNI) TERHADAP MENCIT PUTIH JANTAN GALUR SWISS WEBSTER Toyang, Gresilia; Fitriawati, Anna; Wardani, Tatiana Siska
PREPOTIF : JURNAL KESEHATAN MASYARAKAT Vol. 8 No. 2 (2024): AGUSTUS 2024
Publisher : Universitas Pahlawan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/prepotif.v8i2.29047

Abstract

Jahe merah (Zingiber Officinale Var. Rubrum) merupakan salah satu tanaman obat tradisional yang mengandung senyawa oleoresin dan minyak atsiri yang memiliki khasiat sebagai tonikum. Daun kayu manis (Cinnamomum burmanni) mengandung   senyawa alkaloid, flavonoid, saponin dan minyak atsiri yang mempunyai banyak manfaat salah satunya yaitu tonikum, stimulan dan menyegarkan. Penelitian ini menggunakan hewan uji mencit putih jantan galur Swiss Webster yang dikelompokan menjadi 7 kelompok dan setiap kelompok terdiri dari 5 ekor hewan uji. ke-7 kelompok terdiri dari kontrol negatif (aquadest), kontrol positif (kafein), FI sediaan jahe merah (100%), FII sediaan daun kayu manis (100%), FIII kombinasi sediaan jahe merah daun kayu manis (75% : 25%), FIV kombinasi sediaan jahe merah dan daun kayu manis (25% : 75%), FV kombinasi jahe merah dan daun kayu manis (50% : 50%). Berdasarkan hasil penelitian diperoleh hasil sediaan seduhan tunggal jahe FI lebih efektif. Hasil uji efek tonikum pada sediaan FI sebesar 9,42 menit, FII 7,22 menit, FIII 10,36 menit,  FIV 8,23 menit, dan FV 8,64 menit.  Dapat disimpulkan hasil penelitian yang didapatkan yaitu sediaan seduhan tunggal jahe merah FI lebih efektif dibandingkan sediaan seduhan kombinasi FIV, dan FV karena tidak ada perbedaan yang signifikan.
Optimasi Formula Bedak Dingin Ekstrak Temu Giring (Curcuma heyneana) dengan Metode Simplex Lattice Design dan Uji Aktivitas Antioksidan Hasna Afifah, Diyana; Fitriawati, Anna; Luthfiyanti, Niken
GALENICAL : Jurnal Kedokteran dan Kesehatan Mahasiswa Malikussaleh Vol. 4 No. 5 (2025): GALENICAL : Jurnal Kedokteran dan Kesehatan Mahasiswa Malikussaleh - Oktober 20
Publisher : Program Studi Kedokteran Fakultas Kedokteran Universitas Malikussaleh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29103/jkkmm.v4i5.24153

Abstract

Rimpang temu giring memiliki sifat antioksidan dan anti-inflamasi yang kuat sebagai bahan anti-penuaan. Rimpang temu giring kaya akan kandungan senyawa seperti minyak atsiri, kurkumin, tanin, saponin, flavonoid, dan pati. Tujuan penelitan ini mengetahui aktivitas antioksidan pada ekstrak temu giring, mengetahui mutu fisik dan mengetahui aktivitas antioksidan formula optimum. Metode penelitian secara kuantitatif menggunakan SLD. Penelitian ini membuat 5 formula. Pengujian aktivitas antioksidan menggunakan DPPH. Formula yang sudah diuji mutu fisik kemudian dianalisis dan diverifikasi menggunakan uji statistik ANOVA. Hasil uji ANOVA diperoleh p-value <0,05 dan f-value >0,05. Hasil uji sediaan formula optimum bedak dingin ekstrak temu giring telah memenuhi syarat parameter uji mutu fisik yaitu uji organoleptik yaitu warna kuning, bau khas dan tekstur padat. Uji pH 5,94. Uji daya sebar 5,36cm. Uji daya lekat 04,82 detik. Uji waktu kering 16.17.61 menit. Hasil IC50 dari ekstrak 74,56 dan formula optimum 94,72 termasuk golongan antioksidan kuat.
Formulasi Sabun Cair Berbahan Baku Virgin Coconut Oil VCO dengan Penambahan Ekstrak Daun Pepaya Carica Papaya L. untuk Peningkatan Aktivitas Anti Bakteri Staphylococcus Epidermidis ATCC 12238 Raden Rara Anteng Pujowati; Anna Fitriawati; Tatiana Siska Wardani
EduInovasi:  Journal of Basic Educational Studies Vol. 4 No. 3 (2024): EduInovasi:  Journal of Basic Educational Studies
Publisher : Intitut Agama Islam Nasional Laa Roiba Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47467/edu.v4i3.4842

