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Anna Fitriawati
Universitas Duta Bangsa Surakarta
Religion Aerospace Engineering Agriculture, Biological Sciences & Forestry Humanities Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Electrical & Electronics Engineering Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Languange, Linguistic, Communication & Media Mathematics Mechanical Engineering Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary Other

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Formulasi Sabun Cair Berbahan Baku Virgin Coconut Oil VCO dengan Penambahan Ekstrak Daun Pepaya Carica Papaya L. untuk Peningkatan Aktivitas Anti Bakteri Staphylococcus Epidermidis ATCC 12238 Raden Rara Anteng Pujowati; Anna Fitriawati; Tatiana Siska Wardani
EduInovasi:  Journal of Basic Educational Studies Vol. 4 No. 3 (2024): EduInovasi:  Journal of Basic Educational Studies
Publisher : Intitut Agama Islam Nasional Laa Roiba Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47467/edu.v4i3.4842

Abstract

Acne is a chronic inflammatory disease caused by Staphylococcus epidermidis. Papaya leaves (Carica papaya L.) contain antibacterial substances, namely alkaloids carpaine, flavonoids, tocophenols. Of this study was to determine the physical quality of liquid soap, increasing antibacterial activity. Papaya leaves were extracted with 96% ethanol solvent, then evaporated with a water bath. Antibacterial activity test using the disc diffusion method in concentrations of 5%, 15% and 25% and liquid soap will be made F0 0%, F1 5%, F2 10%, and F3 25% against Staphylococcus epidermidis ATCC 12238. Amoxicillin tab as a positive control and distilled water as a negative control. Bacterial activity appears a clear zone around the disc paper. And see the physical quality test according to the requirements. The results of the bacterial test data are made in table form, and analyzed using the SPSS method Formula with the addition of papaya leaf extract can be made and according to the physical quality conditions of liquid soap. The results of the 25% concentration extract test are an inhibition zone of 20.8 mm, the highest liquid soap formula is an inhibition zone of 23.8 mm in inhibiting the growth of Staphylococcus epidermidis ATCC 12238. Liquid soap preparations and papaya leaf extract have antibacterial activity against Staphylococcus epidermidis ATCC 12238 bacteria and according to the physical quality requirements of liquid soap.
Uji Aktivitas Antibakteri Ekstrak dan Fraksi n-Heksan, Etil Asetat, Air Kulit Buah Naga Putih (Hylocereus Undatus) Terhadap Staphylococcus Epidermidis ATCC 12238 Muhammad Abdul Azis; Tatiana Siska Wardani; Anna Fitriawati
OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan Vol. 2 No. 4 (2024): Juli : OBAT: Jurnal Riset Ilmu Farmasi dan Kesehatan
Publisher : Asosiasi Riset Ilmu Kesehatan Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61132/obat.v2i4.478

Abstract

Research on the antibacterial test of dragon fruit peel extract carried out by Anggraini & Harris (2017) shows that white dragon fruit extract is able to inhibit the growth of epidermal Staphylococcus bacteria with the lowest concentration, namely 25%, producing an average diameter of the inhibition zone of 13.7 mm, while for the highest concentration, namely 100%, it produces an average diameter of the inhibition zone of 17.7 mm. To determine the more effective antibacterial effect of white dragon fruit peel extract, the research continued to the fractionation stage to separate compounds based on polarity level. The solvents used are water which is a polar solvent, ethyl acetate which is a semi-polar solvent, and n-hexane which is a nonpolar solvent (Yohanes, 2020). Based on the description above, researchers are interested in conducting research on testing the antibacterial activity of ethanol extract and n-hexane fraction of white dragon fruit peel (Hylocereus undatus) against Staphylococcus epidermidis bacteria.
ACTIVITY OF INHIBITING THE GROWTH OF STAPHYLOCOCCUS AUREUS ATCC 25923 LEAVES OF DURI SPINACH (AMARANTHUS SPINOSUS LINN. ) USING THE MACERATION METHOD Fitriawati, Anna; Lestari, Vera Fuji; Dwi S, Anita
Proceeding of the International Conference Health, Science And Technology (ICOHETECH) 2023: Proceeding of the 4th International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/icohetech.v4i1.3386

