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UTEROTONIC USE IN THE ACTIVE MANAGEMENT OF THIRD STAGE OF LABOR (AMTSL): SYSTEMATIC REVIEW Putri, Noviyati Rahardjo; Megasari, Anis Laela
Placentum: Jurnal Ilmiah Kesehatan dan Aplikasinya Vol 10, No 1 (2022): February
Publisher : Program Studi Kebidanan Fakultas Kedokteran Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/placentum.v10i1.58438

Abstract

Background: Maternal mortality rate in Indonesia has decreased from 184/100,000 live birth (LB) (2016) to 177/100,000 LB (2017), but this number is still high enough than SDGs target of 70/100,000 LB. The one of direct cause of maternal death is hemorrhage, especially postpartum hemorrhage (PPH). Causes of PPH are uterine atony, laceration of birth canal, resistant placenta and uterine inversion. PPH prevention method is Active Management of Third Stage of Labor (AMTSL). The objective of this systematic review is to analyze the use of uterotonics in AMTSL.Methods: This systematic review used the PRISMA protocol, articles taken from Google Scholar, Science Direct, and Pub Med. The time span of the research article was 2010 to 2021.Result: The results of the study describe that the use of uterotonics in single use or combination in third stage of labor can reduce the risk of PPH and shorten the time of the stage. The side effects were reported in misoprostol and methyl ergometrine than oxytocin. In addition, combination therapy with oxytocin and misoprostol can reduce the length of the third stage and the potential for a decrease in hemoglobin within 24 hours of delivery. In Indonesia, if oxytocin is not available, maternal nipple stimulation is performed as nonpharmacological therapy or ergometrine 0.2 mg is given to patients without complications of high blood pressure.Conclusion: The use of uterotonics is adjusted to its cost-effectiveness, ability to store and refrigerate also the benefits compare to the side effects to the patients.
Co-Authors Agus Winarno, Agus Aji Saputra Arief, Khumaidi Aripa, Lusyana Ashani, Nayla Asri Yusviputri Ayatullah Ayatullah, Ayatullah Betan, Abu Bakar Cahya, Mochamad Robby Fajar Cahyani, Nurfadila Cahyanto, Erindra Budi Ciami, Ciami Dewi, Mariza Mustika Erindra Budi Fatma Risda Hidayanti Fatsena, Rizka Adela Firdaus, Haya Abkarin Fitri Andriani, Fitri Fitriana, Azizah Nur Fitriana, Fia Fresthy Astrika Yunita GONSALVES, DOMINGGOS Hardianti Hardianti, Hardianti hardiningsih, hardiningsih Hilal, Achmad Hutomo, Cahyaning Setyo Ika Subekti Wulandari Ika Subekti Wulandari, Ika Subekti Islaeli, Islaeli Islameytha, Ghizela Vanya Kanthi Suratih Kartikasari, M Nur Dewi Kurniawati Kurniawati Kusmawati, Iffah Indri Lahru Riatma, Darmawan Laisouw, Meilany Larasati, Disa M. Nur Dewi Kartikasari Mahendika, Devin Mahoklory, Serly Sani Malawat, Ratna Masbahah Maula, Sheyla Najwatul Mesa, Novita Dewi Kok Mutiah, Cut Ningrum, Dita Cahaya Noviantari, Yonanda Regita Oktavia, Elsa Maulana Pannyiwi, Rahmat Parwatiningsih, Sri Anggarini Pella, Yosin Herloheti Putri, Noviyati Rahardjo Putri, Safridha Kemala Putri, Yaasmiin Dzakiyyah Nesya Rahardjo Putri, Noviyati Rahayu, Umi Margi Rahmah, Ulinuha Aufa Ramadhani, Aura Kamilla Rizka Adela Fatsena Ropitasari Ropitasari Safridha Kemala Putri Sari, Ropita Setiawan, Ahmad Eri Siswiyanti, Ikha Siti Khuzaiyah, Siti Sri Mulyani Sri Mulyani Sri Wahyuni Suat, Hatty Supriyatno, Abigael Thea Rahmany Susilowati, Amanda Bintang Tri Budi Santoso Tri Widodo Ubaydillah, Mahfudh Wachyudi Muchsin Wahyuningtias, Anggita Galuh Ajeng Wijaya, Ghaitsa Aulia Sakinah Wiranti, Bhakti YANTI, PENTI DORA Yunanda, Eka Yunifah Yunifah Yusviputri, Nayla Asri