Abstract

Acne is a chronic inflammatory disease caused by Staphylococcus epidermidis. Papaya leaves (Carica papaya L.) contain antibacterial substances, namely alkaloids carpaine, flavonoids, tocophenols. Of this study was to determine the physical quality of liquid soap, increasing antibacterial activity. Papaya leaves were extracted with 96% ethanol solvent, then evaporated with a water bath. Antibacterial activity test using the disc diffusion method in concentrations of 5%, 15% and 25% and liquid soap will be made F0 0%, F1 5%, F2 10%, and F3 25% against Staphylococcus epidermidis ATCC 12238. Amoxicillin tab as a positive control and distilled water as a negative control. Bacterial activity appears a clear zone around the disc paper. And see the physical quality test according to the requirements. The results of the bacterial test data are made in table form, and analyzed using the SPSS method Formula with the addition of papaya leaf extract can be made and according to the physical quality conditions of liquid soap. The results of the 25% concentration extract test are an inhibition zone of 20.8 mm, the highest liquid soap formula is an inhibition zone of 23.8 mm in inhibiting the growth of Staphylococcus epidermidis ATCC 12238. Liquid soap preparations and papaya leaf extract have antibacterial activity against Staphylococcus epidermidis ATCC 12238 bacteria and according to the physical quality requirements of liquid soap.
Uji Aktivitas Antibakteri Ekstrak dan Fraksi n-Heksan, Etil Asetat, Air Kulit Buah Naga Putih (Hylocereus Undatus) Terhadap Staphylococcus Epidermidis ATCC 12238 Muhammad Abdul Azis; Tatiana Siska Wardani; Anna Fitriawati
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 4 (2024): Juli : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i4.478

Abstract

Research on the antibacterial test of dragon fruit peel extract carried out by Anggraini & Harris (2017) shows that white dragon fruit extract is able to inhibit the growth of epidermal Staphylococcus bacteria with the lowest concentration, namely 25%, producing an average diameter of the inhibition zone of 13.7 mm, while for the highest concentration, namely 100%, it produces an average diameter of the inhibition zone of 17.7 mm. To determine the more effective antibacterial effect of white dragon fruit peel extract, the research continued to the fractionation stage to separate compounds based on polarity level. The solvents used are water which is a polar solvent, ethyl acetate which is a semi-polar solvent, and n-hexane which is a nonpolar solvent (Yohanes, 2020). Based on the description above, researchers are interested in conducting research on testing the antibacterial activity of ethanol extract and n-hexane fraction of white dragon fruit peel (Hylocereus undatus) against Staphylococcus epidermidis bacteria.
Synergistic Impact of The Combination of Moringa Leaves and Butterfly Pea Flowers Infusion on Cognitive Enhancement Annie Rahmatillah; Anna Fitriawati; Anisa Fadilah Kumala Putri
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/n9214f64