Abstract

Antibacterial is a substance that can inhibit or kill the growth of bacteria. One of the plants that can be used for antibacterial is spinach thorns. Spinach (Amaranthus spinosus Linn.) is a plant originating from the tropical lowlands of America, widely distributed in the tropics and subtropics of Africa, Southeast Asia and in India and even in Indonesia. The purpose of this study was to determine the activity of spinach leaves (Amaranthus spinosus Linn.) on inhibiting the growth of Staphylococcus aureus bacteria by maceration method. This study uses an experimental method. Spinach leaves (Amaranthus spinosus Linn.) were macerated using 70% ethanol solvent. The concentrations used for each method were concentrations of 30%, 40%, 50%, ciprofloxacin positive control and 1% DMSO negative control. Each of these concentrations was tested for antibacterial activity against Staphylococcus aureus using the diffusion and dilution method. The results of the antibacterial activity test by diffusion in the maceration method obtained an average inhibition zone result at a concentration of 30% of 8.73mm, a concentration of 40% of 9.93mm, a concentration of 50% of 11.53mm and a positive control of 12.73mm.
Antioksidan Ekstrak Etanol Daun Pedada (Sonneratia ovata Backer) Raharjo, Danang; Fitriawati, Anna; Aminulloh, Muhammad
Proceeding of the International Conference Health, Science And Technology (ICOHETECH) 2024: Proceeding of the 5th International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/icohetech.v5i1.4194

Abstract

Free radicals are reactive oxygen compounds that are known to be compounds that have free or unpaired electrons. Free radicals will look for new partners so that they will easily bind to other substances such as proteins, fats, and DNA in the body, resulting in cell damage and causing various degenerative diseases. To overcome the negative effects of free radicals, a substance that acts as an antioxidant is needed. Sonneratia Ovata or often called pedada by coastal communities is often used to treat various diseases including diabetes, ulcers, analgesic diarrhea, inflammation, pain and accelerate wound healing. This study aims to examine the levels of flavonoid compounds in the ethanol extract of S. ovata leaves using the colorimetric method and antioxidant activity using the ABTS method (2,2 azinobis (3-ethylbenzothiazolin-6- sulfonic acid) and DPPH (2,2-diphenyl-1-picrylhydrazyl) on the ethanol extract of S. ovata leaves. The research process began with the extraction of S. ovata leaves with 96% ethanol, followed by determination of total flavonoid levels and antioxidant testing. From the results of the determination of total flavonoid levels, it was found that the ethanol extract of S. ovata leaves had a flavonoid content of 38,248 ± 0.142 mgQE/gram. In measuring antioxidant activity using the DPPH and ABTS methods, the IC50 values were 31.785 ± 0.047 ppm and 28.303 ± 0.558 ppm, respectively. Based on these results, the ethanol extract of S. ovata provided very strong antioxidant activity with an IC50 value of less than 50 ppm.
Growth Inhibiting Activity Of Staphylococcus Aureus ATCC 25923 Kirinyuh Leaves (Chromolaena Odorata L.) Using The Soxhletation Method Fitriawati, Anna; Rahmad Adji, Alenda; Ardiyantoro, Bagas; Abdul Wahab Sabrina, Azimah; Karim, Karim
Proceeding of the International Conference Health, Science And Technology (ICOHETECH) 2024: Proceeding of the 5th International Conference Health, Science And Technology (ICOHETECH)
Publisher : LPPM Universitas Duta Bangsa Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47701/icohetech.v5i1.4227

