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All Journal VALENSI Jurnal Penelitian Pendidikan Indonesian Journal of Tropical and Infectious Disease Jurnal Pendidikan Ekonomi & Bisnis DIJB (Diponegoro International Journal of Business) Jurnal Medik Veteriner Journal of Applied Veterinary Science and Technology Makara Journal of Science Borneo Journal of Pharmacy Biosaintifika: Journal of Biology & Biology Education Svāsthya: Trends in General Medicine and Public Health Indonesian Journal of Jamu Genbinesia Journal of Biology Journal of Strategic Innovation and Business Management
Adi Sofyan Ansori, Muhammad
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Decision Sciences, Operations Research & Management Earth & Planetary Sciences Economics, Econometrics & Finance Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences Veterinary

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Anti-Dengue, Anti-Bacterial, and Cytotoxicity Effect of Psidium guajava Fruit Extract Soares, Engracia Natalia Desena; Sucipto, Teguh Hari; Susetyo, Rizky Danang; Agustini, Rudiana; Damayanti, Mamik; Herdyastuti, Nuniek; Setyawati, Harsasi; Setyarini, Wahyu; Ansori, Arif Nur Muhammad; Hariyono, Hariyono
Indonesian Journal of Tropical and Infectious Disease Vol. 14 No. 1 (2026): January - April Edition
Publisher : Institute of Topical Disease Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/ijtid.v14i1.73075

Abstract

One of the main public health issues with increasing morbidity and mortality rates in tropical countries like Indonesia is dengue hemorrhagic fever (DHF). Antiviral treatments are still unobtainable and the curative value of current vaccines is limited. Many bioactive compounds, including flavonoids and tannins, identified in the tropical fruit Psidium guajava, which are utilized extensively in traditional medicine, have shown possible antiviral, antibacterial, and antioxidant effects. The focus of this research is to determine Psidium guajava extract's antiviral activity against DENV-1, cytotoxic effects on Vero cells, and antibacterial activity towards Escherichia coli. The extract was tested on DENV-1 in Vero cells using the Viral ToxGloTM assay, and the selectivity index (SI) was determined by using the IC50. The  CellTiter 96Ò Aqueous One Solution Cell Proliferation Assay method was applied for cytotoxicity tests, while the disc diffusion method on Mueller-Hinton Agar was utilized for testing the antibacterial effect towards Escherichia coli. With an IC50 value of 67.74 µg/mL, the findings suggest that guava extract effectively inhibits DENV-1 replication. The level of cytotoxicity of this extract against Vero cells showed a good result, namely <200 µg/mL, which can be categorized as moderate cytotoxicity. Also, the Psidium guava extract indicated antibacterial effect against Escherichia coli, at a concentration of 100 mg/mL with an inhibition zone of 4.6 to 5.0 mm. Based on these findings, Psidium guajava extract has the potential to be a natural therapeutic substance with a good safety record towards antiviral, cytotoxicity and antibacterial effects. 
Co-Authors Afnani, Moh. Royhan Agung Ulan Tirta Sari, Anak Aini, Nur Sofiatul Alifiansyah, Mochamad Radika Tory Amaq Fadholly Anggraini, Dhea Arli Aditya Parikesit Asih Kuswardinah Bezhinar, Tatyana Burkov, Pavel Chandra, Nelson DAMAYANTI, MAMIK Dasilva, Jasmine Aulia Deky Aji Suseno, Deky Aji Derkho, Marina Dewi Astriany Dharmawan, Muhammad Alsyifaa Dhea Kharisma, Viol Dian, Farida Aryani Dings, Tim Godefridus Antonius Endang Suprihati Fajilago, Ria Santos Fetty, Amelia Julia Tria Fimaputra, Jatu Maranatha Gudz, Petr Hariyono Hariyono Harsasi Setyawati Herdiansyah, Mochammad Aqilah Hery Purnobasuki Hikam, Agus Mohammad I Gede Widhiantara I Made Gde Sudyadnyana Sandhika Jakhmola, Vikash Joana, Amanda Bernadette Khairullah, Aswin Rafif Kharisma, Viol Dhea Kolesnik, Evgeniy Kurniawan, Muhammad 'Ahdi Kusnoto Kusnoto, Kusnoto Lucia Tri Suwanti, Lucia Tri Maksimiuk, Nikolai Melvia Sundalian Moses, Ikechukwu Benjamin Mufasirin Munawir Sazali Murtadlo, Ahmad Affan Ali Nastiti Wijayanti NI KADEK YUNITA SARI Nuniek Herdyastuti Nurul Jadid Mubarokati Nury Ariani Wulansari Panjaitan, Novaria Sari Dewi Perez, Elizabeth Furio Permatasari , Anak Agung Ayu Putri Poedji Hastutiek Pratama, Bima Putra Priyono, Qiara Amelia Putri Putri, Fadillaisyia Riandani Putu Angga Wiradana R.C. Hidayat Soesilohadi Rahadian Zainul Rasyadan Taufiq Probojati Rebezov, Maksim Riwu, Katty Hendriana Priscilia Rollando, Rollando Rosidah Rosidah Rudiana Agustini Sandy Arief Setyarini, Wahyu Soares, Engracia Natalia Desena Sukirno Sukirno Susetyo, Rizky Danang Sutriyansyah, Riska Ayu Tacharina, Martia Rani Tamam, Muhammad Badrut Teguh Hari Sucipto, Teguh Hari Tri Wibawa Turista, Dora Dayu Rahma Ullah, Md. Emdad Umi Baroroh, Umi Waruwu, Ernawati Wicaksono, Adhityo Widyananda, Muhammad Hermawan Yee, Jonie C. Yulianna Puspitasari Yusniasari, Putri Antika