Abstract

Oxidative stress can induce memory loss, which may be mitigated by antioxidants. Moringa leaves (Moringa oleifera) and butterfly pea flowers (Clitoria ternatea) possess flavonoid chemicals that function as natural antioxidants. This study seeks to evaluate the impact of combined Moringa leaf and butterfly pea flower infusions on enhancing the memory of mice and to identify the optimal dosage. The research utilized male white mice (Mus musculus), categorized into six groups: a normal group, a negative control (aquadest), a positive control (Ginkgo biloba), and three treatment groups receiving various infusion doses. The procedure had three phases: acclimatization (T0), intraperitoneal administration of hyoscine butylbromide (T1), and therapy (T2). The manufacture of INDUK BUNTEL (an infusion of moringa leaves and butterfly pea flowers) was conducted using an infusion extraction method. Testing on test subjects was conducted utilizing the Radial Arm Maze methodology. The findings indicated that the infusion combination at dose III (100 mg/KgBW: 100 mg/KgBW) was the most efficacious in enhancing the memory of mice. The mean mistake rate in mice was 16.44%, representing the lowest score among the treatment groups. The one-way ANOVA test indicated no significant difference across treatment groups with three distinct dose combinations (p > 0.05).
ACTIVITY OF INHIBITING THE GROWTH OF STAPHYLOCOCCUS AUREUS ATCC 25923 LEAVES OF DURI SPINACH (AMARANTHUS SPINOSUS LINN. ) USING THE MACERATION METHOD Fitriawati, Anna; Lestari, Vera Fuji; Dwi S, Anita
Proceeding of the International Conference Health, Science And Technology (ICOHETECH) 2023: Proceeding of the 4th International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/icohetech.v4i1.3386

Abstract

Antibacterial is a substance that can inhibit or kill the growth of bacteria. One of the plants that can be used for antibacterial is spinach thorns. Spinach (Amaranthus spinosus Linn.) is a plant originating from the tropical lowlands of America, widely distributed in the tropics and subtropics of Africa, Southeast Asia and in India and even in Indonesia. The purpose of this study was to determine the activity of spinach leaves (Amaranthus spinosus Linn.) on inhibiting the growth of Staphylococcus aureus bacteria by maceration method. This study uses an experimental method. Spinach leaves (Amaranthus spinosus Linn.) were macerated using 70% ethanol solvent. The concentrations used for each method were concentrations of 30%, 40%, 50%, ciprofloxacin positive control and 1% DMSO negative control. Each of these concentrations was tested for antibacterial activity against Staphylococcus aureus using the diffusion and dilution method. The results of the antibacterial activity test by diffusion in the maceration method obtained an average inhibition zone result at a concentration of 30% of 8.73mm, a concentration of 40% of 9.93mm, a concentration of 50% of 11.53mm and a positive control of 12.73mm.
Antioksidan Ekstrak Etanol Daun Pedada (Sonneratia ovata Backer) Raharjo, Danang; Fitriawati, Anna; Aminulloh, Muhammad
Proceeding of the International Conference Health, Science And Technology (ICOHETECH) 2024: Proceeding of the 5th International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/icohetech.v5i1.4194

Abstract

Free radicals are reactive oxygen compounds that are known to be compounds that have free or unpaired electrons. Free radicals will look for new partners so that they will easily bind to other substances such as proteins, fats, and DNA in the body, resulting in cell damage and causing various degenerative diseases. To overcome the negative effects of free radicals, a substance that acts as an antioxidant is needed. Sonneratia Ovata or often called pedada by coastal communities is often used to treat various diseases including diabetes, ulcers, analgesic diarrhea, inflammation, pain and accelerate wound healing. This study aims to examine the levels of flavonoid compounds in the ethanol extract of S. ovata leaves using the colorimetric method and antioxidant activity using the ABTS method (2,2 azinobis (3-ethylbenzothiazolin-6- sulfonic acid) and DPPH (2,2-diphenyl-1-picrylhydrazyl) on the ethanol extract of S. ovata leaves. The research process began with the extraction of S. ovata leaves with 96% ethanol, followed by determination of total flavonoid levels and antioxidant testing. From the results of the determination of total flavonoid levels, it was found that the ethanol extract of S. ovata leaves had a flavonoid content of 38,248 ± 0.142 mgQE/gram. In measuring antioxidant activity using the DPPH and ABTS methods, the IC50 values were 31.785 ± 0.047 ppm and 28.303 ± 0.558 ppm, respectively. Based on these results, the ethanol extract of S. ovata provided very strong antioxidant activity with an IC50 value of less than 50 ppm.
Growth Inhibiting Activity Of Staphylococcus Aureus ATCC 25923 Kirinyuh Leaves (Chromolaena Odorata L.) Using The Soxhletation Method Fitriawati, Anna; Rahmad Adji, Alenda; Ardiyantoro, Bagas; Abdul Wahab Sabrina, Azimah; Karim, Karim
Proceeding of the International Conference Health, Science And Technology (ICOHETECH) 2024: Proceeding of the 5th International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/icohetech.v5i1.4227