Abstract

Kirinyuh leaves (Chromolaena odorata L.) have the potential as a medicinal plant because of the active compounds contained in kirinyuh leaves (Chromolaena odorata L.). The purpose of this study was to determine the antibacterial activity of ethanol extract of kirinyuh leaves (Chromolaena odorata L.) against the growth of Staphylococcus aureus ATCC 25923 bacteria. Kirinyuh leaf extract (Chromolaena odorata L.) was carried out using the soxhletation method and the solvent used was 96% ethanol. The concentrations used for each treatment were 30%, 40% and 50%. Each concentration was tested for antibacterial activity against Staphylococcus aureus bacteria using the disc diffusion method. The results showed that the extract of kirinyuh leaves (Chromolaena odorata L.) with a concentration of 30% had an average diameter of the inhibition zone of 9.2 mm, a concentration of 40% had an average diameter of the inhibition zone of 12.36 mm, and a concentration of 50% had an average diameter of the inhibition zone of 13.71 mm. The research conducted can be concluded that the extract of kirinyuh leaves can provide the best effect of inhibiting bacterial growth at a concentration of 50% with the results of the anova test p <0.05 which means there is a significant difference compared to other concentrations
PENDEKATAN COMPUTER-AIDED DRUG DESIGN TERHADAP TURUNAN CARYOPHYLLENE KEMANGI (OCIMUM X AFRICANUM) SEBAGAI INHIBITOR BCL-2 Krisnantari, Ni Luh Novelia; Listyani, Tiara Ajeng; Fitriawati, Anna
Jurnal Kesehatan Tambusai Vol. 7 No. 1 (2026): MARET 2026
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jkt.v7i1.55133

Abstract

Kanker lambung menyebabkan sekitar 700.000 kematian setiap tahun di seluruh dunia dan menempati urutan kedua dalam hal frekuensi. Terapi konvensional menggunakan venetoclax memiliki efek yang spesifik sebagai inhibitor B-Cell Lymphoma (BCL-2), namun sering dilaporkan efek samping neurotropenia, trombositopenia, hingga risiko tumor lysis syndrome (TLS). Minyak atsiri tanaman kemangi (Ocimum x africanum) diketahui memiliki kandungan metabolit sekunder sebagai inhibitor BCL-2. Penelitian ini bertujuan untuk mengevaluasi potensi senyawa turunan caryophyllene minyak atsiri kemangi sebagai kandidat inhibitor BCL-2 pada kanker lambung secara in silico. Penelitian ini menggunakan metode komputasi molecular docking dengan PyRx-AutoDock Vina, visualisasi ikatan residu asam amino dengan BIOVIA Discovery Studio Visualizer, prediksi parameter absorpsi, distribusi, metabolisme, ekskresi (ADME) dengan SwissADME berdasarkan Lipinski’s Rules, dan prediksi toksisitas berdasarkan Cramer Rules dengan ToxTree. Desain senyawa obat baru dari caryophyllene menunjukkan hasil nilai binding affinity -6.4 kkal/mol, Root Mean Square Deviation (RMSD) 1.76 Å, ikatan asam amino yang serupa dengan ligan natif, prediksi ADME sesuai parameter Lipinski’s Rules dan toksisitas sesuai parameter Cramer Rules. Dari penelitian ini yaitu bahwa senyawa baru turunan caryophyllene dapat digunakan dalam pengembangan sebagai kandidat obat oral baru sebagai inhibitor BCL-2, tetapi diperlukan uji lebih lanjut.
Formulasi Gel dan Karakterisasi Mutu Fisik Ekstrak Etanol Daun Dadap Serep (Erythrina subumbrans) dengan Variasi Gelling Agent HPMC dan Carbopol Danang Raharjo; Ones Kotouki; Anna Fitriawati
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 6 No. 2 (2026): Juli: Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v6i2.11021

