Claim Missing Document
Check
Articles

Found 2 Documents
Search
Journal : Science and Technology Indonesia

Cholesterol-Lowering Effects of Turmeric Effervescent Dosage in Preventing Atherosclerosis Pomalango, Zulkifli B.; Paneo, Mohamad Aprianto; Pakaya, Nasrun; Aman, La Ode; Hutuba, Ariani H.
Science and Technology Indonesia Vol. 10 No. 2 (2025): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.2.482-492

Abstract

This study aims to evaluate the cholesterol-lowering effects of turmeric (Curcuma domestica) in an effervescent powder drink formulation to prevent atherosclerosis. The effervescent preparation was produced using standard effervescent techniques, with organoleptic tests revealing an orange color, the characteristic aroma of turmeric, and a slightly sweet taste. The formulation’s pH was approximately 5.9, with a flowability test result of 14 seconds, a powder angle of repose of 30°, and a dissolution time of  4 minutes and 20 seconds. Curcumin shows potential as an anticholesterol as a preventive measure of atherosclerosis disease  through molecular docking testing using autodock-vina. Qualitative test on turmeric effervescent with Sprektrofotometer UV-VIS, Scanning Electon Microscopy (SEM) and Fourier Transform Infrared Spectroscopy (FTIR). Cholesterol testing was conducted on mice induced with cholesterol using margarine over a one-week period, resulting in increased cholesterol levels of maximum 290 mg/dL. Following administration of the converted turmeric dosage, cholesterol levels significantly maximum decreased in the first week to  165 mg/dL. By the second week, further reductions were observed, with cholesterol levels maximum dropping to 143 mg/dL. These results suggest that turmeric effervescent formulation exhibits promising cholesterol-lowering properties and may contribute to the prevention of atherosclerosis
Biopotential of Gorontalo Hulu’u Fish (Giuris margaritacea) Albumin in a Novel Spray Gel Formulation for the Treatment of BurnWounds: In Vivo Evaluation in Rats Paneo, Mohamad Aprianto; Djuwarno, Endah Nurrohwinta; Habibie, Sitty Ainsyah; Thomas, Nurain; Latif, Multiani S.; Munafri, Nur Alifia Karina; Anasiru, Rayhan Firman
Science and Technology Indonesia Vol. 11 No. 2 (2026): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2026.11.2.389-404

Abstract

This study aimed to evaluate the efficacy of different concentrations of Hulu’u fish albumin-based spray gels in promoting wound healing in burn injuries in male white rats. The formulations included 10%, 15%, and 20% concentrations of Hulu’u fish albumin, which were compared to a commercial snakehead fish albumin gel (positive control) and a spray gel base without albumin (negative control). Wound diameter reduction was assessed over seven days. The results indicated a clear dose response relationship, with the 20% Hulu’u fish albumin formulation (F3) achieving the most significant reduction in wound diameter, averaging 1.57 mm (range: 1.5–1.6 mm), representing a 91.8% improvement compared to the negative control group, which showed an average reduction of 19.13 mm (range: 18.1–19.7 mm). The Positive Control (snakehead fish albumin gel) demonstrated a moderate reduction with an average of 6.97 mm (range: 6.6–7.6 mm). The 10% Hulu’u fish albumin (F1) and 15% Hulu’u fish albumin (F2) formulations showed moderate improvements, with average reductions of 4.73 mm (range: 4.4–5.1 mm) and 4.5 mm (range: 4.7–3.9 mm), respectively. These findings suggest that higher concentrations of Hulu’u fish albumin, particularly the 20% formulation, offer superior wound healing properties, outperforming both the negative control and the commercial snakehead fish albumin gel. The study highlights the potential of Hulu’u fish albumin as a novel bioactive compound for burn wound treatment and warrants further investigation for clinical applications.
Co-Authors A. Unga, Rani Orelia Abdulkadir, Widi Susanti Anasiru, Rayhan Firman Andi Makkulawu Anggai, Rifka Anggraini ANWAR IBRAHIM, ANWAR Ariani H. Hutuba Arifin, Lutfia Nurfadila Arsyad, Rival Al-fazri Ayu Maloho, Sity Nur Rahayu Maloho Ayuhastuti, Angreni Balikan, Virginia Banne, Pratiwi Zesika Basri, Rakhmadana Fitraeni Cristian Polamolo Djayadi Azis Djayadi Azis Dolih Gozali Dr. Apt. Hamsidar Hasan S.Si.,M.Si Endah Nurrohwinta Djuwarno Faradila Ratu Cindana Fika Nuzul Ramadhani Hiola, Faramita Irmayanti Irmayanti, Irmayanti Ishak Isa Ishak, Siti Magfira Jumantrin, Nur Fitriah Kahar, Oktaviani La Ode Aman LATIF, MULTIANI S Latif, Multiani S. Lihawa, Karmila Madania, Madania Mahdalena Sy Pakaya Makkulawu, Andi Manno, Mohamad Reski Manno, Mohammad Reski Moh. Rivai Nakoe Mohamad Adam Mustapa Moo, Faradila Ratu Cindana Muhammad Taupik Multiani S Latif Mumtazah, Naharil Munafri, Nur Alifia Karina Nani, Indriyati Nasrun Pakaya Nur Ain Thomas Nur Rasdianah Nurain Abdullah Nurkamiden, Firman Nurkamiden, Sri Devi Maharani Pakaya, Nikmasari Palowa, Mohamad Tahir Papeo, Dizky Ramadani Putri Pido, Nur Huda Pratiwi Abdullah Puluhulawa, Lisa Efriani Rahmola, Fauziah Raji, Andre Rasdiana, Nur Rauf, Shalwa Azahrah Rismayani, Nur Robert Tungadi Sabrina, Putri Sabrina, Putri Febbiyanti Serly Daud Sitty Ainsyah Habibie Solang, Wicawati Van Suleman, Putri Rawe Suryadi, A Mu'thi Andy Suryadi, A. Mu'thi Andy Suryadi, A. Mu’thi Andy Suyadi, A. Mu’thi Andy Taofik Rusdiana Teti Sutriyati Tuloli Thamrin, Rahmulia Thomas , Nur Ain Timo, Nur Kharisma Ekaputri Toana, Kadaria Tuloli, Teti Sutriyati Tuloli Sutriyati Widy Susanti Abdulkadir Widy Susanti Abdulkadir Zulkifli B. Pomalango