Abstract

Kirinyuh leaves (Chromolaena odorata L.) have the potential as a medicinal plant because of the active compounds contained in kirinyuh leaves (Chromolaena odorata L.). The purpose of this study was to determine the antibacterial activity of ethanol extract of kirinyuh leaves (Chromolaena odorata L.) against the growth of Staphylococcus aureus ATCC 25923 bacteria. Kirinyuh leaf extract (Chromolaena odorata L.) was carried out using the soxhletation method and the solvent used was 96% ethanol. The concentrations used for each treatment were 30%, 40% and 50%. Each concentration was tested for antibacterial activity against Staphylococcus aureus bacteria using the disc diffusion method. The results showed that the extract of kirinyuh leaves (Chromolaena odorata L.) with a concentration of 30% had an average diameter of the inhibition zone of 9.2 mm, a concentration of 40% had an average diameter of the inhibition zone of 12.36 mm, and a concentration of 50% had an average diameter of the inhibition zone of 13.71 mm. The research conducted can be concluded that the extract of kirinyuh leaves can provide the best effect of inhibiting bacterial growth at a concentration of 50% with the results of the anova test p <0.05 which means there is a significant difference compared to other concentrations
Co-Authors Abdul Wahab Sabrina, Azimah Adhe Wibawa Mahardika Putra Agustiningrum, Nurul Alifia, Neha Azziza Cherrysha Alya Atla Lidya Aminnulloh, Muhammad Aminnulloh, Muhhamad Aminulloh, Muhammad Anisa Fadilah Kumala Putri Bagas Ardiyantoro Bangkit Riska P Bryan Dwi Multi Danang Raharjo Diyah Nurayuni Dwi S, Anita Emin Karoba Endang Suciati Evania Yudya Prameswari, Ninda Fitrohrezky Akbar Maulana Hasna Afifah, Diyana Hendra, Naufal Dhuha Indi yatno, Aurora Shalfa Alkhariza Karim Karim, Karim Kharisma Jayak P Krisnantari, Ni Luh Novelia Kusumaningrum, Indah Mega Lestari, Vera Fuji Listyani, Tiara Ajeng Luthfiyanti, Niken Mei Vita Rachma Pertiwi Muhammad Abdul Azis Nia Kurniati Ningrum, Della Puspita ningsih, endang wahyu Nurul Agustiningrum Nurul Fatimah Olga Nordeka, Marcela Ones Kotouki P, Kharisma Jayak Peni Indrayudha Permata, Bangkit Riska Pradina Arifah Nurcahyani Pratama, Kharisma Jayak Prity, Intan Qurrota'Ain, Rusyda Raden Rara Anteng Pujowati Rahmad Adji, Alenda Rahmat Hidayat Rahmatillah, Annie Riska P, Bangkit Riska Permata, Bangkit Riztiandi Ardiansyah Rochayati, Popiy Eko Sari, Cantyka Eka Viemala Sari, Sindy Avita Septian Maulid W Septian Maulid Wicahyo siska, Tatiana Tanoyo, William Toyang, Gresilia Wahana Ayu Saputri Wahyu, Rizka Wardani, Lydia Puspita Wardani, Tatiana Siska Wulandari, Diana