Abstract

Dadap serep leaves (Erythrina subumbrans) contain flavonoid compounds with antioxidant and anti-inflammatory activities, thus have potential to be developed as topical gel preparations. This study aimed to formulate and characterize the physical quality of ethanol extract gel of dadap serep leaves with variations of HPMC and Carbopol 940 as gelling agents and to determine the best formula. The extract was obtained by maceration method using 96% ethanol. Gels were prepared in five formulas with variations in HPMC and Carbopol 940 concentrations: F I (HPMC 2%), F II (Carbopol 0.5% + HPMC 1.5%), F III (Carbopol 2%), F IV (Carbopol 1% + HPMC 1%), and F V (Carbopol 1.5% + HPMC 0.5%). Physical quality evaluation included organoleptic, homogeneity, pH, viscosity, spreadability, and adhesion tests. Data were analyzed using one-way ANOVA followed by Tukey's post-hoc test (α=0.05). The results showed that variations in gelling agents significantly affected pH (p<0.05), viscosity (p<0.001), spreadability (p<0.05), and adhesion (p<0.001). The higher the Carbopol concentration, the viscosity and adhesion increased but spreadability decreased. All formulas had brownish-green color, characteristic extract odor, thick consistency, good homogeneity, and pH within the range of 4.5-6.5. Formula I had adhesion of 3.1 seconds which did not meet the requirement (>4 seconds). Formula II (Carbopol 0.5% + HPMC 1.5%) was selected as the best formula because it met all requirements with pH 5.62, viscosity 12,670 cPs, spreadability 6.2 cm, and adhesion 4.2 seconds, showing an optimal balance between ease of spreading and adhesive ability. Further research is recommended including long-term stability tests, pharmacological activity tests, and safety tests of the preparation.
Uji Aktivitas Antibakteri Fraksi n-Heksan, Etil Asetat, dan Air Ekstrak Daun Jambu Air (Syzygium aqueum) terhadap Bakteri Staphylococcus epidermidis ATCC 12238 Adhe Wibawa Mahardika Putra; Tatiana Siska Wardani; Anna Fitriawati
Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF) Vol. 3 No. 4 (2025): Oktober : Jurnal Riset Ilmu Kesehatan Umum dan Farmasi (JRIKUF)
Publisher : LPPM STIKES KESETIAKAWANAN SOSIAL INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.57213/jrikuf.v3i4.866

Abstract

This study aimed to evaluate the antibacterial activity of water apple (Syzygium aqueum) leaf extract against Staphylococcus epidermidis. The leaves were collected from Pranan Village, Sukoharjo District. After proper botanical identification (determination) at B2P2TOOT Karanganyar, the leaves were dried, ground into simplicia powder, and extracted using 70% ethanol through maceration. The ethanol extract was then fractionated based on solvent polarity using n-hexane (nonpolar), ethyl acetate (semipolar), and water (polar). Antibacterial testing was conducted using various concentrations (25%, 12.5%, 6.25%, 3.125%, and 1.565%), with clindamycin as a positive control and DMSO as a negative control. The study assessed antibacterial effectiveness through inhibition zone measurements, Minimum Inhibitory Concentration (MIC), and Minimum Bactericidal Concentration (MBC). Results demonstrated that both the ethanol extract and ethyl acetate fraction exhibited antibacterial activity against Staphylococcus epidermidis. The 25% concentration of the ethyl acetate fraction produced the largest inhibition zone (27.57 mm), followed by the ethanol extract (21.53 mm). Both the ethanol extract and the most active fraction showed MIC values of 1.565%, with the MBC of the ethyl acetate fraction also at 1.565%. These findings suggest that water apple leaves possess promising antibacterial properties, especially in the ethyl acetate fraction, against Staphylococcus epidermidis.leaves (Syzygium aqueum) against the growth of Staphylococcus epidermidis ATCC 12238.
Synergistic Impact of The Combination of Moringa Leaves and Butterfly Pea Flowers Infusion on Cognitive Enhancement Annie Rahmatillah; Anna Fitriawati; Anisa Fadilah Kumala Putri
Jurnal FARMASIMED (JFM) Vol 8 No 1 (2025): Jurnal Farmasimed (JFM)
Publisher : Fakultas Farmasi Institut Kesehatan Medistra Lubuk Pakam

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35451/n9214f64

Abstract

Oxidative stress can induce memory loss, which may be mitigated by antioxidants. Moringa leaves (Moringa oleifera) and butterfly pea flowers (Clitoria ternatea) possess flavonoid chemicals that function as natural antioxidants. This study seeks to evaluate the impact of combined Moringa leaf and butterfly pea flower infusions on enhancing the memory of mice and to identify the optimal dosage. The research utilized male white mice (Mus musculus), categorized into six groups: a normal group, a negative control (aquadest), a positive control (Ginkgo biloba), and three treatment groups receiving various infusion doses. The procedure had three phases: acclimatization (T0), intraperitoneal administration of hyoscine butylbromide (T1), and therapy (T2). The manufacture of INDUK BUNTEL (an infusion of moringa leaves and butterfly pea flowers) was conducted using an infusion extraction method. Testing on test subjects was conducted utilizing the Radial Arm Maze methodology. The findings indicated that the infusion combination at dose III (100 mg/KgBW: 100 mg/KgBW) was the most efficacious in enhancing the memory of mice. The mean mistake rate in mice was 16.44%, representing the lowest score among the treatment groups. The one-way ANOVA test indicated no significant difference across treatment groups with three distinct dose combinations (p > 0.05).
Optimasi Sediaan Lotion dan Uji Aktivitas Antioksidan Ekstrak Etanol Daun Belimbing Wuluh (Averrhoa bilimbi L) Della Puspita Ningrum; Anna Fitriawati; Bagas Ardiyantoro
Jurnal Analis Farmasi Vol 10, No 2 (2025): JURNAL ANALIS FARMASI
Publisher : Universitas Malahayati

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jaf.v10i2.21940

Abstract

Penelitian Antioksidan dan Optimasi formula lotion
Co-Authors Abdul Wahab Sabrina, Azimah Adhe Wibawa Mahardika Putra Agustiningrum, Nurul Alya Atla Lidya Aminnulloh, Muhammad Aminnulloh, Muhhamad Aminulloh, Muhammad Anisa Fadilah Kumala Putri Annie Rahmatillah Bagas Ardiyantoro Bangkit Riska P Bryan Dwi Multi Danang Raharjo Della Puspita Ningrum Diyah Nurayuni Dwi S, Anita Effendi Nursalim Emin Karoba Endang Suciati Hendra, Naufal Dhuha Indi yatno, Aurora Shalfa Alkhariza Karim Karim, Karim Kharisma Jayak P Kharisma Jayak Pratama Krisnantari, Ni Luh Novelia Kusumaningrum, Indah Mega Lestari, Vera Fuji Listyani, Tiara Ajeng Luthfiyanti, Niken Mei Vita Rachma Pertiwi Muhammad Abdul Azis Neha Azziza Cherrysha Alifia Nia Kurniati ningsih, endang wahyu Nurul Agustiningrum Nurul Fatimah Olga Nordeka, Marcela Ones Kotouki P, Kharisma Jayak Peni Indrayudha Permata, Bangkit Riska Pradina Arifah Nurcahyani Pratama, Kharisma Jayak Prity, Intan Qurrota'Ain, Rusyda Raden Rara Anteng Pujowati Rahmad Adji, Alenda Rahmat Hidayat Rahmatillah, Annie Riska P, Bangkit Riztiandi Ardiansyah Rochayati, Popiy Eko Sari, Cantyka Eka Viemala Sari, Sindy Avita Septian Maulid W Septian Maulid Wicahyo siska, Tatiana Tanoyo, William Tatiana Siska Wardani Toyang, Gresilia Wahyu, Rizka Wardani, Lydia Puspita Wardani, Tatiana Siska Wulandari, Diana